NMR of Biomolecules - Muriel DELEPIERRE

Activities of the Unit

Our research is dedicated to understanding biological processes through the study of the structure, interactions and dynamics of biomolecules. To this end, we mainly use NMR, biophysical and biochemical techniques. We are particularly interested in bacterial nutrient transport systems, viral transcription, carbohydrates for vaccinal approaches and fungal cell wall biosynthesis, as well as in human signalling pathways.


The most significant three publications
1. Caillet-Saguy, C., Piccioli, M., Turano, P., Izadi-Pruneyre, N., Delepierre, M., Bertini, Y., Lecroisey, A. (2009) Mapping the Interaction betweeen the hemophore HasA and its 98kDa outer membrane receptor HasR in DPC micelles using CRINEPT-TROSY NMR. J. Am. Chem. Soc. 131 (5), 1736-1744.

2. Prehaud, C., Wolff, N., Terrien, E., Lafage, M., Megret, F., Babault, F., Cordier, F., Tan, G.S., Maitrepierre, E., Menager, P., Chopy, D., Hoos, S., England, P., Delepierre, M., Schnell, M.J., Buc, H., Lafon, M. (2010) Attenuation of rabies virulence: take-over by the cytoplasmic domain of the envelope protein. Science Signal. 3(105) ra5.

3. Guilliere, F, Peixeiro, N., Kessler, A., Rayal, B., Desnoues, N., Keller, J., Delipierre, M., Pranguishvili, D., Sezonov, G., Guijarro, J.I. (2009) Structure, function and targets of the transcriptional regulator SvtR from the hyperthermophilic archaeal virus SIRV1. J. Biol. Chem. 284 (33), 22222-22237.