Structural Microbiology / Publications / Publications 2012

Publications 2012



Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site.

Busschots K, Lopez-Garcia LA, Lammi C, Stroba A, Zeuzem S, Piiper A, Alzari PM, Neimanis S, Arencibia JM, Engel M, Schulze JO, Biondi RM.

Chem Biol. 2012 Sep 21;19(9):1152-63. 


Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria.

Urresti S, Albesa-Jové D, Schaeffer F, Pham HT, Kaur D, Gest P, van der Woerd MJ, Carreras-González A, López-Fernández S, Alzari PM, Brennan PJ, Jackson M, Guerin ME.

J Biol Chem. 2012 Jul 13;287(29):24649-61.


Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.

Mechaly AE, Haouz A, Miras I, Barilone N, Weber P, Shepard W, Alzari PM, Bellinzoni M.

FEBS Lett. 2012 Jun 4;586(11):1606-11.