Teaching / Mechanisms of Living Organisms

Mouse Genetics 2011-2012


     Directors :

   Dr Xavier Montagutelli
   Mouse Fonctional Genetics Unit,
   Institut Pasteur

   Pr Jean-Jacques Panthier
   Mouse Fonctional Genetics Unit,
   Institut Pasteur
   Alfort Veterinary Medical School
   

 

Candidates must have a good knowledge of Molecular Biology and Genetics, equivalent to a Master level. This course is also intended for research scientists and PhD students who already have laboratory experience.

This course will be taught in French.


This course provides training in the most topical areas of mouse Genetics. It concentrates on analysis of gene function at all levels: the gene and its product, the cell and cellular interactions, embryonic tissues and the entire animal.
The theoretical part of this course deals, in particular, with the early embryo biology, pluripotent stem cells, cellular and molecular mechanisms controling embryogenesis and methods to study cell lineage in mouse embryos, gene inactivation and conditional expression systems for transgenes, the role of small RNAs, and genetic analysis of mendelian and complex traits.
The practical part teaches students methods and techniques that will allow them to derive induced pluripotent stem cells (iPS) from differentiated cells, to study behavioral traits and to analyze gene function in embryonic and adult mutants, to map mendelian traits and perform positional cloning, and to identify QTLs. They illustrate the use of RNA interference to silence gene expression.

Full-time, except Saturdays, from January 09, to February 14, 2012 (examinations included)
Number of students: 12
Closing-date for applications: September 06, 2011


Diplomas:

The Institut Pasteur Diploma will be awarded to students having successfully completed the final examination,

This course is run in agreement with the Université Pierre et Marie Curie and Paris-Diderot and a University Diploma may also be granted,

Credits for Masters (second year) from Universités Paris-Descartes, Pierre et Marie Curie and Paris-Diderot,  for students registered at this universities (masters).

 

Members of the Teaching Committee:

J. Aghion* (Université Paris-Diderot), E. Coeffier (Institut Pasteur), J.-L. Guénet, X. Montagutelli (Institut Pasteur), O. Ozier-Kalogeropoulos (Institut Pasteur/ Université P. et M. Curie), C. Parsot (Institut Pasteur), J.-J. Panthier* (Institut Pasteur, Ecole Nationale Vétérinaire d’Alfort), B. Robert (Institut Pasteur), J.-P. Rousset* (Université Paris-Sud 11), F. Toledo*(Université P. et M. Curie).

* University Representatives

Lecturers:

MM. Joël AGHION, Christophe ANTONIEWSKI, Mme Geneviève AUBIN-HOUZELSTEIN, MM. Boris BARDOT, Fabrice CHRETIEN, Mme Constance CIAUDO, M. Michel COHEN-TANNOUDJI, Mme Dominique DAEGELEN, MM. Bernard de MASSY, Simon FOOTE, Mme Sylvie GRANON-CRESSANT, MM. Jean-Louis GUENET, Yann HERAULT, Frédéric JAISSER, Jean JAUBERT, Yvan LALLEMAND, Jean-François LE GARREC, Jean LIVET, Mme Sigolène MEILHAC, MM. Xavier MONTAGUTELLI, Andras PALDI, Jean-Jacques PANTHIER, Fernando PARDO MANUEL DE VILLENA, Benoît ROBERT, Mme Céline ROBERT, MM. Jean-Pierre ROUSSET, Nicolas TORQUET, Franck TOLEDO, Mme Diana TRONIK-LE ROUX.