Regulation of Retroviral Infections

Unité de Régulation des Infections Rétrovirales

Head of the Unit: Françoise Barré-Sinoussi

The research for the development of a preventive anti-HIV vaccine has used every established technology that yielded effective vaccines against other pathogens, yet it has failed to afford effective and long lasting protection both in monkey models and in humans. These failures dramatically highlight the need to define the immune correlates of protection against HIV infection for vaccine research and the correlates of protection against AIDS for immunotherapy. Along these lines, our Unit is focusing its research on the mechanisms of host control of HIV infection both at the cell level and at the level of the immune response. We are studying examples of natural protection against infection, such as HIV-exposed but uninfected individuals (EU) and the placental barrier against HIV in utero transmission; or of natural protection against disease, such as HIV controllers (HIC) and animal models of non pathogenic infection (African Green Monkey, AGM /SIVagm). Each one of these models provides unique opportunity to investigate the role of host factors in protection.

Régulation des Infections Rétrovirales
Institut Pasteur
25, Rue du Docteur Roux
75724 Paris Cedex 15 FRANCE

Tel +33 (0)1 45 68 87 33
Fax + 33 (0)1 45 68 89 57

For questions, comments or problems with this web site contact

Françoise Barré-Sinoussi, Nobel Prize in Medicine 2008

The Nobel Assembly at Karolinska Institutet has decided to award
The Nobel Prize in Medicine for 2008 to

Harald zur Hausen

for his discovery of "human papilloma viruses causing cervical cancer"

and jointly to

Françoise Barré-Sinoussi and Luc Montagnier

for their discovery of "human immunodeficiency virus"
Paris, Aeroport Charles de Gaulle, 8-10-08, 6:20 am