Biology of Gram positive Pathogens Unit
The main goals of our research activity aim at elucidating new pathways/mechanisms involved in the pathogenesis of low GC% Gram positive pathogens. We believe that the in-depth understanding of infectious processes will contribute to the development of new therapeutics or innovative tools for the treatment, prevention and control of infections due to Gram positive bacteria.
We have chosen S. aureus and S. agalactiae, as models of extracellular human pathogens and L. monocytogenes as a model human intracellular pathogen.
Our main research topics are :
• Gene regulation in relation with :
- Stress response
- Environmental adaptation (two-component regulatory systems)
- Expression of virulence
• Bacterial surface components and interaction with the host :
- Lipoteichoic acids
- Cell-wall anchored proteins