Research / Scientific departments / Structural Biology and Chemistry / Units and Groups / Structural Microbiology / Publications / Publications de 1997 à 2005
Publications de 1997 à 2005
Publications 2005
Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism.
Refinement of docked protein-ligand and protein-DNA structures using low frequency normal mode amplitude optimization.
dentification of the critical residues involved in peptidoglycan detection by Nod1.
Girardin SE, Jéhanno M, Mengin-Lecreulx D, Sansonetti PJ, Alzari PM, Philpott DJ.
J Biol Chem. 2005 Nov 18;280(46):38648-56.Hible G, Renault L, Schaeffer F, Christova P, Zoe Radulescu A, Evrin C, Gilles AM, Cherfils J.
J Mol Biol. 2005 Oct 7;352(5):1044-59.Durán R, Villarino A, Bellinzoni M, Wehenkel A, Fernandez P, Boitel B, Cole ST, Alzari PM, Cerveñansky C.
Biochem Biophys Res Commun. 2005 Aug 5;333(3):858-67.Villarino A, Duran R, Wehenkel A, Fernandez P, England P, Brodin P, Cole ST, Zimny-Arndt U, Jungblut PR, Cerveñansky C, Alzari PM.
J Mol Biol. 2005 Jul 29;350(5):953-63.
Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress.
Guimarães BG, Souchon H, Honoré N, Saint-Joanis B, Brosch R, Shepard W, Cole ST, Alzari PM.
J Biol Chem. 2005 Jul 8;280(27):25735-42.
Action pattern of Fusarium moniliforme endopolygalacturonase towards pectin fragments: Comprehension and prediction.
André-Leroux G, Tessier D, Bonnin E.
Biochim Biophys Acta. 2005 May 20;1749(1):53-64.Guerin ME, Buschiazzo A, Korduláková J, Jackson M, Alzari PM.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt 5):518-20.
A sialidase mutant displaying trans-sialidase activity.
Paris G, Ratier L, Amaya MF, Nguyen T, Alzari PM, Frasch AC.
J Mol Biol. 2005 Jan 28;345(4):923-34.I Microbiology. TB--a new target, a new drug.
Cole ST, Alzari PM.
Science. 2005 Jan 14;307(5707):214-5.Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism.
Taly A, Delarue M, Grutter T, Nilges M, Le Novère N, Corringer PJ, Changeux JP.
Biophys J. 2005 Jun;88(6):3954-65.Refinement of docked protein-ligand and protein-DNA structures using low frequency normal mode amplitude optimization.
Lindahl E, Delarue M.
Nucleic Acids Res. 2005 Aug 8;33(14):4496-506.Publications 2004
First structural glimpse at a bacterial Ser/Thr protein phosphatase. Structure (Camb). 2004 Nov;12(11):1923-4.
Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation. EMBO J. 2004 Aug 18;23(16):3196-205.
Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus. Biochem J. 2004 Sep 1;382(Pt 2):501-10.
Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase. Structure (Camb). 2004 May;12(5):775-84.
Deciphering the function of an ORF: Salmonella enterica DeoM protein is a new mutarotase specific for deoxyribose. Protein Sci 2004; 13:1295-1303.
Enforcing large amplitude and collective movements in the refinement of macromolecular models with low resolution data. Proc Natl Acad Sci USA 2004; 101:6957-6961.
Molecular Basis of the Amylose-like Polymer Formation Catalyzed by Neisseria polysaccharea Amylosucrase. J. Biol. Chem,Vol 279, pp726-734 (2004).
Roles of Tyrosine 105 and Threonine 212 at Outermost Subsites -6 and +4 in Substrate Specificity, Oligosaccharide Cleavage Pattern, and Multiple Binding Modes of Barley α-Amylase 1 J. Biol. Chem., Vol 279, pp10093-10102 (2004).
Putative Implication of α-amylase Loop 7 in the Mechanism of Substrate Binding and Reaction Products Release. Biopolymers, Vol 75, pp 95-108 (2004).
Comprehensive Conformational Study of key Interactions Involved in Zearalenone Complexation in a -D Glucans. Biomacromolecules, Vol5, No6, pp 2176-2185 (2004).
Publications 2003
Sub-families of alpha/beta barrel enzymes: a new adenine deaminase family. J Mol Biol. 2003 Dec 12;334(5):1117-31.
PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis. Mol Microbiol. 2003 Sep;49(6):1493-508.
Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile. J Am Chem Soc. 2003 Jun 25;125(25):7532-3. No abstract available.
Preliminary crystallographic studies of glycogen synthase from Agrobacterium tumefaciens. Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):526-8. Epub 2003 Feb 21.
The crystal structure of a plant lectin in complex with the Tn antigen. FEBS Lett. 2003 Feb 11;536(1-3):106-10.
Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis. J Biol Chem. 2003 Apr 11;278(15):13094-100. Epub 2003 Jan 27.
The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase. J Mol Biol. 2003 Jan 24;325(4):773-84.
Enzymatic and structural studies of inhibitors designed against thymidylate kinase from M. tuberculosis: insight into the phosphoryl transfer mechanism. J Biol Chem 2003; 278:4963-71.
Crystal structure of several intermediates along the reaction pathway of M. tuberculosis thymidylate kinase. J Mol Biol 2003; 327:1077-1092.
Sub-families of alpha/beta barrel enzymes: a new adenine deaminase family. J Mol Biol. 2003 Dec 12;334(5):1117-31.
PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis. Mol Microbiol. 2003 Sep;49(6):1493-508.
Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile. J Am Chem Soc. 2003 Jun 25;125(25):7532-3. No abstract available.
Preliminary crystallographic studies of glycogen synthase from Agrobacterium tumefaciens. Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):526-8. Epub 2003 Feb 21.
The crystal structure of a plant lectin in complex with the Tn antigen. FEBS Lett. 2003 Feb 11;536(1-3):106-10.
Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis. J Biol Chem. 2003 Apr 11;278(15):13094-100. Epub 2003 Jan 27.
The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase. J Mol Biol. 2003 Jan 24;325(4):773-84.
Enzymatic and structural studies of inhibitors designed against thymidylate kinase from M. tuberculosis: insight into the phosphoryl transfer mechanism. J Biol Chem 2003; 278:4963-71.
Crystal structure of several intermediates along the reaction pathway of M. tuberculosis thymidylate kinase. J Mol Biol 2003; 327:1077-1092.
Publications 2002
The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis. Mol Cell. 2002 Oct;10(4):757-68.
Physical estimation of triplet phases from two new proteins. Acta Crystallogr D Biol Crystallogr. 2002 Oct;58(Pt 10 Pt 2):1780-6. Epub 2002 Sep 28.
Advantages of high-resolution phasing: MAD to atomic resolution. Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1433-41. Epub 2002 Aug 23.
The crystal structure and catalytic mechanism of cellobiohydrolase CelS, the major enzymatic component of the Clostridium thermocellum Cellulosome. J Mol Biol. 2002 Jul 12;320(3):587-96.
The trans-sialidase from the african trypanosome Trypanosoma brucei. Eur J Biochem. 2002 Jun;269(12):2941-50.
1H, 13C, 15N NMR sequence-specific resonance assignment of a Clostridium thermocellum type II cohesin module. J Biomol NMR. 2002 May;23(1):73-4. No abstract available.
Crystallization and preliminary X-ray analysis of the hydroperoxidase I C-terminal domain from Escherichia coli. Acta Crystallogr D Biol Crystallogr. 2002 May;58(Pt 5):853-5. Epub 2002 Apr 26.
The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol. 2002 Jun;9(6):442-6.
Induction of protective immunity by synthetic Vibrio cholerae hexasaccharide derived from V. cholerae O1 Ogawa lipopolysaccharide bound to a protein carrier. J Infect Dis. 2002 Apr 1;185(7):950-62. Epub 2002 Mar 19.
Crystallization and preliminary crystallographic analysis of a novel cytochrome P450 from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):704-5. Epub 2002 Mar 22.
Atomic (0.94 A) resolution structure of an inverting glycosidase in complex with substrate. J Mol Biol. 2002 Mar 8;316(5):1061-9.
Mapping by site-directed mutagenesis of the region responsible for cohesin-dockerin interaction on the surface of the seventh cohesin domain of Clostridium thermocellum CipA. Biochemistry. 2002 Feb 19;41(7):2115-9.
Duplicated dockerin subdomains of Clostridium thermocellum endoglucanase CelD bind to a cohesin domain of the scaffolding protein CipA with distinct thermodynamic parameters and a negative cooperativity. Biochemistry. 2002 Feb 19;41(7):2106-14.
Cryo-photoloysis of caged compounds: a technique for trapping intermediates in protein crystals. Acta Crystallogr D 2002; 58:607-614.
Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods. Enzyme Inh Med Chem 2002; 17:167-174.
Structural and nucleotide-binding properties of YajQ and YnaF, two Escherichia coli proteins of unknown function. Protein Sci 2002; 11:2551-2560.
Automated molecular replacement. In Protein Structure: Determination, Analysis, and Applications for Drug Discovery, edited by D. Chasman.Dekker (2002).
Simplified normal mode analysis of the open-closed transition in DNA-dependent polymerases. J Mol Biol 2002; 320:1011-1024.
Crystal structures at 2.35 Angstrom resolution of a template independent DNA polymerase: murine terminal desoxynucleotidyltransferase. EMBO J 2002; 21:427-439.
Molecular replacement and high throughput structure determination. Zeits Kristallogr 2002; 217:715-721.
The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis. Mol Cell. 2002 Oct;10(4):757-68.
Physical estimation of triplet phases from two new proteins. Acta Crystallogr D Biol Crystallogr. 2002 Oct;58(Pt 10 Pt 2):1780-6. Epub 2002 Sep 28.
Advantages of high-resolution phasing: MAD to atomic resolution. Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1433-41. Epub 2002 Aug 23.
The crystal structure and catalytic mechanism of cellobiohydrolase CelS, the major enzymatic component of the Clostridium thermocellum Cellulosome. J Mol Biol. 2002 Jul 12;320(3):587-96.
The trans-sialidase from the african trypanosome Trypanosoma brucei. Eur J Biochem. 2002 Jun;269(12):2941-50.
1H, 13C, 15N NMR sequence-specific resonance assignment of a Clostridium thermocellum type II cohesin module. J Biomol NMR. 2002 May;23(1):73-4. No abstract available.
Crystallization and preliminary X-ray analysis of the hydroperoxidase I C-terminal domain from Escherichia coli. Acta Crystallogr D Biol Crystallogr. 2002 May;58(Pt 5):853-5. Epub 2002 Apr 26.
The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol. 2002 Jun;9(6):442-6.
Induction of protective immunity by synthetic Vibrio cholerae hexasaccharide derived from V. cholerae O1 Ogawa lipopolysaccharide bound to a protein carrier. J Infect Dis. 2002 Apr 1;185(7):950-62. Epub 2002 Mar 19.
Crystallization and preliminary crystallographic analysis of a novel cytochrome P450 from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):704-5. Epub 2002 Mar 22.
Atomic (0.94 A) resolution structure of an inverting glycosidase in complex with substrate. J Mol Biol. 2002 Mar 8;316(5):1061-9.
Mapping by site-directed mutagenesis of the region responsible for cohesin-dockerin interaction on the surface of the seventh cohesin domain of Clostridium thermocellum CipA. Biochemistry. 2002 Feb 19;41(7):2115-9.
Duplicated dockerin subdomains of Clostridium thermocellum endoglucanase CelD bind to a cohesin domain of the scaffolding protein CipA with distinct thermodynamic parameters and a negative cooperativity. Biochemistry. 2002 Feb 19;41(7):2106-14.
Cryo-photoloysis of caged compounds: a technique for trapping intermediates in protein crystals. Acta Crystallogr D 2002; 58:607-614.
Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods. Enzyme Inh Med Chem 2002; 17:167-174.
Structural and nucleotide-binding properties of YajQ and YnaF, two Escherichia coli proteins of unknown function. Protein Sci 2002; 11:2551-2560.
Automated molecular replacement. In Protein Structure: Determination, Analysis, and Applications for Drug Discovery, edited by D. Chasman.Dekker (2002).
Simplified normal mode analysis of the open-closed transition in DNA-dependent polymerases. J Mol Biol 2002; 320:1011-1024.
Crystal structures at 2.35 Angstrom resolution of a template independent DNA polymerase: murine terminal desoxynucleotidyltransferase. EMBO J 2002; 21:427-439.
Molecular replacement and high throughput structure determination. Zeits Kristallogr 2002; 217:715-721.
Publications 2001
Paris, G., Cremona, M.L., Amaya, M.F., Buschiazzo, A., Giambiagi, S., Frasch, A.C.C., Alzari, P.M. Probing molecular function of trypanosomal sialidases : single point mutations can change substrate specificity and increase hydrolytic activity. Glycobiology,11 : 305-311
Pitcovsky, T.A., Mucci, J., Alvarez, P., Leguizamon, M.S., Burrone, O., Alzari, P.M., Frasch, A.C.C., Campetella, O. The epitope mapping of the trans-sialidase from Trypanosoma cruzi reveals the presence of several cross-reactive determinants. Infection & Immunity, 69 : 1869-1875
Crystal structure of Mycobacterium tuberculosis TMP kinase complexed with TMP at 1.95 Å resolution. J Mol Biol 2001; 311:87-10.
Publications 2000
Schaeffer, F. Energies and forces of biomacromolecular interactions: quantitative aspects. Microcalorimetry studies of biomolecular interactions. Cahier du C.N.R.S. Physique et Chimie du Vivant 2, 47-56
Pritsch, O., Magnac, C., Dumas, G., Bouvet, J.-P., Alzari, P.M., Dighiero, G. Can isotype switch modulate antigen binding affinity and influence clonal selection? European Journal of Immunology, 30 : 3387-3395
Oppezzo, P., Osinaga, E., Tello, D., Bay, S., Cantacuzène, D., Irigoin, F., Ferreira, A., Cayota, A., Alzari, P.M., Pritsch, O. Production and functional characterization of two mouse/human chimeric antibodies with specificity for the tumor-associated Tn antigen. Hybridoma, 19 : 229-239
Villeneuve, S., Souchon, H., Riottot, M.M., Mazie, J.C., Kovacs, P., Fournier, J.M., Alzari, P.M. The X-ray structure of an anti-carbohydrate antibody directed against Vibrio cholerae in complex with antigen. Proceedings of the National Academy of Sciences USA, 97 : 8433-8438
Lascombe, M.-B., Grégoire, C., Tavares, G.A., Poncet, P., Rosinski-Chupin, I., Rabillon, J., Goubran-Botros, H., Mazié, J.-C., David, B., Alzari, P.M. Crystal structure of the major horse allergen Equ c 1, a dimeric lipocalin with restricted IgE-reactive epitopes. Journal of Biological Chemistry, 275 : 21572-21577
Eckenberg, R., Rose, T., Moreau, J.-L., Weil, R., Gesbert, F., Dubois, S., Tello, D., Bossus, M., Gras, H., Tartar, A., Bertoglio, J., Chouaib, S., Goldberg, M., Jacques, Y., Alzari, P.M., Thèze, J. The first alpha-helix of interleukin IL-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta-chain and induces lymphokine-activated killer cells. Journal of Experimental Medicine 191 : 529-540
Osinaga, E., Bay, S., Tello, D., Babino, A., Pritsch, O., Assemat, K., Cantacuzène, D., Nakada, H., Alzari, P.M. Analysis of the fine specificity of Tn-binding proteins using synthetic glycopeptide epitopes and a biosensor based on surface plasmon resonance spectroscopy. FEBS Letters 469 : 24-28
Buschiazzo, A., Tavares, G.A., Campetella, O., Spinelli, S., Cremona, M.L., Paris, G., Amaya, M.F., Frasch, A.C.C., Alzari, P.M. Stuctural basis of sialyltransferase activity in Trypanosomal sialidases. EMBO Journal 19 : 16-24
Medeiros, A., Bianchi, S., Calvete, J.J., Balter, H., Bay, S., Robles, A., Cantacuzène, D., Nimtz, M., Alzari, P.M., Osinaga, E. Biochemical and functional characterization of the Tn-specific lectin from Salvia sclarea seeds. European Journal of Biochemistry 267 : 1434-1440
Schaeffer, F. Energies and forces of biomacromolecular interactions: quantitative aspects. Microcalorimetry studies of biomolecular interactions. Cahier du C.N.R.S. Physique et Chimie du Vivant 2, 47-56
Pritsch, O., Magnac, C., Dumas, G., Bouvet, J.-P., Alzari, P.M., Dighiero, G. Can isotype switch modulate antigen binding affinity and influence clonal selection? European Journal of Immunology, 30 : 3387-3395
Oppezzo, P., Osinaga, E., Tello, D., Bay, S., Cantacuzène, D., Irigoin, F., Ferreira, A., Cayota, A., Alzari, P.M., Pritsch, O. Production and functional characterization of two mouse/human chimeric antibodies with specificity for the tumor-associated Tn antigen. Hybridoma, 19 : 229-239
Villeneuve, S., Souchon, H., Riottot, M.M., Mazie, J.C., Kovacs, P., Fournier, J.M., Alzari, P.M. The X-ray structure of an anti-carbohydrate antibody directed against Vibrio cholerae in complex with antigen. Proceedings of the National Academy of Sciences USA, 97 : 8433-8438
Lascombe, M.-B., Grégoire, C., Tavares, G.A., Poncet, P., Rosinski-Chupin, I., Rabillon, J., Goubran-Botros, H., Mazié, J.-C., David, B., Alzari, P.M. Crystal structure of the major horse allergen Equ c 1, a dimeric lipocalin with restricted IgE-reactive epitopes. Journal of Biological Chemistry, 275 : 21572-21577
Eckenberg, R., Rose, T., Moreau, J.-L., Weil, R., Gesbert, F., Dubois, S., Tello, D., Bossus, M., Gras, H., Tartar, A., Bertoglio, J., Chouaib, S., Goldberg, M., Jacques, Y., Alzari, P.M., Thèze, J. The first alpha-helix of interleukin IL-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta-chain and induces lymphokine-activated killer cells. Journal of Experimental Medicine 191 : 529-540
Osinaga, E., Bay, S., Tello, D., Babino, A., Pritsch, O., Assemat, K., Cantacuzène, D., Nakada, H., Alzari, P.M. Analysis of the fine specificity of Tn-binding proteins using synthetic glycopeptide epitopes and a biosensor based on surface plasmon resonance spectroscopy. FEBS Letters 469 : 24-28
Buschiazzo, A., Tavares, G.A., Campetella, O., Spinelli, S., Cremona, M.L., Paris, G., Amaya, M.F., Frasch, A.C.C., Alzari, P.M. Stuctural basis of sialyltransferase activity in Trypanosomal sialidases. EMBO Journal 19 : 16-24
Medeiros, A., Bianchi, S., Calvete, J.J., Balter, H., Bay, S., Robles, A., Cantacuzène, D., Nimtz, M., Alzari, P.M., Osinaga, E. Biochemical and functional characterization of the Tn-specific lectin from Salvia sclarea seeds. European Journal of Biochemistry 267 : 1434-1440
Publications 1999
Barale, J.C., Blisnick, T., Fujioka, H., Alzari, P.M., Aikawa, M., Braun-Breton, C., Langsley, G. Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite-surface-protein 1-42 maturase. Proceedings of the National Academy of Sciences USA 96 : 6445-6450
Susin, S.A., Lorenzo, H.K., Zamzami, N., Marzo, I., Snow, B.E., Brothers, G.M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., Larochette, N., Goodlett, D.R., Aebersold, R., Siderovski, D.P., Penninger, J.M., Kroemer, G. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397 : 441-446
Goldberg, M.E., Schaeffer, F., Guillou, Y., Djavadi-Ohaniance, L. Pseudo-native motifs in the noncovalent heme-apocytochrome C complex : evidence from antibody binding studies by enzyme-linked immunosorbent assay and microcalorimetry. Journal of Biological Chemistry 274 : 16052-16061
Marina, A., Alzari, P.M., Bravo, J., Uriarte, M., Barcelona, B., Fita, I., Rubio, V. Structure of carbamate kinase, the key enzyme for fermentative ATP production from arginine Protein Science 8 : 934-940
Saint-Joanis, B., Souchon, H., Wilming, M., Johnsson, K., Alzari, P.M., Cole, S.T. Use of site-directed mutagenesis to probe structure, function and isoniazid-activation by catalase-peroxidase, KatG, from Mycobacterium tuberculosis Biochemical Journal 338 : 753-760
Grégoire, C., Tavares, G.A., Lorenzo, H.K., Dandeu, J.P., David, B., Alzari, P.M. Crystallization and preliminary crystallographic analysis of the major horse allergen Equ c 1. Acta Crystallographica D55 : 880-882
Maté, M.J., Zamocky, M., Nykyri, L.M., Herzog, C., Alzari, P.M., Betzel, C., Koller, F., Fita, I. Structure of catalase A from Saccharomyces cerevisiae. Journal of Molecular Biology 286 : 135-149
Susin, S.A., Lorenzo, H.K., Zamzami, N, Marzo, I, Brenner, C., Larochette, N., Prevost, M.C., Alzari, P.M., Kroemer, G. Mitochondrial release of caspases-2 and -9 during the apoptotic process. Journal of Experimental Medicine 189 : 381-393
Barale, J.C., Blisnick, T., Fujioka, H., Alzari, P.M., Aikawa, M., Braun-Breton, C., Langsley, G. Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite-surface-protein 1-42 maturase. Proceedings of the National Academy of Sciences USA 96 : 6445-6450
Susin, S.A., Lorenzo, H.K., Zamzami, N., Marzo, I., Snow, B.E., Brothers, G.M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., Larochette, N., Goodlett, D.R., Aebersold, R., Siderovski, D.P., Penninger, J.M., Kroemer, G. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397 : 441-446
Goldberg, M.E., Schaeffer, F., Guillou, Y., Djavadi-Ohaniance, L. Pseudo-native motifs in the noncovalent heme-apocytochrome C complex : evidence from antibody binding studies by enzyme-linked immunosorbent assay and microcalorimetry. Journal of Biological Chemistry 274 : 16052-16061
Marina, A., Alzari, P.M., Bravo, J., Uriarte, M., Barcelona, B., Fita, I., Rubio, V. Structure of carbamate kinase, the key enzyme for fermentative ATP production from arginine Protein Science 8 : 934-940
Saint-Joanis, B., Souchon, H., Wilming, M., Johnsson, K., Alzari, P.M., Cole, S.T. Use of site-directed mutagenesis to probe structure, function and isoniazid-activation by catalase-peroxidase, KatG, from Mycobacterium tuberculosis Biochemical Journal 338 : 753-760
Grégoire, C., Tavares, G.A., Lorenzo, H.K., Dandeu, J.P., David, B., Alzari, P.M. Crystallization and preliminary crystallographic analysis of the major horse allergen Equ c 1. Acta Crystallographica D55 : 880-882
Maté, M.J., Zamocky, M., Nykyri, L.M., Herzog, C., Alzari, P.M., Betzel, C., Koller, F., Fita, I. Structure of catalase A from Saccharomyces cerevisiae. Journal of Molecular Biology 286 : 135-149
Susin, S.A., Lorenzo, H.K., Zamzami, N, Marzo, I, Brenner, C., Larochette, N., Prevost, M.C., Alzari, P.M., Kroemer, G. Mitochondrial release of caspases-2 and -9 during the apoptotic process. Journal of Experimental Medicine 189 : 381-393
Publications 1998
Mounier, C., Hackeng,T.M., Schaeffer, F., Faure, G., Bon, C. & Griffin, J.H. Inhibition of prothrombinase by human secretory phospholipase A2 involves binding to factor Xa Journal of Biological Chemistry 273 : 23764-23772
Tavares, G.A., Souchon, H., Guérin, D.M.A., Lascombe, M.-B., Alzari, P.M. Structural studies of the cellulosome, in Carbohydrases from Trichoderma reesei and other microorganisms, edited by M. Claeyssens, W. Nerinckx, K. Piens, pp. 174-181. Royal Society of Chemistry: Cambridge
Alzari, P.M. Immunoglobulin-type domains, in Encyclopedia of Immunology (second edition), edited by I.M.Roitt & P.J.Delves. Academic Press: London
Terenzi, H., Alzari, P.M., Zakin, M.M. Structural features involved in the formation of a complex between the monomeric or the dimeric form of Rev-erb beta DNA-binding domain and its DNA reactive sites. Biochemistry 37 : 11488-11495
Béguin, P., Alzari, P.M. The cellulosome of Clostridium thermocellum. Biochemical Society Transactions, 26 : 178-185
Demangel, C., Rouyre, S., Alzari, P.M., Nato, F., Longacre, S., Lafaye, P., Mazie, J.C. Phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate. Biological Chemistry 379 : 65-70
Mounier, C., Hackeng,T.M., Schaeffer, F., Faure, G., Bon, C. & Griffin, J.H. Inhibition of prothrombinase by human secretory phospholipase A2 involves binding to factor Xa Journal of Biological Chemistry 273 : 23764-23772
Tavares, G.A., Souchon, H., Guérin, D.M.A., Lascombe, M.-B., Alzari, P.M. Structural studies of the cellulosome, in Carbohydrases from Trichoderma reesei and other microorganisms, edited by M. Claeyssens, W. Nerinckx, K. Piens, pp. 174-181. Royal Society of Chemistry: Cambridge
Alzari, P.M. Immunoglobulin-type domains, in Encyclopedia of Immunology (second edition), edited by I.M.Roitt & P.J.Delves. Academic Press: London
Terenzi, H., Alzari, P.M., Zakin, M.M. Structural features involved in the formation of a complex between the monomeric or the dimeric form of Rev-erb beta DNA-binding domain and its DNA reactive sites. Biochemistry 37 : 11488-11495
Béguin, P., Alzari, P.M. The cellulosome of Clostridium thermocellum. Biochemical Society Transactions, 26 : 178-185
Demangel, C., Rouyre, S., Alzari, P.M., Nato, F., Longacre, S., Lafaye, P., Mazie, J.C. Phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate. Biological Chemistry 379 : 65-70
Publications 1997
Guillouard, I., Alzari, P.M., Saliou, B., Cole, S.T. The carboxy-terminal C2-like domain of the alpha-toxin from Clostridium perfringens mediates calcium-dependent membrane recognition. Molecular Microbiology 26 : 867-876
Babino, A., Pritsch, O., Oppezzo, P., Du Pasquier, R., Roseto, A., Osinaga, E., Alzari, P.M. Molecular cloning of a monoclonal anti-tumor antibody specific for the Tn antigen and expression of an active single-chain Fv fragment. Hybridoma 16 : 317-324
Tavares, G., Béguin, P., Alzari, P.M. The crystal structure of a type I cohesin domain at 1.7 Å resolution. Journal of Molecular Biology 273 : 701-713
Osinaga, E., Tello, D., Batthyani, C., Bianchet, M., Tavares, G., Durán, R., Cerveñansky, C., Camoin, L., Roseto, A., Alzari, P.M. Amino acid sequence and three-dimensional structure of the Tn-specific isolectin B4 from Vicia villosa. FEBS Letters 412 : 190-196
Eckenberg, R., Xu, D., Moreau, J.-L., Bossus, M., Mazié, J.-C., Tartar, A., Liu, X. Y., Alzari, P.M., Bertoglio, J., Thèze, J. Analysis of human IL-2/IL-2 receptor beta chain interactions: monoclonal antibody H2-8 and new IL-2 mutants define the critical role of alpha helix A of IL-2. Cytokine 9, 488-498
Lorenzo, H.K., Farber, D., Germain, V., Acuto, O., Alzari,P.M. The MBP-fusion protein restores the activity of the first phosphatase domain of CD45. FEBS Letters 411 : 231-235
Berthet, S., Nykyri, L.M., Bravo, J., Maté, M.J.,Berthet-Colominas, C., Alzari, P.M., Koller, F., Fita, I. Crystallization and preliminary structural analysis of catalase-A from Saccharomyces cerevisiae. Protein Science, 6, 481-483
Diaw,L., Magnac, C., Pritsch, O., Buckle, M., Alzari, P.M., Diguiero,G. Structural and affinity studies of IgM polyreactive natural antibodies. Journal of Immunology 158 : 968-976
Guillouard, I., Alzari, P.M., Saliou, B., Cole, S.T. The carboxy-terminal C2-like domain of the alpha-toxin from Clostridium perfringens mediates calcium-dependent membrane recognition. Molecular Microbiology 26 : 867-876
Babino, A., Pritsch, O., Oppezzo, P., Du Pasquier, R., Roseto, A., Osinaga, E., Alzari, P.M. Molecular cloning of a monoclonal anti-tumor antibody specific for the Tn antigen and expression of an active single-chain Fv fragment. Hybridoma 16 : 317-324
Tavares, G., Béguin, P., Alzari, P.M. The crystal structure of a type I cohesin domain at 1.7 Å resolution. Journal of Molecular Biology 273 : 701-713
Osinaga, E., Tello, D., Batthyani, C., Bianchet, M., Tavares, G., Durán, R., Cerveñansky, C., Camoin, L., Roseto, A., Alzari, P.M. Amino acid sequence and three-dimensional structure of the Tn-specific isolectin B4 from Vicia villosa. FEBS Letters 412 : 190-196
Eckenberg, R., Xu, D., Moreau, J.-L., Bossus, M., Mazié, J.-C., Tartar, A., Liu, X. Y., Alzari, P.M., Bertoglio, J., Thèze, J. Analysis of human IL-2/IL-2 receptor beta chain interactions: monoclonal antibody H2-8 and new IL-2 mutants define the critical role of alpha helix A of IL-2. Cytokine 9, 488-498
Lorenzo, H.K., Farber, D., Germain, V., Acuto, O., Alzari,P.M. The MBP-fusion protein restores the activity of the first phosphatase domain of CD45. FEBS Letters 411 : 231-235
Berthet, S., Nykyri, L.M., Bravo, J., Maté, M.J.,Berthet-Colominas, C., Alzari, P.M., Koller, F., Fita, I. Crystallization and preliminary structural analysis of catalase-A from Saccharomyces cerevisiae. Protein Science, 6, 481-483
Diaw,L., Magnac, C., Pritsch, O., Buckle, M., Alzari, P.M., Diguiero,G. Structural and affinity studies of IgM polyreactive natural antibodies. Journal of Immunology 158 : 968-976