Units and groups of the Department of Structural Biology and Chemistry

Biochemistry of Macromolecular Interactions
Head : Daniel LADANT

Key-words :
Toxin, adenylyl cyclase, translocation, membrane interaction, cell division

Cellular and Structural Biochemistry
Head : Michel VERON

Key-words :

NF-kB, IKK complex, Ubiquitin, Peptide mediators, Opioid pathways

Chemistry and Biocatalysis
Head :  Sylvie POCHET

Key-words :

Nucleoside analogues, nucleotide metabolism enzymes, chemo-enzymatic approaches, anti-infectious agents, chemical library screening

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Chemistry of Biomolecules
Head : Laurence MULARD

Key-words :

Cancer, Carbohydrate-protein interactions, HIV, Shigella, Glycoconjugate vaccines

Molecular Mechanisms of Membrane Transport
Head : Nicolas REYES

Key-words :
X-ray crystallography, calorimetry, fluorescence spectroscopy, electrophysiology


Laboratory "Pharmacology of Pain"
Head : Catherine ROUGEOT

Key-words :
Molecular and behavioral Pharmacology, Peptide mediators, Pain, mu- and delta-Opioïds pathways, Metalloectopeptidases


NMR of Biomolecules
Head : Muriel DELEPIERRE

Key-words :

Heme acquisition, signalling pathways, transcription regulation, shigella vaccin, Aspergillus fumigatus cell wall

Structural BioInformatic
Head : Michael NILGES

Key-words :

Structural Bioinformatics, Molecular Dynamics, Genome Analysis, Structure Prediction, Protein/Protein Interactions

G5 Structural Biology of Bacterial Secretion

Key-words :

Horizontal gene transfer, Bacterial secretion, Protein complex, Nosocomial infection, Antibiotics resistance.

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Structural Dynamics of Macromolecules
Head :  Marc DELARUE

Key-words :

DNA Polymerase, Topoisomerase,
Membrane protein, X-ray crystallography, Normal modes, Coarse-grained models.



Structural Microbiology
Head : Pedro ALZARI

Key-words :


Structural enzymology, Bacterial protein phosphorylation, Two-component systems, Bacterial régulation of lipid biosynthesis , Mycobacterium tuberculosis


Structural Mass Spectrometry
and Proteomics

Key-words :

Mass spectrometry, proteomics, posttranslational modification,
protein identification and quantification, H/D exchange, covalent cross-linking, native mass spectrometry.

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Biophysics of Macromolecules
and their interactions
Head : Patrick ENGLAND

Key-words :

Spectroscopy, Hydrodynamics, Thermodynamics, Kinetics, Proteins

Crystallogenesis and X-Ray Diffraction
Head : Ahmed HAOUZ

Key-words :

Protein crystallography, Structural genomics, automated crystallogenesis, X-ray diffraction, Human pathogens

Web site of the PF6

Production of Recombinant Proteins and Antibodies
Head : Patrick ENGLAND

Head : julia CHAMOT-ROOKE

Key-words :

Proteomics, 2D-electrophoresis, mass spectrometry, LC-MS MS, signaling

Ultrastructural Microscopy
Head :  Marie-Christine PREVOST

Structural Immunology
Head : Graham BENTLEY

Unit closed