Medical Bacteriology

Directors : Pr. Alain Philippon Faculty of Medicine Paris René Descartes Dr Patrick Trieu-Cuot Biology of Gram-positive Pathogens Unit, Institut Pasteur Head of Studies : Dr Martine Kiredjian Fungi Culture Collection, Institut Pasteur

Candidates must have a good knowledge of genetics, molecular biology and biochemistry, equivalent to a Master level.
This course will be taught in French.
The specificity of the course consists in combining bench practical work with an in-depth analysis of genomic data in silico.
Lectures will address the fundamental aspects of genomics (structure and comparison of genomes, analysis of transcriptomes and proteomes), examples of medical and biotechnological applications.
Practical classes will include three parts:
1. Use of computing tools, in silico analysis of genome sequences and annotations, comparative genomics and molecular phylogeny.
2. Functional genomics by RNA interference (RNAi) in the ciliate Paramecium tetraurelia.
3. Basic and applied studies of genome instability in the yeast Saccharomyces cerevisiae with a focus on spontaneous duplications of large chromosomal fragments, genes involved in expansion and contraction of DNA tandem repeats, use of microsatellites for strain genotyping.


* Full-time, except Saturdays, February 16, to April 10, 2009 – examinations included
• This course is run every other year
* Number of students: 24
* Closing-date for applications: November 22, 2008



Diplomas:

The Institut Pasteur Diploma will be awarded to students having successfully completed the final examination,

This course is run in agreement with the Université Pierre et Marie Curie-Paris 6 and Denis Diderot-Paris 7 and a University Diploma may also be granted,

"Mastère spécialisé" for the Ecole Pasteur/Cnam in public Health

Members of the Teaching Committee:

J.-M. Alonso (Institut Pasteur), A. Andremont* (Université D. Diderot-Paris 7), E. Coeffier-Vicart (Institut Pasteur), L. Gutmann* (Université P. et M. Curie-Paris 6), M. Kiredjian (Institut Pasteur), A. Klier* (Université D. Diderot-Paris 7), O. Ozier-Kalogeropoulos (Institut Pasteur/ Université P. et M. Curie-Paris 6), A. Philippon (Faculté de Médecine Cochin/Port-Royal), C. Poyart (Faculté de Médecine Cochin/Port-Royal), I. Saint Girons (Institut Pasteur), P. Trieu-Cuot (Institut Pasteur).

* University Representatives

Lecturers:
A. Andremont, G. Arlet, M-C. Bébear, F. Barbut, P. Berche, C. Bizet, P. Boiron, H-. Boulouis, O. Bouvet, S. Brisse, E. Carbonelle, J-P. Carlier, O. Chesneau, M. Cornet, L. Dubreuil, I. Filliol, P. E. Fournier, O. Gaillot, B. Garin-Bastuji, P. Glaser, P. Grimont, N. Guiso, M-C. Gutierrez, V. Jarlier, S. Jarraud, B. Jaulhac, M-L. Joly-Guillou, R. Leclercq, M. Lecuit, A. Le Monnier, J-L. Mainardi, H. Marchandin, P. Mariani, F. Mégraud, A. Morvan, M-H. Nicolas-Chanoine, P. Nordmann, P. Plesiat, I. Podglajen, M-R. Popoff, C. Poyart, M-L. Quilici, J.Raymond, P. Riegel, C. Scieux, M. Simonet, C-J. Soussy, M-K. Taha, P. Trieu-Cuot, F. Vandenesch,V. Vincent, F-X. Weill.