Cytokines & Inflammation / Publications


The 10 most cited research papers :

1. Munoz C, Carlet J, Fitting C, et al. 418 x
Dysregulation of in vitro cytokine production by monocytes during sepsis
Journal of Clinical Investigation 88 (5): 1747-1754 Nov 1991

2. Perdomo OJJ, Cavaillon JM, Huerre M, et al. 169 x
Acute-inflammation causes epithelial invasion and mucosal destruction in experimental shigellosis
Journal of Experimental Medicine 180 (4): 1307-1319 Oct 1 1994

3. Adrie C, Adib-Conquy M, Laurent I, et al. 168 x 
Successful cardiopulmonary resuscitation after cardiac arrest as a "sepsis-Like" syndrome 
CIRCULATION  2002, 106( 5):562-568  


4. Haeffner-Cavaillon N, Cavaillon JM, Ciancioni C, et al. 166 x
In vivo induction of interleukin-1 during hemodialysis.
Kidney International 35 (5): 1212-1218 May 1989

5. Haeffner-Cavaillon N, Cavaillon JM, Laude M, et al. 156 x
C3a(C3adesarg) induces production and release of interleukin-1 by cultured human-monocytes
Journal of Immunology 139 (3): 794-799 Aug 1 1987

6. Zychlinsky A, Fitting C, Cavaillon JM, et al. 140 x
Interleukin-1 is released by murine macrophages during apoptosis induced by Shigella-flexneri
Journal of Clinical Investigation 94 (3): 1328-1332 Sep 1994


7. Cavaillon JM, Fitting C, Haeffner-Cavaillon N 139 x
Recombinant c5a enhances interleukin-1 and tumor-necrosis-factor release by lipopolysaccharide-stimulated monocytes and macrophages
European Journal of Immunology 20 (2): 253-257 Feb 1990

8. Cavaillon JM, Fitting C, Haeffner-Cavaillon N, et al. 130 x
Cytokine response by monocytes and macrophages to free and lipoprotein-bound Lipopolysaccharide
Infection and Immunity 58 (7): 2375-2382 Jul 1990

9. Marty C, Misset B, Tamion F, et al. 129 x
Circulating interleukin-8 concentrations in patients with multiple organ failure of septic and nonseptic origin .
Critical Care Medicine 22 (4): 673-679 Apr 1994

10. Munoz C, Misset B, Fitting C, et al. 119 x
Dissociation between plasma and monocyte-associated cytokines during sepsis
European Journal of Immunology 21(9): 2177-84 Sep1991




The most recent papers (2005 – 2011) :


Petit-Bertron A-F., Pedron T., Groß U., Coppée J-Y., Sansonetti P.J., Cavaillon J-M., Adib-Conquy M.
Adherence modifies the regulation of gene expression induced by interleukin-10
Cytokine 2005, 29, 1-12

Azevedo Z. M., Luz R. A., Victal S. H., Kurdian B., Fonseca V. M., Fitting C, Câmara F. P.,
Haeffner-Cavaillon N., Cavaillon J-M., Gaspar Elsas M. I. C., Xavier Elsas P.
Increased tumor necrosis factor- a production in whole blood cultures from children with primary malnutrition.
Braz. J Med Biol Res. 2005, 38, 171-183


Tirsoaga A, Novikov A., Adib-Conquy M., Werts C., Fitting C., Cavaillon J-M., Caroff M.
A simple method for the re-purification of endotoxins for biological use.
Applied and Environmental Microbiology 2007; 73: 1803-1808.

Liang X., Lin T., Sun G., Beasley-Topliffe L., Cavaillon J-M., Warren H.S. 
Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages 
J. Leuk. Biol. 2009, 86, 229-235
Warren H.S., Fitting C., Hoff E., Adib-Conquy M., Beasley-Topliffe L., Tesini B., Liang X., Valentine C., Hellman J., Hayden D., Cavaillon J-M.
Resilience to bacterial infection: difference between species could be due to proteins in serum 
J. Infect. Dis. 2010, 201: 223-232 

Ciornei C.D., Novikov A., Beloin C., Fitting C., Caroff M., GhigoJ-M., Cavaillon J-M., Adib-Conquy A. 
Biofilm-forming Pseudomonas aeruginosa bacteria undergo lipopolysaccharide structural modifications and induce enhanced inflammatory cytokine response in human monocytes. 
Innate Immun. 2010 Oct;16(5):288-301

Philippart F, Fitting C, Cavaillon JM. Lung microenvironment contributes to the resistance of alveolar macrophages to develop tolerance to endotoxin*.
Crit Care Med. 2012 Nov;40(11):2987-96


Fritz H.J., Girardin S.E., Fitting C., Werts C., Mengin-Lecreulx D., Caroff M., Cavaillon J-M.,
Philpott D.J., Adib-Conquy M.
Synergistic stimulation of monocytes and dendritic cells by Toll-like receptor 4, Nod1- and Nod2-activating agonists.
Eur. J. Immunol. 2005, 35, 2459-2470

Wullaer A, Verstrepen L, Van Huffel S, Adib-Conquy M, Cornelis S, Kreike M, Haegman M, El Bakkouri K, Sanders M, Verhelst K. Carpentier I, Cavaillon J-M, Heyninck K, Beyaert R.
LIND/ABIN-3 is a novel LPS-inducible inhibitor of NF- k B activation.
J. Biol. Chem. 2007, 282, 81-90.

Kapetanovic R., Nahori M-A., Balloy V, Fitting C., Philpott D.J., Cavaillon J-M., Adib-Conquy M.
Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages.
Infect. Immun. 2007, 75, 830-837

Verstrepen L, Adib-Conquy M, Kreike M, Carpentier I, Adrie C, Cavaillon JM, Beyaert R.
Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappaB.
J Cell Mol Med. 2008 ;12(1):316-29.

Thiriot A., DrapierA-M., MémetS., Fitting C., Sturnu-Leclere A., Cavaillon J-M., Cazenave P-A., Freitas A., Rueff-Juy D. 
Wild-derived mouse strains, a valuable model to study B cell response. 
Mol. Immunol. 2009, 46, 601-612 
Kapetanovic R, Jouvion G., Fitting C., Parlato M., C. Blanchet, Huerre M., Cavaillon J-M., Adib-Conquy M.
Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia
Microbes Infect. 2010, 12: 759-767

 Kapetanovic R., Parlato M., Fitting C., Quesniaux V., Cavaillon J-M., Adib-Conquy M.
Mechanisms of TNF induction by heat-killed Staphylococcus aureus differ upon the origin of mononuclear phagocytes.
Am. J. Physiol. - Cell Physiol. 2011, 300, C850-C859


Maxime V, Fitting C, Annane D, Cavaillon J-M.
Corticoides normalize leukocyte production of macrophage migration inhibitory factor in septic shock
J. Infect. Dis. 2005, 191, 138-144

Adib-Conquy M., Adrie C., Fitting C., Gattolliat O., Beyaert R, Cavaillon J-M.
Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients
Crit Care Med. 2006, 34, 2377-2385. (+ editorial pp 2498-5000)

Adib-Conquy M., Monchi M., Goulenok C., Laurent I., Thuong M., Cavaillon J-M., Adrie C.
Enhanced Plasma Levels of Soluble Triggering Expressed on Myeloid Cells-1 and Procalcitonin after Cardiac Surgery and Cardiac Arrest in the Absence of Infection
Shock. 2007 Oct;28(4):406-10.

Kim O.Y., Monsel A, Bertrand M., Cavaillon J-M., Coriat P., Adib-Conquy M 
Translocation of bacterial NOD2 agonist and its link with inflammation 
Crit. Care 2009, 13: R124 

Payen D., Mateo J. Cavaillon J-M., Fraisse F., Florriot F., Vicaut E., Haemofiltration & Sepsis Group of the College National de Réanimation et de Médecine d’Urgence des Hôpitaux extra-Universitaires. 
Impact of continuous venovenous hemifiltration on organ failure during the early phase of severe sepsis. A randomized controlled trial 
Crit. Care Med. 2009, 37, 803-810 

Adrie C., Monchi M., Fulgencio J-P., Cottias P., Haouache H., Alvarez-Gonzalvez A., Guerrini P., Cavaillon J-M., Adib-Conquy M. 
Immune status and apoptosis activation during brain death. 
Shock 2010, 33: 353-362

Kim O.Y., Monsel A., Bertrand M., Coriat P, Cavaillon J-M., Adib-Conquy M. 
Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation 
Crit. Care 2010, 14(2):R61 

Cavaillon, J-M.
Polymyxin B for endotoxin removal in sepsis.

Fitting C, Parlato M, Adib-Conquy M, Memain N, Philippart F, Misset B, Monchi M, Cavaillon JM, Adrie C.
DNAemia detection by multiplex PCR and biomarkers for infection in systemic inflammatory response syndrome patients.
PLoS One. 2012;7(6):e38916

Souza-Fonseca-Guimaraes F, Parlato M, Philippart F, Misset B, Cavaillon JM, Adib-Conquy M; the
Captain study group. Toll-like receptors expression and interferon-γ production by NK cells in human sepsis.
Crit Care. 2012 Oct 25;16(5):R206.


Asehnoune K., Fitting C., Edouard A.R., Cosson C., Benhamou D., Cavaillon J-M., Moine P.
Influence of resuscitation volume on blood cells TNF production in a murine model of haemorrhage
Resuscitation 2006, 68: 127-133

Asehnoune K., Fitting C., Edouard A.R., Minville V., Benhamou D, Cavaillon J-M., Moine P.
Beta-2 adrenoreceptor blockade partially restore ex vivo TNF production following hemorrhagic shock
Cytokine 2006, 34, 212-218

Geny B., Khun H., Fitting C., Zarantonelli L., Cayet N., Szatanick M., Alonso J-M., Prevost M-C, Cavaillon J-M., Huerre M., Popoff M.
Clostridium sordellii lethal toxin kills mice by producing a major increase in vascular permeability in the absence of inflammation .
Am. J. Pathol. 2007; 170, 1003-1017

Souza-Fonseca-Guimaraes F, Parlato M, Fitting C, Cavaillon JM, Adib-Conquy M.
NK Cell Tolerance to TLR Agonists Mediated by Regulatory T Cells after Polymicrobial Sepsis.
J Immunol. 2012 Jun 15;188(12):5850-8.


Tabary O., Corvol H., Boncoeur E., Chadelat K., Fitting C., Cavaillon JM., Clément A., J. Jacquot.
Adherence of airway neutrophils and inflammatory response is increased in CF airway epithelial cell-neutrophil interactions
Am J Physiol. Lung Cell Mol. Physiol, 2006; 290(3): L588-96

Adib-Conquy M, Pedron T, Petit-Bertron AF, Tabary O, Corvol H, Jacquot J, Clément A, Cavaillon JM.
Neutrophils in cystic fibrosis display a distinct gene expression pattern.
Mol Med. 2008 Jan-Feb;14(1-2):36-44

Petit-Bertron AF, Tabary O, Corvol H, Jacquot J, Clément A, Cavaillon JM, Adib-Conquy M.
Circulating and airway neutrophils in cystic fibrosis display different TLR expression and responsiveness to interleukin-10.
Cytokine. 2008 Jan;41(1):54-60.


Ibrahim-Granet O., Jouvion G., Hohl T.M., Droin-Bergere S., Philippart F., Kim O.Y., Adib-Conquy M., Schwendener R., Cavaillon J-M., Brock M. 
In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis. 
BMC Microbiol. 2010;10(1):105 

Ibrahim-Granet O, Dubourdeau M, Latgé JP, Ave P, Huerre M, Brakhage AA, Brock M.
Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis.
Cell Microbiol. 2008 Jan;10(1):134-48.

Moreno MA, Ibrahim-Granet O, Vicentefranqueira R, Amich J, Ave P, Leal F, Latgé JP, Calera JA.
The regulation of zinc homeostasis by the ZafA transcriptional activator is essential for Aspergillus fumigatus virulence.
Mol Microbiol. 2007 Jun;64(5):1182-97.

Lamarre C, Ibrahim-Granet O, Du C, Calderone R, Latgé JP.
Characterization of the SKN7 ortholog of Aspergillus fumigatus.
Fungal Genet Biol. 2007 Jul;44(7):682-90. Epub 2007 Jan 30.

Schöbel F, Ibrahim-Granet O, Avé P, Latgé JP, Brakhage AA, Brock M.
Aspergillus fumigatus does not require fatty acid metabolism via isocitrate lyase for development of invasive aspergillosis.
Infect Immun. 2007 Mar;75(3):1237-44. Epub 2006 Dec 18.

Dubourdeau M, Athman R, Balloy V, Huerre M, Chignard M, Philpott DJ, Latgé JP, Ibrahim-Granet O.
Aspergillus fumigatus induces innate immune responses in alveolar macrophages through the MAPK pathway independently of TLR2 and TLR4.
J Immunol. 2006 Sep 15;177(6):3994-4001.

Chabane S, Sarfati J, Ibrahim-Granet O, Du C, Schmidt C, Mouyna I, Prevost MC, Calderone R, Latgé JP.
Glycosylphosphatidylinositol-anchored Ecm33p influences conidial cell wall biosynthesis in Aspergillus fumigatus.
Appl Environ Microbiol. 2006 May;72(5):3259-67.

Berkova N, Lair-Fulleringer S, Féménia F, Huet D, Wagner MC, Gorna K, Tournier F, Ibrahim-Granet O, Guillot J, Chermette R, Boireau P, Latgé JP.
Aspergillus fumigatus conidia inhibit tumour necrosis factor- or staurosporine-induced apoptosis in epithelial cells.
Int Immunol. 2006 Jan;18(1):139-50. Epub 2005 Dec 15.

Knechtle P, Goyard S, Brachat S, Ibrahim-Granet O, d’Enfert C.
Phosphatidylinositol-dependent phospholipases C Plc2 and Plc3 of Candida albicans are dispensable for morphogenesis and host-pathogen interaction.
Res Microbiol. 2005 Aug;156(7):822-9

Jouvion G, Brock M, Droin-Bergère S, Ibrahim-Granet O.
Duality of liver and kidney lesions after systemic infection of immunosuppressed and immunocompetent mice with Aspergillus fumigatus.

Slesiona S, Ibrahim-Granet O, Olias P, Brock M, Jacobsen ID.
Murine infection models for Aspergillus terreus pulmonary aspergillosis reveal long-term persistence of conidia and liver degeneration.
J Infect Dis. 2012 Apr 15;205(8):1268-77.

Fekkar A, Pionneau C, Brossas JY, Marinach-Patrice C, Snounou G, Brock M, Ibrahim-Granet O, Mazier D.
DIGE enables the detection of a putative serum biomarker of fungal origin in a mouse model of invasive aspergillosis.
J Proteomics. 2012 May 17;75(9):2536-49.

Schrettl M, Ibrahim-Granet O, Droin S, Huerre M, Latgé JP, Haas H.
The crucial role of the Aspergillus fumigatus siderophore system in interaction with alveolar macrophages.
Microbes Infect. 2010 Nov;12(12-13):1035-41.


Gumy A, Aseffa A, Rachinel N, Breton M, Otten L, Tacchini-Cottier F, Röcken M, Doyen N, Acha-Orbea H, Locksley RM, MacDonald HR, Launois P, Louis J.
LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major.
Eur J Immunol. 2006 Jun;36(6):1465-73.

Abou Fakher FH , Rachinel N , Klimczak M , Louis J , Doyen N
TLR9-dependent activation of dendritic cells by DNA from Leishmania major favors Th1 cell development and the resolution of lesions. 
J Immunol.2009 Feb 1;182(3):1386-96



Annane D., Bellissant E., Cavaillon J-M.
Septic Shock
The Lancet, 2005, 365, 63-78

Cavaillon J-M., Adrie c., Fitting C;, Adib-Conquy M.
Reprogramming of circulatory cells in sepsis and SIRS
J. Endotoxin Res. 2005, 11, 311-320

Cavaillon J-M., Adib-Conquy M.
Monocytes / macrophages and sepsis
Crit. Care Med. 2005, 33, S506-S509

Cavaillon J-M., Annane D.
Compartmentalization of the inflammatory response in sepsis and SIRS
J. Endotoxin Res. 2006, 12, 151-170

Cavaillon J-M., Adib-Conquy M.
Endotoxin tolerance as a model of immune deactivation in sepsis
Crit. Care 2006, 10, 233

Cavaillon J-M., Munford R.S.
A tribute to Ernst Th. Rietschel: the gentleman scientist.
J. Endotoxin Res. 2007;13(1):3-5.

Cavaillon J-M., Adib-Conquy M.
Determining the degree of immunodysregulation in sepsis
Contr. Nephrol 2007, 156: 101-111

Adib-Conquy M., Cavaillon J-M.
Stress proteins in sepsis and systemic inflammatory response syndrome
FEBS Lett. 2007 Jul 31;581(19):3723-33.

Kapetanovic R, Cavaillon J-M.
Early events in innate immunity in the recognition of microbial pathogens
Expert Opinion Biol. Therapy 2007 Jun;7(6):907-18

Philippart F, Cavaillon J-M.
Sepsis mediators.
Curr Infect Dis Rep. 2007 Sep;9(5):358-65.

Cavaillon J-M. 
Commentary: Monocyte TREM-1 membrane expression in non-infectious inflammation 
Crit. Care, 2009, 13:15

Cavaillon J-M., Adib-Conquy M.
Immune  status in sepsis: the bug, the site of infection and the severity can make the difference.
Cavaillon J-M.
The historical milestones in the understanding of leukocyte biology initiated by Elie Metchnikoff

Cavaillon JM.
Good and bad fever.

Souza-Fonseca-Guimaraes F, Adib-Conquy M, Cavaillon JM.
Natural killer (NK) cells in antibacterial innate immunity: angels or devils?


Cavaillon J-M.
Médiateurs de l’Inflammation
IN "Sepsis Sévère et choc septique" Collection "Le point sur…" (J-L. Vincent, C. Martin, Eds)
Edition Springer-Verlag, 2005, pp. 23-49

Cavaillon, J-M.
Molecular mediators : cytokines
IN "Encyclopedia of Molecular Cell Biology and Molecular Medicine", 2nd Edition
Wiley-VCH Verlag, Weinheim, Germany, 2005, Vol. 8, pp 431-460

Cavaillon J-M., Adib-Conquy M
Compartmentalized activation of immune cells during sepsis and organ dysfunction
IN "Update in Intensive Care and Emergency Medicine" – "Mechanisms of sepsis induced organ
dysfunction and recovery" (E. Abraham & M. Singer Eds) Springer-Verlag, Heidelberg; pp 161-182

Cavaillon J-M.
Médiateurs de l’Inflammation
IN "Physiologie Humaine Appliquée" (Sous la direction de C. Martin, B. Riou & B. Vallet)
Arnette, 2006, pp 927-945

Cavaillon J-M.
Molecular Mediators: Cytokines
IN "Proteins: From Analytics to Structural Genomics"
Robert A. Meyers (Editor); Volume 2. Wiley-VCH Verlag, Weinheim, Germany, October 2006

J-M. Cavaillon
Molecular Mediators: Cytokines
IN "Immunology: From Cell Biology to Disease"
Robert A. Meyers (Editor), Wiley-VCH Verlag, Weinheim, Germany, June 2007

Cavaillon J-M ., M. Adib-Conquy 
Réponse cellulaire et immunologique à l’agression
IN "Réanimation Médicale" 2e édition (Tome II, Éditeurs : F. Zéni & P. Charbonneau) 
Edition Masson, 2009, p.245-253.


Cavaillon J-M. and Adrie C.
Sepsis and Non-infectious Systemic Inflammation: From Biology to Critical Care
Wiley-VCH Verlag, Germany, 2009