Research / Scientific departments / Immunology / Publications

Publications

2013


Neutrophils mediate antibody-induced anti-tumor effects in mice.
Albanesi M, Mancardi DA, Jönsson F, Iannascoli B, Fiette L, Di Santo JP, Lowell CA, Bruhns P.

Blood. 2013 Aug 26. [Epub ahead of print]. PMID:23980063

 

Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines.
Hannani D, Locher C, Yamazaki T, Colin-Minard V, Vetizou M, Aymeric L, Viaud S, Sanchez D, Smyth MJ, Bruhns P, Kroemer G, Zitvogel L. Cell Death Differ.

2013 Jun 7. PMID:23744294

 

Neutrophils in local and systemic antibody-dependent inflammatory and anaphylactic reactions.
Jönsson F, Mancardi DA, Albanesi M, Bruhns P. J Leukoc Biol. 2013 May 21. PMID:23532517

 

Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA.

Griffiths SJ, Riddell NE, Masters J, Libri V, Henson SM, Wertheimer A, Wallace D, Sims S, Rivino L, Larbi A, Kemeny DM, Nikolich-Zugich J, Kern F, Klenerman P, Emery VC, Akbar AN.,

J Immunol. 2013 Jun 1;190(11):5363-72. doi: 10.4049/jimmunol.1203267. Epub 2013 May 1.

Regulation of microRNA biogenesis and turnover by animals and their viruses.

Libri V, Miesen P, van Rij RP, Buck AH., ,

Cell Mol Life Sci. 2013 Oct;70(19):3525-44. doi: 10.1007/s00018-012-1257-1. Epub 2013 Jan 26

 

Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4+ T cells.

Corre B, Perrier J, El Khouri M, Cerboni S, Pellegrini S, Michel F.

Eur J Immunol. 2013 Jul 10. doi: 10.1002/eji.201242977. [Epub ahead of print]

PMID: 23839924

 

Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent.

Li Z, Gakovic M, Ragimbeau J, Eloranta ML, Rönnblom L, Michel F, Pellegrini S.

J Immunol. 2013, 190 :2335-44. PMID: 23359498

 

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells.

Pierson, W., Cauwe, B., Policheni, A., Schlenner, S.M., Franckaert, D., Berges, J., Humblet-Baron, S., Schönefeldt, S., Herold, M.J., Hildeman, D., Strasser, A., Bouillet, P., Lu, L.-F., Matthys, P., Freitas, A.A., Luther, R.J., Weaver, C.J., Dooley, J., Gray, D.H.D. & Liston, A.

Nature Immunol. 14 : 959-966 (2013)

 

Origin, trafficking, and intraepithelial fate of gut-tropic T-cells.

Guy-Grand, D., Vassalli, P., Eberl, G., Pereira, P., Burlen-Defranoux, O., Lemaitre, F., Di Santo, J. P., Freitas, A.A., Cumano, A. & Bandeira, A.

J. Exp. Med. 210 : 1839-1854 (2013)

 

A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL-10 dependent derivatives of inflammatory monocytes.

Fevre, C., Almeida, A.S., Taront, S., Pedron, T., Huerre, M., Prevost, M.-C., Kieusseian, A., Cumano, A., Brisse, S., Sansonetti, P.J. & Tournebize, R.

EMBO Mol. Med. 5 : 516-530 (2013)

 

Thymocyte selection regulates the homeostasis of IL-7-expressing thymic cortical epithelial cells in vivo

Ribeiro, A.R., Rodrigues, P.M., Meireles, C., Di Santo, J.P. and Alves, N.L. (2013).

Journal of Immunology 191:1200-1209.

 

Origin, hemolymphatic cycle and intraepithelial fate of gut-tropic T cells.

Guy-Grand, D., Vassalli, P., Eberl, G., Pereira, P., Burlen-Defranoux, O., Lemaitre, F., Di Santo, J.P., Freitas, A.A., Cumano, A. and Bandeira, A. (2013)

Journal of Experimental Medicine 210:1839-1854.

 

Rag2Il2rbDmd mouse: a new dystrophic and immunodeficient model to assess innovating therapeutic strategies for muscular dystrophies.

Vallese, D., Negroni, E. Duguez, S., Ferry, A., Trollet, C., Aamiri, A., Vosshenrich, C.A.J., Fuchtbauer, E.-M., Di Santo, J.P., Vitiello, L., Butler-Browne, G. and Mouly, V. (2013) Molecular Therapy (in press).

 

Taming the beast: regulation of innate lymphoid cell homeostasis and function.

Xu, W. and Di Santo, J.P. (2013)

The Journal of Immunology (in press).

 

The impact of macroautophagy on CD8(+) T-cell-mediated antiviral immunity.

Perot BP, Ingersoll MA, Albert ML.

Immunol Rev. 2013 Sep;255(1):40-56. doi: 10.1111/imr.12096.

PMID: 23947346

 

CXCL10 antagonism and plasma sDPPIV correlate with increasing liver disease in chronic HCV genotype 4 infected patients.

Ragab D, Laird M, Duffy D, Casrouge A, Mamdouh R, Abass A, Shenawy DE, Shebl AM, Elkashef WF, Zalata KR, Kamal M, Esmat G, Bonnard P, Fontanet A, Rafik M, Albert ML.

Cytokine. 2013 Aug;63(2):105-12

 

Phenotypic CD8+ T Cell Diversification Occurs before, during, and after the First T Cell Division.

Lemaître F, Moreau HD, Vedele L, Bousso P.

J Immunol. 2013 Aug 15;191(4):1578-85. doi: 10.4049/jimmunol.1300424. Epub 2013 Jul 8.

PMID: 23836060

 

Shigella impairs T lymphocyte dynamics in vivo.

Salgado-Pabón W, Celli S, Arena ET, Nothelfer K, Roux P, Sellge G, Frigimelica E, Bousso P, Sansonetti PJ, Phalipon A.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4458-63. doi: 10.1073/pnas.1300981110. Epub 2013 Feb 15. PMID: 23417297

Innate lymphoid cells - a proposal for uniform nomenclature.

Spits, H., Artis, D., Colonna, M., Diefenbach, A., Di Santo, J.P., Eberl, G., Koyasu, S., Locksley, R.M., McKenzie, A.N., Mebius, R.E., Powrie, F., Vivier, E.

Nature Reviews. Immunology 13:145-9

Developmental programming of natural killer and innate lymphoid cells.

Vosshenrich, C.A., Di Santo, J.P.

Current Opinion in Immunology 25:130-8.

Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells.

Klein Wolterink, R.G., Serafini, N., van Nimwegen, M., Vosshenrich, C.A., de Bruijn, M.J., Fonseca Pereira, D., Veiga Fernandes, H., Hendriks, R.W., Di Santo, J.P.

Proceedings of the National Academy of Sciences USA. [Epub ahead of print].

Thymocyte selection regulates the homeostasis of IL-7-expressing thymic cortical epithelial cells in vivo.

Ribeiro, A.R., Rodrigues, P.M., Meireles, C., Di Santo, J.P. and Alves, N.L. (2013) Journal of Immunology (in press).

Origin, hemolymphatic cycle and intra-epithelium dynamics of gut tropic T-cells.

Guy-Grand, D., Vassalli, P., Eberl, G., Pereira, P., Burlen-Defranoux, O., Lemaitre, F., Di Santo, J.P., Freitas, A.A., Cumano, A. and Bandeira, A. (2013)

Journal of Experimental Medicine (in press).


Monoclonal antibodies toward different Tn-amino acid backbones display distinct recognition patterns on human cancer cells. Implications for effective immuno-targeting of cancer.

Mazal D, Lo-Man R, Bay S, Pritsch O, Dériaud E, Ganneau C, Medeiros A, Ubillos L, Obal G, Berois N, Bollati-Fogolin M, Leclerc C, Osinaga E.

Cancer Immunol Immunother. 2013 Jun;62(6):1107-22. doi: 10.1007/s00262-013-1425-7. Epub 2013 Apr 21.

 

Combinatorial Control of Th17 and Th1 Cell Functions by Genetic Variations in Genes Associated With the Interleukin-23 Signaling Pathway in Spondyloarthritis.

Coffre M, Roumier M, Rybczynska M, Sechet E, Law HK, Gossec L, Dougados M, Bianchi E, Rogge L.

Arthritis Rheum. 2013 Jun;65(6):1510-21. doi: 10.1002/art.37936.

 

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation.

Guenin-Macé L, Veyron-Churlet R, Thoulouze MI, Romet-Lemonne G Hong H, Leadlay PF, Danckaert A, Ruf MT, Mostowy S, Zurzolo C, Bousso P, Chrétien F, Carlier MF, Demangel C

J Clin Invest. 2013 Apr 1;123(4):1501-12. doi: 10.1172/JCI66576. Epub 2013 Mar 15.


GATA-3 promotes T cell specification by repressing B cell potential in pro-T cells.

Garcia-Ojeda M.E., Klein Wolterink R.G., Lemaitre F., Richard-Le Goff O., Hasan M., Hendriks R.W., Cumano A. & Di Santo J.P.

Blood 121 : 1749-1759 (2013)


BCG-Mediated Bladder Cancer Immunotherapy: Identifying Determinants of Treatment Response Using a Calibrated Mathematical Model.

Rentsch CA, Biot C, Gsponer JR, Bachmann A, Albert ML, Breban R.

PLoS One. 2013;8(2):e56327. doi: 10.1371/journal.pone.0056327. Epub 2013 Feb 25.

PMID: 23451041

 

Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers.

Chaumeil J, Micsinai M, Ntziachristos P, Deriano L, Wang JM, Ji Y, Nora EP, Rodesch MJ, Jeddeloh JA, Aifantis I, Kluger Y, Schatz DG, Skok JA.

Cell Rep. 2013 Feb 13. doi:pii: S2211-1247(13)00031-4. 10.1016/j.celrep.2013.01.024. [Epub ahead of print]

PMID: 23416051

 

Neonatal plasmacytoid dendritic cells (pDCs) display subset variation but can elicit potent anti-viral innate responses.

Zhang X, Lepelley A, Azria E, Lebon P, Roguet G, Schwartz O, Launay O, Leclerc C, Lo-Man R.

PLoS One. 2013;8(1):e52003. doi: 10.1371/journal.pone.0052003. Epub 2013 Jan 10.

PMID:

23326320

 

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis.

Supply P, Marceau M, Mangenot S, Roche D, Rouanet C, Khanna V, Majlessi L, Criscuolo A, Tap J, Pawlik A, Fiette L, Orgeur M, Fabre M, Parmentier C, Frigui W, Simeone R, Boritsch EC, Debrie AS, Willery E, Walker D, Quail MA, Ma L, Bouchier C, Salvignol G, Sayes F, Cascioferro A, Seemann T, Barbe V, Locht C, Gutierrez MC, Leclerc C, Bentley SD, Stinear TP, Brisse S, Médigue C, Parkhill J, Cruveiller S, Brosch R.

Nat Genet. 2013 Feb;45(2):172-9. doi: 10.1038/ng.2517. Epub 2013 Jan 6.

 

B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells.

Mahévas M, Patin P, Huetz F, Descatoire M, Cagnard N, Bole-Feysot C, Le Gallou S, Khellaf M, Fain O, Boutboul D, Galicier L, Ebbo M, Lambotte O, Hamidou M, Bierling P, Godeau B, Michel M, Weill JC, Reynaud CA.

J Clin Invest. 2013 Jan 2;123(1):432-42. doi: 10.1172/JCI65689. Epub 2012 Dec 17.

PMID:23241960

 

Tracking antigen-specific CD8 T cells using MHC class I multimers.

Alanio C, Bouvier I, Jusforgues-Saklani H, Albert ML.

Methods Mol Biol. 2013;960:309-26.


Quorum-sensing contributes to activated Igm-Secreting B cell homeostasis

Montaudouin, C., Anson, M., Hao, Y., Duncker, S.V., Fernandez, T., Gaudin, E., Ehrestein, M., Kerr, W.G., Colle, J.-H., Bruhns, P., Daeron, M. & Freitas, A.A.

J. Immunol. 190 : 106-114 (2013)

 

GATA-3 promotes T cell specification by repressing B cell potential in pro-T cells

García-Ojeda ME, Klein Wolterink RG, Lemaître F, Richard-Le Goff O, Hasan M, Hendriks RW, Cumano A, Di Santo JP

Blood. Jan 3(2013)


Dynamics of NK cell interactions in vivo.

Deguine J, Bousso P (2013).

Immunol Rev 251(1):154-159.
 

The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis and anti-tumor immunotherapy.

  David A. Mancardi, Marcello Albanesi, Fiederike Jönsson, Bruno Iannasoli, Nico Van Rooijen, Xiaoqiang Kang, Patrick England, Marc Daëon, and Pierre Bruhns.

Blood January 4. (2013).

 

2012



Litchi-associated acute encephalitis in children, Northern Vietnam, 2004-2009.

Paireau J, Tuan NH, Lefrançois R, Buckwalter MR, Nghia ND, Hien NT, Lortholary O, Poirée S, Manuguerra JC, Gessain A, Albert ML, Brey PT, Nga PT, Fontanet A.

Emerg Infect Dis. 2012 Nov;18(11):1817-24. doi: 10.3201/eid1811.111761.

PMID: 23092599

 

RANKL induces organized lymph node growth by stromal cell proliferation.

Hess E, Duheron V, Decossas M, Lézot F, Berdal A, Chea S, Golub R, Bosisio MR, Bridal SL, Choi Y, Yagita H, Mueller CG.

J Immunol. 2012 Feb 1;188(3):1245-54. doi: 10.4049/jimmunol.1101513. Epub 2011 Dec 30.

PMID: 22210913

 

A streamlined method for detecting structural variants in cancer genomes by short read paired-end sequencing.

Mijušković M, Brown SM, Tang Z, Lindsay CR, Efstathiadis E, Deriano L, Roth DB.

PLoS One. 2012;7(10):e48314. doi: 10.1371/journal.pone.0048314. Epub 2012 Oct 29.

PMID: 23144753


Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors.

Pereira de Sousa A., Berthault C., Granato A., Dias S., Ramond C., Kee B.L., Cumano A. & Vieira P.

J. Immunol. 189 : 3822-3830 (2012).

 

Homeostatic and tissue reparation defaults in mice carrying selective genetic invalidation of CXCL12/proteoglycan interactions.

Rueda P., Richart A., Récalde A., Gasse P., Vilar J., Guérin C., Lortat-Jacob H., Vieira P., Baleux F., Chretien F., Arenzana-Seisdedos F. & Silvestre J.-S.

Circulation, 126 : 1882-1895 (2012).

 

Cutting Edge: Tumor-Targeting Antibodies Enhance NKG2D-Mediated NK Cell Cytotoxicity by Stabilizing NK Cell-Tumor Cell Interactions.

Deguine J, Breart B, Lemaître F, Bousso P (2012).

J Immunol. 189(12):5493-5497.

 

Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph borne viral particles.

Garcia Z, Lemaître F, van Rooijen N, Albert ML, Levy Y, Schwartz O, Bousso P (2012).

Blood 120(24);4744-4750.

 

Dissecting T Cell Contraction In Vivo Using a Genetically Encoded Reporter of Apoptosis.

 Garrod KR, Moreau H, Garcia Z, Lemaître F, Bouvier I, Albert ML, Bousso P (2012).

Cell reports 2(5);1438-1447.

 

Functional immunoimaging: the revolution continues.

Bousso P, Moreau H (2012).

Nat. Rev. Immunol. 12(12);858-864.

 

How many dendritic cells are required to initiate a T cell response?

Celli S, Day M, Müller AJ, Molina-Paris C, Lythe G, Bousso P (2012).

Blood 120(19):3945-3948.

 

DISC: a guide to in vivo cytometry.

Moreau H, Bousso P (2012).

Intravital 1(1):27-31.

 

Dynamic In Situ Cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo.

Moreau H, Lemaître F, Terriac E, Azar G, Piel M, Lennon-Dumenil A, Bousso P. (2012).

Immunity 37(2):351-363.

 

CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation.

Müller AJ, Filipe-Santos O, Eberl G, Aebischer T, Späth GF, Bousso P. (2012).

Immunity 37(1):147-157.
 

Cutting Edge: FcγRIII (CD16) and FcγRI (CD64) Are Responsible for Anti-Glycoprotein 75 Monoclonal Antibody TA99 Therapy for Experimental Metastatic B16 Melanoma.

Albanesi M, Mancardi DA, Macdonald ME, Iannasoli B, Zitvolgel L, Murphy AJ, Leusen JH, Brunhs P.

The Journal of Immunology December 15, vol. 189 no. 12 5513-5517 (2012).

 


Induction of protective immunity against Mycobacterium tuberculosis by delivery of ESX Antigen into airway dendritic cells Mucosal Immunology.

H. Dong, O. Stanek, Rudilla-Salvador, F., U. Langër, E. Morillon, C. Ung, P. Sebo, C. Leclerc and L. Majlessi.,

Mucosal Immunity 2012, doi:10.1038/mi.2012.92


Slowing down the differentiation of engrafted human myoblasts into immunodeficient mice correlates with increased proliferation and migration.

Riederer, I., Negroni, E., Benczel, M., Wolf, A., Aamiri, A., Di Santo, J.P., Silva-Barbosa, S., Butler-Browne, G., Savino, W. and Mouly, V. (2012)

Molecular Therapy 20:146-154.

 

Myf5 haploinsufficiency reveals distinct cell fate potentials for adult skeletal muscle stem cells.

Gayraud-Morel, B., Chrétien, F., Negroni, E., Jory, A., Sambasivan, R., Flamant, P., Soubigou, G., Coppée, J.-Y., Di Santo, J., Cumano, A., Mouly, V. and Tajbakhsh, S. (2012)

Journal of Cell Science 125:1738-1749.

 

Thymocytes may persist and differentiate without any input from bone marrow progenitors.

Peaudecerf, L., Lemos, S., Galgano, A., Krenn, G., Vasseur, F., Di Santo, J.P., Ezine, S. and Rocha, B. (2012)

Journal of Experimental Mecidine 209:1401-1408.

 

IL-2 receptor g-chain molecule is critical for intestinal T-cell reconstitution in humanized mice.Denton.

P.W., Nochi, T., Lim, A., Krisko, J.F., Martinez-Torres, F. , Choudhary, S.K., Wahl, A., Olesen, R., Zou, W., Di Santo, J.P., Margolis, D.M. and Garcia, J.V. (2012)

Mucosal Immunology 5:555-566.

 

Production of hepatitis B défective particles is dependent on liver status.
Redelsperger, F., Lekbaby, B., Mandouri, Y., Giang, E., Duriez, M., Desire, N., Roque Afonso, A.M., Brichler, S., Dubreuil, P., Dobrin, A., Perlemuter, G., Prevot, S., Bacon, N., Grange, J.D., Zatla, F., Le Pendeven, C., Pol, S., Strick-Marchand, H., Di Santo, J., Kremsdorf, D. and Soussan, P. (2012)

Virology 431:21-28.

Interleukin-12-dependant NKp46(+) Innate Lymphoid Cells Control Intestinal Inflammation by Recruiting Inflammatory Monocytes.

Schulthess, J., Meresse, B., Ramiro-Puig, E., Montcuquet, N., Darche, S., Bègue, B., Ruemmele, F., Combadière, C., Di Santo, J.P., Buzoni-Gatel, D. and Cerf-Bensussan, N. (2012) Immunity 37:108-121.

 

Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms.

Lucas, S., Taront, S., Magnan, C., Fauconnier, L., Delacre, M., Macia, L., Delanoye, A., Verwaerde, C., Spriet, C., Saule, P., Goormachtig, G., Héliot, L., Ktorza, A., Movassat, J., Polakowska, R., Auriault, C., Poulain-Godefroy, O., Di Santo, J.P., Froguel, P. and Wolowczuk, I., (2012) PLoS One 7:e40351.

Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer.

Biot C, Rentsch CA, Gsponer JR, Birkhäuser FD, Jusforgues-Saklani H, Lemaître F, Auriau C, Bachmann A, Bousso P, Demangel C, Peduto L, Thalmann GN, Albert ML. (2012).

Sci Transl Med. 4(137):137ra72.

 

USP18 establishes the transcriptional and anti-proliferative interferon α/β differential.

Francois-Newton V, Livingstone M, Payelle-Brogard B, Uzé G, Pellegrini S.

Biochem J. 2012 Sep 15;446(3):509-16.

PMID: 22731491

 

Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury.

S. Dulauroy, S.E. Di Carlo, F. Langa, G. Eberl and L. Peduto. 2012.

Nat. Med., advanced online.

 

The T-cell receptor repertoire of tumor-infiltrating regulatory T lymphocytes is skewed toward public sequences.

Sainz-Perez A, Lim A, Lemercier B, Leclerc C.

Cancer Res., 2012, 72, 3557-69


Mathematical model of tumor immunotherapy for bladder carcinoma identifies the limitations of the innate immune response.

Breban R, Bisiaux A, Biot C, Rentsch C, Bousso P, Albert ML.

Oncoimmunology. 2012 Jan 1;1(1):9-17.

 

Preexisting BCG-Specific T Cells Improve Intravesical Immunotherapy for Bladder Cancer.

Biot C, Rentsch CA, Gsponer JR, Birkhäuser FD, Jusforgues-Saklani H, Lemaître F, Auriau C, Bachmann A, Bousso P, Demangel C, Peduto L, Thalmann GN, Albert ML.

Sci Transl Med. 2012 Jun 6;4(137):137ra72.


Antigen Cross-Priming of Cell-Associated Proteins is Enhanced by Macroautophagy within the Antigen Donor Cell.

Joubert PE, Albert ML.

Front Immunol. 2012;3:61. Epub 2012 Mar 28.

 

A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes.

Mesel-Lemoine M, Millet J, Vidalain PO, Law H, Vabret A, Lorin V, Escriou N, Albert ML, Nal B, Tangy F.

J Virol. 2012 Jul;86(14):7577-87. Epub 2012 May 2.

Pivotal role of plasmacytoid dendritic cells in inflammation and NK cell responses following TLR9 triggering in mice.

Guillerey, C., J. Mouries, G. Polo, N. Doyen, H.K. Law, S. Chan, P. Kastner, C. Leclerc, and G. Dadaglio.

Blood, 2012, 120, 90-99


Development and function of intestinal innate lymphoid cells.

M. Cherrier, C. Ohnmacht, S. Cording and G. Eberl. 2012.

Curr. Opin. Immunol., in press.

 

The development of LTi cells.

M. Cherrier and G. Eberl. 2012.

Curr. Opin. Immunol., 24:178-183.

 

Notch, Id2 and RORgt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.

M. Cherrier, S. Sawa and G. Eberl. 2012.

J. Exp. Med., 209:729-740

 

Innate NKTgd and NKTab cells exert similar functions and compete for a thymic niche.

Pereira P. & Boucontet L

Eur. J. Immunol. 42: 1272-1281 (2012)

 

Strong Immunogenicity and Cross-Reactivity of Mycobacterium tuberculosis ESX-5 Type VII Secretion -Encoded PE-PPE Proteins Predicts Vaccine Potential.

Sayes F, Sun L, Di Luca M, Simeone R, Degaiffier N, Fiette L, Esin S, Brosch R, Bottai D, Leclerc C, Majlessi L.

Cell Host Microbe, 2012, 11(4):352-63.

 

Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores.

 Fiser R, Masin J, Bumba L, Pospisilova E, Fayolle C, Basler M, Sadilkova L, Adkins I, Kamanova J, Cerny J, Konopasek I, Osicka R, Leclerc C, Sebo P.

PLoS Pathog. 2012 Apr;8(4):e1002580. Epub 2012 Apr 5


Combination of a TLR4 ligand and anaphylatoxin C5a for the induction of antigen-specific cytotoxic T cell responses.

Rudilla F, Fayolle C, Casares N, Durantez M, Arribillaga L, Lozano T, Villanueva L, Pio R, Sarobe P, Leclerc C, Prieto J, Lasarte JJ.

Vaccine. 2012 Apr 16;30(18):2848-58.

 

Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.

Bottai D, Di Luca M, Majlessi L, Frigui W, Simeone R, Sayes F, Bitter W, Brennan MJ, Leclerc C, Batoni G, Campa M, Brosch R, Esin S.

 

PP2A targeting by viral proteins : a widespread biological strategy from DNA/RNA tumor viruses to HIV-1.

Guergnon, J., Godet, A.N., Galioot, A., Falanga, P.B., Colle, J.-H., Cayla, X. & Garcia, A.

Biochim. Biophys. Acta 1812 : 1498-1507 (2011)

 

Pteridium aquilinum and its ptaquiloside toxin induce DNA damage response in gastric epithelial cells, a link with gastric carcinogenesis.

Gomes, J., Magalhaes, A., Michel, V., Amado, I.F., Aranha, P., Ovesen, R.G., Hansen, H.C.B., Gärtner, F., Reis, C.A. & Touati, E.

Toxicol. Sciences, 126 : 60-71 (2012)

 

Temporal predisposition to  αβ and γδ T T cell fates in the thymus.

Pereira P., Boucontet L. & Cumano A.

J. Immunol. 188 : 1600-1608 (2012)

Sequentially orchestrate the fetal development of lymphoid tissue inducer cells. Notch, Id2 and RORgt

M. Cherrier, S. Sawa and G. Eberl. 2012.
J. Exp. Med., in press.

Complexes of Streptavidin-Fused Antigens with Biotinylated Antibodies Targeting Receptors on Dendritic Cell Surface: A Novel Tool for Induction of Specific T-Cell Immune Responses.

Stanek O, Linhartova I, Majlessi L, Leclerc C, Sebo P.

Mol Biotechnol. 2011 Oct 18. [Epub ahead of print]

 

Eradication of large tumors expressing human papillomavirus E7 protein by therapeutic vaccination with E7 fused to the extra domain a from fibronectin.

Mansilla C, Berraondo P, Durantez M, Martínez M, Casares N, Arribillaga L, Rudilla F, Fioravanti J, Lozano T, Villanueva L, Sarobe P, Borrás F, Leclerc C, Prieto J, Lasarte JJ.

Int J Cancer. 2011 Sep 2. doi: 10.1002/ijc.26412. [Epub ahead of print

 

Oral macrophage-like cells play a key role in tolerance induction following sublingual immunotherapy of asthmatic mice.

Mascarell L, Saint-Lu N, Moussu H, Zimmer A, Louise A, Lone Y, Ladant D, Leclerc C, Tourdot S, Van Overtvelt L, Moingeon P.

Mucosal Immunol. 2011 Nov;4(6):638-47.

 

Msx genes define a population of mural cell precursors required for head blood vessel maturation.

Lopes M., Goupille O., Saint Cloment C., Lallemand Y., Cumano A. & Robert B.

Development 138 : 3055-3066 (2011)

 

Notch signaling is necessary for adult, but not fetal, development of RORgt+ innate lymphoid cells.

Possot C., Schmutz S., Chea S., Boucontet L., Louise A., Cumano A. & Golub R.

Nature Immunol. 12 : 949-959 (2011)

 

Characterization of Pax3-expressing cells from adult blood vessels.

Goupille O., Pallafacchina G., Relaix F., Conway S.J., Cumano A., Robert B., Montarras D. & Buckingham M.

J. Cell. Sci. 124 : 3980-3988 (2011

 

The RAG2 C-terminus suppresses genomic instability and lymphomagenesis

L. Deriano, J. Chaumeil, M. Coussens, A. Multani, Y. Chou, A.V. Alekseyenko, S. Chang, J.A. Skok, D.B. Roth..

Nature. 2011 Mar 3; 471(7336): 119-2.

 

Roles for NBS1 in alternative end joining of V(D)J recombination intermediates

L. Deriano, T.H. Stracker, A. Baker, J.H.J. Petrini, D.B. Roth..

Mol Cell. 2009 Apr 10; 34(1): 13-25.

 

RAG mutations reveal robust alternative end joining.

B. Corneo*, R.L. Wendland*, L. Deriano*, X. Cui, I.A. Klein, S. Wong, S. Arnal, A.J. Holub, G.R. Weller, B.A. Pancake, S. Shah, V.L. Brandt, K. Meek, D.B. Roth

Nature, 2007 Sep; 449(7161): 483-6. (*Equal contribution)

 

Mutagenicity of non-homologous end joining DNA repair in a resistant subset of human chronic lymphocytic leukaemia B cells.

L. Deriano,  H. Merle-Beral, O. Guipaud, L. Sabatier, J. Delic.

Br J Haematol. 2006 Jun; 133(5): 520-5.

 

Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway.

L. Deriano, O. Guipaud, H. Merle-Béral, J. L. Binet, M. Ricoul, V. Favaudon, C. Muller, B. Salles, L. Sabatier, J. Delic

Blood. 2005 Jun 15; 105(12): 4776-83.


The dialog between microbiota and the immune system: Shaping the partners through development and evolution.

N. Cerf-Bernussan and G. Eberl

Semin Immunol. 2012 Feb;24(1):1-2. Epub 2011 Dec 16.

 

Development and evolution of RORgt+ cells in a microbe’sworl

G. Eberl

Immunology, 2012 ; Rev. 2012, 245-177-188.

2011

Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.

Lasserre R, Cuche C, Blecher-Gonen R, Libman E, Biquand E, Danckaert A, Yablonski D, Alcover A, Di Bartolo V.

J Cell Biol. 2011 Nov ; 28;195(5):839-53. Epub 2011 Nov 21.

PMID: 22105350

 

The RAG2 C-terminus suppresses genomic instability and lymphomagenesis.

L. Deriano, J. Chaumeil, M. Coussens, A. Multani, Y. Chou, A.V. Alekseyenko, S. Chang, J.A. Skok, D.B. Roth.

Nature. 2011 Mar 3; 471(7336): 119-2.

 

A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins.

Chany, A.C., Casarotto, V., Schmitt, M., Tarnus, C., Guenin-Macé, L., Demangel, C., Mirguet, O., Eustache, J. and Blanchard, N.

Chemistry 2011 ; 17(51):14413-9.


Targeted gene correction of a1-antitrypsin deficiency in induced pluripotent stem cells.

Yusa K, Rashid ST, Strick-Marchand H, Varela I, Liu PQ, Paschon DE, Miranda E,

Ordonez A, Hannan NR, Rouhani FJ, Darche S, Alexander G, Marciniak SJ, Fusaki N, Hasegawa M, Holmes MC, Di Santo JP, Lomas DA, Bradley A, Vallier L.

Nature. 2011 Oct 12; 478(7369):391-4. doi: 10.1038/nature10424.

PubMed PMID

 

Slowing Down Differentiation of Engrafted Human Myoblasts Into Immunodeficient Mice Correlates With Increased Proliferation and Migration.

Riederer I, Negroni E, Bencze M, Wolff A, Aamiri A, Di Santo JP, Silva-Barbosa

SD, Butler-Browne G, Savino W, Mouly V.

Mol Ther. 2011 Sep 20. doi: 10.1038/mt.2011.193.

[Epub ahead of print] PubMed

PMID: 21934656.1


Animal models for arthritis: Innovative tools for prevention and therapy.
Kollias, G., Papadaki, P., Apparailly, F., Vervoordeldonk, M.J., Holmdahl, R., Baumans, V., Desaintes, C, Di Santo, J., Distler, J., Garside, P., Hegen, M., Huizinga, T., Jungel, A., Klareskog, L., McInnes, I., Ragoussis, I., Schett, G., t’Hart, B., Toes, R., van den Berg, W., Wurst, W. and Gay, S.
Annals of Rheumatoid Diseases. 2011. 70:1357-62. PMID : 21628308.

 

 

Functional CD47/signal regulatory protein alpha (SIRPα) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo.
Legrand, N., Huntington, N.D., Nagasawa, M., Bakker, A.Q., Schotte, R., Strick-Marchand, H., de Geus, S.J., Pouw, S.M., Bohne, M., Weijer, K., Di Santo, J.P. and Spits, H. Proceedings of the National Academy of Sciences (USA). 2011. 108:13224-13229. PMID : 21788504

 

Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice.
Huntington, N.D., Alves, N.L., Legrand, N., Lim, A.M., Strick-Marchand, H., Plet, A., Weijer, K., Jacques, Y., Spits, H. and Di Santo, J.P.
European Journal of Immunology. 2011. Jul 8. doi: 10.1002/eji.201141586. PMID : 21739431

 

USP18-based negative feedback control is induced by Type I and Type III interferons and specifically inactivates interferon a response.
François-Newton V, Magno de Freitas Almeida G, Payelle-Brogard B, Monneron D, Pichard-Garcia L, Piehler J, Pellegrini S, Uzé G.
PLoS One. 2011;6(7):e22200.
PMID: 21779393

Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression.
Guenin-Macé, L., Carrette, F., Asperti-Boursin, F., Le Bon, A., Caleechurn, L., Di Bartolo, V., Fontanet, A., Bismuth, G. and Demangel, C.
Proc. Natl. Acad. Sci. 2011. USA, in press.

Mycolactone Diffuses into the Peripheral Blood of Buruli Ulcer Patients - Implications for Diagnosis and Disease Monitoring
Sarfo, F.S., Le Chevalier, F., Aka, N., Phillips, R.O., Amoako, Y., Boneca, I.G., Lenormand, P., Dosso, M. Wansbrough-Jones, M., Veyron-Chrulet, R., Guenin-Macé, L. and Demangel, C..
PLoS Neg Trop Dis. 2011. in press.

Cutting Edge: A Dual Role for Type I IFNs during Polyinosinic-Polycytidylic Acid-Induced NK Cell Activation.
Beuneu H, Deguine J, Bouvier I, Di Santo JP, Albert ML, Bousso P.
J Immunol. 2011 Sep 1;187(5):2084-8. Epub 2011 Aug 1.
PMID: 21810605 [PubMed - in process]

Chronic infections capture little attention of the masses.
Bousso P.
Immunity. 2011 May 27;34(5):699-701.
PMID: 21616441 [PubMed]

Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy.
Celli S, Albert ML, Bousso P.
Nat Med. 2011 Jun;17(6):744-9. Epub 2011 May 15.
PMID: 21572426 [PubMed - indexed for MEDLINE]

A role for the immediate early gene product c-fos in imprinting T cells with short-term memory for signal summation.
Clark CE, Hasan M, Bousso P.
PLoS One. 2011 Apr 28;6(4):e18916.
PMID: 21552553 [PubMed - indexed for MEDLINE]

A Strain of Lactobacillus casei Inhibits the Effector Phase of Immune Inflammation.
Schiffer C, Lalanne AI, Cassard L, Mancardi DA, Malbec O, Bruhns P, Dif F, Daëron M.
J Immunol. 2011 Sep 1;187(5):2646-55. Epub 2011 Aug 1.
PMID: 21810608 [PubMed - in process]

Anti-SARS-CoV Spike Antibodies Trigger Infection of Human Immune Cell via a pH- and Cysteine Protease-Independent Fc{gamma}R Pathway.
Jaume M, Yip MS, Cheung CY, Leung HL, Li PH, Kien F, Dutry I, Escriou N, Altmeyer R, Nal B, Daëron M, Bruzzone R, Peiris JS.
J Virol. 2011 Jul 20. [Epub ahead of print]
PMID: 21775467 [PubMed - as supplied by publisher]


Interferon induced protein 10 remains a useful biomarker of treatment failure in patients stratified for the interleukin-28B rs12979860 haplotype.
Albert ML, Casrouge A, Chevaliez S, Hézode C, Rosa I, Renard P, Mallet V, Fontanet A, Pawlotsky JM, Pol S.
Hepatology. 2011 Apr;53(4):1410-1.

Can viruses form biofilms ?
Thoulouze M.I., Alcover A.
Trends Microbiol. 2011. 19(6):257-62.

Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family.
Ben-Ali M, Corre B, Manry J, Barreiro LB, Quach H, Boniotto M, Pellegrini S, Quintana-Murci L. 2011. Hum. Mutat. 32:643-52.  
PMID:   21618349

Simultaneous assessment of autophagy and apoptosis using multispectral imaging cytometry.
de la Calle C, Joubert PE, Law HK, Hasan M, Albert ML.
Autophagy. 2011 Sep 1;7

Identification of a novel neuropathogenic Theiler's murine encephalomyelitis virus.
Buckwalter MR, Nga PT, Gouilh MA, Fiette L, Bureau JF, Laird ME, Buchrieser J, Ozden S, Cheval J, Eloit M, Manuguerra JC, Gessain A, Brey PT, Fontanet A, Albert ML.
J Virol. 2011 May 4.

TRIM5 is an innate immune sensor for the retrovirus capsid lattice.
Pertel T, Hausmann S, Morger D, Züger S, Guerra J, Lascano J, Reinhard C, Santoni FA, Uchil PD, Chatel L, Bisiaux A, Albert ML, Strambio-De-Castillia C, Mothes W, Pizzato M, Grütter MG, Luban J.
Nature. 2011 Apr 21;472(7343):361-5.

The adjuvant effect of TLR agonists on CD4(+) effector T cells is under the indirect control of regulatory T cells.

Olivier A, Sainz-Perez A, Dong H, Sparwasser T, Majlessi L, Leclerc C.
Eur J Immunol. 2011 Apr 29. doi: 10.1002/eji.201041387. [Epub ahead of print PMID: 21538349

ESAT-6 Secretion-Independent Impact of ESX-1 Genes espF and espG1 on Virulence of Mycobacterium tuberculosis.
Bottai D, Majlessi L, Simeone R, Frigui W, Laurent C, Lenormand P, Chen J, Rosenkrands I, Huerre M, Leclerc C, Cole ST, Brosch R.
J Infect Dis. 2011 Apr;203(8):1155-64. Epub 2010 Dec 31.

Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses.
Freire T, Lo-Man R, Bay S, Leclerc C.
J Biol Chem. 2011 Mar 11;286(10):7797-811. Epub 2010 Dec 30.

IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo.

Huntington ND, Alves NL, Legrand N, Lim A, Strick-Marchand H, Mention JJ, Plet A, Weijer K, Jacques Y, Becker PD, Guzman C, Soussan P, Kremsdorf D, Spits H, Di Santo JP.
Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6217-22. Epub 2011 Mar 28. PubMed PMID: 21444793; PubMed Central PMCID: PMC3076818.

CD4+ T cells are not essential for control of early acute Cryptosporidium parvum infection in neonatal mice.
Korbel DS, Barakat FM, Di Santo JP, McDonald V.
Infect Immun. 2011 Apr;79(4):1647-53. Epub 2011 Jan 31. PubMed PMID: 21282414; PubMed Central PMCID: PMC3067537.

Lymphotoxin-β receptor-independent development of intestinal IL-22-producing NKp46+ innate lymphoid cells
Satoh-Takayama, N., Lesjean-Pottier, S., Sawa, S., Vosshenrich, C.A.J., Eberl G. and Di Santo, J.P.
Eur J Immunol. 2011 Apr;41(4):1075-85. doi: 10.1002/eji.201040878. Epub 2011 Mar 14. PubMed PMID: 21400499.

IL-22 is produced by γC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality.

Dumoutier, L., de Heusch, M., Orabona, C., Satoh-Takayama, N., Eberl, G., Sirard, J.-C., Di Santo, J.P. and Renauld, J.-C.
Eur J Immunol. 2011 Mar;41(3):780-6. doi:
10.1002/eji.201040851. Epub 2011 Feb 1. PubMed PMID: 21341264

Lymphotoxin-β receptor-independent development of intestinal IL-22-producing NKp46+ innate lymphoid cells.
Satoh-Takayama, N., Lesjean-Pottier, S., Sawa, S., Vosshenrich, C.A.J., Eberl G. and Di Santo, J.P.
Eur J Immunol. DOI: 10.1002/eji.201040851

Proinflammatory environment dictates the IL-17-producing capacity of human invariant NKT cells.
Moreira-Teixeira L, Resende M, Coffre M, Devergne O, Herbeuval JP, Hermine O, Schneider E, Rogge L, Ruemmele FM, Dy M, Cordeiro-da-Silva A, Leite-de-Moraes MC.
J Immunol. 2011 Apr 8. [Epub ahead of print]. PMID: 21478400

Contribution of IL-17-producing gd T cells to the efficacy of anticancer chemotherapy.

Ma Y., Aymeric L., Locher C., Mattarollo S.R., Delahaye N.F., Pereira P., Boucontet L., Apetoh L., Ghringhelli F., Casares N., Lasarte J.J., Matsuzaki G., Ikuta K., Ryffel B., Benlagha K., Tesniere A., Ibrahim N., Déchanet-Merville J., Chaput N., Smith M.J., Kroemer G. & Zitvogel L.
J. Exp. Med. 208 : 491-503 (2011)

Mouse and human neutrophils induce anaphylaxis.
Jönsson F, Mancardi DA, Kita Y, Karasuyama H, Iannascoli B, Van Rooijen N, Shimizu T, Daëron M, Bruhns P.
J Clin Invest. 2011 Mar 23. pii: 45232. doi: 10.1172/JCI45232. [Epub ahead of print] PMID: 21436586

Cutting Edge: Intravenous Ig Inhibits Invariant NKT Cell-Mediated Allergic Airway Inflammation through Fc{gamma}RIIIA-Dependent Mechanisms.
Araujo LM, Chauvineau A, Zhu R, Diem S, Bourgeois EA, Levescot A, Huerre M, Gombert JM, Bayry J, Daëron M, Bruhns P, Kaveri SV, Herbelin A.
J Immunol. 2011 Mar 15;186(6):3289-93. Epub 2011 Feb 11. PMID: 21317388

Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells.
Lochner, M., Bérard, M., Sawa, S., Hauer, S., Gaboriau-Routhiau, V., Fernandez, T.D., Snel, J., Bousso, P., Cerf-Bensussan, N. & Eberl, G.
J. Immunol. 186 : 1531-1537 (2011)

Cell-to-cell interactions and signals involved in the reconstitution of peripheral CD8+ TCM and TEM cell pools.
Zaragoza, B., Evaristo, C., Kissenpfennig, A., Libri, V., Malissen, B., Rocha, B., Freitas, A.A. & Almeida, A.R.M.
PLoS ONE 6 : e17423 (2011)

Can viruses form biofilms?
Thoulouze MI, Alcover A.
Trends Microbiol. 2011 Mar 31. [Epub ahead of print]

Innate Sensing of HIV-Infected Cells.
Lepelley A, Louis S, Sourisseau M, Law HK, Pothlichet J, Schilte C, Chaperot L, Plumas J, Randall RE, Si-Tahar M, Mammano F, Albert ML, Schwartz O.
PLoS Pathog. 2011 Feb;7(2):e1001284. Epub 2011 Feb 17.

The Murine High-Affinity IgG Receptor FcgRIV Is Sufficient for Autoantibody-Induced Arthritis.

Mancardi, D.A*.,  Jönsson, F*., Iannascoli, B., Khun, H., Van Rooijen, N., Huerre, M.  Daëron, M. & Bruhns, P. (*: Equal contributors).,
J. Immunol. Cutting Edge. 2011, 186: 1899-1903.

Neutrophils as inducers of anaphylaxis.
Jönsson, F.*, Mancardi, D.A.*, Kita, Y., Karasuyama, H., Iannascoli, B., Van Rooijen, N., Shimizu, T., Daëron, M.‡, & Bruhns, P.‡ (*: Equal contributors. ‡: Shared senior authorship).
J. Clin. Invest., 2011, in press.

RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota.

S. Sawa, M. Lochner, N. Satoh-Takayama, S. Dulauroy, M. Bérard, M. Kleinschek, D. Cua, J.P. Di Santo and G. Eberl. 2011.
Nat. Immunol., in press. 

The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling.
Spits H, Di Santo JP.
Nat Immunol. 2011 Jan;12(1):21-7. Epub 2010 Nov 28.
PMID: 21113163
oinflammatory Environment Dictates the IL-17-Producing Capacity of Human Invariant NKT Cells.

2010

Entrapment of intracytosolic bacteria by septin cages.
Mostowy, S., M. Bonazzi, M. Hamon, T. N. Tham, A. Mallet, M. Lelek, E. Gouin, C. Demangel, R. Brosch, C. Zimmer, A. Sartori, M. Kinoshita, M. Lecuit, and P. Cossart. (2010),
Cell Host Microbe, 8(5):433-444.

 Mycobacterim leprae phenoglycolipid-1 expressed by engineered M. bovis BCG modulates eary interaction with human phagocytes.
Tabouret, G. Astarie-Dequeker, C.n Demangel, C. Malaga, W., Constant, P., Ray, A., Honoré, N. D., Fatimah Bello, N., Perez, E., Daffé, M. and Guilhot, C.
PLoS Pathogens. 2010. 6(10) :e1001159.



Circulating plasmacytoid dendritic cells in acutely infected patients with hepatitis C virus genotype 4 are normal in number and phenotype.
Mansour H, Laird ME, Saleh R, Casrouge A, Eldin NS, El Kafrawy S, Hamdy M, Decalf J, Rosenberg BR, Fontanet A, Abdel-Hamid M, Mohamed MK, Albert ML, Rafik M.

J Infect Dis. 2010 Dec 1;202(11):1671-5. Epub 2010 Oct 19.

PMID: 20958210

Development of promyelocytic zinc finger and ThPOK-expressing innate  T cells is controlled by strength of TCR signaling and Id3.
Alonzo E.S., Gottschalk R.A., Das J., Egawa T., Hobbs R.M., Pandolfi P.P., Pereira P., Nichols K.E., Koretzky G.A., Jordan M.S. & Sant’Angelo D.B.
J. Immunol. 184 : 1268-1279 (2010)

Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells.
Verykokakis M, Boos MD, Bendelac A, Adams EJ, Pereira P, Kee BL.
PLoS One. 2010 Feb 19;5(2):e9303.
PMID: 20174563

Reduced EBF expression underlies loss of B-cell potential of hematopoietic progenitors with age.
Lescale C, Dias S, Maës J, Cumano A, Szabo P, Charron D, Weksler ME, Dosquet C, Vieira P, Goodhardt M.
Aging Cell. 2010 Jun;9(3):410-9. Epub 2010 Mar 13.
PMID: 20331442

Gene targeted inactivation of Ets-1 triggers systemic autoimmunity due to impaired development and function of Foxp3 regulatory T-cells.
Mouly E., Chemin K., Nguyen H.V., Chopin M., Menard L., Leite-de-Moraes M., Burlen-Defranoux O., Bandeira A. & Bories J.-C.
J. Exp. Med. 207 : 2113-2125 (2010)

Cutting edge: Thymic NK cells develop independently from T cell precursors.
Ribeiro VS, Hasan M, Wilson A, Boucontet L, Pereira P, Lesjean-Pottier S, Satoh-Takayama N, Di Santo JP, Vosshenrich CA.
J Immunol. 2010 Nov 1;185(9):4993-7. Epub 2010 Oct 1.
PMID: 20889548

Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo.
Lagha M, Sato T, Regnault B, Cumano A, Zuniga A, Licht J, Relaix F, Buckingham M.
BMC Genomics. 2010 Dec 8;11:696.
PMID: 21143873

T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells.

Dong S, Corre B, Nika K, Pellegrini S, Michel F.
PLoS One. 2010 Nov 30;5(11):e15114.
PMID: 21152094

IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function.
Elkabets M, Ribeiro VS, Dinarello CA, Ostrand-Rosenberg S, Di Santo JP, Apte RN, Vosshenrich CA.
Eur J Immunol. 2010 Dec;40(12):3347-57.
PMID: 21110318

Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17 biased T cell responses.
Freire T, Lo-Man R, Bay S, Leclerc C.
J Biol Chem. 2010 Dec 30.
PMID: 21193402


The intrathymic crossroads of T and NK cell differentiation.
Klein Wolterink RG, García-Ojeda ME, Vosshenrich CA, Hendriks RW, Di Santo JP.
Immunol Rev. 2010 Nov;238(1):126-37. doi: 10.1111/j.1600-065X.2010.00960.x.
PMID: 20969589

Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like receptor 2.
Crellin NK, Trifari S, Kaplan CD, Satoh-Takayama N, Di Santo JP, Spits H.
Immunity. 2010 Nov 24;33(5):752-64. Epub 2010 Nov 4.
PMID: 21055975

Cytoskeletal cross-talk in the control of T cell antigen receptor signaling.

Lasserre R, Alcover
A. FEBS Lett. 2010 Sep 7. [Epub ahead of print]PMID: 20828561

 

[Viral extracellular biofilms: a novel spreading trick of viruses?]
Thoulouze MI, Alcover A.
Med Sci (Paris). 2010 Jun-Jul;26(6-7):571-3.
PMID: 20619153

 

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.
Lasserre R, Charrin S, Cuche C, Danckaert A, Thoulouze MI, de Chaumont F, Duong T, Perrault N, Varin-Blank N, Olivo-Marin JC, Etienne-Manneville S, Arpin M, Di Bartolo V, Alcover A.
EMBO J. 2010 Jul 21;29(14):2301-14. Epub 2010 Jun 15.
PMID: 20551903

 

Mycolactone suppresses T cell responsiveness by altering both early signaling and posttranslational events.
Boulkroun S, Guenin-Macé L, Thoulouze MI, Monot M, Merckx A, Langsley G, Bismuth G, Di Bartolo V, Demangel C.J
Immunol. 2010 Feb 1;184(3):1436-44. Epub 2009 Dec 30.

PMID: 20042571

 

Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses.
Pais-Correia AM, Sachse M, Guadagnini S, Robbiati V, Lasserre R, Gessain A, Gout O, Alcover A, Thoulouze MI.
Nat Med. 2010 Jan;16(1):83-9. Epub 2009 Dec 20.
PMID: 20023636

 

Vesicle traffic to the immunological synapse: a multifunctional process targeted by lymphotropic viruses. Alcover A, Thoulouze MI.
Curr Top Microbiol Immunol. 2010;340:191-207. Review.
PMID: 19960315

Endogenous TCR recombination in TCR Tg single RAG-deficient mice uncovered by robust in vivo T cell activation and selection.
Montaudouin C, Boucontet L, Mailhé-Lembezat MP, Mariotti-Ferrandiz ME, Louise A, Six A, Freitas AA, Garcia S.
PLoS One. 2010 Apr 29;5(4):e10238.
PMID: 20454452

 

In vivo expansion of naive and activated CD4+CD25+FOXP3+ regulatory T cell populations in interleukin-2-treated HIV patients.
Weiss L, Letimier FA, Carriere M, Maiella S, Donkova-Petrini V, Targat B, Benecke A, Rogge L, Levy Y.
Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10632-7. Epub 2010 May 24.
PMID: 20498045

 

The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation.
Fernandez-Sanchez ME, Sechet E, Margottin-Goguet F, Rogge L, Bianchi E.
J Biol Chem. 2010 Jun 4;285(23):17390-7. Epub 2010 Apr 8.
PMID: 20378537

 

Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice.
Becker PD, Legrand N, van Geelen CM, Noerder M, Huntington ND, Lim A, Yasuda E, Diehl SA, Scheeren FA, Ott M, Weijer K, Wedemeyer H, Di Santo JP, Beaumont T, Guzman CA, Spits H.
PLoS One. 2010 Oct 4;5(10). pii: e13137.
PMID: 20957227

 

Intravital Imaging Reveals Distinct Dynamics for Natural Killer and CD8(+) T Cells during Tumor Regression.
Deguine J, Breart B, Lemaître F, Di Santo JP, Bousso P.
Immunity. 2010 Oct 13. [Epub ahead of print]
PMID: 20951068

 

Lineage Relationship Analysis of ROR{gamma}t+ Innate Lymphoid Cells.
Sawa S, Cherrier M, Lochner M, Satoh-Takayama N, Fehling HJ, Langa F, Di Santo JP, Eberl G.
Science. 2010 Sep 23. [Epub ahead of print]
PMID: 20929731

 

Cutting edge: thymic NK cells develop independently from T cell precursors.
Ribeiro VS, Hasan M, Wilson A, Boucontet L, Pereira P, Lesjean-Pottier S, Satoh-Takayama N, Di Santo JP, Vosshenrich CA.
J Immunol. 2010 Nov 1;185(9):4993-7. Epub 2010 Oct 1.
PMID: 20889548

 

The innate side of TOX.
Di Santo JP.
Nat Immunol. 2010 Oct;11(10):885-6. No abstract available.
PMID: 20856218

 

An IL-1beta-dependent switch in innate mucosal immunity?
Di Santo JP.
Immunity. 2010 Jun 25;32(6):734-6.
PMID: 20620939

 

Immunology. A guardian of T cell fate.
Di Santo JP.
Science. 2010 Jul 2;329(5987):44-5.
PMID: 20595605

 

A ’natural’ way to provide innate mucosal immunity.
Di Santo JP, Vosshenrich CA, Satoh-Takayama N.
Curr Opin Immunol. 2010 Aug;22(4):435-41. Epub 2010 Jun 21.
PMID: 20573491

 

Cutting Edge: a thymocyte-thymic epithelial cell cross-talk dynamically regulates intrathymic IL-7 expression in vivo.
Alves NL, Huntington ND, Mention JJ, Richard-Le Goff O, Di Santo JP.
J Immunol. 2010 Jun 1;184(11):5949-53. Epub 2010 May 3.
PMID: 20439914

 

Gamma(c) deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors.
Decaluwe H, Taillardet M, Corcuff E, Munitic I, Law HK, Rocha B, Rivière Y, Di Santo JP.
Proc Natl Acad Sci U S A. 2010 May 18;107(20):9311-6. Epub 2010 May 3.
PMID: 20439728

 

Interleukin-7, a new cytokine targeting the mouse hypothalamic arcuate nucleus: role in body weight and food intake regulation.
Macia L, Viltart O, Delacre M, Sachot C, Héliot L, Di Santo JP, Wolowczuk I.
PLoS One. 2010 Apr 1;5(4):e9953.
PMID: 20376352

 

IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors.
Satoh-Takayama N, Lesjean-Pottier S, Vieira P, Sawa S, Eberl G, Vosshenrich CA, Di Santo JP.
J Exp Med. 2010 Feb 15;207(2):273-80. Epub 2010 Feb 8.
PMID: 20142427

 

Isolation of a highly myogenic CD34-negative subset of human skeletal muscle cells free of adipogenic potential.
Pisani DF, Dechesne CA, Sacconi S, Delplace S, Belmonte N, Cochet O, Clement N, Wdziekonski B, Villageois AP, Butori C, Bagnis C, Di Santo JP, Kurzenne JY, Desnuelle C, Dani C.
Stem Cells. 2010 Apr;28(4):753-64.
PMID: 20135684

 

Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity.
Sellge G, Magalhaes JG, Konradt C, Fritz JH, Salgado-Pabon W, Eberl G, Bandeira A, Di Santo JP, Sansonetti PJ, Phalipon A.
J Immunol. 2010 Feb 15;184(4):2076-85. Epub 2010 Jan 20.
PMID: 20089698

 

Quantifying subcellular distribution of fluorescent fusion proteins in cells migrating within tissues.
Melichar HJ, Li O, Herzmark P, Padmanabhan RK, Oliaro J, Ludford-Menting MJ, Bousso P, Russell SM, Roysam B, Robey EA.
Immunol Cell Biol. 2010 Oct 19. [Epub ahead of print]
PMID: 20956985

 

Intravital Imaging Reveals Distinct Dynamics for Natural Killer and CD8(+) T Cells during Tumor Regression.
Deguine J, Breart B, Lemaître F, Di Santo JP, Bousso P.
Immunity. 2010 Oct 13. [Epub ahead of print]
PMID: 20951068

 

Visualizing the functional diversification of CD8+ T cell responses in lymph nodes.
Beuneu H, Lemaître F, Deguine J, Moreau HD, Bouvier I, Garcia Z, Albert ML, Bousso P.
Immunity. 2010 Sep 24;33(3):412-23.
PMID: 20850354

 

Signal 0 for guided priming of CTLs: NKT cells do it too.
Bousso P, Albert ML.
Nat Immunol. 2010 Apr;11(4):284-6. Review. No abstract available.
PMID: 20300136

 

Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes.
Azar GA, Lemaître F, Robey EA, Bousso P.
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3675-80. Epub 2010 Feb 4.
PMID: 20133676

 

Lineage Relationship Analysis of ROR{gamma}t+ Innate Lymphoid Cells.
Sawa S, Cherrier M, Lochner M, Satoh-Takayama N, Fehling HJ, Langa F, Di Santo JP, Eberl G.
Science. 2010 Sep 23.
PMID: 20929731

 

Bacteria and MAMP-induced morphogenesis of the immune system.
Eberl G, Boneca IG.
Curr Opin Immunol. 2010 Aug;22(4):448-54. Epub 2010 Jun 25.
PMID: 20580214

 

Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis.
Thaunat O, Patey N, Caligiuri G, Gautreau C, Mamani-Matsuda M, Mekki Y, Dieu-Nosjean MC, Eberl G, Ecochard R, Michel JB, Graff-Dubois S, Nicoletti A.
J Immunol. 2010 Jul 1;185(1):717-28. Epub 2010 Jun 4.
PMID: 20525884

 

A new vision of immunity: homeostasis of the superorganism.
Eberl G.
Mucosal Immunol. 2010 Sep;3(5):450-60. Epub 2010 May 5.
PMID: 20445502

 

Immunology: Close encounters of the second type.
Eberl G.
Nature. 2010 Apr 29;464(7293):1285-6
PMID: 20428154

 

IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors.
Satoh-Takayama N, Lesjean-Pottier S, Vieira P, Sawa S, Eberl G, Vosshenrich CA, Di Santo JP.
J Exp Med. 2010 Feb 15;207(2):273-80. Epub 2010 Feb 8.
PMID: 20142427

 

Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity.
Sellge G, Magalhaes JG, Konradt C, Fritz JH, Salgado-Pabon W, Eberl G, Bandeira A, Di Santo JP, Sansonetti PJ, Phalipon A.
J Immunol. 2010 Feb 15;184(4):2076-85. Epub 2010 Jan 20
PMID: 20089698

 

Opening the crypt: current facts and hypotheses on the function of cryptopatches.
Eberl G, Sawa S.
Trends Immunol. 2010 Feb;31(2):50-5. Epub 2009 Dec 16.
PMID: 20015688

 

Tumor therapy in mice by using a tumor antigen linked to modulin peptides from Staphylococcus epidermidis.
Durantez M, Fayolle C, Casares N, Belsue V, Riezu-Boj JI, Sarobe P, Prieto J, Borrás-Cuesta F, Leclerc C, Lasarte JJ.
Vaccine. 2010 Oct 18;28(44):7146-54. Epub 2010 Sep 15.
PMID: 20817012

 

Induction of anti-Tat neutralizing antibodies by the CyaA vector targeting dendritic cells: influence of the insertion site and of the delivery of multicopies of the dominant Tat B-cell epitope.
Fayolle C, Davi M, Dong H, Ritzel D, Le Page A, Knipping F, Majlessi L, Ladant D, Leclerc C.Vaccine. 2010 Oct 4;28(42):6930-41. Epub 2010 Aug 20.
PMID: 20728521

 

Glycosidic Tn-based vaccines targeting dermal DC favor germinal center B cell development and potent antibody responses in the absence of adjuvant.
Freire T, Zhang X, Dériaud E, Ganneau C, Vichier-Guerre S, Azria E, Launay O, Lo-Man R, Bay S, Leclerc C.
Blood. 2010 Aug 18. [Epub ahead of print]
PMID: 20720186

 

Towards a rational approach to vaccine development.
Leclerc C.
Hum Vaccin. 2010 Apr;6(4):292-6. Epub 2010 Apr 17.
PMID: 20372073

 

Adenylate cyclase toxin translocates across target cell membrane without forming a pore.
Osickova A, Masin J, Fayolle C, Krusek J, Basler M, Pospisilova E, Leclerc C, Osicka R, Sebo P.
Mol Microbiol. 2010 Mar;75(6):1550-62. Epub 2010 Feb 23.
PMID: 20199594

 

Expression of IFNgammaR2 mutated in a dileucine internalization motif reinstates IFNgamma signaling and apoptosis in human T lymphocytes.
Boselli D, Ragimbeau J, Orlando L, Cappello P, Capello M, Ambrogio C, Chiarle R, Marsili G, Battistini A, Giovarelli M, Pellegrini S, Novelli F.
Immunol Lett. 2010 Aug 13. [Epub ahead of print]
PMID: 20709103

 

Biochemical monitoring of the early endocytic traffic of the type I interferon receptor.
Payelle-Brogard B, Pellegrini S.
J Interferon Cytokine Res. 2010 Feb;30(2):89-98.
PMID: 20028207

 

Circulating Plasmacytoid Dendritic Cells in Acutely Infected Patients with Hepatitis C Virus Genotype 4 Are Normal in Number and Phenotype.
Mansour H, Laird ME, Saleh R, Casrouge A, Eldin NS, Kafrawy SE, Hamdy M, Decalf J, Rosenberg BR, Fontanet A, Abdel-Hamid M, Mohamed MK, Albert ML, Rafik M.
J Infect Dis. 2010 Oct 19. [Epub ahead of print]
PMID: 20958210

 

Harnessing naturally occurring tumor immunity: a clinical vaccine trial in prostate cancer.
Frank MO, Kaufman J, Tian S, Suárez-Fariñas M, Parveen S, Blachère NE, Morris MJ, Slovin S, Scher HI, Albert ML, Darnell RB.
PLoS One. 2010 Sep 1;5(9). pii: e12367.
PMID: 20824184

 

Biology and pathogenesis of chikungunya virus.
Schwartz O, Albert ML.
Nat Rev Microbiol. 2010 Jul;8(7):491-500.
PMID: 20551973

 

Bilateral brain regions associated with naming in older adults.
Obler LK, Rykhlevskaia E, Schnyer D, Clark-Cotton MR, Spiro A 3rd, Hyun J, Kim DS, Goral M, Albert ML.
Brain Lang. 2010 Jun;113(3):113-23.
PMID: 20399492

 

Signal 0 for guided priming of CTLs: NKT cells do it too.
Bousso P, Albert ML.
Nat Immunol. 2010 Apr;11(4):284-6. Review. No abstract available.
PMID: 20300136

 

Enumeration of human antigen-specific naive CD8+ T cells reveals conserved precursor frequencies.
Alanio C, Lemaitre F, Law HK, Hasan M, Albert ML.
Blood. 2010 May 6;115(18):3718-25. Epub 2010 Mar 3.
PMID: 20200354

 

A whodunit: an appointment with death.
Giodini A, Albert ML.
Curr Opin Immunol. 2010 Feb;22(1):94-108. Epub 2010 Feb 18. Review.
PMID: 20171862

 

Type I IFN controls chikungunya virus via its action on nonhematopoietic cells.
Schilte C, Couderc T, Chretien F, Sourisseau M, Gangneux N, Guivel-Benhassine F, Kraxner A, Tschopp J, Higgs S, Michault A, Arenzana-Seisdedos F, Colonna M, Peduto L, Schwartz O, Lecuit M, Albert ML.
J Exp Med. 2010 Feb 15;207(2):429-42. Epub 2010 Feb 1.
PMID: 20123960

 

C5a receptor enables participation of mast cells in immune complex arthritis independent of Fc gamma receptor modulation.
Nigrovic PA, Malbec O, Lu B, Markiewski MM, Kepley C, Gerard N, Gerard C, Daëron M, Lee DM.
Arthritis Rheum. 2010 Jul 26. [Epub ahead of print]
PMID: 20662064

 

Sumoylation by Ubc9 Regulates the Stem Cell Compartment and Structure and Function of the Intestinal Epithelium in Mice.
Demarque MD, Nacerddine K, Neyret-Kahn H, Andrieux A, Danenberg E, Jouvion G, Bomme P, Hamard G, Romagnolo B, Terris B, Cumano A, Barker N, Clevers H, Dejean A.
Gastroenterology. 2010 Oct 13. [Epub ahead of print]
PMID: 20951138

 

CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism.
Lalanne AI, Moraga I, Hao Y, Pereira JP, Alves NL, Huntington ND, Freitas AA, Cumano A, Vieira P.
J Immunol. 2010 May 15;184(10):5678-85. Epub 2010 Apr 16.
PMID: 20400700

 

Reduced EBF expression underlies loss of B-cell potential of hematopoietic progenitors with age.
Lescale C, Dias S, Maës J, Cumano A, Szabo P, Charron D, Weksler ME, Dosquet C, Vieira P, Goodhardt M.
Aging Cell. 2010 Jun;9(3):410-9. Epub 2010 Mar 13.
PMID: 20331442

 

An adult tissue-specific stem cell in its niche: a gene profiling analysis of in vivo quiescent and activated muscle satellite cells.
Pallafacchina G, François S, Regnault B, Czarny B, Dive V, Cumano A, Montarras D, Buckingham M.
Stem Cell Res. 2010 Mar;4(2):77-91. Epub 2009 Oct 28.
PMID: 19962952

 

2009

Roles for NBS1 in alternative end joining of V(D)J recombination intermediates.

Petrini, D.B. Roth. L. Deriano, T.H. Stracker, A. Baker, J.H.J

Mol Cell. 2009 ; Apr 10; 34(1): 13-25.


 Immunosuppressive signature of cutaneous Mycobacterium ulcerans infection in the peripheral blood of Buruli ulcer patients.

Phillips, R., Sarfo, F.S., Guenin-Macé, L., Decalf, J., Wansbrought-Jones, M., Albert, M.L. and Demangel, C.

J Infect Dis. 2009. 200:1675-1684

Demangel, C., Stinera, T.P. and Cole, S.T.

Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans.

Nat Rev Microbiol. 2009. 7:50-60. Revue.


Wild-derived mouse strains, a valuable model to study B cell responses.

Thiriot A, Drapier AM, Mémet S, Fitting C, Sturny-Leclere A, Cavaillon JM, Cazenave PA, Freitas AA, Rueff-Juy D.

Mol Immunol. 2009 Feb;46(4):601-12. Epub 2008 Oct 31

PMID: 18951634

 

Homeostasis of naive T cells/ the Foxo that fixes.

Freitas AA, Rocha B.

Nat Immunol. 2009 Feb;10(2):133-4

PMID: 19148194

 

The role of TCR specificity and clonal competition during reconstruction of the peripheral T cell pool.

Leitão C, Freitas AA, Garcia S.

J Immunol. 2009 May 1;182(9):5232-9

PMID: 19380769

 

Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients.

Rose T, Lambotte O, Pallier C, Delfraissy JF, Colle JH.

J Immunol. 2009 Jun15;182(12):7389-97

PMID: 19494261

 

Tractus Immuno-logicus : a brief history of the immune system.
Antonio A. de Freitas. Eds Landes Bioscience (2009)

 

Integration of distinct intracellular signaling pathways at distal regulatory elements directs T-bet expression in human CD4+ T cells.

Placek K, Gasparian S, Coffre M, Maiella S, Sechet E, Bianchi E, Rogge L.

J Immunol. 2009 Dec 15;183(12):7743-51. Epub .

PMID: 19923468

 

Genetic and epigenetic networks controlling T helper 1 cell differentiation.

Placek K, Coffre M, Maiella S, Bianchi E, Rogge L.

Immunology. 2009 Jun;127(2):155-62. Review.

PMID: 19476511

 

IL-7 enhances thymic human T cell development in "human immune system" Rag2-/-IL-2Rgammac-/- mice without affecting peripheral T cell homeostasis.

van Lent AU, Dontje W, Nagasawa M, Siamari R, Bakker AQ, Pouw SM, Maijoor KA, Weijer K, Cornelissen JJ, Blom B, Di Santo JP, Spits H, Legrand N.

J Immunol. 2009 Dec 15;183(12):7645-55. Epub .

PMID: 19923447

 

The natural cytotoxicity receptor NKp46 is dispensable for IL-22-mediated innate intestinal immune defense against Citrobacter rodentium.

Satoh-Takayama N, Dumoutier L, Lesjean-Pottier S, Ribeiro VS, Mandelboim O, Renauld JC, Vosshenrich CA, Di Santo JP.

J Immunol. 2009 Nov 15;183(10):6579-87. Epub 2009 Oct 21.

PMID: 19846871

 

Thymic epithelial cells: the multi-tasking framework of the T cell "cradle".

Alves NL, Huntington ND, Rodewald HR, Di Santo JP.

Trends Immunol. 2009 Oct;30(10):468-74. Epub 2009 Sep 24.

PMID: 19781995

 

A defining factor for natural killer cell development.

Di Santo JP.

Nat Immunol. 2009 Oct;10(10):1051-2

PMID: 19767724

 

Renaissance for mouse models of human hematopoiesis and immunobiology.

Manz MG, Di Santo JP.

Nat Immunol. 2009 Oct;10(10):1039-42. Review.

PMID: 19767720

 

Epitope specificity and relative clonal abundance do not affect CD8 differentiation patterns during lymphocytic choriomeningitis virus infection.

Munitic I, Decaluwe H, Evaristo C, Lemos S, Wlodarczyk M, Worth A, Le Bon A, Selin LK, Rivière Y, Di Santo JP, Borrow P, Rocha B.

J Virol. 2009 Nov;83(22):11795-807. Epub 2009 Sep 2.

PMID: 19726518

 

Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice.

Haridass D, Yuan Q, Becker PD, Cantz T, Iken M, Rothe M, Narain N, Bock M, Nörder M, Legrand N, Wedemeyer H, Weijer K, Spits H, Manns MP, Cai J, Deng H, Di Santo JP, Guzman CA, Ott M.

Am J Pathol. 2009 Oct;175(4):1483-92. Epub 2009 Aug 28.

PMID: 19717639

 

Roles for NK cells and an NK cell-independent source of intestinal gamma interferon for innate immunity to Cryptosporidium parvum infection.

Barakat FM, McDonald V, Di Santo JP, Korbel DS.

Infect Immun. 2009 Nov;77(11):5044-9. Epub 2009 Aug 17.

PMID: 19687195

 

Dynamic behavior of NK cells during activation in lymph nodes.

Beuneu H, Deguine J, Breart B, Mandelboim O, Di Santo JP, Bousso P.

Blood. 2009 Oct 8;114(15):3227-34. Epub 2009 Aug 10.

PMID: 19667398

 

Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P.

Cell Host Microbe. 2009 Jul 23;6(1):5-9. Review.

PMID: 19616761

 

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7.

Huntington ND, Labi V, Cumano A, Vieira P, Strasser A, Villunger A, Di Santo JP, Alves NL.

Int Immunol. 2009 Jun;21(6):715-25. Epub 2009 May 19.

PMID: 19454543

 

Enhancement of myogenic and muscle repair capacities of human adipose-derived stem cells with forced expression of MyoD.

Goudenege S, Pisani DF, Wdziekonski B, Di Santo JP, Bagnis C, Dani C, Dechesne CA.

Mol Ther. 2009 Jun;17(6):1064-72. Epub 2009 Apr 7.

PMID: 19352326

 

Characterization of the thymic IL-7 niche in vivo.

Alves NL, Richard-Le Goff O, Huntington ND, Sousa AP, Ribeiro VS, Bordack A, Vives FL, Peduto L, Chidgey A, Cumano A, Boyd R, Eberl G, Di Santo JP.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1512-7. Epub 2009 Jan 21.

PMID: 19164539

 

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo.

Huntington ND, Legrand N, Alves NL, Jaron B, Weijer K, Plet A, Corcuff E, Mortier E, Jacques Y, Spits H, Di Santo JP.

J Exp Med. 2009 Jan 16;206(1):25-34. Epub 2008 Dec 22.

PMID: 19103877

 

The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses.

Gaboriau-Routhiau V, Rakotobe S, Lécuyer E, Mulder I, Lan A, Bridonneau C, Rochet V, Pisi A, De Paepe M, Brandi G, Eberl G, Snel J, Kelly D, Cerf-Bensussan N.

Immunity. 2009 Oct 16;31(4):677-89

PMID: 19833089

 

Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice.

Lahl K, Mayer CT, Bopp T, Huehn J, Loddenkemper C, Eberl G, Wirnsberger G, Dornmair K, Geffers R, Schmitt E, Buer J, Sparwasser T.

J Immunol. 2009 Nov 1;183(9):5662-72. Epub 2009 Oct 7.

PMID: 19812199

 

The development of intestinal lymphoid tissues at the interface of self and microbiota.

Eberl G, Lochner M.

Mucosal Immunol. 2009 Nov;2(6):478-85. Epub 2009 Sep 9. Review.

PMID: 19741595

 

The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity.

Klotz L, Burgdorf S, Dani I, Saijo K, Flossdorf J, Hucke S, Alferink J, Nowak N, Beyer M, Mayer G, Langhans B, Klockgether T, Waisman A, Eberl G, Schultze J, Famulok M, Kolanus W, Glass C, Kurts C, Knolle PA.

J Exp Med. 2009 Sep 28;206(10):2079-89. Epub 2009 Sep 8. Erratum in: J Exp Med. 2009 Dec 21;206(13):3159. Novak, Natalija [corrected to Nowak, Nina].

PMID: 19737866

 

Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-related orphan receptor (gamma)t+ and respond preferentially under inflammatory conditions.

Doisne JM, Becourt C, Amniai L, Duarte N, Le Luduec JB, Eberl G, Benlagha K.

J Immunol. 2009 Aug 1;183(3):2142-9. Epub 2009 Jul 8.

PMID: 19587013

 

Inflammation recapitulates the ontogeny of lymphoid stromal cells.

Peduto L, Dulauroy S, Lochner M, Späth GF, Morales MA, Cumano A, Eberl G.

J Immunol. 2009 May 1;182(9):5789-99.

PMID: 19380827

 

Characterization of the thymic IL-7 niche in vivo.

Alves NL, Richard-Le Goff O, Huntington ND, Sousa AP, Ribeiro VS, Bordack A, Vives FL, Peduto L, Chidgey A, Cumano A, Boyd R, Eberl G, Di Santo JP.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1512-7. Epub 2009 Jan 21.

PMID: 19164539

 

Receptor density is key to the alpha2/beta interferon differential activities.

Moraga I, Harari D, Schreiber G, Uzé G, Pellegrini S.

Mol Cell Biol. 2009 Sep;29(17):4778-87. Epub 2009 Jun 29.

PMID: 19564411

 

Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense.

Barreiro LB, Ben-Ali M, Quach H, Laval G, Patin E, Pickrell JK, Bouchier C, Tichit M, Neyrolles O, Gicquel B, Kidd JR, Kidd KK, Alcaïs A, Ragimbeau J, Pellegrini S, Abel L, Casanova JL, Quintana-Murci L.

PLoS Genet. 2009 Jul;5(7):e1000562. Epub 2009 Jul 17.

PMID: 19609346

 

Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils.

Zhang X, Majlessi L, Deriaud E, Leclerc C, Lo-Man R.

Immunity. 2009 Nov 20;31(5):761-71. Epub 2009 Nov 12.

PMID: 19913447

 

The dendritic cell-like functions of IFN-producing killer dendritic cells reside in the CD11b+ subset and are licensed by tumor cells.

Terme M, Mignot G, Ullrich E, Bonmort M, Minard-Colin V, Jacquet A, Schultze JL, Kroemer G, Leclerc C, Chaput N, Zitvogel L.

Cancer Res. 2009 Aug 15;69(16):6590-7.

 

Induction of a melanoma-specific antibody response by a monovalent, but not a divalent, synthetic GM2 neoglycopeptide.

Bay S, Fort S, Birikaki L, Ganneau C, Samain E, Coïc YM, Bonhomme F, Dériaud E, Leclerc C, Lo-Man R.

ChemMedChem. 2009 Apr;4(4):582-7

PMID: 19226501

 

Protection against tuberculosis induced by oral prime with Mycobacterium bovis BCG and intranasal subunit boost based on the vaccine candidate Ag85B-ESAT-6 does not correlate with circulating IFN-gamma producing T-cells.

Badell E, Nicolle F, Clark S, Majlessi L, Boudou F, Martino A, Castello-Branco L, Leclerc C, Lewis DJ, Marsh PD, Gicquel B, Winter N.

Vaccine. 2009 Jan 1;27(1):28-37. Epub 2008 Oct 31.

 

Dynamic behavior of NK cells during activation in lymph nodes.

Beuneu H, Deguine J, Breart B, Mandelboim O, Di Santo JP, Bousso P.

Blood. 2009 Oct 8;114(15):3227-34. Epub 2009 Aug 10.

PMID: 19667398

 

A dynamic map of antigen recognition by CD4 T cells at the site of Leishmania major infection.

Filipe-Santos O, Pescher P, Breart B, Lippuner C, Aebischer T, Glaichenhaus N, Späth GF, Bousso P.

Cell Host Microbe. 2009 Jul 23;6(1):23-33.

PMID: 19616763

 

Immunosuppressive signature of cutaneous Mycobacterium ulcerans infection in the peripheral blood of patients with buruli ulcer disease.

Phillips R, Sarfo FS, Guenin-Macé L, Decalf J, Wansbrough-Jones M, Albert ML, Demangel C.

J Infect Dis. 2009 Dec 1;200(11):1675-84.

PMID: 19863437

 

Orchestration of the immune response by dendritic cells.

Buckwalter MR, Albert ML.

Curr Biol. 2009 May 12;19(9):R355-61. Review. No abstract available.

PMID: 19439254

 

Molecular analyte profiling of the early events and tissue conditioning following intravesical bacillus calmette-guerin therapy in patients with superficial bladder cancer.

Bisiaux A, Thiounn N, Timsit MO, Eladaoui A, Chang HH, Mapes J, Mogenet A, Bresson JL, Prié D, Béchet S, Baron C, Sadorge C, Thomas S, Albert EB, Albert PS, Albert ML.

J Urol. 2009 Apr;181(4):1571-80. Epub 2009 Feb 23.

PMID: 19230924

 

Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells.

Uhl M, Kepp O, Jusforgues-Saklani H, Vicencio JM, Kroemer G, Albert ML.

Cell Death Differ. 2009 Jul;16(7):991-1005. Epub 2009 Feb 20.

PMID: 19229247

 

Hypersensitivity and allergy: from mice to men.

Rothenberg ME, Daëron M.

Curr Opin Immunol. 2009 Dec;21(6):658-9. Epub 2009 Oct 30. No abstract available.

PMID: 19879743

 

Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis.

Hudrisier D, Clemenceau B, Balor S, Daubeuf S, Magdeleine E, Daëron M, Bruhns P, Vié H.

J Immunol. 2009 Nov 15;183(10):6102-13. Epub 2009 Oct 19.

PMID: 19841164

 

Human basophils express the glycosylphosphatidylinositol-anchored low-affinity IgG receptor FcgammaRIIIB (CD16B).

Meknache N, Jönsson F, Laurent J, Guinnepain MT, Daëron M.

J Immunol. 2009 Feb 15;182(4):2542-50.

PMID: 19201911

 

Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses.

Bruhns P, Iannascoli B, England P, Mancardi DA, Fernandez N, Jorieux S, Daëron M.

Blood. 2009 Apr 16;113(16):3716-25. Epub 2008 Nov 18.

PMID: 19018092

 

 

Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors.

Lagha M, Brunelli S, Messina G, Cumano A, Kume T, Relaix F, Buckingham ME.

Dev Cell. 2009 Dec;17(6):892-9.

PMID: 20059958

 

Numb promotes an increase in skeletal muscle progenitor cells in the embryonic somite.

Jory A, Le Roux I, Gayraud-Morel B, Rocheteau P, Cohen-Tannoudji M, Cumano A, Tajbakhsh S.

Stem Cells. 2009 Nov;27(11):2769-80.

PMID: 19785007

 

Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression.

Crist CG, Montarras D, Pallafacchina G, Rocancourt D, Cumano A, Conway SJ, Buckingham M.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13383-7. Epub 2009 Jul 28.

PMID: 19666532

 

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7.

Huntington ND, Labi V, Cumano A, Vieira P, Strasser A, Villunger A, Di Santo JP, Alves NL.

Int Immunol. 2009 Jun;21(6):715-25. Epub 2009 May 19.

PMID: 19454543

 

Inflammation recapitulates the ontogeny of lymphoid stromal cells.

Peduto L, Dulauroy S, Lochner M, Späth GF, Morales MA, Cumano A, Eberl G.

J Immunol. 2009 May 1;182(9):5789-99.

PMID: 19380827

 

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation.

Auffray C, Fogg DK, Narni-Mancinelli E, Senechal B, Trouillet C, Saederup N, Leemput J, Bigot K, Campisi L, Abitbol M, Molina T, Charo I, Hume DA, Cumano A, Lauvau G, Geissmann F.

J Exp Med. 2009 Mar 16;206(3):595-606. Epub 2009 Mar 9.

PMID: 19273628

Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.

Stracker TH, Williams BR, Deriano L, Theunissen JW, Adelman CA, Roth DB, Petrini JH.

Mol Cell Biol. 2009 Jan;29(2):503-14. doi: 10.1128/MCB.01354-08. Epub 2008 Nov 17.

PMID:19015239