Brief Curriculum Vitae

NAME: Tomohiro MATSUI (Male)
DATE OF BIRTH: February 17, 1972 (Age: 38 years old)
PLACE OF BIRTH: Saiki, Oita, JAPAN
NATIONALITY: Japanese
MARITAL STATUS: Married (December 25, 2001)
CHILD: One girl (Date of birth: December 26, 2005)
BUSINESS ADDRESS:
Department of Laboratory Sciences,
Faculty of Health Sciences,
Yamaguchi University Graduate School of Medicine,
1.1.1Minami-kogushi, Ube, Yamaguchi 755-8505, JAPAN
TEL/FAX: +81-836-22-2865
E-mail: giants@yamaguchi-u.ac.jp or giants-ygc@umin.ac.jp
HOME ADDRESS:
1-5-31 Nishi-kogushi, Ube, Yamaguchi 755-0049, JAPAN
TEL/FAX: +81-836-35-8553

EDUCATION:
1990 - 1994 Division of Medical Technology,
School of Allied Health Sciences, Faculty of Medicine,
Tokyo Medical and Dental University, Tokyo, JAPAN
1994 - 1996 Division of Food and Nutritional Sciences,
Graduate School of Nutritional and Environmental Sciences,
University of Shizuoka, Shizuoka, JAPAN
1996 - 1999 Institution of International Health, Graduate School of Medicine,
The University of Tokyo, Tokyo, JAPAN

DEGREES:
March 29, 1994 B.S. (Health Sciences) (Tokyo Medical and Dental University)
March 22, 1996 M.S. (Food and Nutritional Sciences) (University of Shizuoka)
March 29, 1999 Ph.D. (Health Sciences) (The University of Tokyo)

LICENSE:
October 31, 1994 Clinical Laboratory Technician (#120747) (JAPAN)

EMPLOYMENT:
July 1998 - March 1999 Research Fellow (DC2)
Japan Society for the Promotion of Science, Tokyo, JAPAN
April 1999 - March 2000 Assistant Professor
Division of Laboratory Medicine,
School of Allied Health Sciences, Yamaguchi University, Yamaguchi, JAPAN
April 2000 - September 2000 Assistant Professor
Department of Medical Humanities, Faculty of Medicine,
Yamaguchi University School of Medicine, Yamaguchi, JAPAN
October 2000 - December 2003 Assistant Professor
Department of Laboratory Sciences, Faculty of Health Sciences,
Yamaguchi University School of Medicine, Yamaguchi, JAPAN
January 2004 - September 2004 Research Fellow
Department of Anesthesiology, University of California-San Diego, San Diego, CA, U.S.A.
October 2004 - March 2007 Assistant Professor
Department of Laboratory Sciences, Faculty of Health Sciences,
Yamaguchi University School of Medicine, Yamaguchi, JAPAN
April 2007 - September 2008 Assistant Professor
Department of Laboratory Sciences, Faculty of Health Sciences,
Yamaguchi University Graduate School of Medicine, Yamaguchi, JAPAN
October 2008 - September 2009 Research Fellow
Unit of Cytokines & Inflammation, Department of Infection and Epidemiology, Institut Pasteur, Paris, France
October 2009 - Present Assistant Professor
Department of Laboratory Sciences, Faculty of Health Sciences,
Yamaguchi University Graduate School of Medicine, Yamaguchi, JAPAN

RESEARCH GRANTS (Principal Investigator):
1998 - 1999
"Immunological and cellular biological studies of bone resorption in pregnant women with high estrogen levels"
Research Fellowship of the Japan Society for the Promotion of Science for Young Scientists. (JPY 900,000)
2000 - 2002
"Cytokine imbalance between pro- and anti-inflammatory cytokines in hypothermia for neuronal protection"
The Ministry of Education, Culture, Sports, Science, and Technology of Japan, Grant-in-Aid for Scientific Research No. 12770822. (JPY 2,100,000)
2002 - 2004
"Role of cytokine imbalance in relation to immune functions for neuronal protection by hypothermia"
The Ministry of Education, Culture, Sports, Science, and Technology of Japan, Grant-in-Aid for Scientific Research No. 14770773. (JPY 3,100,000)
2004 - 2006
"The relationship between microglia and their cytokine production in hypothermic neuronal protection"
The Ministry of Education, Culture, Sports, Science, and Technology of Japan, Grant-in-Aid for Scientific Research No. 16790877. (JPY 3,300,000)
2006 - 2008
"The mechanism of neuronal protection by hypothermia: the interaction between microglia and neurons, and role of interleukin-10"
The Ministry of Education, Culture, Sports, Science, and Technology of Japan, Grant-in-Aid for Scientific Research No. 18791082. (JPY 3,500,000)
2008 - 2010
"Temperature-dependent responses in neuronal injury by hypoxia-induced microglia"
The Ministry of Education, Culture, Sports, Science, and Technology of Japan, Grant-in-Aid for Scientific Research No. 20791077. (JPY 3,300,000)
2010 - 2012
"The effect of hypothermia and hyperthermia on microglia regulated by TLR activation and hypoxia"
The Ministry of Education, Culture, Sports, Science, and Technology of Japan, Grant-in-Aid for Scientific Research No. 20791077. (JPY 2,900,000)

BIBLIOGRAPHY:
Book
1.Matsui T.: Detection of red cell antibodies. In: Kubota T., Kato R., Fujita K., Kajiwara M. and Nagao N. eds. Immunological Laboratory Sciences (The 2nd edition). Tokyo: Ishiyaku Publishers, Inc., 304-312, 2010. (in Japanese)
2.Matsui T.: Search and identification of irregular antibodies. In: Nagao N. eds. The Practicum Textbook of Laboratory Sciences for Blood Transfusion and Transplantation. Tokyo: Ishiyaku Publishers, Inc., 2010. (in Japanese) (in press)

Original articles (Selected recent publications)
1.Yamamoto S., Nakanishi O., Matsui T., Shinohara N., Kinoshita H., Lambert C. and Ishikawa T. Intrathecal adenosine A1 receptor agonist attenuates hyperalgesia without inhibiting spinal glutamate release in the rats. Cell. Mol. Neurobiol., 23(2), 175-185, 2003.
2.Matsui T., Ishikawa T., Takeuchi H., Tsukahara M. and Maekawa T. Mild hypothermia inhibits IL-10 production in peripheral blood mononuclear cells. Acta Anaesthesiol. Scand., 48, 205-210, 2004.
3.Takeuchi H., Fujita H., Iwasaki F., Takeuchi T., Imadome K., Okumiya T., Matsui T. and Takahashi M. A case of Epstein-Barr virus (EBV)-associated thymic carcinoid and investigation of existence of EBV-infected cells in thymus and thymic tumors. J. Clin. Microbiol., 42(6), 2850-2854, 2004.
4.Hua X-Y., Svensson CI., Matsui T., Fitzsimmons B., Yaksh TL. and Webb M. Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia. Eur. J. Neurosci., 22, 2431-2440, 2005.
5.Matsui T., Ishikawa T., Takeuchi H., Okabayashi K. and Maekawa T. Mild hypothermia promotes pro-inflammatory cytokine production in cultured monocytes. J. Neurosurg. Anesthesiol., 18(3), 189-193, 2006.
6.Matsui T. and Kakeda T. IL-10 production is reduced by hypothermia but augmented by hyperthermia in rat microglia. J. Neurotrauma, 25(6), 709-716, 2008.
7.Matsui T., Camilla I Svensson, Yuka Hirata, Kanae Mizobata, Xiao-Ying Hua, and Tony L Yaksh. Release of PGE2 and NO from spinal microglia is dependent on activation of p38 MAPK. Anesth. Analg., 2010 (in press)