Structural Bioinformatics

Structural Bioinformatics group (Michael Nilges)

The structural bioinformatics research group was created in March 2001 (see our definition of bioinformatics). Our research focuses on the relationship between sequence, three-dimensional structure, and function of proteins, using, among others, modelling techniques and molecular dynamics simulations. We also continue the development of software for automated NMR structure calculations, and are collaborating with structural genomics projects and the structure databases. We have established collaborations with experimental groups at the Institut Pasteur and elsewhere, for example, in atomic force spectroscopy, X-ray crystallography, and microscopy. Our work is aimed at helping in the interpretation of experimental data, and generating hypotheses that can be tested experimentally.