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Identification et caractérisation de nouveaux facteurs de virulence de Listeria monocytogenes

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H. Bierne, Adapted from S.K. Mazmanian

L. monocytogenes expresses surface proteins that have critical roles in host-bacterium interactions. Surface proteins harboring a C-terminal sorting signal with an LPXTG motif are covalently linked to the cell wall peptidoglycan by a transamidase named sortase. Two genes encoding putative sortases, termed srtA and srtB, were identified in the Listeria genome.