Research / Scientific departments / Immunology

The Immunology Department


The Department of Immunology, which includes 13 research units and 2 technical platforms composed of 170 scientists, has a shared interest in exploring the fundamental processes of immunity  with the hope to provide new insight into disease pathogenesis, inspire novel vaccines and design unique therapeutic strategies. Moreover, we share a commitment to  training the next generation of scientists dedicated to research excellence in the field of immunology.

The department recruits

The Institut Pasteur announces an international call for candidates wishing to create independent young researcher groups on its Paris campus in France. Outstanding candidates fostering new concepts in immunology and/or genetics are encouraged to apply.

 In the context of this recruitment, the Immunology Department wishes to develop new themes of research including (but not limited to): systems and computational analyses of immunity, harnessing innate and adaptive immunity for vaccine development, molecular, environmental and systemic control of inflammation; identification of new mechanisms of immune regulation, and statistical and computational genetics.
(more information on the Institut Pasteur Website)

Upcoming seminars

Jeudi 5 AVRIL 2012 - 11 heures 00

Ø      Pamela SCHWARTZBERG NIH, University of Princeton, Etats-Unis (Philippe Bousso)
Titre :

 

Vendredi 13 Avril 2012 -12 heures 00

Ø    Margaret HARNET, Department of Immunology, University of Glasgow, Glasgow. (Caroline Demangel).

Titre : Capturing signalling in the immune system in situ

 

Vendredi 20 Avril 2012 – 12 heures 00

Ø    Caetano REIS e SOUSA, American Cancer Society, Etats-Unis. (Helena Soares)

Titre : Innate regulation of adaptive immunity by dendritic cells

 

Vendredi 27 Avril 2012 -12 heures 00

Ø    Yasmine BELKAID, NIH Bethesda, Etats-Unis. (Claude Leclerc).

Titre : Host-microbes at barrier sites: Role of commensals and nutrients.

News in the Department

Graft rejection at the cellular level filmed in 3D

Observing this "cellular choreography" has most notably proven the existence of a mechanism that contributes to the immune reaction underlying rejection. This discovery, published in Nature Medicine, paves the way towards the optimization of immunosuppressive therapies and promotes successful grafting techniques.
In an effort to clarify these mechanisms immunologists from the Institut Pasteur and Inserm - Philippe Bousso (1) and Susanna Celli (2), of the Dynamics of Immune Responses unit, and Matthew Albert (3), of the Dendritic Cell Immunobiology unit – have used high power microscopy technology to non-invasively film the cellular process in animals. It was on a murine ear skin graft model that they were, for the first time, able to watch in vivo, in real-time, and within the thickness of the tissues, the “ballet” of immune cells taking their places during the graft rejection.
(See the film)


Publication: Chemokine antagonism during HCV infection

22/12/2010
AlbertJCI
Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV. J. Clin. Invest (Albert lab)

Publication: Tertiary lymphoid tissues and intestinal immunodeficiency

20/12/2010
GEJem
Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of ROR{gamma}t and LTi cells. J. Exp. Med (Eberl lab)

Publication: The origin of innate lymphoid cells

19/10/2010
GEScience
Lineage Relationship Analysis of ROR{gamma}t+ Innate Lymphoid Cells. Science. (Eberl lab)

Publication: NK and T cell dynamics  during tumor regression

14/10/2010
boussoImmunity2
Intravital Imaging Reveals Distinct Dynamics for Natural Killer and CD8(+) T Cells during Tumor Regression. Immunity (Bousso lab)

Publication: Intravital imaging reveals the early functional diversification during T cell activation in lymph nodes.

29/09/2010
BoussoImm2010s
Visualizing the functional diversification of CD8+ T cell responses in lymph nodes. Immunity (Bousso lab)

Publication: Counting human naive antigen-specific T cells

31/05/2010
AlbertBloood
Enumeration of human antigen-specific naive CD8+ T cells reveals conserved precursor frequencies. Blood (Albert lab)