Research / Scientific departments / Microbiology / Units and groups / Research / Interactions Bacteriophages-Bacteria in Animals / Research / Lung infection model with Pseudomonas aeruginosa

Lung infection model with Pseudomonas aeruginosa

Pulmonary infections are one of the leading cause of death in the world. To determine which conditions are governing the efficacy of bacteriophages to treat pulmonary bacterial infections we developed animal models using in particular live real-time imaging technologies.
The opportunistic pathogen Pseudomonas aeruginosa is the bacterium that is most often found infecting
cystic fibrosis patients. We isolated several bacteriophages infecting P. aeruginosa strains and we have successfully demonstrated their in vivo effecacy in our model.


This work receives support from Vaincre La Mucoviscidose




References

Debarbieux L, Leduc D, Maura D, Morello E, Criscuolo A, Grossi O, Balloy V, Touqui L. (2010) Bacteriophages can treat and prevent Pseudomonas aeruginosa lung infections. Journal of Infectious Diseases. 201(7):1096-1104
 
Morello E, Saussereau E, Maura D, Huerre M, Touqui L, Debarbieux L. (2011) Pulmonary bacteriophage therapy on Pseudomonas aeruginosa cystic fibrosis strains: first steps towards treatment and prevention. PLoS One. 6(2):e16963.
 
Saussereau E, Debarbieux L. (2012) Bacteriophages in the experimental treatment of Pseudomonas aeruginosa infections in mice. Advances in Virus Research 83:123-141.
 
Henry M, Lavigne R, Debarbieux L. (2013) Predicting in vivo efficacy to guide the choice of therapeutic bacteriophages to treat pulmonary infections. Antimicrobial Agents Chemotherapy. Sep 16 (ahead of print).