The Immunology Department

The Department of Immunology, which includes 13 research units and 2 technical platforms composed of 170 scientists, has a shared interest in exploring the fundamental processes of immunity  with the hope to provide new insight into disease pathogenesis, inspire novel vaccines and design unique therapeutic strategies. Moreover, we share a commitment to  training the next generation of scientists dedicated to research excellence in the field of immunology.

Upcoming seminars

June 7th – 12 :00 pm


The Washington university in St Louis, Etats-Unis

 (invited by Gérard Eberl).

Title: Host-microbe interactions that incite damage and stimulate repair


June 14th – 12 :00 pm


Max Planck Institute for Infection Biology, Berlin, Allemagne

(Invited by Matthew Albert).

Title: Neutrophil Extracellular Traps


June 28th – 12 : 00 pm

Michael DUSTIN

New York University  Cancer Institute, Etats-Unis (Invited by Philippe Bousso).

Title: Getting to the center of the immunological synapse


June 28th – 12 : 00 pm

SEMINAIRE CONJOINT du Département de Biologie Cellulaire et Infection

et du Département d’Immunologie


St Jude Children ‘s research Hospital, Memphis, Etats-Unis

(invited by Nouara Lhocine).

Title: Amino acid communication and sensing between T cells and

and APCs

July 12th – 12 : 00 pm


Université de Toronto, Canada (Invited by Gérard Eberl).

Title: Meningeal Follicle-like Structures in a rodent model of MS: Dissecting the involvement of the Lymphotoxin pathway


News in the Department

Hugo Mouquet's ERC 2013 has been awarded

Hugo Mouquet presented a research project for a ERC 2013 starting grant. His project: Human Antibody Responses to Viruses has been awarded.

James Di Santo awarded the "2013 Distinguished Alumnus Award" from the Weill Cornell Graduate School of Medical Sciences of Cornell University.

This award was presented to James Di Santo on May 30th during the 2013 Commencement ceremonies for the Weill Cornell Medical College and Graduate School of Medical Sciences at Carnegie Hall, NYC. The award was made in recognition of "distinguished, lifelong contributions to biomedical research and education". Dr Di Santo is the 14th (and youngest) recipient of this award given to an alumnus of the Weill Cornell Graduate School of Medical Sciences. Dr. Di Santo received his PhD in 1989 and his MD in 1991 from Cornell University as part of their joint MD-PhD program. He currently directs the Innate Immunity Unit (Institut Pasteur / INSERM U668) with a focus on the developmental biology of innate lymphocytes in mice and man.

  Matthew Albert was awarded the "Jean Hamburger" Grand Prize of Medicine and Medical Research of the City of Paris.

This prize is awarded for a discovery or an important advance made by a young researcher. Head of a Institut Pasteur / INSERM joint research unit, Matthew Albert and his team work on the fundamental aspects of the cross-presentation of antigen as well as the clinical translation of their findings to better understand the pathogenesis of hepatitis C and bladder cancer. Specific discoveries include the identification of chemokine antagonism in chronically infected hepatitis C patients that might explain the failure of these patients to clear the infection. The team also developed and validated a panel of biomarkers to improve the management of patient care. In regard to bladder cancer, the team defined  mechanisms by which BCG may induce tumor immunity by priming specific cytotoxic T cells. This translational approach could not be achieved without close collaboration with clinical teams including Prof. Pol Mallet at Cochin Hospital and Prof. Pfister at Rouen University Hospital. Five clinical trials are currently underway and a multinational Phase III immune regulation and anti-tumor immunity trial is currently under development.

Publication: Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation


Caroline Demangel and her team at the Institut Pasteur in Paris with researchers of the CNRS, in collaboration with the Universities of Basel and Cambridge have identified the mechanism by which Mycobacterium ulcerans causes Buruli ulcers, paving the way for new therapeutic approaches against this skin disease which is emerging for several decades.


Georges, Jacques et Elias Canetti 2012 Prize to Claude Leclerc

Claude Leclerc received the Jacques et Elias Canetti 2012 Prize on December 4th.
Her laboratory activity  is focused on the understanding of the mechanisms that control the activation and regulation of T cell responses and on the development of new strategies of vaccination against tumors and infections.


The Department of Immunology coordinates an Initial Training Network (ITN

The Department of Immunology coordinates an Initial Training Network (ITN) funded by the European Union Marie Curie Actions called HOMIN: « Host Microbe Interactions in Health and Disease : Interface with the Immune System ». This program aims to provide scientific education through the study of host-microbe interactions with particular focus on immune responses and vaccine development. Five institutions based in three European countries participate in the HOMIN program and will collaborate with an array of European academic and private associated partners. Four PhD student positions in the Department of Immunology will be available within this program, see job offers.

For more information on the network please visit here


Gérard Eberl winner of the Pasteur Vallery-Radot 2012 Prize

Gérard Eberl team has recently demonstrated how symbiotic bacteria
communicate with the gut immune system to participate in its development.