The Immunology Department
The Department of Immunology, which includes 13 research units and 2 technical platforms composed of 170 scientists, has a shared interest in exploring the fundamental processes of immunity with the hope to provide new insight into disease pathogenesis, inspire novel vaccines and design unique therapeutic strategies. Moreover, we share a commitment to training the next generation of scientists dedicated to research excellence in the field of immunology.
News in the Department
James Di Santo awarded the "2013 Distinguished Alumnus Award" from the Weill Cornell Graduate School of Medical Sciences of Cornell University.
Matthew Albert was awarded the "Jean Hamburger" Grand Prize of Medicine and Medical Research of the City of Paris.
This prize is awarded for a discovery or an important advance made by a young researcher. Head of a Institut Pasteur / INSERM joint research unit, Matthew Albert and his team work on the fundamental aspects of the cross-presentation of antigen as well as the clinical translation of their findings to better understand the pathogenesis of hepatitis C and bladder cancer. Specific discoveries include the identification of chemokine antagonism in chronically infected hepatitis C patients that might explain the failure of these patients to clear the infection. The team also developed and validated a panel of biomarkers to improve the management of patient care. In regard to bladder cancer, the team defined mechanisms by which BCG may induce tumor immunity by priming specific cytotoxic T cells. This translational approach could not be achieved without close collaboration with clinical teams including Prof. Pol Mallet at Cochin Hospital and Prof. Pfister at Rouen University Hospital. Five clinical trials are currently underway and a multinational Phase III immune regulation and anti-tumor immunity trial is currently under development.
Lymphocyte Development and Oncogenesis lab news:
October 10, 2011: The LDO lab is open!
November 28, 2011: The FRM “Amorçage de Jeunes Equipes” program supports our research.
December 7, 2011: Marie Bedora-Faure joins the LDO lab as a research technician.
February 6, 2012: Chloé Lescale joins the LDO lab as a post-doctoral fellow.
November 2012: The Ville de Paris “EMERGENCES” program supports our research.
November 13, 2012: Tyama El Chaar joins the LDO lab as a post-doctoral fellow.
February 2013: the European Research Council starting grants program funds our lab.
Georges, Jacques et Elias Canetti 2012 Prize to Claude Leclerc
Claude Leclerc received the Jacques et Elias Canetti 2012 Prize on December 4th.
Her laboratory activity is focused on the understanding of the mechanisms that control the activation and regulation of T cell responses and on the development of new strategies of vaccination against tumors and infections.
The Department of Immunology coordinates an Initial Training Network (ITN)
The Department of Immunology coordinates an Initial Training Network (ITN) funded by the European Union Marie Curie Actions called HOMIN: « Host Microbe Interactions in Health and Disease : Interface with the Immune System ». This program aims to provide scientific education through the study of host-microbe interactions with particular focus on immune responses and vaccine development. Five institutions based in three European countries participate in the HOMIN program and will collaborate with an array of European academic and private associated partners. Four PhD student positions in the Department of Immunology will be available within this program, see job offers.For more information on the network please visit: here
Our Immunology Department Days: October 15th to 17th In St Malo
Gérard Eberl winner of the Institut Pasteur Vallery-Radot 2012 Price
communicate with the gut immune system to participate in its development.
Publication : Chikungunya virus–induced autophagy delays caspase-dependent cell death
Graft rejection at the cellular level filmed in 3D
In an effort to clarify these mechanisms immunologists from the Institut Pasteur and Inserm - Philippe Bousso (1) and Susanna Celli (2), of the Dynamics of Immune Responses unit, and Matthew Albert (3), of the Dendritic Cell Immunobiology unit – have used high power microscopy technology to non-invasively film the cellular process in animals. It was on a murine ear skin graft model that they were, for the first time, able to watch in vivo, in real-time, and within the thickness of the tissues, the “ballet” of immune cells taking their places during the graft rejection.
(See the film)