Unit : Dynamics of Host-Pathogen Interactions
Unit leader: Jost Enninga, Ph.D.
Our unit “Dynamique des interactions hôte-pathogène” or “Dynamics of host pathogen-interactions” was created in January 2008. We are developing novel approaches to investigate the interactions between pathogens and their hosts in single cells in real time.
We are convinced that deciphering the molecular and cellular details of the invasion strategies used by the bacterial pathogens will identify novel drug targets and will provide new insight into fundamental cell biological processes.
We have obtained generous funding for our research by the following agencies and institutions during recent years and for the coming years: the Institut Pasteur, the Agence Nationale pour la Recherche (ANR), the European Union (ERC program and Marie Curie program), the Fondation Schlumberger pour l'Education et la Recherche, the Fundação para a Ciência e Tecnologia (FCT), the French Foreign Ministry, EMBO and HFSPO. We would like to thank them for their support.
Jost ENNINGA - Principal investigator
Allon WEINER - Postdoc
Juliane LIPPMANN - Postdoc
Jennifer FREDLUND - Postdoc
Nora MELLOUK - Postdoc
José VIEIRA dos SANTOS - Ph D student
Camille REY - Ph D student
Virginie STEVENIN - Ph D student
Patricia LATOUR-LAMBERT - Engineer
Laurence LANGLAIS - Assistant
Laurent AUDRY - Technician, webmaster
Selected recent publications
1. Mellouk N, Weiner A, Aulner N, Schmitt C, Elabaum M, Shorte SL, Danckaert A, Enninga J, Shigella subverts the host recycling compartmeent to rupture its vacuaole. Cell Host Microbe 2014 Oct 16(4)517-530
2. Keller C, Mellouk N, Danckaert A, Simeone R, Brosch R, Enninga J, Bobard A., Single cell measurements of vacuolar rupture caused by intracellular pathogens . J Vis Exp. 2013 Jun 12;(76):e50116. doi: 10.3791/50116.
3.Simeone R. (*), Bobard A. (*), Lippmann J., Bitter W., Majlessi L., Brosch R. (*) and Enninga J. (*), Phagosomal translocation of Mycobacterium tuberculosis results in toxicity and host cell death, PLoS Pathogens, 2012 Feb;8(2):e1002507.
If you like to obtain more information on what we are doing, follow the link :
Our address is :
Groupe “Dynamique des interactions hôte-pathogène”
25, rue du Dr. Roux