Dendritic Cell Immunobiology / Clinical studies

Clinical studies

TUMOR IMMUNITY

•    PROSTATE

Title : A phase I/II study to evaluate the safety and immunogenicity of the subcutaneous administration of autologous DCs pulsed with apoptotic LNCaP prostate tumor cells in prostate cancer patients

Study site : The Rockefeller University Hospital, USA
PI : Robert Darnell
COMPLETED

•    BLADDER
Title :
Study of mechanisms of tumour immunity and tumour mediated immune evasion in patients with transitional cell carcinoma of the bladder
Study site : The Necker Hospital, Paris
PI : Nicolas Thiounn
Scientific investigator : Matthew Albert
Sponsor : Institut Pasteur (RBM 2004-09)
Support : Ligue / Institut Pasteur/INCa
COMPLETED

Title : Study of innate immune responses following BCG therapy for patients with transitional cell carcinoma of the bladder
Study site : The Necker Hospital, Paris
PI : Nicolas Thiounn
Scientific investigator : Matthew Albert
Sponsor : Institut Pasteur (RBM 2006-02)
Support : Ligue / Institut Pasteur/INCa
COMPLETED

Title :
Identification de marqueurs prédictifs de succès à la BCGthérapie chez des patients ayant un cancer superficiel de la vessie
Multi-study sites :  APHP Necker, Tenon, Henri-Mondor;  CHU Rouen and CHU Amiens
PI : Christian Pfister, CHU Rouen
Scientific investigator : Matthew Albert
Sponsor : Institut Pasteur (RBM 2007-40)
Support : Ligue / Institut Pasteur/INCa
ONGOING


INFECTIOUS DISEASE


•    HCV


Title : Identification de lymphocytes T CD8+ spécifiques du VHC par la méthode des tétramères - Etude TETRA
Multi-study sites : AP-HP Hôpital Cochin
PI : Stanislas Pol/Vincent Mallet, AP-HP Hôpital Cochin, Paris
Scientific investigators : Matthew Albert et Darragh Duffy
Sponsor : Inserm (C11-33)
Support : Inserm, Ligue, ERC
ONGOING


Title : Identification of Biomarkers for the study of a predictive algorithm to the response of HCV standard treament
Multi-study sites : AP-HP Hôpital Cochin, AP-HP Hôpital Henri Mondor, Centre Hospitalier Intercommunal Créteil, Centre Hospitalier Victor Dupuy (Argenteuil)
PI : Stanislas Pol, AP-HP Hôpital Cochin, Paris
Scientific investigator : Matthew Albert
Sponsor : Inserm (C10-08)
Support : Inserm, Ligue, ERC
ONGOING

Title : Hepatitis C virus pathogenesis and dendritic cell biology
Study site : APHP Necker, Paris
PI : Stanislas Pol
Scientific investigator : Matthew Albert
Sponsor : Inserm
Support : Inserm, Ligue
COMPLETED

Title : Chronic HCV responsiveness to IFN/Ribavirin therapy
Study site : AP-HP Hôpital Cochin, Paris
PI : Stanislas Pol
Scientific investigator : Matthew Albert
Sponsor : Inserm
Support : Inserm
COMPLETED

Title : IP-10 as a negative biomarker for responsiveness to treatment for chronic HCV
Study sites : AP-HP Hôpital Cochin, Paris (Coordinating site); Hôpital Henri-Mondor, Paris; Hôpital Saint Antoine, Paris; CHU Sud-Francilien-Site Louise Michel; Site hospitalier Victor Dupuoy, Argenteuil; Centre Hospitalier Intercommunal, Créteil
PI : Stanislas Pol
Scientific investigator : Matthew Albert
Sponsor : Inserm (C07-11)
Support : Inserm, ANRS, ERC
COMPLETED

Title : Defining the role of plasmacytoid dendritic cells in acute hepatitis C (ANRS press release)
Study site : National Hepatology and Tropical Medicine Research Institute, Egypte
PI : Arnaud Fontanet Unité Epidémiologie des Maladies Emergentes, Institut Pasteur Paris / Mostafa Mohamed Faculté de Médecine de Ain Shams Medicine University Cairo
Scientific investigators (immunology): Matthew Albert and Mona Rafik
Sponsor : ANRS
Support : ANRS
ONGOING

Title : HCV transmission and transient HCV infection among health workers in Cairo, Egypt (ANRS press release)

Study site : National Hepatology and Tropical Medicine Research Institute, Egypte
PI : Arnaud Fontanet Unité Epidémiologie des Maladies Emergentes, Institut Pasteur Paris / Mostafa Mohamed Faculté de Médecine de Ain Shams Medicine University Cairo
Scientific investigator (immunology): Matthew Albert and Mona Rafik
Sponsor : ANRS
Support : ANRS
ONGOING

Title : The inflammatory signatures of viral hepatitis (ANRS press release)
Study site : National Hepatology and Tropical Medicine Research Institute, Egypte
PI : Arnaud Fontanet Unité Epidémiologie des Maladies Emergentes, Institut Pasteur Paris / Mostafa Mohamed Faculté de Médecine de Ain Shams Medicine University Cairo
Scientific investigator (immunology): Matthew Albert and Mona Rafik
Sponsor : ANRS
Support : ANRS
ONGOING


•    Ac Mong Virus (publication)
Title : Ac Mong Virus Encephalitis in Northern Vietnam: virological, epidemiological, clinical, and immunological studies of an emerging viral disease
Study site : National Institute of Hygiene and Epidemiology (NIHE), Vietnam
PI : Arnaud Fontanet Unité Epidémiologie des Maladies Emergentes, Institut Pasteur Paris / Phan Thi NGA, Director of Arbovirus Encephalitis Laboratory at the National Institute of Hygiene and Epidemiology (NIHE), Vietnam
Scientific investigator (immunology): Matthew Albert and Matthew Buckwalter
Support : ANR
ONGOING