Group : Dynamics of Host-Pathogen Interactions
Group leader: Jost Enninga, Ph.D.
Our group “Dynamique des interactions hôte-pathogène” or “Dynamics of host pathogen-interactions” was created in January 2008. We are developing novel approaches to investigate the interactions between pathogens and their hosts in single cells in real time.
We are convinced that deciphering the molecular and cellular details of the invasion strategies used by the bacterial pathogens will identify novel drug targets and will provide new insight into fundamental cell biological processes.
We have obtained generous funding for our research by the following agencies and institutions during recent years and for the coming years: the Institut Pasteur, the Agence Nationale pour la Recherche (ANR), the European Union (ERC program and Marie Curie program), the Fondation Schlumberger pour l'Education et la Recherche, the Fundação para a Ciência e Tecnologia (FCT), the French Foreign Ministry, EMBO and HFSPO. We would like to thank them for their support.
Jost ENNINGA - Principal investigator
Alexandre BOBARD - Postdoc
Allon WEINER - Postdoc
Juliane LIPPMANN - Postdoc
Jennifer FREDLUND - Postdoc
Nora MELLOUK - Ph D student
José VIEIRA dos SANTOS - Ph D student
Geneviève JANVIER - Engineer
Patricia LATOUR-LAMBERT - Engineer
Ana Monica CORREIA - Project manager
Camille REY - Master 2 student
Laurent AUDRY - Technician, webmaster
Selected recent publications
1. Simeone R. (*), Bobard A. (*), Lippmann J., Bitter W., Majlessi L., Brosch R. (*) and Enninga J. (*), Phagosomal translocation of Mycobacterium tuberculosis results in toxicity and host cell death, PLoS Pathogens, 2012 Feb;8(2):e1002507.
2. Cebrian I, Visentin G., Blanchard N., Bobard A., Moita C., Enninga J., Moita LF, Amigorena S., Savina A. Sec22b controls the recruitment of endoplasmic reticulum to phagosomes in dendritic cells Cell, 2011 Dec 9;147(6):1355-68.
3. Ehsani S, Santos JC, Rodrigues CD, Henriques R, Audry L, Zimmer C, Sansonetti P, Tran Van Nhieu G, Enninga J. Hierarchies of Host Factor Dynamics at the Entry Site of Shigella flexneri during Host Cell Invasion. Infect Immun. 2012 Jul;80(7):2548-57. Epub 2012 Apr 23.
If you like to obtain more information on what we are doing, follow the link :
Our address is :
Groupe “Dynamique des interactions hôte-pathogène”
25, rue du Dr. Roux