2006 Publications from the department of developmental biology

GENETIQUE ET EPIGENETIQUE DE LA DROSOPHILE (Drosophila Genetics and Epigenetics) - CNRS : URA 2578  (C. ANTONIEWSKI)

van Rij R.P., Saleh M-C, Berry B., Foo C., Houk A., Antoniewski C. & Andino. R. The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster. Genes and Dev (2006) 20(21):2985-95


UNITE DE GENETIQUE MOLECULAIRE MURINE (Mouse Molecular Genetics) - CNRS : URA 2578  (P. AVNER)

Bacher, C.P., Guggiari, M., Brors, B., Augui, S., Clerc, P., Avner, P., Eils, R., Heard, E.   Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation.   Nat. Cell Biol. (2006) 8, 293-9.

Bourdet A, Ciaudo C, Zakin L, Elalouf JM, Rusniol C, Weissenbach J, Avner P.   A SAGE approach to identifying novel trans-acting factors involved in the X inactivation process.    Cytogenet Genome Res. (2006) 113, 325-335.

Ciaudo C, Bourdet A, Cohen-Tannoudji M., Dietz H, Rougeulle C & Avner P.   Nuclear mRNA degradation pathway(s) are implicates in Xist regulation and X-chromosome inactivation.    PLoS Genet. (2006) 2, e94, 874-882.

Clerc P & Avner P.   Random X-chromosome inactivation: skewing lessons for mice and men.  Curr Opin Genet Dev. (2006)16, 246-253.

Duret L, Chureau C, Samain S, Weissenbach J, Avner P.    The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene.    Science (2006) 312, 1653-1655

Hung M-S, Avner P & Rogner UC.    Identification of the transcription factor ARNTL2 as a candidate gene for the tye 1 diabetes locus IDD6.    Human Molecular Genetics (2006) 15, 2732-2742.

Karst, C., Trifonov, V., Romanenko, S.A., Claussen, U., Mrasek, K., Michel, S., Avner, P. & Liehr, T.   Molecular cytogenetic characterization of the mouse cell line WMP2 by spectral karyotyping and multicolor banding applying murine probes.     Int J Mol Med. (2006) 17, 209-213.

Morin J, Boitard C, Vallois D, Avner P & Rogner UC. Mapping of the murine type 1 diabetes locus Idd20 by genetic interaction.     Mammalian Genome  (2006) Nov;17(11):1105-12. Epub 2006 Nov 7.

Navarro P, Page D, Avner P and Rougeulle C.    Tsix-mediated epigenetic switch of a CTCF-flanked region of the Xist promoter determines the Xist transcription program.    Genes & Development (2006) 20, 2787-2792.

Rogner, U.C., Lepault, F., Gagnerault, M.C., Vallois, D., Morin, J., Avner, P. & Boitard, C.   Modulation of regulatory T cell activity by the diabetes type 1 locus Idd6.    Diabetes (2006) 55, 186-192

Vigneau, S., Augui, S., Navarro, P., Avner, P., & Clerc, P.    An essencial role for the DXPas34 tandem repeat and Tsix transcription in the counting process of X-chromosome inactivation.  Proc Natl Acad Sci U S A. (2006) 103, 7390-7395


BIOLOGIE DU DEVELOPPEMENT (Development Biology) – CNRS : URA 2578 (Charles BABINET)


Artus J., Babinet C., & Cohen-Tannoudji M.: The cell cycle of early mammalian embryos: lessons from genetic mouse models.   Cell Cycle (2006) 5: 499-502

Cormier, S., Le Bras, S., Souilhol, C., Vandormael-Pournin, S., Durand, B., Babinet, C., Baldacci, P., & Cohen-Tannoudji, M.: The murine ortholog of Notchless, a direct regulator of the Notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells.   Mol Cell Biol 2006; 26: 3541-9

Mesbah, K., Camus, A., Babinet, C., & Barra, J.   Mutation in the Trap{alpha}/Ssr1 Gene, Encoding Translocon-Associated Protein {alpha}, Results in Outflow Tract Morphogenetic Defects.   Mol Cell Biol (2006) 26: 7760-71

Souilhol, C., Cormier, S., Monet, M., Vandormael-Pournin, S., Joutel, A., Babinet, C., & Cohen-Tannoudji, M.   Nas transgenic mouse line allows visualization of Notch pathway activity in vivo.   Genesis (2006a); 44: 277-86

Souilhol, C., Cormier, S., Tanigaki, K., Babinet, C., & Cohen-Tannoudji, M.:   RBP-J{kappa}-Dependent Notch Signaling Is Dispensable for Mouse Early Embryonic Development.    Mol Cell Biol  (2006b) 26: 4769-74


GENETIQUE MOLECULAIRE DU DEVELOPPEMENT (Molecular Genetics of Development) - CNRS : URA 2578 (Margaret BUCKINGHAM)

Bajanca, F., Luz, M., Raymond, K., Martins, G.G., Sonnenberg, A., Tajbakhsh, S., Buckingham, M. & Thorsteinsdottir, S.    Integrin a6b1-laminin interactions regulate early myotome formation in the mouse embryo.  Development, (2006) 133, 1635-1644.

Bajard, L., Relaix, F., Lagha, M., Rocancourt, D., Daubas, P. & Buckingham, M.E.   A distinct genetic hierarchy controls hypaxial myogenesis : Pax3 directly activates Myf5 in muscle progenitor cells in the limb.   Genes & Dev. (2006) 20, 2450-2464.

Bajolle, F., Zaffran, S., Kelly, R.G., Hadchouel, J., Bonnet, D., Brown, N.A. & Buckingham, M.    Rotation of the myocardial wall of the outflow tract is implicated in the normal positioning of the great arteries.  Circulation Research  (2006)  98, 421-428.

Borello, U., Berarducci, B., Murphy, P., Bajard, L., Buffa, V., Piccolo, S., Buckingham, M. & Cossu, G.   The Wnt/b-catenin pathway regulates the Shh-mediated Myf5 activation during somitogenesis.   Development (2006) 133, 3723-3732.

Buckingham, M.    Myogenic progenitor cells and skeletal myogenesis in vertebrates.   Current Opinion in Genetics and Development (2006) 16, 525-532.

Buckingham, M., Bajard, L., Daubas, P., Esner, M., Lagha, M., Relaix, F. & Rocancourt, D.   Myogenic progenitor cells in the mouse embryo are marked by the expression of Pax3/7 genes that regulate their survival and myogenic potential. Anat. Anat Embryol (Berl). 2006 Dec;211 Suppl 1:51-6. Epub 2006 Oct 13. Review.

Daubas, P. & Buckingham, M.E   Somitogenesis.    In : Ganten, D. & Ruckpaul, K. (eds). Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer, Berlin Heidelberg New York (2006).

Esner, M., Meilhac, S.M., Relaix, F., Nicolas, J.-F., Cossu, G. & Buckingham, M.E.    Smooth muscle of the dorsal aorta shares a common clonal origin with skeletal muscle of the myotome : a model for precursor cell migration from the somite. Development, (2006) 133, 737-749.

Franco, D., Meilhac, S.M., & Buckingham, M.   Left and right ventricular contributions to the the formation of the interventricular septum in the mouse heart.    Dev. Biol, (2006)  294, 366-375.

Marguerie, A., Bajolle, F., Zaffran, S., Brown, N.A., Dickson, C., Buckingham, M.E, & Kelly, R.G.    Congenital heart defects in FGFR2-III and FGF10 mutant mice.    Cardiovascular Research (2006) 71, 50-60.

Relaix, F., Montarras, D., Zaffran, S., Gayraud-Morel, B., Rocancourt, D., Tajbakhsh, S., Mansouri, A., Cumano, A. & Buckingham, M.   Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells.    J. Cell Biol. (2006) 172, 91-102.


MACROPHAGES ET DEVELOPPEMENT DE L’IMMUNITE (Macrophages and Development of Immunity) - CNRS : URA 2578  (Phiippe HERBOMEL)

Murayama E., Kissa K., Zapata A., Mordelet E., Briolat V., Lin HF., Handin R.I., Herbomel P.     Tracing hematopoietic precursor migration to successive hematopoietic organs during zebrafish development.. Immunity. 2006 Dec;25(6):963-75. Epub 2006 Dec 7.


CENTRE D’INGENIERIE GENETIQUE MURINE (Mouse Genetics Engineering Center) (Francina LANGA VIVES)


Delmaghani S, del Castillo FJ, Michel V, Leibovici M, Aghaie A, Ron U, Van Laer L, Ben-Tal N, Van Camp G, Weil D, Langa F, Lathrop M, Avan P, Petit C.  Mutations in the gene encoding pejvakin, a novel protein expressed in the afferent auditory pathway, cause DFNB59 auditory neuropathy in man and mouse.  Nat Genet (2006) 38 (7) : 770-778.


REPRODUCTION, FERTILITE ET POPULATIONS (Reproduction, Fertility and Populations) (Kenneth McELREAVEY)

Barreiro LB, Neyrolles O, Babb CL, Tailleux L, Quach H, McElreavey K, Helden PD, Hoal EG, Gicquel B, Quintana-Murci L.    Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis.   PLoS Med. (2006) 3:e20.

Cheng HH, Ying M, Tian YH, Guo Y, McElreavey K, Zhou RJ.   Transcriptional diversity of DMRT1 (dsx- and mab3-related transcription factor 1) in human testis.   Cell Res. (2006) 16:389-93.

McElreavey K, Ravel C, Chantot-Bastaraud S, Siffroi JP.    Y chromosome variants and male reproductive function.   Int J Androl. (2006) 29:298-303 ; discussion 304-6.

Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, Goudie DR, Sandilands A, Campbell LE, Smith FJ, O’Regan GM, Watson RM, Cecil JE, Bale SJ, Compton JG, DiGiovanna JJ, Fleckman P, Lewis-Jones S, Arseculeratne G, Sergeant A, Munro CS, El Houate B, McElreavey K, Halkjaer LB, Bisgaard H, Mukhopadhyay S, McLean WH.    Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.   Nat Genet. (2006) 38:441-6.

Patin E, Barreiro LB, Sabeti PC, Austerlitz F, Luca F, Sajantila A, Behar DM, Semino O, Sakuntabhai A, Guiso N, Gicquel B, McElreavey K, Harding RM, Heyer E, Quintana-Murci L.     Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.    Am J Hum Genet. (2006) 78:423-36.

Ravel C, Berthaut I, Bresson JL, Siffroi JP.    Genetics Commission of the French Federation of CECOS. Prevalence of chromosomal abnormalities in phenotypically normal and fertile adult males: large-scale survey of over 10,000 sperm donor karyotypes.    Hum Reprod. (2006) 21:1484-9.

Ravel C, Chantot-Bastaraud S, El Houate B, Mandelbaum J, Siffroi JP, McElreavey K.    GR/GR deletions within the azoospermia factor c region on the Y chromosome might not be associated with spermatogenic failure.    Fertil Steril. (2006) 85:229-31.

Ravel C, Chantot-Bastaraud S, McElreavey K, Siffroi JP.  [Molecular anomalies of the Y chromosome: consequences on male fertility.]    Gynecol Obstet Fertil. (2006) Sep 14

Ravel C, Chantot-Bastaraud S, Siffroi JP, Escalier D, Antoine JM, Mandelbaum J.    Tail stump syndrome associated with chromosomal translocation in two brothers attempting intracytoplasmic sperm injection.    Fertil Steril. (2006) 86:719.e1-7.

Ravel C, El Houate B, Chantot S, Lourenço D, Dumaine A, Rouba H, Bandyopadahyay A, Radhakrishna U, Das B, Sengupta S, Mandelbaum J, Siffroi JP, McElreavey K.     Haplotypes, mutations and male fertility: the story of the testis-specific ubiquitin protease USP26     Mol Hum Reprod. (2006) 12:643-646.


REGULATION EPIGENETIQUE (Epigenetic Regulation) - CNRS : FRE 2850  (Christian MUCHARDT)


Batsché E, Yaniv M, Muchardt C.   The human SWI/SNF subunit Brm is a regulator of alternative splicing.    Nat Struct Mol Biol. (2006) 13(1), 22-9.

Coisy-Quivy M, Disson O, Roure V, Muchardt C, Blanchard JM, Dantonel JC.    Role for Brm in cell growth control.    Cancer Res. (2006) 66(10), 5069-76.


BIOLOGIE MOLECULAIRE DU DEVELOPPEMENT (Molecular Biology of Development) – CNRS : URA 2578  (Jean-François NICOLAS)


Mathis, L. & Nicolas, J.F.    Clonal origin of the mammalian forebrain from widespread oriented mixing of early regionalized neuroepithelium precursors.   Dev Biol. (2006) 293(1) :53-63.

Roszko, I., Afonso, C., Henrique, D. & Mathis, L.     Key role played by RhoA in the balance between planar and apico-basal cell divisions in the chick neuroepithelium.    Dev Biol. (2006) 298(1) :212-24.


GENETIQUE FONCTIONNELLE DE LA SOURIS (Mouse functional Genetics) - URA CNRS 2578 / USC INRA 2026 (Jean-Jacques PANTHIER)

Adam, S. G., Caraux, A., Fodil-Cornu, N., Loredo-Osti, J. C., Lesjean-Pottier, S., Jaubert, J., Bubic, I., Jonjic, S., Guénet, J. L., Vidal, S. M., & Colucci, F.:   Cmv4, a new locus linked to the NK cell gene complex, controls innate resistance to cytomegalovirus in wild-derived mice.   J Immunol  (2006); 176: 5478-85

Bashamboo, A., Taylor, A. H., Samuel, K., Panthier, J. J., Whetton, A. D., & Forrester, L. M.  The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway.    J Cell Sci  (2006) 119: 3039-46

Kajaste-Rudnitski, A., Mashimo, T., Frenkiel, M. P., Guénet, J. L., Lucas, M., & Despres, P. The 2’,5’-oligoadenylate synthetase 1b is a potent inhibitor of West Nile virus replication inside infected cells.   J Biol Chem  (2006) 281: 4624-37

Panthier, J. J., Houzelstein, G., & Bellier, S.    Régulation de la taille des organes: génétique et physiopathologie d’un allongement du tube digestif chez la souris.   Bulletin de l’Académie Vétérinaire de France  (2006) 159: 255-259

Simon-Chazottes, D., Tutois, S., Kuehn, M., Evans, M., Bourgade, F., Cook, S., Davisson, M. T., & Guénet, J. L.: Mutations in the gene encoding the low-density lipoprotein receptor LRP4 cause abnormal limb development in the mouse.   Genomics (2006); 87: 673-7


EXPRESSION GENIQUE, DEVELOPPEMENT ET MALADIES (Gene Expression, Development and Diseases) – CNRS : FRE 2850 (Marco PONTOGLIO)

Fischer E., Legué E., Doyen A., Nato F., Nicolas J.F., Torres V., Yaniv M. & Pontoglio M.   Defective planar cell polarization in polycystic kidney disease.    Nat Genetics. (2006) 38 (1) : 21-23

Fischer E, Pontoglio M.    [Planar cell polarity and polycystic kidney disease].    Med Sci (Paris) 2006, 22(6-7):576-8.


GENETIQUE MOLECULAIRE DE LA MORPHOGENESE (Morphogenesis Molecular Genetics) – CNRS : URA 2578 (Benoît ROBERT)

Andersson, E., Tryggvason, U., Deng, Q., Friling, S., Alekseenko, Z., Robert, B., Perlmann, T. & Ericson, J.    Identification of intrinsic determinants of midbrain dopamine neurons.   Cell (2006) 124, 393-405.

Binato, R., Alvarez Martinez, C. E., Pizzatti, L., Robert, B. & Abdelhay, E.    SMAD 8 binding to mice Msx1 basal promoter is required for transcriptional activation.    Biochem J (2006) 393, 141-50.

Levi, G., Mantero, S., Barbieri, O., Cantatore, D., Paleari, L., Beverdam, A., Genova, F., Robert, B. & Merlo, G. R.     Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation.    Mech Dev  (2006) 123, 3-16.

Robert, B. & Lallemand, Y.   Anteroposterior patterning in the limb and digit specification: Contribution of mouse genetics. Dev Dyn (2006) 235, 2337-52.


CELLULES SOUCHES ET DEVELOPPEMENT (Stem Cells and Development) – CNRS : URA 2578 (Shahragim TAJBAKHSH)


Shinin, V., Gayraud-Morel, B., Gomes, D., & Tajbakhsh, S.    Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells.   Nat Cell Biol (2006) 8, 677-82.


GENETIQUE DE LA DIFFERENCIATION (Genetics of Differentiation) – CNRS : URA 2578 (Mary WEISS)

Beaudry JB, Pierreux CE, Hayhurst GP, Plumb-Rudewiez N, Weiss MC, Rousseau GG, Lemaigre FP.  Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1alpha are required for time-specific gene expression during liver development.  Mol Cell Biol. 2006 Aug;26(16):6037-46.

Briançon N, Weiss MC.  In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping.  EMBO J. 2006 Mar 22;25(6):1253-62.

Fougère-Deschatrette C, Imaizumi-Scherrer T, Strick-Marchand H, Morosan S, Charneau P, Kremsdorf D, Faust DM, Weiss MC.  Plasticity of hepatic cell differentiation: bipotential adult mouse liver clonal cell lines competent to differentiate in vitro and in vivo.  Stem Cells. 2006 Sep;24(9):2098-109.