Celebrating the 50th anniversary of the Replicon Theory
March 25-28, 2013 at the Institut Pasteur, Paris
The main objective of the workshop is to celebrate the 50th anniversary of the Replicon Theory by Jacob, Brenner and Cuzin (*). The simple idea that replicator (origin of replication) and initiator (protein) promotes initiation of DNA replication once per cell cycle, provides the paradigm for DNA replication in almost all organisms. The model also predicts a close link between replication and partition, involving chromosomal organization and membranes associated factors. A half-century after the Theory emerged, it has now been validated through repeated testing. The development of sophisticated methods in biochemistry, biophysics, molecular and cellular biology and systems biology has allowed researchers to significantly advance understanding of DNA replication dynamics and its biological impact on genome stability and development. In this anniversary celebration, researchers will review present-day knowledge and share unpublished experimental data, with the aim of stimulating the emergence of new concepts.
(*) On the regulation of DNA replication in bacteria. Cold Spring Harbor Quant. Biol. 28 (1963), pp. 329-348.
Replicon theory (1963):
Benoit Arcangioli – Institut Pasteur, Paris, France
Michelle Debatisse – Institut Curie, Centre de Recherche, Paris, France
Masamichi Kohiyama - Université Paris Diderot
Moshe Yaniv – Institut Pasteur, Paris, France