Publications (2000-2011)

Original and review articles
  1. Pinto, M., Rougeot, C., Gracia, L., Rosa, M., Garcia, A., Arsequell, G., Valencia, G. and Centeno, N. B. (2011) Proposed Bioactive Conformations of Opiorphin, an Endogenous Dual APN/NEP Inhibitor. ACS Med. Chem. Lett. (J. Med. Chem.) 3, 20-24.
  2. Seebach, D., Lukaszuk, A., Patora-Komisarska, K., Podwysocka, D., Gardiner, J., Ebert, M. O., Reubi, J. C., Cescato, R., Waser, B., Gmeiner, P., Hubner, H. and Rougeot, C. (2011) On the terminal homologation of physiologically active peptides as a means of increasing stability in human serum--neurotensin, opiorphin, B27-KK10 epitope, NPY. Chem Biodivers. 8, 711-739.
  3. Messaoudi M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M. and Cazaubiel, J.-M. (2010) Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British J. Nut.. doi:10.1017/S0007114510004319.
  4. Rougeot C., Robert F., Menz L., Bisson J.F. and Messaoudi M. (2010) Systemically active human Opiorphin is a potent yet non-addictive analgesic without drug tolerance effects. J. Physiol.  Pharmacol.. 61, 483-490.
  5. Rougeot C. (2010) La Sialorphine de rat et de l’Opiorphine humaine – deux nouveaux modulateurs physiologiques des voies opioïdergiques – J. AAEIP, 52,  44-47.
  6. Javelot H., Messaoudi M., Garnier S. and Rougeot C. (2010) Human Opiorphin is a naturally occurring antidepressant acting selectively on enkephalin-dependent delta-opioid pathways. J. Physiol.  Pharmacol., 61, 355-362.
  7. Rougeot C. and Messaoudi M. (2008) The Discovery of Rat Sialorphin and Human Opiorphin: new modulators of opioid-dependent pathways. Proceedings of the 4th International Peptide Symposium.  Jackie Wilce (Editor) on behalf of the Australian Peptide Society, 1-3.
  8. Hammoudi-Triki D., Lefort J., Rougeot, C., Robbe-Vincent A., Bon C., Laraba-Djebari F. and Choumet V. (2007) Pharmacokinetic and pharmacodynamic analyses of Androctonus australis hector venom in rats: Optimization of antivenom therapy. Toxicol.  Appl. Pharmacol., 218, 205-214.
  9. Davies K.P., Tar M., Rougeot C. and Melman A. (2007) Sialorphin (The Mature Peptide Product of Vcsa1) Relaxes Corporal Smooth Muscle Tissue and Increases Erectile Function in the Aging Rat. British J. of Urol. Int. Feb., 99, 431-435.
  10. Rougeot C. and Messaoudi M. (2007) Identification of human Opiorphin, a natural anti-nociceptive modulator of opioïd-dependent pathways. Med Sci. (Paris), 23, 33-35.
  11. Medja F., Fontaine R.H., Lebas F., Leroux P., Saria A., Rougeot C., Dournaud P., Lelièvre V. and Gressens P. (2006) Thiorphan, a neutral endopeptidase (NEP) inhibitor used for diarrhea, is neuroprotective in newborn mice. Brain, 129, 3209-3223.
  12. Wisner A., Dufour E., Messaoudi M., Nejdi A., Marcel A., Ungeheuer M.N. and Rougeot C. (2006) Human Opiorphin, a Natural Anti-nociceptive Modulator of Opioid-Dependent Pathways; Proc. Natl. Acad. Sci. USA, 103, 17979-17984.
  13. Messaoudi M., Desor D., Nejdi A., and Rougeot C. (2004) The endogenous androgen-regulated sialorphin modulates male rat sexual behavior. Hormones & Behavior, 46, 684-691.
  14. Rougeot C. (2004) From the gene to candidate drug. The discovery of sialorphin using inverse pharmacology. BIOforum Europe, 5, 52-55.
  15. Winsky-Sommerer R., Grouselle D., Rougeot C., Laurent V., David J.P., Delacourte A., Dournaud P., Seidah N.G., Lindberg I., Trottier S. and Epelbaum J. (2003) The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer’s disease. Neuroscience, 122, 437-447.
  16. Rougeot C., Messaoudi M., Hermitte V., Rigault A.G., Blisnick T., Dugave C., Desor D., and Rougeon F. (2003) Sialorphin, a natural inhibitor of membrane-bound neutral endopeptidase that displays analgesic activity. Proc. Natl. Acad. Sci. USA, 100, 8549-8554.
  17. Chamond N., Grégoire C., Coatnoan N., Rougeot C., Freitas-Junior L.H., Franco da Silveira J., Degrave W.M. and Minoprio P. (2003) Biochemical characterization of proline racemases from the human protozoan parasite Trypanosoma cruzi and definition of putative protein signatures. J. Biol. Chem., 278, 15484-15494.
  18. Krust B., Vienet R., Cardona A., Rougeot C., Jacotot E., Callebaut C., Guichard G., Briand J.P., Grognet J.M., Hovanessian A.G., Edelman L. The anti-HIV pentameric pseudopeptide HB-19 is preferentially taken up in vivo by lymphoid organs where it forms a complex with nucleolin. Proc. Natl. Acad. Sci. USA,  98, 14090-14095.
  19. Rosinski-Chupin I., Huaulme J.F., Rougeot C. and Rougeon F. (2001) The transcriptional response to androgens of the rat VCSA1 gene is amplified by both binary and graded mechanisms. Endocrinology, 142, 4550-4559.
  20. Tan D., Rougeot C., Davison J.S., and Mathison R. (2000) The carboxamide feG(NH2) inhibits endotoxin perturbation of intestinal motility. Eur. J. Pharmacol., 409, 203-205.
  21. Rougeot C., Rosinski-Chupin I., Mathison R. and Rougeon F. (2000) Rodent submandibular gland peptide hormones and other biologically active peptides. Peptides, 21, 443-455.
  22. Reina-San-Martin B., Degrave W., Rougeot C., Cosson A., Cordeiro-Da-Silva A., Arala-Chaves M., Coutinho A. and Minoprio P. (2000) A B-cell mitogen from a pathogenic trypanosome is a novel eukaryotic proline racemase. Nature Med., 6, 890-897.

Newspapers Articles – Movies

2006. La découverte d’une molécule anti-douleur naturelle: une aventure de recherche à l’Institut Pasteur – Vidéo 14 min :
2006. Aussi efficace que la morphine chez le rat ; un puissant analgésique endogène identifié chez l’homme - Le quotidien du médecin n° 8050, p : 7
2007. L’Opiorphine futur traitement de la douleur – Pasteur le Mag (Mag2), p :24
2008. Un anti-douleur naturel – Le Pellerin n°6564, p :38
2010. Catherine Rougeot: l’Opiorphine, Video par SupBiotech: