Scientific Program

9:10-9:40 am: Bruce Beutler, The Scripps Research Institute, La Jolla, USA “Forward genetic analysis of resistance to infection in mice”

9:45 am: Alain Fischer, Hôpital Necker-Enfants Malades, Paris, France "Genetic defects of antibody production and infections" 10:15 am: Claire Fieschi, Hôpital Saint-Louis, Paris, France "Genetics of Common variable ImmunoDeficiency" 10:45-11:15 am: Coffee-break 11:15 am-: Jennifer Puck, University of California San Francisco, USA "Severe combined immunodeficiency : genetic and phenotypic diversity and early diagnostis" + 11.45 am : Alexandre Bolze "Deciphering the genetic basis of Isolated Congenital Asplenia" 12.00 am : Ilia Voskoboinik "How much perforin is needed "to get by" ? Partial perforin deficiency dictates the relative susceptibility to FHL and cancer." 12.15 am : Audrey Grant "Identification of two mutations for Mendelian Susceptibility to Mycobacterial Diseases usinf a novel homozygosity mapping approach accounting for heterogeneity" 12.30 am : Ken Chow "Functionnal interplay between Human Papillomavirus and the CXCL12-signalling axis"

2:30 pm: Erwin Schurr, MacGill University, Montreal, Canada "Complex genetic of leprosy" 3:00 pm: Rolf Horstmann, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany "Human tuberculosis: Match of genomes, first set" 3:30 pm: Adrian Hill, The Wellcome Trust Centre for Human Genetics, Oxford, UK "Genetic susceptibility to common bacterial infections of humans" 4:00-4:30 pm: Coffee-break 4:30-5:00 pm: Eva Medina, Helmholz Centre for Infection Research, Braunschweig, Germany “The Influence of host genetic variations in the outcome of experimental Staphylococcus aureus infection” ++ 5:00 pm : Priscille Brodin "High-content RNAi screen in mammalian macrophages reveals CISH as pivotal celle mediator for Mycobacterium tuberculoisis manipulation of host antibacterial response" 5.15 pm : Aurélie Cobat "Two loci control tuberculin skin test reactivity in an area hyperendemic for tuberculosis" 5.30 pm : Louis De Léséleuc "Functional characterization of the leprosy susceptibility gene PARK2 uncovers a role in the regulation of tumor necrosis factor in human macrophages" 5.45 pm : Etienne Richer "A role for hepcidin during infection with Salmonella" 6.00 pm : Jacinta Bustamante "A novel immunodeficiency affecting the respiratory burst in granulocytes" 6.15 pm : Olivier Disson " Listeria monocytogenes journey in a host : lessons from permissive and genetically modified animals"

9:00 am: Elena Levashina, IBMC, Strasbourg, France "Host Factors controling Plasmodia infections in Anopheles gambiae mosquitoes" 9:30 am: David Modiano, Universita "La Sapienza", Rome, Italy "Human genetics and malaria: not only a matter of resistance/susceptibility" 10:00 am: Etienne Pays, Free University of Brussels, Gosselies, Belgium "Molecular dialogue between African trypanosomes and their mammalian hosts" 10:30-11:00 am: Coffee-break ++ 11.00 am : Brendan McMorran "Platelets kill intraerythrocytic malaria parasites and protect agaisnt infection" 11.15 am : Odile Mercereau Puijalon "Common PLasmodium vivax blood-stage malaria in Duffy-negative Malagasy people" 11.30 am : Chalisa Louicharoen "Positively selected G6PD6Mahidol mutation reduces plasmodium vivaw density in South East Asians" 11.45 am : Christophe Chevillard "Polymorphisms in CTGF are associated with hepatic fibrosis in Chinese, Sudanese, Brasilians populations infected with Schistosomes" 12.00 am : Vanessa Sancho Shimizu "HSE3, a novel locus controlling susceptibility to Herpes Simplex Encephalitis" 12.15 am : Frederic Lantier "Sheep carrying the T112 PrP have an increased resistance to challenge with scrapie or BSE agents"

3.15 pm: Michael Emerman, Fred Hutchinson Cancer Research Center, Seattle, USA "The evolution of primate antiviral defenses" 3.45 pm: Mary Carrington, SAIC-Frederick, Frederick, USA "Immunogenetic variation characterizing exceptional control of HIV" 4:15-4:45 pm: Coffee-break 4:45 pm: David Goldstein, Duke University, Durham, USA "Rare and common variants in the control of HIV-1" 5:15 pm: Lennart Svensson, Linkopings Universitet, Linkopings, Sweden "Mendelian Resistance to Norovirus Infections" 5:45 pm: Jean-Laurent Casanova, Hopital Necker-Enfants Malades, Paris, France and The Rockefeller University, New York, USA "A genetic dissection of herpes simplex encephalitis" ++ 6:15 pm : Maciek Lazarczyk "Cellular zinc homeostasis as a natural anti-HPV barrier" 6.30 pm : Sabine Plancoulaine "Evidence for a dominant major gene predisposing to Hepatitis C Virus Infection in an endemic population from rural area

9:00 am: Bruno Lemaitre, E.P.F.L., Lausanne, Switzerland " Drosophila instestinal response to bacterial infection: Activation of host defense and stem cell proliferation" 9:30 am: Danielle Malo, Mac Gill University, Montreal, Canada "Host genetic diversity and Salmonella susceptibility in experimental mouse models of infection" 10:00 am: Richard Webby, St. Jude Children's Research Hospital, Memphis, USA "Modeling the role of host in H5N1 influenza severity" 10:30-11:00 am: Coffee-break ++ (titles to come) 11:00 am : Tania Zaverucha 11.15 am : Marc Dionne 11.30 am : J. Antonio Gomez 11.45 am : Klaus Schughart 12.00 am : Nathalie Pujol 12.15 am : Dennis Kim

2.30 pm: Stylianos Antonarakis, University of Geneva, Switzerland "The connectivity of Genomic Elements" 3.00 pm: Lluis Quintana-Murci, Institut Pasteur, Paris, France "Evolutionary Dynamics of Innate Immunity Genes in Humans" 3.30 pm: Andrew Clark, Cornell University, Ithaca,USA "Deep resequencing data and inference of the impact of infectious agents on human genetic variation" 4:00-4:30 pm: Coffee-break 4.30 pm: Sara Tishkoff, University of Pennsylvania, Philadelphia, USA "An evolutionary and population genetics approach for identifying malaria susceptibility loci in Africa" ++ 5.00 pm : Alexander Poltorak 5.15 pm : Etienne Patin 5.30 pm :Helene Quach 5.45 pm : Robert Hardwick 6.00 pm : Uberto Pozzoli