Job offers

A postdoctoral position and a bio-informatics position (funded by the European Research Council starting grant program) are available immediately in the Lymphocyte Development & Oncogenesis Lab at the Institut Pasteur in Paris. We are an enthusiastic team that is willing to welcome and share his passion for science with a dynamic, motivated and creative researcher.

Lymphoid cancers are among the most common human malignancies and characteristically harbor genomic aberrations. It has become apparent that the generation of DNA double strand breaks (DSB) during the programmed process of antigen receptor diversification, including RAG1/2-generated DNA breaks during V(D)J recombination and AID-generated DNA breaks during class switch recombination, are key common intermediates in the appearance of lymphoid neoplasm. Using a combination of genetically engineered mouse models, lymphoid cell lines, and molecular, cellular, NGS, and computational technologies, we wish i) to understand the molecular mechanisms underlying genomic instability in developing lymphocytes, and ii) to decipher the genomic lesions underlying B and T cell transformation.

 

Candidates should be highly motivated, committed and be willing to take on intellectual, scientific, technical and competitive challenges. The applicant should have a record of delivering high quality research and strong experience in the subjects of genome integrity, genomics or cancer genetics/biology. Experience in NGS techniques and data analysis and/or computational biology will be highly desirable.

 

To apply: Applicants should send a cover letter with a statement of research experience and research interests and a C.V. to Ludovic Deriano (ludovic.deriano@pasteur.fr).

Postdoc position in inflammation, tissue repair and fibrosis

The Lymphoid Tissue Development Unit is recruiting one postdoctoral fellow to join our interdisciplinary group. Our projects aim at understanding the interactions between the immune system, the symbiotic microbiota, and the stromal network. Whereas a proper crosstalk between these three components is essential to form lymphoid tissues, they are also the basis of the immune response to infection and injury, as well as regulators of homeostasis. The postdoctoral fellow will join the stroma team to study how perturbations of the stromal compartment contributes to inflammation and fibrosis, which develop in many chronic diseases including pulmonary fibrosis, atherosclerosis and cancer.


The Department of immunology opens several PhD student positions

Job offers : The Department of immunology opens several PhD student positions in the frame of the Pasteur-Paris University PhD Program and the European Union Marie Curie Actions Initial Training Network HOMIN. For information visit click here ww.pas

Postdoctoral positions in Immunology at Institut Pasteur (Deriano lab)

Postdoctoral positions are available in the lab to work on ambitious projects aiming to decipher the mechanisms and pathways leading to genomic instability and tumor development in B and T lymphocytes.

Candidates should be highly motivated by cancer biology, cancer genomics and genome integrity research fields and be willing to take on intellectual, scientific and technical challenges. The applicant should have a record of delivering high quality research and strong experience in the subjects of cancer, immunology, genomics, mouse models, or lymphoma/leukemia. Experience in transcriptomic, genomic analysis, bioinformatics and/or computational biology would be highly desirable. Preference will be given to candidates with less than two years of experience after his/her PhD.

Applicants should send a cover letter with a brief statement of research experience, technical expertise and interests, a C.V., a list of publications and three references to Ludovic Deriano (ludovic.deriano@pasteur.fr).

 

Postdoctoral positions in immunology at institut pasteur

Two postdoctoral positions are available immediately in the Lymphocyte Development & Oncogenesis Laboratory in the Immunology Department at the Institut Pasteur Paris to work on ambitious projects aiming to decipher the mechanisms and pathways leading to genome instability and tumor development in B and T lymphocytes.

 Research Keywords: Cancer, Immunology, Mouse models, Lymphocyte development, Genomics,

Genome integrity, DNA repair, DNA damage

 Projects outline: Lymphoid cancers are among the most common human malignancies and characteristically harbor genomic aberrations. We are interested in developing experimental approaches that would provide an understanding of how and which genomic aberrations underlie tumor genesis. It has become apparent that the generation of DNA double strand breaks (DSB) during the programmed process of antigen receptor diversification, including RAG1/2 protein-generated

DNA breaks during V(D)J recombination, are key common intermediates in the appearance of lymphoid neoplasm. We have created a series of mouse models carrying aberrant V(D)J recombination leading to the rapid development of lymphoid tumors, reminiscent of human malignancies. In this project, we aim to elucidate the molecular mechanisms, the genomic lesions and the oncogenic pathways underlying B and T cell cancers using a combination of germline and non- germline genetically engineered mouse models and cutting-edge genomic, transcriptomic and computational technologies.

 Candidate requirements: Candidates should be highly motivated by cancer biology, cancer

genomics and genome integrity research fields and be willing to take on intellectual, scientific and technical challenges. The applicant should have a record of delivering high quality research and strong experience in the subjects of cancer, immunology, genomics, mouse models, or lymphoma and leukemia.  Experience in transcriptomic and genomic analysis and/or computational biology would be desirable. Preference will be given to candidates with less than two years of experience after his/her Ph.D. 

 To apply: Applicants should send a cover letter with a brief statement of research experience,

technical expertise and interests, a C.V., a list of publications and three references to Ludovic Deriano (ludovic.deriano@pasteur.fr)

 

Postdoctoral positions in immunology at institut pasteur

Two postdoctoral positions are available in the Innate Immunity Unit (http://www.pasteur.fr/recherche/UPDATE) in the Immunology Department at the Institut Pasteur starting January 2012 utilizing 'humanized' mice harboring human lympho-hematopoietic systems for projets relating to preclinical studies of human immunology. HIS mouse models provide an opportunity to decipher the molecular mechanisms controlling human lymphocyte development and function. Progress in this area has been rapid (Manz and Di Santo, Nat Immunol 2009) and research and clinical applications for HIS mice are attracting industrial partners at an unprecendented rate. Three-year positions are funded through the ANR (program RPIB, project 'Im_HIS').

 The Innate Immunity Unit has a long-standing interest in the development of xenograft mouse models for the analysis of immune responses to pathogens and cancer. Thanks to a previous award from the Bill and Melinda Gates Foundation (Grand Challenges in Global Health), a series of innovative immunodeficient recipient strain for HIS mouse generation were developed (Huntington et al, JEM 2009; Huntington et al PNAS 2011; Legrand et al PNAS 2011). The successful applicant will use these new HIS models in order to model and study the pathogenesis of human infectious diseases, using state-of-art instruments and in vivo approaches available in the lab and across the institute.

 QUALIFICATIONS: Interested candidates must be completing or should have obtained a Ph.D. or M.D. degree with background in Immunology, Molecular Biology, Cell Biology, Physiology or a related discipline. The applicant should have record of delivering high-quality research using immunology, molecular biology, and/or animal models. Experience in transcriptional analysis, multi-parameter flow cytometry and/or mouse models are highly desirable.

 SALARY/BENEFITS: These positions are fully supported by the ANR and successful candidates will be offered competitive stipend/salary and benefits commensurate with experience and accomplishments.

 

TO APPLY: E-mail your CV and at least 3 references to James Di Santo (james.di-santo@pasteur.fr) by November 15, 2011.

Software engineer for Labex project

The Software Engineer will be responsible first for developing a user interface user-friendly database to facilitate the exchange and storage of all data generated by the project. This should begin before the start of production data. Second, he / she will be responsible for the management and the homogenization of the data, once production begins. Third, he / she will be responsible, under the direction of academic researchers and statisticians involved in the project Labex, development of new algorithms and pipelines, and optimization of those used to process the data. The use of data includes the treatment of endpoints (ie immune phenotypes) and the identification of those variables that explain the effect (ie, genetic polymorphisms that influence a given phenotype immune ). Candidates should be highly competent in managing databases (eg SQL Programming) programming algorithm (eg C / C + +, Python programming, etc..) Development pipeline (eg Shell Programming, Perl) and cluster computing. Knowledge of Biology, Genomics and Immunology is not required but are appreciated.



Technician position in Immunology at the Institut Pasteur (Center for Human Immunology)

The CIH is recruiting a technician for processing human subject samples as part of ongoing clinical trials on cancer and infectious diseases.

Experience in cytometry will be an advantage.




Postdoc position in Immunology at the Institut Pasteur (Eberl lab)

The Lymphoid Tissue Development (LTD) lab is recruiting a postdoctoral fellow to study the regulation of intestinal pro-inflammatory innate lymphoid cells (ILCs). Such ILCs are marked by the nuclear hormone receptor RORγt and have fundamental functions in the development of lymphoid tissues (Eberl, Nat Immunol 2004), intestinal homeostasis (Bouskra, Nature 2008) and defense (Satoh-Takayama, Immunity 2008). We have recently showed that RORγt+ ILCs are programmed to pre-empt colonization of the intestine by bacterial symbionts and display constitutive pro-inflammatory activity that is regulated by microbiota (Sawa et al, Science 2010, Nat. Immunol, in press). Many aspects of the cross-talk between RORγt+ ILCs, microbiota, pathogens and adaptive immunity remain to be elucidated that are critical to intestinal immunity.

The position is open from mid-2011. Applicants should have a strong background in cellular immunology, be highly motivated to do research in this competitive and exciting area, and show an innate ability to work as a team. The LTD lab enjoys numerous collaborations with researchers on campus and beyond that are necessary to advance in the multi-disciplinary field of mucosal immunology. The Pasteur campus offers top expertise in microbiology and immunology, as well as cutting-edge technical platforms, all of which are essential to progress at these scientific frontiers.

Applicants should send their CV, as well as a motivation letter, to gerard.eberl@pasteur.fr.  

 

Postdoc positions in Immunology (Freitas lab)

Applications are sought for a Postdoctoral Research Fellowship to join the Lymphocyte Population Biology Unit at the Pasteur Institute in Paris, France, to work on the European Research Council (ERC) Advanced Grant funded project “Role of Quorum Sensing mechanisms in the Immune System’s regulation”. The successful applicant will be involved in a project that aims to investigate 1) the role of “quorum-sensing” mechanisms in the homeostasis of naturally activated and memory lymphocyte populations. We welcome a highly motivated and gifted scientist with interest in molecular and cellular immunology to join us. Essential requirements for this post include a PhD or equivalent degree in biomedical sciences and scientific accomplishments in immunology, molecular biology, genetic

Postdoc position in Immunology at the Institut Pasteur (Di Santo lab)

A postdoctoral position is available in James Di Santo’s laboratory (Innate Immunity Unit, http://www.pasteur.fr/recherche/RAR/RAR2009/Cytotbnk-en.html) in the Immunology Department at the Institut Pasteur starting January 2011 to study the molecular mechanisms involved in development and function of innate lymphoid cells (ILCs). ILCs are an emerging family of hematopoietic effector cells that play important roles in immunity and tissue remodeling during fetal and adult life (Spits and Di Santo, Nature Immunology 2010, in press). This three-year position is funded through the ANR (program Blanc, project ’Gut_ILC’).

The Innate Immunity Unit is interested in understanding the molecular events that generate functionally diverse ILC subsets and the roles for these innate effectors in tissue homeostasis, and immune responses against infectious pathogens and cancer. The laboratory has a long-standing interest in natural killer (NK) cell development and function (Di Santo, JP. Annu Rev Immunol 2006) and more recently has discovered novel populations of innate IL-22-producing cells that intervene at mucosal surfaces (Satoh-Takayama et al, Immunity 2008; Satoh-Takayama et al, JEM 2010). The successful applicant is expected to study the molecular mechanisms of ILC development and the roles for ILC subsets in animal models of diseases, using state-of-art instruments and in vivo approaches available in the lab and across the institute.

QUALIFICATIONS: Interested candidates must be completing or should have obtained a Ph.D. or M.D. degree with background in Immunology, Molecular Biology, Cell Biology, Physiology or a related discipline. The applicant should have record of delivering high-quality research using immunology, molecular biology, and/or animal models. Experience in transcriptional analysis, multi-parameter flow cytometry and/or mouse models are highly desirable but not required.

SALARY/BENEFITS: These positions are fully supported by the ANR and successful candidates will be offered competitive stipend/salary and benefits commensurate with experience and accomplishments.

TO APPLY: E-mail your CV and at least 3 references to disanto@pasteur.fr by December 15, 2010.