Publications from the Department of Developmental Biology

GENETIQUE ET EPIGENETIQUE DE LA DROSOPHILE (Drosophila Genetics and Epigenetics) - CNRS URA2578  (Christophe ANTONIEWSKI)

• Nayak, A., Berry, B., Tassetto, M., Kunitomi, M., Acevedo, A., Deng, C., Kruchinsky, A., Gross, J., Antoniewski, C., and Andino, R. Animal virus RNA interference (RNAi) suppressors are modulators of virulence. Nature structural & molecular biology. 2010. 17(5):547-54

GENETIQUE MOLECULAIRE MURINE (Mouse Molecular Genetics) - CNRS URA2578  (Philip AVNER)

• Avner P. (2010) Sweetness and Light : Perspectives for rodent models of type 1 Diabetes. Invited review in Disease Models and Mechanisms 3, 426-429.
• Chureau C, Chantalat S, Romito A, Galvani A, Duret L, Avner P and Rougeulle C. (2010) Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region. Human Molecular Genetics (in press)
• He C, Avner P, Boitard C and Rogner UC  (2010)  Downregulation of the circadian rhythm related gene Arntl2 suppresses diabetes protection in Idd6 NOD.C3H congenic mice.  Clinical and Experimental Pharmacology and Physiology 37, 1154-1158. He C, Prevot N, Boitard C, Avner P, Rogner UC. (2010) Inhibition of type-1 diabetes by upregulation of the circadian rhythm related Aryl hydrocarbon receptor nuclear translocator-like protein 2. Immunogenetics  62(9):585-92.
• Hovatta O, Agovic A, Avner P, Heymer A, Lendahl U, Luyten FP, Mertsching H, ter Meulen RHJ, van Osch GJVM, de Pablo F, Stojkovic M, Nogueira MM, Kernan F, Moquin-Pattey C, Berghmans S, Lassmann H, Petrunov B, Hojgaard L, Pavelic K, Varela-Nieto I.  (2010)  Human Stem Cell Research and Regenerative Medicine : a European Perspective on Scientific, Ethical and Legal Issues.   Science Policy Briefing 38: 1-15 of European Science Foundation.  On line : http://www.esf.org/publications/science-policy-briefings.html
• Maenner S, Blaud M, Fouillen L, Savoye A, Marchand V, Dubois A, Sanglier-Cianférani S, Van Dorsselaer A, Clerc P, Avner P, Visvikis A and Branlant C (2009) 2D structure of the A repeat region of Xist RNA and its implication for PRC2 association.  PLoS Biology 2010. 8(1):e1000276
• Navarro P and Avner P. (2010) An embryonic story : Laws and orders governing Xist. Invited review in Bioessays, 32(7): 581-588.
• Navarro P, Oldfield A, Legoupi J, Festuccia N, Dubois A, Attia M, Schoorlemmer J, Rougeulle C, Chambers I and Avner P  (2010)  Molecular coupling of Tsix regulation and pluripotency.  Nature 468, 457-460.
• Rheault M, Kren S, Hartich L, Wall M., Thomas W, Mesa H, Avner P, Lees G, Kashtan C, Segal Y  (2010)  X-inactivation modifies disease severity in female carriers of murine X-linked Alport syndrome.  Nephrology, Diabetes and Transplantation, 25(3): 764-769.

GENETIQUE MOLECULAIRE DU DEVELOPPEMENT (Molecular Genetics of Development) - CNRS URA2578 (Margaret BUCKINGHAM)

• Buckingham M, Desplan C.  Developmental mechanisms, patterning and evolution.  Curr Opin Genet Dev. 2010. 20(4):343-5.
• Crist CG, Buckingham M.  Megarole for microRNA in muscle disease.  Cell Metab. 2010. 3;12(5):425-6.
• Lescroart F, Kelly RG, Le Garrec JF, Nicolas JF, Meilhac SM, Buckingham M.  Clonal analysis reveals common lineage relationships between head muscles and second heart field derivatives in the mouse embryo.  Development. 2010. 137(19):3269-79.
• Meilhac, S.M., and Buckingham, M.E.. The behaviour of cells that form the myocardial compartments of the vertebrate heart.  In : Heart Development and Regeneration. Chapter 3.1, 195-217. Eds N. Rosenthal and R.Harvey, Pub Elsevier. (2010)
• Miquerol L, Moreno-Rascon N, Beyer S, Dupays L, Meilhac SM, Buckingham ME, Franco D, Kelly RG.  Biphasic development of the mammalian ventricular conduction system.  Circ Res. 2010. 107(1):153-61.
• Pallafacchina G., François, S., Regnault, B., Czarny, B., Dive, V., Cumano, A., Montarras, D., & Buckingham, M. (2010). An adult tissue-specific stem cell in its niche: a gene profiling analysis of in vivo quiescent and activated muscle satellite cells. Stem Cell Res., 4, 77-91.
• Sato T, Rocancourt D, Marques L, Thorsteinsdóttir S, Buckingham M.  A Pax3/Dmrt2/Myf5 regulatory cascade functions at the onset of myogenesis.  PLoS Genet. 2010 6(4):e1000897.
• Vincent SD, Buckingham ME.  How to make a heart: the origin and regulation of cardiac progenitor cells.  Curr Top Dev Biol. 2010. 90:1-41. Review.
• Watanabe Y, Buckingham M.  The formation of the embryonic mouse heart: heart fields and myocardial cell lineages.  Ann N Y Acad Sci. 2010 Feb;1188:15-24.
• Watanabe, Y., Miyagawa-Tomita, S., Vincent, S.D., Kelly, R.G., Moon, A.M., & Buckingham, M.E. (2010). Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circ. Res., 106, 495-503.

MACROPHAGES ET DEVELOPPEMENT DE L’IMMUNITE (Macrophages and Development of Immunity) - CNRS URA2578  (Philippe HERBOMEL)

• Aggad D, Stein C, Sieger D, Mazel M, Boudinot P, Herbomel P, Levraud JP, Lutfalla G, Leptin M.  In Vivo Analysis of Ifn-{gamma}1 and Ifn-{gamma}2 Signaling in Zebrafish.  J Immunol. 2010. 85(11):6774-82.
• Kissa K, Herbomel P.   Blood stem cells emerge from aorta endothelium by a novel type of cell transition.   Nature, (2010) 464(7285):112-5
• Ludwig M, Palha N, Torhy C, Briolat V, Colucci-Guyon E, Brémont M, Herbomel P, Boudinot P, Levraud JP  (2010).  Whole-body analysis of a viral infection: vascular endothelium is a primary target of Infectious Hematopoietic Necrosis Virus in zebrafish larva.   PLOS Pathogens,  in press

GENETIQUE DU DEVELOPPEMENT HUMAIN (Human Developmental Genetics)    (Kenneth McELREAVEY)

• Bashamboo A , Ledig S, Wieacker P, Achermann JC, McElreavey K.  New technologies for the identification of novel genetic markers of disorders of sex development (DSD).  Sex Dev. 2010. 4(4-5):213-24. Erratum in: Sex Dev. 2010. 4(4-5):224. Achermann, J [corrected to Achermann, J C]
• Bashamboo A, Ferraz-de-Souza B, Lourenço D, Lin L, Sebire NJ, Montjean D, Bignon-Topalovic J, Mandelbaum J, Siffroi JP, Christin-Maitre S, Radhakrishna U, Rouba H, Ravel C, Seeler J, Achermann JC, McElreavey K.  Human male infertility associated with mutations in NR5A1 encoding steroidogenic factor 1.  Am J Hum Genet. 2010 Oct 8;87(4):505-12.
• Bashamboo A, McElreavey K.   NR5A1/SF-1 and development and function of the ovary.  Ann Endocrinol (Paris). 2010. 71(3):177-82.  Review.
• Brauner R, Bashamboo A, Rouget S, Goulet M, Philibert P, Sarda-Thibault H, Trivin C, Misrahi M, Sultan C, McElreavey K.  Clinical, biological and genetic analysis of prepubertal isolated ovarian cyst in 11 girls. PLoS One. 2010. 5(6):e11282
• Montjean D, Benkhalifa M, Dessolle L, Cohen-Bacrie P, Belloc S, Siffroi JP, Ravel C, Bashamboo A, McElreavey K.  Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts.  Fertil Steril. 2010 Oct 1. [Epub ahead of print]
• Lourenco D, Brauner R, Rybczynska M, Nihoul-Fekete C, McElreavey K,, Bashamboo A.   A loss-of-function mutation in GATA4 causes anomalies of human testicular development.   Proc. Nat. Acad. Sci. USA (In press)

REGULATION EPIGENETIQUE (Epigenetic regulation) - CNRS URA2578 (Christian MUCHARDT)

• Saint-André V, Batsché E, Rachez C and Muchardt C  (2010).  Histone H3 lysine 9 tri-methylation and HP1gamma favor inclusion of alternative exons.   Nat Struct. Mol Biol  (in press)

BIOLOGIE MOLECULAIRE DU DEVELOPPEMENT (Molecular Biology of Development) - CNRS URA2578 (Jean-François NICOLAS)

• Legué E, Sequeira I, Nicolas JF.   Hair follicle renewal: authentic morphogenesis that depends on a complex progression of stem cell lineages.  Development. 2010 Feb;137(4):569-77.
• Dolez M, Nicolas JF and Hirsinger E.   Laminins, via heparan sulfate proteoglycans, participate in zebrafish myotome morphogenesis by modulating the pattern of Bmp responsiveness.   Development, in press.

GENETIQUE FONCTIONNELLE DE LA SOURIS (Mouse Functional Genetics) - CNRS URA2578 - INRA USC2026  (Jean-Jacques PANTHIER)

• Abitbol, M., Thibaud, J. L., Olby, N. J., Hitte, C., Puech, J. P., Maurer, M., Pilot-Storck, F., Hédan, B., Dréano, S., Brahimi, S., Delattre, D., André, C., Gray, F., Delisle, F., Caillaud, C., Bernex, F., Panthier, J.J., Aubin-Houzelstein, G., Blot, S., and Tiret, L. (2010). A canine Arylsulfatase G (ARSG) mutation leading to a sulfatase deficiency is associated with neuronal ceroid lipofuscinosis. Proc Natl Acad Sci U S A107: 14775-14780
  
• Alberts, R., Srivastava, B., Wu, H., Viegas, N., Geffers, R., Klawonn, F., Novoselova, N., Zaverucha do Valle, T., Panthier, J. J., and Schughart, K. (2010). Gene Expression Changes In The Host Response Between Resistant And Susceptible Inbred Mouse Strains After Influenza A Infection. Microbes Infect12:309-318
  
• Artus, J., Panthier, J.J., and Hadjantonakis, A.K. (2010). A role for PDGF signaling in expansion of the extra-embryonic endoderm lineage of the mouse blastocyst. Development137: 3361-337
  
• Beck, L., Leroy, C., Beck-Cormier, S., Forand, A., Salaün, C., Paris, N., Bernier, A., Ureña-Torres, P., Prié, D., Ollero, M., Coulombel, L., and Friedlander, G. (2010). The Phosphate Transporter PiT1 (Slc20a1) Revealed As a New Essential Gene for Mouse Liver Development. PLoS One5:1-14
  
• do Valle, T.Z., Billecocq, A., Guillemot, L., Alberts, R., Gommet, C., Geffers, R., Calabrese, K., Schughart, K., Bouloy, M., Montagutelli, X., and Panthier, J. J. (2010). A New Mouse Model Reveals a Critical Role of Host Innate Immunity in Resistance to Rift Valley Fever. J Immunol 185:6146-6156
  
• L’Hote, D., Laissue, P., Serres, C., Montagutelli, X., Veitia, R. A., and Vaiman, D. (2010). Interspecific resources: a major tool for quantitative trait locus cloning and speciation research. Bioessays32:132-42 [Pubmed].
  
• Perez, C. J., Jaubert, J., Guenet, J. L., Barnhart, K. F., Ross-Inta, C. M., Quintanilla, V. C., Aubin, I., Brandon, J. L., Otto, N. W., Digiovanni, J., Gimenez-Conti, I., Giulivi, C., Kusewitt, D. F., Conti, C. J., and Benavides, F. (2010). Two hypomorphic alleles of mouse ass1 as a new animal model of citrullinemia type I and other hyperammonemic syndromes. Am J Pathol177: 1958-1968
  
• Santos J., Gonzalez-Sanchez L., Villa-Morales M., Ors I., Lopez-Neva P., Vaquero C., Gonzalez-Gugel E., Fernandez-Navarro P., Roncero A.M., Guenet J.L., Montagutelli X., Fernandez-Piqueras JJ (2010) The stromal gene encoding the CD274 antigen as a genetic modifier controlling survival of mice with y-radiation-induced T-cell lymphobiasic lymphomas. Oncogene 38:5265-5273
  
• Schughart, K, SYSGENET consortium. (2010). SYSGENET: a meeting report from a new European network for systems genetics. Mammalian Genome 21:331-336
  
• Blanchet, C., Jaubert, J., Carniel, E., Fayolle, C., Milon, G., Szatanik, M., Panthier, J. J., and Montagutelli, X. (2010). Mus spretus SEG/Pas mice resist virulent Yersinia pestis, under multigenic control. Genes Immun [Epub ahead of print]
  
• Houlard, M., Artus, J., Leguillier, T., Vandormael-Pournin, S. and Cohen-Tannoudji , M. DNA-RNA hybrids contribute to the replication dependent genomic instability induced by Omcg1 deficiency. Cell cycle (in press).

GÉNÉTIQUE DU DÉVELOPPEMENT DE LA DROSOPHILE (Drosophila Developmental Genetics) - CNRS URA2578 (François SCHWEISGUTH)

• Bardin AJ, C.N. Perdigoto, T.D. Southall, A.H. Brand and F. Schweisguth (2010) Transcriptional control of stem cell maintenance in the Drosophila Intestine.    Development, 137, 705-714
• Benhra N., F. Vignaux, A. Dussert, F. Schweisguth and R. Le Borgne (2010) Neuralized promotes basal to apical transcytosis of Delta in epithelial cells.   Molecular Biology of the Cell, 21, 2078-86
• Hamel S., J. Fantini and F. Schweisguth (2010) Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster.   The Journal of Cell Biology, 188, 581-594
• Rouault H., K. Mazouni, L. Couturier, V. Hakim and F. Schweisguth (2010) Genome-wide identification of cis-regulatory motifs and modules underlying gene coregulation using statistics and phylogeny.   Proc. Nat. Acad. Sci. USA , 107, 14615-20

CELLULES SOUCHES ET DEVELOPPEMENT (Stem Cells and Development) - CNRS URA2578 (Shahragim TAJBAKHSH)

• Brigitte, M., Schilte, C., Plonquet, A., Baba-Amer, Y., Henri, A., Charlier, C., Tajbakhsh, S., Albert, M., Gherardi, R. K. and Chrétien, F. (2010). Muscle resident macrophages control the immune cell reaction in a mouse model of notexin-induced myoinjury. Arthritis Rheum 62, 268-279.
• Nowlan, N.C. C. Bourdon, G. Dumas, S. Tajbakhsh, P.J. Prendergast and P. Murphy. (2010) Developing Bones are Differentially Affected by Compromised Skeletal Muscle Formation. Bone. 46: 1275-85.
• Tajbakhsh S. (2010). Comment percer les mystères de la ségrégation asymétrique de l’ADN pendant la mitose. Unravelling the mysteries of biased DNA segregation during mitosis.Med. Sci. 26(8-9):696-8
• Theis S, Patel K, Valasek P, Otto A, Pu Q, Harel I, Tzahor E, Tajbakhsh S, Christ B, Huang R. (2010). The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature. Development 137:2961-2971.