Postdoc
Postdoc positions 2013
The Lymphoid Tissue Development (LTD) Unit is recruiting two postdoctoral fellows. The first position is to study the regulation of the intestinal immune system, in particular of pro-inflammatory RORgt-expressing lymphoid cells. The Unit has recently shown how microbiota regulates the development of intestinal lymphoid tissues (Bouskra, Nature 2008) and the activity of innate lymphoid cells (ILCs) (Sawa et al, Science 2010; Nat. Immunol., 2011), and how pro-inflammatory immunity is required for intestinal homeostasis (Lochner et al, J Exp Med 2010). We know wish to understand how perturbations in RORgt+ cells and the microbial community impact on intestinal immunity, and how such perturbations derail host homeostasis and immune reactivity. Please send applications to: gerard.eberl@pasteur.fr.
The second position is to study the molecular and cellular mechanisms that underlie inflammation and fibrosis, which develop in many chronic diseases including pulmonary fibrosis, atherosclerosis and cancer. We have shown previously that a population of lymphoid stromal (LS) cells are programmed during the fetal development of lymphoid tissues, and re-induced by injury to organize inflammation (Peduto et al., JI 2009). More recently, we have shown that a distinct subset of LS cells, residing in the perivascular space and expressing ADAM12 upon injury, generate a majority of profibrotic cells in acutely injured skin and skeletal muscle (Dulauroy et al., Nature Medicine 2012). Using recently generated reporter and deleter mice for specific subsets of stromal cells, we now aim at deciphering how such stromal cells contribute to the pathogenesis of chronic diseases. Please send applications to: lucie.peduto@pasteur.fr.
The positions are open for 2013. Applicants should have a strong background in cellular immunology, cell biology or physiology, be highly motivated to do research in this competitive and exciting area, and show an innate ability to work as a team. Experience in transcriptional analysis, multi-parameter flow cytometry and/or mouse models are highly desirable. The LTD Unit enjoys numerous collaborations with researchers on campus and beyond that are necessary to advance in the multi-disciplinary fields of mucosal immunology and inflammation. The Pasteur campus offers top expertise in microbiology and immunology, as well as cutting-edge technical platforms, all of which are essential to progress at these scientific frontiers.