Research / Scientific departments / Immunology / Lymphoid Tissue Development / Publications

Publications

2013

  • S. Ivanov, J. Renneson, J. Fontaine, A. Barthelemy, C. Paget, E. Macho Fernandez, F. Blanc, C. De Trez, L. Van Maele, L. Dumoutier, M.R. Huerre, G. Eberl, M. Si-Tahar, P. Gosset, J.C. Renauld, J.C. Sirard, C. Faveeuw and F. Trottein. 2013. Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection. J. Virol., online publication.

  • M. McFall-Ngai, M.G. Hadfield, T.C. Bosch, H.V. Carey, T. Domazet-Loso, A.E. Douglas, N. Dubilier, G. Eberl, et al. 2013. Animals in a bacterial world, a new imperative for the life sciences. PNAS, 110:3229-3236.

  • H. Spits, D. Artis, M. Colonna, A. Diefenbach, J.P. Di Santo, G. Eberl, S. Koyasu, R.M. Locksley, A.N.J. McKenzie, R.E. Mebius, F. Powrie and E. Vivier. 2013. Innate lymphoid cells – a proposal for uniform nomenclature. Nat. Rev. Immunol., 13:145-149.

2012

  • S. Dulauroy, S.E. Di Carlo, F. Langa, G. Eberl and L. Peduto. 2012. Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury. Nat. Med., 18:1262-1270.

  • J.P. Sherlock, B. Joyce-Shaikh, S.P. Turner, C.-C. Chao, M. Sathe, J. Grein, D.M. Gorman, E.P. Bowman, T.K. McClanahan, J.H. Yearley, G.Eberl, C.D. Buckley, R.A. Kastelein, R.H. Pierce, D.M. LaFace and D.J. Cua. 2012. IL-23 induces spondyloarthropathy by acting on RORγt+ CD3+CD4−CD8− entheseal resident T cells. Nat. Med., 18:1069-1076.

  • A. Müller, O. Filipe-Santos, G. Eberl, T. Aebischer, G.F. Späth and P. Bousso. 2012. CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation. Immunity, 37:147-157.

  • C. Biot, C.A. Rentsch, J.R. Gsponer, F.D. Birkhäuser, H. Jusforgues-Saklani, F. Lemaître, C. Auriau, A. Bachmann, P. Bousso, C. Demangel, L. Peduto, G.N. Thalmann and M.L. Albert. 2012. Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer. Sci. Transl. Med., 4:137.

  • P.E. Joubert, S.W. Werneke, C. de la Calle, F. Guivel-Benhassine, A. Giodini, L. Peduto, B. Levine, O. Schwartz, D.J. Lenschow and M.L. Albert. 2012. Chikungunya virus-induced autophagy delays caspase-dependent cell death. J. Exp. Med., 209:1029-1047.

  • M. Cherrier, C. Ohnmacht, S. Cording and G. Eberl. 2012. Development and function of intestinal innate lymphoid cells. Curr. Opin. Immunol., 24:277-283.

  • F. Chalmin, G. Mignot, M. Bruchard, A. Chevriaux, F. Végran, A. Hichami, S. Ladoire, V. Derangère, J. Vincent, D. Masson, S.C. Robson, G. Eberl, J.R. Pallandre, C. Borg, B. Ryffel, L. Apetoh, C. Rébé and F. Ghiringhelli. 2012. Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression. Immunity, 36:362-373.

  • M. Cherrier and G. Eberl. 2012. The development of LTi cells. Curr. Opin. Immunol., 24:178-183.

  • M. Cherrier, S. Sawa and G. Eberl. 2012. Notch, Id2 and RORgt sequentially orchestrate the fetal development of lymphoid tissue inducer cells. J. Exp. Med., 209:729-740.

  • N. Cerf-Bensussan and G. Eberl. 2012. The dialog between microbiota and the immune system: Shaping the partners through development and evolution. Guest Editors. Sem. Immunol., 24:1-2.

  • G. Eberl. 2012. Development and evolution of RORgt+ cells in a microbe's world. Immunol. Rev., 245:177-188.

2011

  • R. Marques and I.G. Boneca. 2011. Expression and functional importance of innate immune receptors by intestinal epithelial cells. Cell. Mol. Life Sci., 68:3661-3673.

  • Y. Simoni, A.S Gautron, L. Beaudoin, L.C. Bui, M.L. Michel, X. Coumoul, G. Eberl, M. Leite-de-Moraes, A. Lehuen. 2011. NOD mice contain an elevated frequency of iNKT17 cells that exacerbate diabetes. Eur. J. Immunol., 41:3574-3585.

  • P. Gasse, N. Riteau, R. Vacher, M.-L. Michel, A. Fautrel, F. di Padova, L. Fick, S. Charron, V. Lagente, G. Eberl, M. Le Bert, V.F.J. Quesniaux, F. Huaux, M. Leite-de-Moraes, B. Ryffel and I. Couillin. 2011. IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis. Plos One, 6:e23185.

  • L. Dumoutier, M. de Heusch, C. Orabona, N. Satoh-Takayama, G. Eberl, J.C. Sirard, J.P. Di Santo and J.C. Renauld. 2011. IL-22 is produced by gc-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality. Eur. J. Immunol., 41:1075-1085.

  • N. Satoh-Takayama, S. Lesjean-Pottier, S. Sawa, C.A. Vosshenrich, G. Eberl and J.P. Di Santo. 2011. Lymphotoxin-b receptor-independent development of intestinal IL-22-producing NKp46+ innate lymphoid cells. Eur. J. Immunol., 41:780-786.

  • S. Sawa, M. Lochner, N. Satoh-Takayama, S. Dulauroy, M. Bérard, M. Kleinschek, D. Cua, J.P. Di Santo and G. Eberl. 2011. RORgt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nat. Immunol., 12:320-326.

  • C. Ohmnacht, R. Marques, L. Presley, S. Sawa, M. Lochner and G. Eberl. 2011. Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity. Cell. Microbiol., 13-653-659.

  • E. Letavernier, B. Dansou, M. Lochner, J. Perez, A. Bellocq, M.T. Lindenmeyer, C.D. Cohen, J.P. Haymann, G. Eberl and L. Baud. 2011. Critical role of the calpain/calpastatin balance in acute allograft rejection. Eur. J. Immunol., 41:473-484.

  • M. Lochner, M. Bérard, S. Sawa, V. Hauer, V. Gaboriau-Routhiau, T.D. Fernandez, J. Snel, P. Bousso, N. Cerf-Bensussan and G. Eberl. 2011. Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells. J. Immunol., 186:1531-1537.

  • M. Lochner, C. Ohnmacht, L. Presley, P. Bruhns, M. Si-Tahar, S. Sawa and G. Eberl. 2011. Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgt and LTi cells. J. Exp. Med., 208:125-134.

2010
  • S. Sawa, M. Cherrier, M. Lochner, N. Satoh-Takayama, H.J. Fehling, F. Langa, J.P. Di Santo and G. Eberl. 2010. Lineage relationship analysis of RORgt+ innate lymphoid cells. Science, 330:665-669.
  • K. Ghoreschi, A. Laurence, X. Yang, C.M. Tato, M.J. McGreachy, J. Konkel, H.L. Ramos, L. Wei, T. Davidson, N. Bouladoux, J. Grainger, Q. Chen, Y. Kanno, W.T. Watford, H. Sun, G. Eberl, E. Shevach, Y. Belkaid, D.J. Cua, W. Chen and J.J. O’Shea. 2010. Enhanced pathogenicity of Th17 cells generated in the absence of transforming growth factor-b signaling. Nature, 467:967-971.
  • G. Eberl and I. Gomperts-Boneca. 2010. Bacteria and MAMP-induced morphogenesis of the immune system. Curr. Opin. Immunol., 22:1-7.
  • O. Thaunat, N. Patey, G. Caligiuri, C. Gautreau, M. Mamani-Matsuda, Y. Mekki, M.C. Dieu-Nosjean, G. Eberl, R. Ecochard, J.B. Michel, S. Graff-Dubois and A. Nicoletti. 2010. Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis. J. Immunol, 185:717-728.
  • G. Eberl. 2010. Close encounters of the second type. Nature, 464:1285-1286.
  • G. Eberl. 2010. A new vision of immunity: homeostasis of the superorganism. Mucosal Immunol., 3:450-460.
  • C. Schilte, T. Couderc, F. Chretien, M. Sourisseau, N. Gangneux, F. Guivel-Benhassine, A.  Kraxner, J. Tschopp, S. Higgs, A. Michault, F. Arenzana-Seisdedos, M. Colonna, L. Peduto, O. Schwartz, M. Lecuit and M.L. Albert. 2010. Type I IFN controls chukungunya virus via its action on nonhematopoietic cels. J. Exp. Med., 207:429-442.
  • N. Satoh-Takayama, S. Lesjean-Pottier, P. vieira, S. Sawa, G. Eberl, C.A. Vosshenrich and J.P. Di Santo. 2010. IL-7 and IL-15 independently program the differentiation of intestinal CD3- NKp46+ cell subsets from Id2-dependent precursors. J. Exp. Med., 207:273-280.
  • G. Sellge, J.G. Magalhaes, C. Konradt, J.H. Fritz, W. Salgado-Pabon, G. Eberl, A. Bandeira, J.P. Di Santo, P.J. Sansonetti and A. Phalipon. 2010. Th17 cells are the predominant T cell subtype primed by Shigella flexneri mediating protective immunity. J. Immunol., 184:2076-2085.
  • G. Eberl and S. Sawa. 2010. Opening the crypt: current facts and hypotheses on the function of cryptopatches. Trends in Immunol., 31:50-55.

2009


  • V. Gaboriau-Routhiau, S. Rakotobe, E. Lécuyer, I. Mulder, A. Lan, C. Bridonneau, V. Rochet, A. Pisi, M. De Paepe, G. Brandi, G. Eberl, J. Snel, D. Kelly and N. Cerf-Bensussan. 2009. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity, 31:677-689.
  • K. Lahl, C.T. Mayer, T. Bopp, J. Huehn, C. Loddenkemper, G. Eberl, G. Wirnsberger, K. Dornmair, R. Geffers, E. Schmidt, J. Buer and T. Sparwasser. 2009. Non-functional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice. J. Immunol., 183:5662-5672.
  • L. Klotz, S. Burgdorf, I. Dani, K. Saijo, J. Flossdorf, S. Hucke, J. Alferink, N. Novak, M. Beyer, G. Meyer, B. Langhans, T. Klockgether, A. Waisman, G. Eberl, J. Schultz, M. Famulok, W. Kolanus, C. Glass, C. Kurtz and P.A. Knolle. 2009. The nuclear receptor PPARγ selectively controls Th17 differentiation in a T cell-intrinsinc fashion and suppresses CNS autoimmunity. J. Exp. Med., 206:2079-2089.

  • G. Eberl and M. Lochner. 2009. The development of intestinal lymphoid tissues at the interface of self and microbiota. Mucosal Immunology, 2:478-485.

  • J.M.  Doisne, C. Becourt, L. Amniai, N. Duarte, J.B. Le Luduec, G. Eberl and K. Benlagha. 2009. Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-Related orphan receptor γt and respond preferentially under inflammatory conditions. J. Immunol., 183:2142-2149.

  • L. Peduto. 2009. ADAM9 as a potential target molecule in cancer. Curr. Pharm. Design, 15:2282-2287.

  • L. Peduto, S. Dulauroy, M. Lochner, G.F. Späth, M.A. Morales, A. Cumano and  G. Eberl. 2009. Inflammation recapitulates the ontogeny of lymphoid stromal cells. J. Immunol., 182:5789-5799.

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  • N.L. Alves, O. Richard-Le Goff, N.D. Huntington, A. Patricia Sousa, F. Langa Vives, L. Peduto, P. Vieira, A. Chidgey, A. Cumano, R. Boyd, G. Eberl and J.P. Di Santo. 2009. Characterization of the thymic IL-7 niche in vivo. PNAS, 106:1512-1517.

2008

  • N. Satoh-Takayama, C.A.J. Vosshenrich, S. Lesjean-Pottier, S. Sawa, M. Lochner, F. Rattis, J.J. Mention, K. Thiam, N. Cerf-Bensussan, O. Mandelboim, G. Eberl and J.P. Di Santo. 2008. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity, 29:958-970.

  • M.L. Michel, D. Mendez-da-Cruz, A. Castro Keller, M. Lochner, E. Schneider, M. Dy, G. Eberl and M.C. Leite-de-Moraes. 2008. Criticial role of RORgt in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation. PNAS, 105:19845-19850.

  • F. Osorio, S. Leubundgut-Landmann, M. Lochner, K. Lahl, T. Sparwasser, G. Eberl, and C. Reis e Sousa. 2008. Dendritic cells activated via dectin-1 convert regulatory T cells into IL-17 producers. Eur. J. Immunol., 38:3274-3281.

  • D. Bouskra, C. Brézillon, M. Bérard, C. Werts, R. Varona, I. Gomperts Boneca, and G. Eberl. 2008. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature, 456:507-510.

  • M. Lochner, L. Peduto, M. Cherrier, S. Sawa, F. Langa,  R. Varona, D. Riethmacher, M. Si-Tahar, J.P. Di Santo, and G. Eberl. 2008. In vivo Equilibrium of pro-inflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgt+ T cells. J. Exp. Med., 205:1381-1393.

2007

  • G. Eberl. 2007. From induced to programmed lymphoid tissues: the long road to pre-empt pathogens. Trends in Immunology, 28:423-428.
  • M.D. Boos, Y. Yokota Y, G. Eberl, and B.L. Kee. 2007. Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity. J Exp Med., 204:1119-1130.
  • T. Sparwasser, and G. Eberl. 2007. BAC to Immunology - Bacterial Artificial Chromosome-mediated transgenesis for targeting of immune cells. Immunology, 121:308-313.
  • G. Eberl. 2007. Development and function of secondary and tertiary lymphoid tissues - meeting report. Eur J Immunol., 37:300-1.
  • K. Lahl, C. Loddenkemper, C. Drouin, J. Freyer, J. Arnason, G. Eberl, A. Hamann, H. Wagner, J. Hühn, and T. Sparwasser. 2007. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J. Exp. Med., 204:57-63.

2006

  • L. Peduto, V.E. Reuter, A. Sehara-Fujisawa, D.R. Shaffer, H.I. Scher and Blobel C.P. 2006. ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression. Oncogene, 25:5462-5466.

2005

  • G. Eberl. 2005. Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway? Nat. Rev. Immunol., 5:413-420.
  • T. Egawa, G. Eberl, I. Taniuchi, K. Benlagha, F. Geissmann, L. Hennighausen, A. Bendelac, and D.R. Littman. 2005. Genetic evidence supporting selection of Va14iNKT cell lineage from double-positive thymocyte precursors. Immunity, 22:705-716.


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2004

  • G. Eberl, and D.R. Littman. 2004. Thymic origin of intestinal ab T cells revealed by fate mapping of RORgt+ cells. Science, 305:248-251.
  • G. Eberl, S. Marmon, M.J. Sunshine, P.D. Rennert, Y. Choi, and D.R. Littman. 2004. An essential function for the nuclear receptor RORgt in the generation of fetal lymphoid tissue inducer cells. Nat. Immunol., 5:64-73.
  • T. Sparwasser, S. Gong, J.Y.H. Li, and G. Eberl. 2004. General method for the modification of different BAC types and the rapid generation of BAC transgenic mice. Genesis, 38:39-50.

2003

  • G. Eberl, and D.R. Littman. 2003. The role of the nuclear hormone receptor RORgt in the development of lymph nodes and Peyer’s patches. Immunol. Rev., 195:81-90.