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Publications 2007

Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases.

Wehenkel A, Bellinzoni M, Schaeffer F, Villarino A, Alzari PM.

J Mol Biol. 2007 Dec 7;374(4):890-8.

Towards new tuberculosis drugs.

Cole ST, Alzari PM.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1321-4.

Remodeling a DNA-binding protein as a specific in vivo inhibitor of bacterial secretin PulD.

Mouratou B, Schaeffer F, Guilvout I, Tello-Manigne D, Pugsley AP, Alzari PM, Pecorari F.

Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):17983-8.

The crystal structure of Trypanosoma cruzi arginine kinase.

Fernandez P, Haouz A, Pereira CA, Aguilar C, Alzari PM.

Proteins. 2007 Oct 1;69(1):209-12.

The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria.

Graña M, Haouz A, Buschiazzo A, Miras I, Wehenkel A, Bondet V, Shepard W, Schaeffer F, Cole ST, Alzari PM.

Protein Sci. 2007 Sep;16(9):1896-904.

Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis.

Stadthagen G, Sambou T, Guerin M, Barilone N, Boudou F, Korduláková J, Charles P, Alzari PM, Lemassu A, Daffé M, Puzo G, Gicquel B, Rivière M, Jackson M.

J Biol Chem. 2007 Sep 14;282(37):27270-6.

Insights into the catalytic mechanism of PPM Ser/Thr phosphatases from the atomic resolution structures of a mycobacterial enzyme.

Bellinzoni M, Wehenkel A, Shepard W, Alzari PM.

Structure. 2007 Jul;15(7):863-72.

 

Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives -- a screening based on affinity for the UMP-CMP binding site.

Topalis D, Kumamoto H, Amaya Velasco MF, Dugué L, Haouz A, Alexandre JA, Gallois-Montbrun S, Alzari PM, Pochet S, Agrofoglio LA, Deville-Bonne D.

FEBS J. 2007 Jul;274(14):3704-14.

 

Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria.

Guerin ME, Kordulakova J, Schaeffer F, Svetlikova Z, Buschiazzo A, Giganti D, Gicquel B, Mikusova K, Jackson M, Alzari PM.

J Biol Chem. 2007 Jul 13;282(28):20705-14.

Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase.

Neres J, Bonnet P, Edwards PN, Kotian PL, Buschiazzo A, Alzari PM, Bryce RA, Douglas KT.

Bioorg Med Chem. 2007 Mar 1;15(5):2106-19.

The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria.

Shepard W, Haouz A, Graña M, Buschiazzo A, Betton JM, Cole ST, Alzari PM.

J Bacteriol. 2007 Mar;189(5):1899-904.

Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1.

Ingvarsson H, Maté MJ, Högbom M, Portnoï D, Benaroudj N, Alzari PM, Ortiz-Lombardía M, Unge T.

Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):249-59.

Towards the molecular understanding of glycogen elongation by amylosucrase.

Albenne C, Skov LK, Tran V, Gajhede M, Monsan P, Remaud-Siméon M, André-Leroux G.

Proteins. 2007 Jan 1;66(1):118-26.