Biophysique des macromolécules et de leurs interactions

Thermodynamic stability of macromolecule
Relevant technologies at the PFBMI

Circular dichroism (CD)

Measurement of secondary and tertiary structures.
Abalyse of conformational changes
Kinetic of folding
Thermal and chemical stability of folding


Differential Scanning Calorimeter (DSC) 

Thermal stability of macromolecules and their complexes

Fluorescence spectroscopy

Analysis of tertiary conformation, of thermal and chemical stability and of molecular interactions: 

intensity, anisotropy and fluorescence life-time.

The PFBMI can advise you or direct you on your choices and give you information on:

* Experiments requirements and constraints
* Lenght if experiments
* Estimations and calculations of physico-chemical parameters
* Methodological links and softwares to be used