Structural Microbiology - Pedro ALZARI
Activities of the Unit
Our research activities in structural microbiology are focused on the molecular characterization of bacterial signaling and regulation processes, using crystallographic, biophysical and biochemical approaches. Our main research projects include the molecular studies of signaling pathways mediated by eukaryotic-like protein kinases in Mycobacterium tuberculosis, the structure and function of bacterial two-component systems, and the regulation mechanisms of lipid biosynthesis in Gram-positive pathogenic bacteria.
The most significant three publications :
1. O’Hare HM, Duran R, Cerveñansky C, Bellinzoni M, Wehenkel A, Pritsch O, Obai G, Baumgartner J, Vialaret J, Johnsson K, Alzari PM (2008) Regulation of glutamate metabolism by protein kinases in mycobacteria. Mol Microbiol 70:1408-1423.
2. Albanesi D, Martin M, Trajtenberg F, Mansilla MC, Haouz A, Alzari PM, de Mendoza D, Buschiazzo A (2009) Structural insights into the signal transduction mechanism of the thermosensor histidine-kinase DesK. Proc Natl Acad Sci USA 106:16185-16190.
3. Hindie V, Stroba A, Zhang H, Lopez-Garcia LA, Idrissova L, Zeuzem S, Hirschberg D, Schaeffer F, Jorgensen TJ, Engel M, Alzari PM, Biondi RM (2009) High resolution complex structure and allosteric effects of low molecular weight activators on the protein kinase PDK1. Nature Chem Biol 5:758-764.