Curriculum vitae Marc Lecuit


Marc LECUIT, MD PhD

Institut Pasteur, Biology of Infection Unit
U1117
28, rue du Dr Roux
75015 Paris-France
Phone: 33 1 40 61 30 29
Fax: 33 1 40 61 34 21
E-mail: marc.lecuit@pasteur.fr

Current Position

Head of the Biology of Infection Unit, Institut Pasteur
Head of the Inserm U1117 Unit
Head of the French National Reference Center and WHO Collaborating Center on Listeria, Institut Pasteur

Professor of Medicine, Infectious Diseases and Tropical Medicine
Paris Descartes University, Sorbonne Paris Cité, Institut Imagine

Necker–Enfants Malades University Hospital
Division of Infectious Diseases and Tropical Medicine
Necker-Pasteur Center for Infectious Diseases
Assistance Publique–Hôpitaux de Paris

Medical Education

1985-1991     6 year-MD Degree program,
                     
Cochin Port-Royal Medical School, Paris Descartes University
1991              Ranking National Exam (concours de l'Internat), Paris, Ile de France
1991-2001     Medical Internship and Residency Program in Paris Hospitals
                      Assistance Publique-Hôpitaux de Paris
2002              MD Thesis, Internal Medicine,
Infectious Diseases and Tropical Medicine
                     
Paris Descartes University

Scientific Education

1993              Degree in Microbiology (Maîtrise), Paris Creteil University
1996              Master in Microbiology (DEA),
Institut Pasteur and Paris Diderot University
1997-2001     Ph.D. in Microbiology, Institut Pasteur and
Paris Diderot University
2004              Ability to supervise research, Paris Descartes University

Past Activity

1993-1995    Virology Unit (E. Chungue, PhD), Pasteur Institute of French Polynesia
                     Institut Louis Malardé
1995-2002    Bacteria-Cells Interactions Unit (P. Cossart, PhD, Head)
                     Institut Pasteur, Paris
2002-2003    Molecular Biology and Pharmacology Department, (J. I. Gordon, MD, Head),

                     Washington University, Saint Louis, MO, USA
2004-2005    Inserm U604, (P. Cossart, PhD, Head), Department of Cell Biology and Infection,
                     Institut Pasteur, Paris
                     Fellow, Department of Infectious Diseases and Tropical Medicine,
                     Necker-Enfants malades hospital, Assistance Publique– Hôpitaux de Paris
                     and Paris Descartes University
Since 2006  Group leader, Inserm
                     Full professorship, Paris Descartes University and Necker-Enfants malades Hospital
Since 2008  Group leader, Institut Pasteur
Since 2013  Head of Unit, Institut Pasteur
Since 2013  Head of Unit, Inserm

Teaching Activity

1993-1998    Courses for Interns in Infectious Diseases, Laennec Center, Paris
1998-2002    
Course in Microbiology,  Institut Pasteur, Paris
Since 2004  
Courses in Infectious Diseases and Microbiology, Paris Descartes University Medical School
Since 2004  
Research adviser of 4 PhD students and 4 Post doctoral fellows

Awards

1999    Research Prize in Nutrition CIDEF (1999)
2000   
Gold Medal of the Residency Program (Médaille d’Or du Concours de Médecine de l’Internat)
2001   
Prix Jean Valade Fondation de France
2002   
EMBO Long-Term Fellowship Award
2002   
Philippe Foundation Award
2003   
Research Award of the College of Professors of Infectious and Tropical Diseases (CMIT)
2004   
European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Young Investigator Award
2005   
Franco-British Prize of the Académie des Sciences and the Royal Society
2006    Inserm "Equipe avenir" award
2008    Institut Pasteur "Groupe à 5 ans" award
2009    Fondation pour la recherche médicale "Equipe" award
2009    Ville de Paris "Equipe" award
2009    Grand Prix Jean Hamburger de la Ville de Paris
2010    Médaille Louis Pasteur, Académie des Sciences
2010    ERC Starting Independent Researcher Grant

Other
- Member of the Faculty of 1000 Biology, Section Microbiology, Cellular microbiology & pathogenesis
- Member of the American Society for Microbiology, the American Society for Cell Biology and
of the European Society of Clinical Microbiology and Infectious Diseases
- Member of the CEREDIH, National Reference Center for Hereditary Immunodeficiencies
-
Member of the scientific advisory board of the “Cochin-Pasteur Clinical Investigation Center in Vaccinology”
- Member of the Necker–Pasteur Center for Infectious Diseases
- Since 2007: Member of the steering committee of the “National prospective survey on encephalitis” coordinated by the InVS
- 2007-2011: Member of European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Scientific Advisory Subcommittee
- 2007-2008:
Member of European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Award Subcommittee
- 2010-2011:
Member of European Society of Clinical Microbiology and Infectious Diseases (ESCMID) program Committee
- 2013: Member of the Expert advisory board of the "Institut de Microbiologie et des Maladies Infectieuses" Aviesan


20 most significant publications

Senior authorships is underlined, 145 entries in PubMed, h-index 35 (ISI web of science, Feb 2013).

Travier L, Guadagnini S, Gouin E, Dufour A, Chenal-Francisque V, Cossart P, Olivo-Marin JC, Ghigo JM, Disson O, Lecuit M
ActA promotes Listeria monocytogenes aggregation, intestinal colonization and carriage
PLOS pathog, 2013;9(1):e1003131

Archambaud C, Nahori MA, Soubigou G, Bécavin C, Laval L, Lechat P, Smkvina T, Langella P, Lecuit M, Cossart P
Impact of lactobacilli on orally acquired listeriosis
Proc Natl Acad Sci U S A. 2012;109(41):16684-9

Nikitas G, Deschamps C, Disson O, Niault T, Cossart P, Lecuit M
Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin
J Exp Med. 2011 Oct 3. 

Tazi A, Disson O, Bellais S, Bouaboud A, Dmytruk N, Dramsi S, Mistou M-Y, Mechler C, Khun H, Tardieux I, Trieu-Cuot P, Lecuit M
, Poyart C

The surface protein HvgA mediates Group B streptococcus hypervirulence and meningeal tropism in neonates

J Exp Med. 2010 Oct 25;207(11):2313-22.

 

Schilte C, Couderc T, Chrétien F, Sourisseau M, Gangneux N, Guivel-Benhassine F, Gruber A, Tschopp J, Higgs S, Michault A, Arenzana-Seisdedos F, Colonna M, Schwartz O, Lecuit M, Albert M.

Type I IFN controls chikungunya virus via its action on non-hematopoetic cells

J Exp Med. 2010 Feb 15;207(2):429-42.


Toledo-Arana A, Dussurget O, Nikitas G, Sesto N, Guet-Revillet H, Balestrino D, Loh E, Gripenland J, Tiensuu T, Vaitkevicius K, Barthelemy M, Vergassola M, Nahori M-A, Soubigou G, Régnault B, Coppée J-Y, Lecuit M, Johansson J, Cossart P

The Listeria transcriptional landscape from saprophytism to virulence

Nature. 2009 Jun 18;459(7249):950-6.


Disson O, Grayo S, Huillet E, Nikitas G, Langa-Vives F, Dussurget O, Ragon M, Le Monnier A, Babinet C, Cossart P, Lecuit M
Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis
Nature, 2008, 455(7216):1114-8.


Couderc T, Chrétien F,Schilte C, Disson O, Brigitte M, Guivel-Benhassine F, Touret Y, Barau G, Prévost MC, Schuffenecker I, Desprès P, Arenzana-Seisdedos F, Michault A, Albert ML, Lecuit M
A mouse model for Chikungunya infection: young age and inefficient type-I interferon signaling are risk factors for severe disease
PLoS Pathog, 2008. 4(2): p. e29.

Gérardin P, Barau G, Michault A, Bintner M, Randrianaivo H, Choker G, Lenglet Y, Touret Y, Bouveret A, Grivard P, Le Roux K, Blanc S, Schuffenecker I, Couderc T, Arenzana-Seisdedos F, Lecuit M, Robillard PY Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La Réunion
PLoS Medicine, 2008. 5(3): p. e60.

Boneca IG, Dussurget O, Cabanes D, Nahori MA, Sousa S, Lecuit M, Psylinakis E, Bouriotis V, Hugot JP, Giovannini M, Coyle A, Bertin J, Namane A, Rousselle JC, Cayet N, Prevost MC, Balloy V, Chignard M, Philpott DJ, Cossart P, Girardin SE.
A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system.
Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):997-1002.

Sousa S, Cabanes D, Archambaud C, Colland F, Lemichez E, Popoff M, Boisson-Dupuis S, Gouin E, Lecuit M, Legrain P, Cossart P.
ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion.
Nat Cell Biol. 2005 Oct;7(10):954-60.

Cabanes D, Sousa S, Cebria A, Lecuit M, Garcia-del Portillo F, Cossart P.
Gp96 is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein.
EMBO J. 2005 Aug 3;24(15):2827-38.

Jacquet C, Doumith M, Gordon JI, Martin PM, Cossart P, Lecuit M.
A molecular marker for evaluating the pathogenic potential of foodborne Listeria monocytogenes.
J Infect Dis. 2004 Jun 1;189(11):2094-100.

Sousa S, Cabanes D, El-Amraoui A, Petit C, Lecuit M, Cossart P
Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells
J Cell Sci. 2004 Apr 15;117(Pt 10):2121-30


Lecuit M
, Nelson DM, Smith SD, Khun H, Huerre M, Vacher-Lavenu MC, Gordon JI, Cossart P.
Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin.
Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6152-7.

Lecuit M, Abachin E, Martin A, Poyart C, Pochart P, Suarez F, Bengoufa D, Feuillard J, Lavergne A, Gordon JI, Berche P, Guillevin L, Lortholary O.
Immunoproliferative small intestinal disease associated with Campylobacter jejuni.
N Engl J Med. 2004 Jan 15;350(3):239-48.

Lecuit M, Vandormael-Pournin S, Lefort J, Huerre M, Gounon P, Dupuy C, Babinet C, Cossart P.
A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier.
Science. 2001 Jun 1;292(5522):1722-5.

Kussel-Andermann P, El-Amraoui A, Safieddine S, Nouaille S, Perfettini I, Lecuit M, Cossart P, Wolfrum U, Petit C.
Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex.
EMBO J. 2000 Nov 15;19(22):6020-9.

Lecuit M, Hurme R, Pizarro-Cerda J, Ohayon H, Geiger B, Cossart P.
A role for alpha-and beta-catenins in bacterial uptake.
Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10008-13.

Lecuit M, Dramsi S, Gottardi C, Fedor-Chaiken M, Gumbiner B, Cossart P.
A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes.
EMBO J. 1999 Jul 15;18(14):3956-63.