Cytokines & Inflammation
The unit "Cytokines & inflammation was created on July 2001, as a provisional unit. After a four-year period, twelve external experts and the Scientific Council reviewed the scientific report. On March 2006, the unit "Cytokines & inflammation" was created by the Administrative Council of the Institut Pasteur, and by the Director.
Our aim is to study the production of cytokines by immune cells and the cytokine network in response to bacteria, fungi or parasites and to pathogen associated molecular patterns (PAMPs), particularly the endotoxin of Gram-negative bacteria (lipopolysaccharide, LPS). The aim is to understand the cooperative signals between PAMPs, and to investigate the influence of stressful conditions (trauma, sepsis, brain death, surgery, ischemia-reperfusion) on cytokine production. The altered immune status described in intensive care unit patients is reminiscent of the phenomenon of endotoxin tolerance and may favor the sensitivity of these patients to nosocomial infections.
Since August 2006, the unit is localized in building "Biotop", 5th floor (see below)
The unit is part of the department ’Infection and Epidemiology"