Biologie cellulaire de l'infection par <i>Listeria monocytogenes</i>
Figure from Pizarro-Cerda J, Cossart P. J Pathol. 2006 Jan;208(2):215-23.
Figure 1. The intracellular cycle of L. monocytogenes. L. monocytogenes is able to induce its entry into target cells mainly by the activity of two invasion proteins, InlA and InlB (1). The bacteria are initially trapped within a phagocytic vacuole (2), but through the activity of the hAemolysin LLO and two other phospholipases the parasite-containing compartment is lysed. (3). Once in the cytoplasm, the freed bacteria are able to multiply and also to polymerize cellular actin (4). L. monocytogenes moves inside the cytosol of infected cells thanks to the actin-based motility system, until it encounters the plasma membrane of the infected cell: the bacteria then push this membrane and create an invagination in the membrane of a neighbouring cell, invading it (5). The bacteria are then found in a double membrane-bound compartment (6): these membranes are lysed again due to the activity of LLO and the phospholipases (7), and L. monocytogenes is ready to start a new infection cycle.