Genome Analysis
Directors : Pr Bernard Dujon Yeast Molecular Genetics Unit, Institut Pasteur Dr Odile Ozier-Kalogeropoulos Yeast Molecular Genetics Unit, Institut Pasteur Heads of Studies : Dr Lionel Frangeul Genome Analisis and Integration, Institut Pasteur |
Candidates must have a good knowledge of genetics, molecular biology and biochemistry, equivalent to a Master level.
This course will be taught in French.
The specificity of the course consists in combining bench practical work with an in-depth analysis of genomic data in silico.
Lectures will address the fundamental aspects of genomics (structure and comparison of genomes, analysis of transcriptomes and proteomes), examples of medical and biotechnological applications.
Practical classes will include three parts:
1. Use of computing tools, in silico analysis of genome sequences and annotations, comparative genomics and molecular phylogeny.
2. Functional genomics by RNA interference (RNAi) in the ciliate Paramecium tetraurelia.
3. Basic and applied studies of genome instability in the yeast Saccharomyces cerevisiae with a focus on spontaneous duplications of large chromosomal fragments, genes involved in expansion and contraction of DNA tandem repeats, use of microsatellites for strain genotyping.
* Full-time, November 3, to December 19, 2008 (examinations: December 15 to 19, 2008)
* Number of students: 20
* Closing-date for applications: June 22, 2008
Laboratory courses:
Laboratory courses are organized by:
- Unit of molecular genetics of yeasts, Institut Pasteur
- Group of Genetics of Cellular Dynamics in Paramecium, Centre de Génétique Moléculaire, CNRS, Gif sur Yvette
- Pasteur Genopole (platforms of Genomics, DNA Micro-arrays, Genome Analysis and Integration, Proteomics)
- Group of Biological Software and Databases; group of Systems and Network
Diplomas:
The Institut Pasteur Diploma will be awarded to students having successfully completed the final examination,
This course is run in agreement with the Université Pierre et Marie Curie-Paris 6 and Denis Diderot-Paris 7 and a University Diploma may also be granted,
Credits for Masters (second year) from Universités René Descartes-Paris5, Pierre et Marie Curie-Paris 6, Denis Diderot-Paris 7, Orsay-Paris11 and Versailles Saint-Quentin, for students registered at this universities (masters),
Module(s) from Doctoral Schools (modules)
Members of the Teaching Committee:
G. Achaz*(Université P. et M. Curie-Paris 6), E. Coeffier-Vicart (Institut Pasteur), A. Ducruix* (Faculté de Pharmacie, Université R. Descartes-Paris 5), B. Dujon (Institut Pasteur/Université P. et M. Curie-Paris 6), R.A. Veitia* (Université D. Diderot-Paris 7), F. Devaux (Ecole normale supérieure, Paris), H. de Reuse (Institut Pasteur), B. Limbourg-Bouchon* (Université Versailles Saint-Quentin), R. Mastrippolito (Université Paris-Sud 11), C. Medigue (Génoscope), O. Ozier-Kalogeropoulos (Institut Pasteur/Université P. et M. Curie-Paris 6), A. Sainsard-Chanet* (Université Paris-Sud 11), I. Saint Girons (Institut Pasteur)
* University Representatives
Lecturers (preliminary list):
C. Antoniewski, C. Buschrieser, A. Danchin, H. de Reuse, S. Duharcourt, A. Ducruix, L. Duret, G. Lelandais, C. Medigue, C. Neuveglise, L. Quintana-Murci, F. Radvanyi, H. Roest-Crollius, B. Seraphin, T. Vallaeys et S. Wain-Hobson.