Research / Scientific departments / Immunology

The Immunology Department


The Department of Immunology, which includes 13 research units and 2 technical platforms composed of 170 scientists, has a shared interest in exploring the fundamental processes of immunity  with the hope to provide new insight into disease pathogenesis, inspire novel vaccines and design unique therapeutic strategies. Moreover, we share a commitment to  training the next generation of scientists dedicated to research excellence in the field of immunology.

Upcoming seminars

January 11th – 12 :00 pm

  • Simon FILLATREAU, Deutsches Rheuma-Forschungszentrum, Berlin, Allemagne

Title:  Roles of activated B cells as negative regulators of Immunity.

 

January 18th – 12 :00 pm

Miguel SOARES, Instituto Gulbenkian de Ciência, Oeiras, Portugal

Title:  Disease Tolerance: A host defense strategy against infection.

 

 

February 1st – 12 :00 pm

Michael SIXT, Institute of Science and Technology, Klosterneuburg Austria

 

February 4th – 15 :00 pm  Département d'Immunologie and Département Génomes et Génétique seminar - Milieu Intérieur LabEx projet-

Philipp de JAGGER, Brigham & Women’s Hospital, Boston, Etats-Unis

Title: Deconstructing inflammatory diseases: Exploring the causal chain linking genetic risk to variation in immune function and clinical syndromes

 

February 8th – 12 :00 pm

Lucienne CHATENOUD, Université Paris Descartes - Paris V, France

 

 

March 1st – 12 :00 pm

Dinis CALADO, Max-Delbrück-Center for Molecular Medecine (MDC), Berlin, Allemagne

 

 

March 8th – 12 :00 pm

Andreas WACK

London Research Institute, London, Grande-Bretagne

 

 

March 14th– 12 :00 pm

Albert BENDELAC

The University of Chicago, Etats-Unis.

Title:  Transcriptional pathways for the development of innate and innate-like lymphocytes.

 

 

March 15th – 12 :00 pm

Oreste ACUTO

Sir William Dunn School of Pathology, University of Oxford, Grande-Bretagne.

 

 

March 22nd – 12 :00 pm

Nicolas MANEL

Institut Curie, Paris.

 

 

March 26th – 12 :00 pm

Bali PULENDRAM

Emory Vaccine Center, Atlanta, Etats-Unis.

 

 

April 5th – 12 :00 pm

Michael SIGVARDSSON

Linköping University, Linköping, Suède.

 

 

April 12th – 12 :00 pm

Manolis PASPARAKIS

Institute for Genetics, Cologne, Allemagne.

 

 

April 26th – 12 :00 pm

Jochen HUEHN

Helmholtz Centre for Infection Research, Braunschweig, Allemagne.

 

 

May 3rd – 12 :00 pm

Jean SOULIER

Institut Universitaire d'Hématologie, université Paris-Diderot.

 

 

May 10th – 12 :00 pm

Dana PHILPOT

Université de Toronto.

 

 

May 21st – 12 : 00 pm

David ARTIS

Université de Pennsylvanie.

 

 

May 31st – 12 :00 pm

Clifford LOWELL

The Johns Hopkins University School of Medicine, San Francisco, Etats-Unis

 

 

June 7th – 12 :00 pm

Thad STAPPENBECK

The Washington university in St Louis, Etats-Unis

 

 

June 14th – 12 :00 pm

Arturo ZYCHLINSKY

Max Planck Institute for Infection Biology, Berlin, Allemagne

 

 

June 21st – 12 : 00 pm

Ofer LEVY

Boston Children's Hospital, Boston, Etats-Unis

 

 

June 28th – 12 : 00 pm

Michael DUSTIN

New York University  Cancer Institute, Etats-Unis

 

 

July 12th – 12 : 00 pm

Jennifer GOMMERMAN

Université de Toronto, Canada

 

 

News in the Department

Georges, Jacques et Elias Canetti 2012 Prize to Claude Leclerc

Claude Leclerc received the Jacques et Elias Canetti 2012 Prize on December 4th.
Her laboratory activity  is focused on the understanding of the mechanisms that control the activation and regulation of T cell responses and on the development of new strategies of vaccination against tumors and infections.
more

The Department of Immunology coordinates an Initial Training Network (ITN)

The Department of Immunology coordinates an Initial Training Network (ITN) funded by the European Union Marie Curie Actions called HOMIN: « Host Microbe Interactions in Health and Disease : Interface with the Immune System ». This program aims to provide scientific education through the study of host-microbe interactions with particular focus on immune responses and vaccine development. Five institutions based in three European countries participate in the HOMIN program and will collaborate with an array of European academic and private associated partners. Four PhD student positions in the Department of Immunology will be available within this program, see job offers.

For more information on the network please visit: here

Our Immunology Department Days: October 15th to 17th In St Malo

DSC08863 - copie DSC08886 - copie DSC09013 - copie

Gérard Eberl winner of the Institut Pasteur Vallery-Radot 2012 Price

Gérard Eberl team has recently demonstrated how symbiotic bacteria
communicate with the gut immune system to participate in its development.
more

Publication : Chikungunya virus–induced autophagy delays caspase-dependent cell death

J Exp Med-2012
May 2012



more

Graft rejection at the cellular level filmed in 3D

Observing this "cellular choreography" has most notably proven the existence of a mechanism that contributes to the immune reaction underlying rejection. This discovery, published in Nature Medicine, paves the way towards the optimization of immunosuppressive therapies and promotes successful grafting techniques.
In an effort to clarify these mechanisms immunologists from the Institut Pasteur and Inserm - Philippe Bousso (1) and Susanna Celli (2), of the Dynamics of Immune Responses unit, and Matthew Albert (3), of the Dendritic Cell Immunobiology unit – have used high power microscopy technology to non-invasively film the cellular process in animals. It was on a murine ear skin graft model that they were, for the first time, able to watch in vivo, in real-time, and within the thickness of the tissues, the “ballet” of immune cells taking their places during the graft rejection.
(See the film)


Publication: Chemokine antagonism during HCV infection

22/12/2010
AlbertJCI
Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV. J. Clin. Invest (Albert lab)

Publication: Tertiary lymphoid tissues and intestinal immunodeficiency

20/12/2010
GEJem
Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of ROR{gamma}t and LTi cells. J. Exp. Med (Eberl lab)

Publication: The origin of innate lymphoid cells

19/10/2010
GEScience
Lineage Relationship Analysis of ROR{gamma}t+ Innate Lymphoid Cells. Science. (Eberl lab)

Publication: NK and T cell dynamics  during tumor regression

14/10/2010
boussoImmunity2
Intravital Imaging Reveals Distinct Dynamics for Natural Killer and CD8(+) T Cells during Tumor Regression. Immunity (Bousso lab)

Publication: Intravital imaging reveals the early functional diversification during T cell activation in lymph nodes.

29/09/2010
BoussoImm2010s
Visualizing the functional diversification of CD8+ T cell responses in lymph nodes. Immunity (Bousso lab)

Publication: Counting human naive antigen-specific T cells

31/05/2010
AlbertBloood
Enumeration of human antigen-specific naive CD8+ T cells reveals conserved precursor frequencies. Blood (Albert lab)