Publications  (2002-2011)

  1. Chiaravalli, J., Fontan, E., Fsihi, H., Coïc, Y.-M., Baleux, F., Véron, M. and Agou, F. (2011) Direct Inhibition of NF-kB activation by peptide targeting the NOA ubiquitin binding domain of NEMO. Biochem. Pharmacol.; 82, 1163-1174..
  2. Chapuis, N., Park, S., Leotoing, L., Tamburini, J., Verdier, F., Bardet, V., Green, A. S., Willems, L., Agou F., Ifrah, N., Dreyfus, F., Bismuth, G., Baud, V., Lacombe, C., Mayeux, P. and Bouscary, D. (2011) IkB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia. Blood, 20, 4242-4250.
  3. Hubeau, M., Ngadjeua, F., Puel, A., Israel, L., Feinberg, J., Chrabieh, M., Belani, K., Bodemer, C., Fabre, I., Plebani, A., Boisson-Dupuis, S., Picard, C., Fischer, A., Israël, A., Abel, L., Véron, M., Casanova, J.-L., Agou, F. and Bustamante, J. (2011) A new mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein. Blood, 118, 926-935.
  4. Gautheron, J., Pescatore, A., Fusco, F., Esposito, E. Yamaoka, S., Agou, F., Ursini, M. V. and Courtois, G. ., (2011) Identification of a new NEMO/TRAF6 interface affected in Incontinentia pigmenti pathology. (2010) Hum. Mol. Genet., 19, 3138-3149.
  5. Rameix-Welti, M. A., Munier, S., Le Gal, S., Cuvellier, F., Agou, F., Enouf, V., Naffakh, N. and van der Werf, S. (2011) Neuraminidase of 2007-2008 influenza A(H1N1) viruses shows increased affinity for sialic acids due to the D344N substitution. Antivi. Ther., 16, 597-603.
  6. Grubisha, G., Kaminska, M., Duquerroy, S., Fontan, E., Cordier, F., Haouz, A., Raynal, B., Chiaravalli, J., Delepierre, M., Israël, A., Véron, M. & Agou, F. (2010) DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin-binding. J. Mol. Biol., 395, 89-104.
  7. Laplantine, E., Fontan, E., Chiaravalli, J., Lopez, T., Lakisic, G., Véron, M., Agou, F. & Israël, A. (2009) NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain. EMBO J., 28, 2885-2895.
  8. Cordier, F., Grubisha, O., Traincard, F., Veron, M., Delepierre, M. & Agou, F. (2009) The Zinc Finger of NEMO Is a Functional Ubiquitin-binding Domain. J. Biol. Chem.,  284, 2902-2907.
  9. Cordier, F., Vinolo, E., Veron, M., Delepierre, M. & Agou, F. (2008) Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation. J. Mol. Biol., 377, 1419-1432.
  10. Fontan, E., Traincard, F., Levy, S. G., Yamaoka, S., Veron, M. & Agou, F. (2007) NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex. FEBS J., 274, 2540-2551.
  11. Wyler, E., Kaminska, M., Coïc, Y.-M., Baleux, F., Véron, M., and Agou, F. (2007) Inhibition of NF kB activation with designed ankyrin-repeat proteins targeting the ubiquitin-binding/oligomerization domain of NEMO. Protein Sci., 16, 2013-2022
  12. Carvalho, G., Fabre, C., Braun, T., Grosjean, J., Ades, L., Agou, F., Tasdemir, E., Boehrer, S., Israel, A., Veron, M., Fenaux, P. & Kroemer, G. (2007) Inhibition of NEMO, the regulatory subunit of the IKK complex, induces apoptosis in high-risk myelodysplastic syndrome and acute myeloid leukemia. Oncogene, 26, 2299-2307.
  13. Rameix-Welti, M. A., Agou, F., Buchy, P., Mardy, S., Aubin, J. T., Veron, M., van der Werf, S. & Naffakh, N. (2006) Natural variation can significantly alter the sensitivity of influenza A (H5N1) viruses to oseltamivir. Antimicrob. Agents Chemother., 50, 3809-3815.
  14. Santos, O. F., Bustamante, J., Haverkamp, M., Vinolo, E., Ku, C.-K., Puel, A., Frucht, D., Senechal, B., Feinberg, J., Fieschi, C., Durandy, A., Christel, K., Chapgier, A., Vogt, G., de Beaucoudrey, L., von Bernuth, H., Picard, C., Kutukculer, N., Plebani, A., Notarangelo, L., Bodemer, C., Geissmann, F., Israel, A., Veron, M., Knackstedt, M., Magdorf, K., Gendrel, D., Agou, F., Holland, S. M. & Casanova, J.-L. (2006) X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production. J. Exp. Med., 203, 1745-1759.
  15. Vinolo, E., Sebban, H., Chaffotte, A., Israel, A., Courtois, G., Veron, M. & Agou, F. (2006) A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation. J. Biol. Chem., 281, 6334-6348.
  16. Agou, F., Courtois, G., Chiaravalli, J., Baleux, F., Coïc, Y.-M., Traincard, F., Israël, A. and Véron, M. (2004) Inhibition of NF-kB activation by peptides targeting NEMO oligomerisation. J. Biol. Chem., 279, 54248-54257.
  17. Agou, F., Traincard, F., Vinolo, E., Courtois, G., Yamaoka, S., Israël, A., Véron, M. (2004) The trimerization domain of NEMO is composed of the interacting C terminal CC2 and LZ coiled-coil subdomains. J. Biol. Chem., 279, 27861-27869.
  18. Agou, F., Ye, F., Goffinont, S., Courtois, G. Yamaoka, S., Israël, A. and Véron, M. (2002) NEMO trimerizes though its coiled-coil C-terminal domain. J. Biol. Chem., 277, 17464-17475.