Faculty
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Matthew ALBERT Immunobiology of Dendritic cells Our lab focuses on the characterization of the cellular and molecular mechanisms underlying the cross-priming of tumor and viral-specific cytolytic T lymphocytes (CTLs). To achieve this goal and maintain a strong link to physiologic and pathologic problems, the laboratory is organised using a bedside-to-bench approach to biomedical research. |
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Andrès ALCOVER Lymphocyte Cell Biology We investigate the molecular mechanisms that generate immunological synapses and their role in T cell activation. We also study how lymphotropic retroviruses subvert these mechanisms to modulate T cell responses and to spread efficiently from cell to cell.
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Philippe BOUSSO Dynamics of Immune Responses We are studying how cell contacts established by T cells or NK cells are regulated in vivo and how these interactions modulate the efficiency of immune responses against tumors or pathogens.
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Ana CUMANO Lymphocyte Development Hematopoietic cell development occurs through a succession of events involving hematopoietic stem cell generation, self-renewal, lineage commitment and differentiation. The different members of the Unit for Lymphocyte Development study in an integrative manner different aspects of hematopoietic and lymphocyte development.
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Marc DAERON Molecular and Cellular Allergology Signals triggered by FcRs are integrated in signalosomes that are organized by transmembrane adapters. Our unit studies 1) signals generated by activating and by inhibitory FcRs and their integration, 2) the roles of the various FcRs and the cells by which they are expressed in murine models of inflammatory (allergic and autoimmune) diseases and 3) FcR-dependent activation and negative regulation in cells from normal donors and allergic patient.
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Immunobiology of Infection
Our aims are to develop innovative approaches against mycobacterial infections and advance our understanding of the host immune responses to these major pathogens. Mycobacterium tuberculosis, M. leprae and M. ulcerans have evolved complex lipids strategically located at the interface with the immune system that play dual roles in bacterial virulence and host immunomodulation. Our objectives are to study the mechanisms by which they operate, mine bacterial lipidomes for novel immunomodulatory compounds, and translate our basic knowledge of these natural products into medical treatments against mycobacterial infections and inflammatory pathologies.
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Lymphocyte Development and Oncogenesis
Our research focuses on understanding the mechanisms by which a cell maintains the integrity of its DNA and prevents genomic instability and transformation. More precisely, our lab studies the DNA recombination processes that are part of B- and T-cell development and the mechanisms and pathways that lead to lymphoid cancers. Research keywords: lymphocyte development, cancer, mouse models, genome stability, DNA repair, DNA damage. Postdoctoral positions available! |
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James DI SANTO Innate Immunity Our research aims to define the molecular signals that drive lymphocyte development and control lymphocyte homeostasis, in order to know how these signals can potentially impact and regulate immune responses. A main area of interest involves deciphering the genetic program of NK cell differentiation in both mice and man. A second group develops humanized mice to model human disease.
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Gérard EBERL Lymphoid Tissue Development Our projects aim at understanding the impact of symbiotic microbiota and inflammation on the development of the immune system. In particular, we dissect the role of innate lymphoid cells and active stromal cells in homeostasis and disease.
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Antonio FREITAS Lymphocyte Population Biology |
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Claude LECLERC Immune Regulation and Vaccinology The activity of our laboratory is focused on the understanding of the mechanisms that control the activation and regulation of T cell responses and on the development of new strategies of vaccination against tumors and infections.
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Sandra PELLEGRINI Cytokine Signalling Our research centers on the molecular mechanisms of type I IFN action, with particular attention to receptor and Jak tyrosine kinases functioning, differential activities of IFNα2 and IFNβ, and mechanisms leading to cell desensitization. We also study how type I IFNs modulate human T cell activation and effector function. |
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Lars ROGGE Immunoregulation Our lab studies the molecular mechanisms that control the differentiation and function of human helper T cell subsets, and analyzes their roles in infectious and inflammatory diseases.
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