Cell Polarity, Migration & Cancer

Welcome to Sandrine Etienne-Manneville lab


Cells that form living organisms can migrate. Cell migration is required during development as well as in the adult where it contributes, for instance, to tissue renewal, wound healing, or immune cell trafficking. Cell migration is highly controlled and occurs only in particular circumstances. However, in tumours, cancer cells have gained the ability to migrate, escaping the normal mechanisms of control. Cancer cells can thus invade the surrounding tissues, and possibly lead to the formation of metastases.

We study the migration of astrocytes in particular. Astrocytes represent a large proportion of cells in the central nervous system. Among their large variety of functions, they contribute to wound healing and to the regeneration of cerebral tissues, following all kinds of injuries. Astrocytes can also give rise to tumours called gliomas (which include astrocytomas and glioblastomas), which correspond to a majority of cerebral tumours. Glioblastomas are particularly invasive which render them difficult to treat. As a consequence, they are generally associated with a bad prognosis.

Our work involves the study of the molecular mechanisms which allow and control the migration of normal astrocytes whilst investigating the alterations of these mechanisms in cancer cells. This work will lead to a better understanding of the fundamental mechanisms of cell migration and should enable better control of migration in normal and pathological circumstances. This, we hope, will allow us to improve tissue renewal, wound healing and to find new therapeutic tools to prevent tumour invasion.



Open Positions in the lab

Master 2 students (here & here), PhD students and Post-docs interested in joining the lab, please send your resume to Sandrine Etienne Manneville at setienne@pasteur.fr



Meetings & Seminars

- French Microtubule Network, July 1st & 2nd, Pharmacy faculty, Marseille, France