Images

Figure from Pizarro-Cerda J, Cossart P. J Pathol. 2006 Jan;208(2):215-23.

Figure 2. The InlA-invasion pathway. A. Schematic model of the main molecules required for the internalization of L. monocytogenes via the InlA-invasion pathway: InlA interacts with its receptor E-cadherin, which recruits b and a catenin molecules to its cytoskeletal tail. This latter catenin interacts with actin, but also recruits the Rho GAP protein ARHGAP10, which is involved in the recruitment of vezatin and the unconventional myosin VIIA to the bacterial entry site, providing the motor force to internalize the bacteria by phagocytosis. B. Immunofluorescence showing the recruitment of the b (green) and a (red) catenins (overlay: yellow) to the entry site of L. monocytogenes (rod shape) in the human polarized intestinal cell line Caco-2. Co-localization of these molecules in the cellular adherens junctions is also observed (reprinted from reference 87).