Team / Members

Unité de Virologie Structurale


 
   Giovanna Barba-Spaeth, PhD
   Researcher IP
   Curriculum vitae







Dr. Barba-Spaeth earned her B.S. and M.S from the University of Palermo in Italy in Biology and Pathology, respectively. She pursued graduate work at the University of Mainz, Germany and received her Ph.D. in 1994 in immunogenetics. She trained as a postdoctoral fellow from 1994-1998 at the University of Paris V, France, in the laboratory of Christian Brechot and from 1998-2001 at Washington University in St.Louis, USA, in the laboratory of Charles Rice. From 2001-2005 she followed Dr. Rice as staff faculty at Rockefeller University in New York, USA before joining the Rey laboratory in 2005.

Dr. Barba-Spaeth is studying the yellow fever virus vaccine strain 17D. In particular she is interested in understanding, through a comparison with the wild type strain YF Asibi, the structural and molecular basis of YF17D attenuation. In collaboration with Dr. Jean Lepault (CNRS, Gif-sur-Yvette) she studies the process of fusion on infectious virus by cryomicroscopy.
In addition, taking advantage from the remarkable immunogenicity of 17D, Dr. Barba-Spaeth is designing recombinant viruses expressing antigens of Plasmodium falciparum, to generate dual vaccines targeting pediatric population in which yellow fever and malaria are endemic. This work is done in collaboration with Jim Di Santo (immunology) and Robert Ménard (Parasitology).


Book chapter

Giovanna Barba-Spaeth*, Catherine L. Murray, Charles M. Rice. Hepacivirus. The Springer Index of Viruses. Christian Tidona and Gholamreza Darai editors. 2001. Second edition 2010. *corresponding author.

Articles

Stoyanov CT, Boscardin SB, Deroubaix S, Barba-Spaeth G, Franco D, Nussenzweig RS, Nussenzweig M, Rice CM.
Immunogenicity and protective efficacy of a recombinant yellow fever vaccine against the murine malarial parasite Plasmodium yoelii. Vaccine. 2010 Jun 23;28(29):4644-52.

Marcello T, Grakoui A, Barba-Spaeth G, Machlin ES, Kotenko SV, MacDonald MR, Rice CM.
Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics.
Gastroenterology. 2006 Dec;131(6):1887-98.

Barba-Spaeth G, Longman RS, Albert ML, Rice CM.
Live attenuated yellow fever 17D infects human DCs and allows for presentation of endogenous and recombinant T cell epitopes.
J Exp Med. 2005 Nov 7;202(9):1179-84.

Tao D, Barba-Spaeth G, Rai U, Nussenzweig V, Rice CM, Nussenzweig RS.
Yellow fever 17D as a vaccine vector for microbial CTL epitopes: protection in a rodent  malaria model.
J Exp Med. 2005 Jan 17;201(2):201-9.

AWARDES AND GRANTS

2009-2012 ANR-MIE NKTVIR “Mechanisms of activation and role of invariant Natural Killer T lymphocytes during viral infections”. Co-investigator.

2008-2011 PTR N.261 « Vaccines for endemic areas : yellow fever 17D carrying malaria antigens ». Principal Investigator, Institut Pasteur (IP)


Support Staff


Alicia Maugein
01/03/2008-31/10/2009
Programme Transversaux de Recherche N°261
"Vaccines for endemic areas : yellow fever 17D carrying malaria antigens"



Nelly Peufly
01/06/2010
Programme Transversaux de Recherche N°261
"Vaccines for endemic areas : yellow fever 17D carrying malaria antigens"