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Cellular and Structural Biochemistry Unit (CNRS UMR 3528) -
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Head of the Unit Michel VERON, PhD Directeur de Recherche at CNRS (DR1) Professor at Institut Pasteur Phone: 33 (0)1 45 68 84 03 Cell phone : 33 (0)6 78 49 51 51 Email: michel.veron@pasteur.fr
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| Secretary Catherine TRAN Phone : 33(0)1 40 61 34 17 Fax : 33 (0)1 45 68 83 99 Email: catherine.tran@pasteur.fr |
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- The « NEMO team » (PI: Fabrice Agou) is studying the structure of the NEMO protein (NF-kB Essentiel Modulator) and the mechanism by which it regulates the activity of the IKK complex. This central element of the NF-kB signal transduction pathway has been shown to be involved in inflammation and, more recently, in cancer progression via its role in the control of apoptosis.
- The « Opiorphin team » (PI : Catherine Rougeot) is studying new natural peptide mediators of the adaptive responses to stress: Sialorphin in rats and its functional analog in human, Opiorphin. These molecules play a central role in modulating pain perception and emotional states.
Both projects have important application potential which lied to the development of R&D contracts with Pharma companies.
Key-words:
NEMO team
Molecular signalisation, NF-κB pathway, Structural biology, Biophysics, Inflammation, Cancer.
Opiorphin team
Pharmaco-chemistry, Peptide mediators, Pain, mu and delta Opioïds pathways, metalloectopeptidases.
For summary of recent results, see: http://www.pasteur.fr/recherche/RAR/RAR2010/Reac-en.html
Postal address:
Unité de Biochimie Structurale et Cellulaire
Institut Pasteur
25-28 Rue du Docteur Roux
75724 PARIS Cedex 15
France
Last update of this site : November 2010