Identification et caractérisation de nouveaux facteurs de virulence de <i>Listeria monocytogenes</i>
A. Toledo-Arana et al. (2007). Current Opinion in Microbiology, 10:182–188
Mechanisms of action of sRNAs controlling virulence. (a) Translation activation by sRNA–mRNA hybrid formation. Stem–loop structure blocks the translation of the hla mRNA by occluding the RBS. RNAIII hybridizes to the anti-RBS region of the mRNA, desequestering the RBS. (b) Translation repression by sRNA–mRNA hybrid formation. The sRNA hybridizes to the RBS region, repressing translation by occluding the RBS and promoting mRNA degradation. (c) Translation modulation by protein sequestration. CsrA (or RsmA) family proteins are translation regulators binding to the RBS region of mRNAs. Csr (or Rsm) sRNAs have several stem–loop structures mimicking the RBS regions recognized by CsrA (or RsmA) proteins. Csr (or Rsm) sRNAs sequester and antagonize CsrA (or RsmA) proteins.