Dr Andrès Alcover
Lymphocyte Cell Biology Unit,
Pr Antonio Freitas
Lymphocyte Population Biology Unit,
Head of Studies :
Dr François Huetz
Lymphocyte Population Biology Unit,
This five-week intensive laboratory and lecture course imparts advanced teaching on major topics in Cellular and Molecular Immunology.
The main course comprises:
- Three weeks of state of the art laboratory practical course are meant to introduce students to a research subject investigated by a variety of experimental approaches. It focuses on the characterization of two functions of the AID protein (Activation Induced Cytidine Deaminase) in B cells: isotypic switch and somatic hypermutation.These roles of AID will be studied in B cells from wild type or AID-KO mice by FACS, ELISA analyses, reporter gene transfection assays, siRNA silencing, sequencing genes undergoing somatic hypermutation and real-time PCR. Some experiments are carried out in the BSL2+ facility of the Institut Pasteur Center for Human Immunology (CIH)
- Two weeks of lectures dealing with advanced studies on major topics in cellular and molecular immunology, such as: development of the immune system, lymphocyte differentiation, molecular basis of antigen recognition by B and T lymphocytes, repertoire selection, lymphocyte homeostasis, tolerance, cellular communication, immune responses, innate immunity and various aspects of immunopathology
- Three days of thematic bibliography analysis seminars, given early January by groups of students and supervised by two senior scientists. These seminars are mandatory for students enrolled in Master programs and optional for other participants.
The program of the course organized the previous year can be downloaded (pdf file, 400 Ko) to get detailed information on the general frame of the course; some topics and practical works may change each year, without altering the general aims and means of the course.
1) Since Type-2 Biosafety laboratory facilities will be used during the course, students’ updated tetanos and hepatitis B vaccination certificates are required.
2) The course requires the students’ personal work during evenings and weekends. Students are asked not to take any engagements in that period of time. For instance, MDs or Pharmacists are asked to get no hospital duties during the period of the course, including during the bibliography seminars week.
3) Candidates must have a good knowledge in biochemistry, molecular biology and genetics, as well as a performing first year master level in immunology (or equivalent).
4) Students should have good knowledge of English language to be able to understand full lectures, ask questions and deliver the bibliography analysis seminar in English. Understanding of French language is useful, but not mandatory, for daily interactions.
5) Students not enrolled in Paris Universities’ Master Programs will have the final exam and finish the course on Saturday after the last lecture. These students may make the thematic bibliography analysis presentations during the workshop type lectures.
The committee of the course will evaluate applications.
Full-time, Saturdays included, from november 18th, 2013 to december 20th, 2013
From November 18th, to December 20th, 2013 for students following the Institut Pasteur Course only.
December 21st : exam for students not enrolled in a Paris universities Master-2 program.The students enrolled in University Master Programs will have the exam and the thematic bibliography seminars from January 6 to 10, 2014.
Number of students: 24
Closing-date for applications: June 15th, 2013 (online registration)
The Institut Pasteur Diploma will be awarded to students having successfully completed the final examination,
This course is run in agreement with the Université Pierre et Marie Curie and Paris-Diderot and a University Diploma may also be granted,
Credits for Masters (second year) from Universités Paris-Descartes, Pierre et Marie Curie and Paris-Diderot, for students registered at this universities (masters).
Students enrolled in Immunology Programs: Advanced Immunology (Immunologie Approfondie) or Physiopathology of Immune Responses will follow two weeks of “Introduction to Immunology” at the University before starting the Institut Pasteur course.Doctoral School Modules.
Members of the Teaching Committee:
A. Alcover (Institut Pasteur), E. Coeffier (Institut Pasteur), A. Freitas (Institut Pasteur), C. Fridman* (Université Paris-Descartes), F. Huetz (Institut Pasteur), C. Parsot (Institut Pasteur), A. Six* (Université P. et M. Curie), M. Viguier* (Université Paris-Diderot), A. Zider (Université Paris-Diderot).
* University Representatives
M. Albert, A. Alcover, A. Bandeira, T. Boehm, I. Boneca C. Bourgeois, P. Bousso, M. Cavazzana-Calvo, A. Cumano, G. Dadaglio, M. Daëron, V. Di Bartolo, J. Di Santo, L. Du Pasquier, G. Eberl, A. Fischer, A. Freitas, M. Goodhardt, A. Hayday, M. Heikenwaelder, L. Klein, R. Lasserre, C. Leclerc, J. P. Levraud, L. Majlessi, R. Mebius, P. Pereira, J. M. Reichhart, C. A. Reynaud, B. Rocha, H.-R. Rodewald, O. Schwartz, C. Tanchot, J. P. de Villartay, N. Van Baren, M. Veldhoen, C. Vosshenrich.