Postdoc and PhD students

The Lymphoid Tissue Development (LTD) Unit is recruiting one postdoctoral fellow. The position is to study the regulation of the intestinal immune system by microbiota, in particular of pro-inflammatory RORgt-expressing lymphoid cells. The Unit has recently shown how microbiota regulates the development of intestinal lymphoid tissues (Bouskra, Nature 2008) and the activity of innate lymphoid cells (ILCs) (Sawa et al, Science 2010; Nat. Immunol., 2011), and how pro-inflammatory immunity is required for intestinal homeostasis (Lochner et al, J Exp Med 2010). We know wish to understand how perturbations in RORgt+ cells and the microbial community impact on intestinal immunity, and how such perturbations derail host homeostasis and immune reactivity.  Please send applications to:

The Lymphoid Tissue Development (LTD) Unit is recruiting one PhD student (or Master M2). The position is to study the regulation of immune responses by stromal cells, in particular stromal cells in lymphoid organs and in lymphocyte-rich organs such as the gut, and stromal cells in inflammation. We have previously shown that inflammatory lesions need to develop a specialized stromal network to organize the recruitment and survival of lymphocytes (Peduto et al., JI 2009), and that a distinct subset of these activated stromal cells develop a profibrotic fate (Dulauroy et al., Nature Medicine 2012). Using recently generated reporter and deleter mice for specific subsets of stromal cells, we now aim at deciphering how such subsets of stromal cells regulate immune responses after injury, infection or tumors. Please send applications to:

The positions are open for 2014. Applicants should have a strong background in cellular immunology, cell biology or physiology, be highly motivated to do research in this competitive and exciting area, and show an innate ability to work as a team. Experience in transcriptional analysis, multi-parameter flow cytometry and/or mouse models are highly desirable. The LTD Unit enjoys numerous collaborations with researchers on campus and beyond that are necessary to advance in the multi-disciplinary fields of mucosal immunology and inflammation. The Pasteur campus offers top expertise in microbiology and immunology, as well as cutting-edge technical platforms, all of which are essential to progress at these scientific frontiers.