Statistical and Mathematical Modeling in Biological Applications
|
The seminar series Statistical and Mathematical Modeling in Biological Applications (SaMMBA) features monthly lectures and discussions with leading modelers in biological sciences. Presentations are in English or French and target an interdisciplinary audience. Seminars are held on the campus of Institut Pasteur. Access is free. However, to enter the campus, one needs a badge that is obtained at the main gate in exchange of a piece of ID (passport, citizen card or driver licence).
For additional information about the series contact the organizers: Pierre-Yves Böelle, Romulus Breban, Vittoria Colizza, Judith Legrand, Virginie Supervie, Laura Temime and Elisabeta Vergu. To arrange to meet with an invited speaker, contact the host of that speaker.
|
Next Lecture
|
On the use of mechanistic models for HIV clinical trials Abstract: Mechanistic models are mathematical models defined according to biological processes and most often based on a set of differential equations. These models have first been applied in HIV infection in mid-nineties revealing the very high turnover of the virus and of the CD4+ T cells. The improvement of statistical methods to estimate parameters has allowed to use this type of models with more sparse data. Here we show how these models can be useful to analyse data from clinical trials evaluating antiretrovirals or immunotherapies. In addition to quantify the effect of an intervention, they provide very good individual predictions. A next step is the use of these models to design new clinical trials or for treatment monitoring. We show applications with real clinical trials involving antiretrovirals and/or exogeneous cytokines. Contact: Romulus BREBAN |
Full Schedule 2012-2013
|
Cost-effectiveness of diacetylmorphine versus methadone for chronic opioid dependence refractory to treatment |
Wed, Sep 12th, 2012
12 noon -1 pm |
||
|
Epidémie cachée du VIH : Que peut-on apprendre des modèles |
Tue, Oct 16th, 2012
12 noon -1 pm |
||
|
Adaptive constraints at the genomic and genic level in E. coli |
Tue, Nov 6th, 2012
12 noon -1 pm |
||
|
Trends of pneumococcal meningitis: unmasking the role of winter viruses and antimicrobial drugs |
|||
|
On the use of mechanistic models for HIV clinical trials |
Tue, Jan 8th, 2013
12 noon -1 pm Room Jean-Paul Aubert |
||
|
|
|
|
Tue, Feb 5th, 2013
12 noon -1 pm Room Jean-Paul Aubert |
|
Challenges for statistical modelling during the STEC/HUS outbreak in Germany, 2011 |
|
||
|
TBA |
|
||
|
TBA |
|
||
|
Vaccine scares and the interplay between disease dynamics and strategic individual vaccinating choices |
|
