Immunology Department Activity Report

10-best 2009 publications

Pais-Correia A. M., Sachse M., Guadagnini S., Robbiati V., Lasserre R., Gessain A., Gout O., Alcover A., Thoulouze M. I. 2010. Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses.Nature Med. 16:83-9

Zhang X, Majlessi L, Dériaud E, Leclerc C, Lo-Man R. 2009. Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils. Immunity 31:761-71

Schilte C, Couderc T,Chretien F, Sourisseau M, Guivel-Benhassine F, Michault A, Arenzana-Seisdedos F, Colonna C, Schwartz O, Lecuit M and Albert ML. 2009. Chikungunya virus infection is controlled by type I IFN produced by non-hematopoetic cells. J Exp Med in press

Alves NL, Richard-Le Goff O, Huntington ND, Sousa AP, Ribeiro VS, Bordack A, Vives FL, Peduto L, Chidgey A, Cumano A, Boyd R, Eberl G, Di Santo JP. 2009. Characterization of the thymic IL-7 niche in vivo. Proc Natl Acad Sci U S A. 106:1512-7

Bruhns P, Iannascoli B, England P, Mancardi D, Fernandez N, Jorieux S and Daëron M. 2009. Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. Blood,113:3716-25

Beuneu H, Deguine J, Breart B, Mandelboim O, Di Santo JP and Bousso P. 2009. Dynamic behavior of NK cells during activation in lymph nodes. Blood114:3227

Barreiro, L., M. Ben Ali, H. Quach, G. Laval, E. Patin, J. Pickrell, C. Bouchier, M. Tichit, O. Neyrolles, B. Gicquel, J. R. Kidd, K. K. Kidd, A. Alcaïs, J. Ragimbeau, S. Pellegrini, L. Abel, J.-L. Casanova, and L. Quintana-Murci. 2009. Evolutionary dynamics of human toll-like receptors and their different contributions to host defense. PLoS Genet. 5:e1000562

Toma A, Laïka T, Haddouk S, Luce S, Briand JP, Camoin L, Connan F, Lambert M, Caillat-Zucman S, Carel JC, Muller S, Chopin J, Lemonnier F, Boitard C. 2009. Recognition of human proinsulin leader sequence by class-I restricted T cells in HLA-A*0201 transgenic mice and human type 1 diabetis. Diabetes, 58:394-402

Filipe-Santos, O., Pescher, P., Breart, B., Lippuner, C., Aebischer, T., Glaichenhaus, N., Späth, G., and P. Bousso. 2009. A dynamic map of antigen-recognition by CD4 T cells at the site of Leishmania major infection. Cell Host Microbe, 6:23

Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P. (2009) Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe. 6:5-9.

2009 salient events

- The Department of Immunology ranked A+ following its evaluation by AERES

-Transformation of the 5-year Group Dynamique des Réponses immunes directed by Philippe Bousso into an Institut Pasteur Research Unit.

-Transformation of the 5-year Group Développement des tissus lymphoïdes directed by Gérard Eberl into an Institut Pasteur Research Unit.

- Transformation of the Unité Postulante Biologie cellulaire des Lymphocytes directed by Andrés Alcover into an Institut Pasteur Research Unit.

- Research Unit Immunité cellulaire antivirale directed by François Lemonier closed following the retirement of its Head.

- Création of the start-up Axenisdedicated to the use of 'humanized' mice for biomedical research and development (James Di Santo).

- Production of a GMP batch for a candidate vaccine (CyaA-tyrosinase) and toxocology study, enabling a clinical trial to be organized in melanoma patients (Claude Leclerc).

- Opening of a new multicentric observational study Study of innate immune responses following BCG therapy for patients with transitional cell carcinoma of the bladder. Participating clinical centers: CHU Rouen (PI), Necker, Henri-Mondor, Tenon, Suresnes (Matthew Albert).

- Publication of the book Tractus Immuno-logicus: a brief history of the immune system, by Antonio A. de Freitas, Landes Bioscience Ed.

2009 Nominations/Promotions/Distinctions/Awards

- Antonio Freitas, ERC Advanced Grant

- James Di Santo, Jacques OudinAward of the Société Française d’Immunologie

- Matthew Albert, Cino del Duca Cancerology Award of the Académie des Sciences

- Marc Daëron, Directeur de Recherche de Classe Exceptionnelle at Inserm

- Gérard Eberl, Chef de Laboratoireat Institut Pasteur

- Richard Lo-Man, Chef de LaboratoireatInstitut Pasteur

- Cheng-Ming Sun, Chargé de Recherche de 2è classe at Inserm