The laboratory of Dendritic Cell Immunobiology
Unité mixte Pasteur / INSERM U818
Head of Lab : Matthew Albert, MD, PhD
• General Interests
The Albert lab is a mixed INSERM / Pasteur Unit. Our group’s basic science and clinical research goals are to investigate the cellular and molecular mechanisms underlying the different immunologic outcomes of antigen cross-presentation — cross-priming versus cross-tolerization. These pathways impact many homeostatic and pathological processes. Specifically the lab focuses on questions of tumor and viral immunity. We aim to identify key points of regulation involved in activating cytolytic T lymphocytes (CTLs) as well as key points of disregulation where tumor and viral proteins interfere with the generation of specific immunity.
Over recent years the laboratory has obtained a series of significant results, including:
- identification of dying cells as an active participant in the processing of antigen for cross-presentation
- evidence for autophagy as a critical pathway in preparing cell-associated antigen for delivery to DCs for efficient CD8+ T cell priming
- characterization of key intracellular signaling networks that regulate antigen cross-presentation
- mechanistic information concerning the role of CD4+ T cell help in defining the immunologic outcome of cross-presentation
- establishment of two new human models for the study of cross-presentation
- evidence for chemokine antagonism in chronic HCV patients
- generation of a 1st generation map of the inflammatory response to intravesical BCG
- description of innate immune sensors responsible for the control of chikungunya
• Contact and localisation
Immunobiology of Dendritic Cells
Institut Pasteur
Bâtiment Metchnikoff
25, rue du Docteur Roux
75724 Paris Cedex 15
France
Office : (33) 1 45 68 89 02
Lab : (33) 1 44 38 95 02
Fax : (33) 1 45 68 85 48
• Thank you to all our sponsors
Head of Lab : Matthew Albert, MD, PhD
• General Interests
The Albert lab is a mixed INSERM / Pasteur Unit. Our group’s basic science and clinical research goals are to investigate the cellular and molecular mechanisms underlying the different immunologic outcomes of antigen cross-presentation — cross-priming versus cross-tolerization. These pathways impact many homeostatic and pathological processes. Specifically the lab focuses on questions of tumor and viral immunity. We aim to identify key points of regulation involved in activating cytolytic T lymphocytes (CTLs) as well as key points of disregulation where tumor and viral proteins interfere with the generation of specific immunity.
Over recent years the laboratory has obtained a series of significant results, including:
- identification of dying cells as an active participant in the processing of antigen for cross-presentation
- evidence for autophagy as a critical pathway in preparing cell-associated antigen for delivery to DCs for efficient CD8+ T cell priming
- characterization of key intracellular signaling networks that regulate antigen cross-presentation
- mechanistic information concerning the role of CD4+ T cell help in defining the immunologic outcome of cross-presentation
- establishment of two new human models for the study of cross-presentation
- evidence for chemokine antagonism in chronic HCV patients
- generation of a 1st generation map of the inflammatory response to intravesical BCG
- description of innate immune sensors responsible for the control of chikungunya
• Contact and localisation
Immunobiology of Dendritic Cells
Institut Pasteur
Bâtiment Metchnikoff
25, rue du Docteur Roux
75724 Paris Cedex 15
France
Office : (33) 1 45 68 89 02
Lab : (33) 1 44 38 95 02
Fax : (33) 1 45 68 85 48
• Thank you to all our sponsors
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