Jean-Paul LATGE
Aspergillus Unit
Institut Pasteur 25-28 rue du docteur Roux, 75015 Paris
 
Research area of the Unit
 
The focus of the research of the Aspergillus Unit is on the biology of Aspergillus fumigatus. Expertise is mainly in the fields of fungal biochemistry, molecular biology and immunology. Main achievements concern : (1) the isolation and biochemical characterization of > a dozen of antigens and proteins of A. fumigatus putatively involved in pathogenesis, cloning and disruption of the encoding genes and testing for pathogenicity in a murine model of pulmonary aspergillosis ; (2) the study of the host-A. fumigatus interactions with special emphasis on the analysis of the innate and cellular immunity directed towards A. fumigatus (3) the structural analysis of the cell wall and extracellular matrix of hyphae and conidia of A. fumigatus and the characterization of synthases, glycosidases and glycosyltransferases involved in the cell wall assembly of A. fumigatus.  
 
 
Contribution to the programme
 
Development of a strategy to control emerging fungal pathogens, such as Zygomycetes. Our project will be the understanding of antifungal drug resistance and the identification of released antigens with putative diagnostic interest.
 
 
References over the past 5 years
1.      Henry C, Latgé JP, Beauvais A. (2012) {alpha}(1-3)Glucans are dispensable in Aspergillus fumigatus. Eukaryotic cell. 11(1):26. Epub 2011 Nov 4
2.      Fontaine T, Delangle A, Simenel C, Coddeville B, Van Vliet S, Van Kooyk Y, Bozza S, Moretti S, Schwarz F, Trichot C, Aebi M, Delepierre M, Elbim C, Romani L, Latgé JP. (2011) Galactosaminogalactan, a new immunosuppressive polysaccharide of Aspergillus fumigatus. Plos Pathogens e1002372
3.      Gastebois A, Fontaine T, Latgé JP, Mouyna I. (2010) The {beta}(1-3)glucanosyltransférase Gel4p is essential for Aspergillus fumigatus. Eukaryot Cell. 9:1294-1298.
4.      Gastebois A, Mouyna I, Simenel C, Clavaud C, Coddeville B, Delepierre M, Latgé JP and Fontaine T. (2010) Characterization of a new Beta(1-3)glucan branching activity of Aspergillus fumigatus. JBC 22;285(4):2386-96.
5.      Lambou K, Lamarre C, Beau R, Dufour N, Latgé JP. (2010) Functional analysis of the superoxide dismutase family in Aspergillus fumigatus. Mol Microbiol. 75(4):910-23.
6.      Aimanianda V, Bayry J, Biozza S, Kniemeyer O, Perruccio K, Elluru R, Clavaud C, Paris S, Brakhage AA, Kaveri SV, Romani L, Latgé JP. (2009) Surface hydrophobin prevents immune recognition of airborne fungal conidia. Nature. 460:1117-1123
7.      Lamarre C, Beau R, Balloy V, Fontaine T, Wong Sak Hoi J, Guadagnini S, Berkova N, Chignard M, Beauvais A and Latgé JP. (2009) Galactofuranose attenuates cellular adhesion of Aspergillus fumigatus. Cell Microbiol. 11:1612-1623.