Curriculum vitae Pascale Cossart
Name : Pascale COSSART
Date of Birth : 1948, March 21st
Place of Birth : Cambrai (Nord) France
Citizenship: French
Professional address :
INSTITUT PASTEUR
Bacteria-cell interactions Unit – INSERM U604 – INRA USC2020
Department of Cell biology and Infection
25 rue du Docteur Roux -75724 PARIS Cedex 15-France.
Tel : + 33 (1) 45 68 88 41 (secretary: + 33 (1) 40 61 30 32).
Fax : + 33 (1) 45 68 87 06
E-mail : pcossart@pasteur.fr
Present Position and Status :
Head of the "Unité des Interactions Bactéries-Cellules"
Director of the INSERM Unit, U604 and of the INRA Unit, USC2020
Director of the Cell Biology and Infection Department
Status "Professor at the Pasteur Institute" Classe exceptionelle
Academic titles :
1968 Maîtrise ès Sciences (Chemistry) (Lille University, France)
1971 Master of Science (Georgetown University, Washington DC, USA)
1977 Doctorat ès-Sciences physiques (Paris VII University, France)
Positions :
| Oct. 1969 - Sept.1970 | Assistante à l’IUT de Biologie appliquée de Lille |
| Oct. 1970 - Sept.1971 | University fellow à Georgetown University, Washington D. C. |
| Mar. 1972 - Sept. 1972 | Boursière de la Fondation Philippe. Institut Pasteur, Paris |
| Oct. 1972 - Sept. 1974 | Boursière de la Fondation Roux. Institut Pasteur, Paris |
| Oct. 1974 - Dec. 1975 | Professeur de Biochimie à l’Ecole Royale de Médecine, Vientiane, Laos |
| Jan. 1976 - Dec 1979 | Assistante à l’Institut Pasteur, Paris |
| Jan. 1980 - Déc. 1987 | Chargée de Recherches à l’Institut Pasteur, Paris |
| Jan. 1988 - Dec 1996 | Chef de Laboratoire à l’Institut Pasteur, Paris |
| Jan. 1997 - Dec 2005 | Professeur à l’Institut Pasteur, Paris |
| Jan 2006- | Professeur de Classe Exceptionnelle à l’Institut Pasteur, Paris |
Laboratories :
| 1968 - 1970 |
Laboratoire de Chimie Biologique de la Faculté des Sciences de Lille (Pr Jean Montreuil) |
| Jul. 1970 –Aug. 1971 |
Laboratory of Protein Chemistry, Department of Chemistry, Georgetown University, Washington, D.C., USA (Pr J. Steinhardt) |
| Sept - Oct 1971 |
Laboratoire de Chimie Biologique de la faculté de Médecine de Lille (Pr Boulanger) |
| Dec. 1971 - Sept. 1974 | Unité de Biochimie Cellulaire, Institut Pasteur (Pr G. Cohen) |
| Jan. 1976 - Dec. 1977 | Unité de Biochimie Cellulaire, Institut Pasteur (Pr G. Cohen) |
| Jan. 1978 - Aug. 1980 | Unité des Virus Oncogènes, Institut Pasteur (Pr M. Yaniv) |
| Sept. 1980 - Feb. 1986 | Unité de Biochimie Cellulaire, Institut Pasteur ( Pr G. Cohen) |
| Mar. 1986 - Mar. 1991 | Unité de Génie Microbiologique, Institut Pasteur (Pr J. Davies) |
| Mar. 1991 - Mar. 1994 |
Laboratoire de Génétique Moléculaire des Listeria., Institut Pasteur (Dr P. Cossart) |
| Apr. 1994- | Unité des Interactions Bactéries-Cellules, Institut Pasteur, Paris (Pr P. Cossart) |
Distinctions and Prizes :
- EMBO member, since 1995
- ACADEMIA EUROPAE member, since 1998
- Corresponding member of the French "Académie des Sciences", Paris, since March 1999
- Member of the "Deutsche Akademie der Naturforscher LEOPOLDINA", Germany, since October 2001
- Member of the French "Académie des Sciences", Paris, since October 2002
- Member of the CCNE (Comité Consultatif National d’Ethique), since 2003
- Member of the American Academy of Microbiology, since April 2004
- UNESCO Price "Carlos FINLAY", November 1995
- Louis RAPKINE Awards, April 1997
- L’Oreal/UNESCO Awards for Women in Science, January 1998
- Richard LOUNSBERY Price, Académie des Sciences, Paris/National Academy of Sciences, USA, June 1998
- NESTLE Price "L’homme et sa nutrition", February 2000
- Louis PASTEUR Gold Medal, Swedish Society of Medicine, Stockholm, October 2000
- VALADE Senior Price, Fondation de France, 2003
- INSERM Price of Fundamental Research, 2005
- Howard HUGHES Medical Institute, International Research Scholar, September 2000-2005, September 2005-2010
- Glaxo Smith Kline International Member of the Year Award, (ASM , Toronto), May 2007
- Robert KOCH Prize 2007, Berlin, November 2007
- RenÈ DESCARTES Prize (2008) for collaborative research, Brussels,(2008)
- Louis-JEANTET Prize for Medicine, 2008
- ERC Advanced Grant Award (2008)
- Chevalier de la Légion d’honneur, April 1998
- Officier de l’Ordre National du Mérite, November 2002
- Officier de la Legion d’honneur, mai 2007
Honorary Lectures :
- May 18-24, 1996 : Lecture and Visiting Professor at the Weizmann Institute of Science, Rehovot, Israel
- April 16, 1997 : Louis Rapkine lecture. Birmingham, UK
- February 11, 1998. The Normanby Lecture - Moyne Institute, Trinity College, Dublin, Ireland
- May 19-23, 2002 : Division B lecture, ASM : 102nd General Meeting, Salt lake city, Utah, USA
- March 5-6, 2003 : The Chiron Lectures - University of California, Berkeley, USA
- May 7, 2003 : The NIH Director’s Lecture, Margaret Pittman Lecture - National Institutes of Health, Behesda, USA
- February 24, 2004 : RGE Murray Lectureship, London, Canada.
- May 21, 2004 : The Meyer Lecture - University of California, San Francisco, USA
- December 1-3, 2004 : The Embo Lecture - XXVI Annual Meeting of the Chilean Society for Microbiology, Valparaiso, Chile
- May 24, 2005 : The Marvin E. Brennecke Lecture - Washington University, Saint-Louis, USA
- January 25-26, 2006 : The BBVA Foundation Lectures, Granada and Madrid, Spain
- June 18, 2006 : The E.C. Slater Plenary Lecture, 20th IUBMB Int. Congress of Biochem. and Molecul. Biology and 11th FAOBMB Congress, Kyoto, Japan
- November 17, 2006 : The 22nd Shipley Symposium, Harvard Medical School, USA.
- November 20, 2006 : The Mayer Lecture, Biology Colloquium, Massachussets Institute of Technology, USA
- December 14th, 2006 : The Rickett symposium Lecture, University of Chicago, Chicago, USA
- May 22nd, 2007 : The International Member of the Year Lecture, ASM, Toronto (Canada)
- November 8th, 2007 : The Robert KOCH Lecture, Berlin, Germany
- March 2008 : Opening lecture, Genomes 2008, Paris, France
- July 23rd , 2008 : The Robert KOCH Lecture, Tubingen, Germany
- September 2008 : Opening lecture, ELSO 2008, Nice France
- January 2009 : Ernst A. H. Friedheim Memorial Lecture – Rockeffeler University, New-York, USA
- February 2009 : "Perspectives in Molecular Medicine" Lecture, Goethe University of Frankfurt, Frankfurt, Germany
Editorial Boards :
- "Current opinion in Microbiology", since 1998, Chief Editor since 2001
- "Journal of Cell Biology", Monitoring Editor since 2003
- "PLoS Pathogens", Associate Editor since 2005
- "Molecular Microbiology", 1992-2003
- "EMBO Journal", since 1996
- "Trends in Cell Biology", since 1999
- "Cellular Microbiology", since 2000
- "Nature Reviews Molecular Cell Biology", 2000-2005
- "Microbes and Infection", since 2000
- "EMBO Reports", since 2001
- "FEBS Letters", Editor since 2002
- "International Journal of Medical Microbiology", since 2004
- Member of "Faculty of 1000"
- "Cell : Host and Microbe", Editorial board since 2007
- "Cell", Editorial board 2008
Scientific Societies :
Member of the Société Française de Microbiologie since 1977 / Member of the American Society for Microbiology since 1987 / Member of the American
Society for Cell Biology since 1993 / Member of the Sociéte Française de Biologie Cellulaire since 2007/ Member of the Société Française de Biochimie et de Biologie Moléculaire since 2007
Main present activities :
- Director of the Cell Biology and Infection Department, Pasteur Institute since 2006-
- Member of the Scientific Advisory Board of the Biozentrum, University of Basel, Switzerland, since 2002
- Member of the Jury of the L’Oréal-UNESCO Awards for Women in Science, since 1999
- Member of the « Comité de Pilotage » of ANR, the Agence Nationale pour la Recherche, « Microbiologie, Immunologie et Maladies Emergentes », since
2006-
- Member of the FEBS Advanced Course Committee, since 2008-
- Member of the Scientific Council of HFSPO, 2008-
- Member of the Scientific Council of FRM, 2008-
- ERC expert 2008-2012
Main recent activities :
- Member of the Scientific Council of the Institut Pasteur, 2002-2006, President 2003-2005
- Member of the Scientific Council of INRA, 1998- 2006. In charge of "Mission Microbiologie in INRA" in 2001
- Member of the EMBO Course and Workshop Committee, 1999-2004. "Chair" 2001-2004
- Member of the Review Panel of the EMBL « Cell Biology and Biophysics Unit », Heidelberg, Germany, May 2005
- Member of the Jury of the 2006 INBEV-Baillet Latour Health Prize, FNRS, Brussels, 2006
- Member of the Scientific Council of the Fondation Bettencourt-Schueller, 2003-2007
- Member of the Scientific Council of the CNRS, 2005-2006
- Member of the Program Committee, of the 2006 ASCB Annual Meeting in San Diego, US, December 2006
- Member of the Scientific Council of the « Ville de Paris », 2003-2008
- Member of the Scientific Advisory Board of the Research Center for Infectious Diseases, Würzburg University, Germany, 2000-2008
Meeting and courses organization :
- Organization of an international INSERM/P.Laudat Conference "Microbial pathogenesis and Cell Biology", Aix-les Bains, France, October 1995
- Co-organization of a "Cellular Microbiology" EMBO-EBNIC Workshop, Sienna, Italy, January 1999
- Organization of an ESF/EMBO Conference "Frontiers of Cellular Microbiology and Cell Biology", Giens, France, October 2000
- Co-organization of the Meeting "New challenges in Biological Research : Pasteurian missions in 21st century", Académie des Sciences, Institut de
France ; Arc et Senans, France, October 2000
- Organization of EMBO/FEBS Lecture Course "Molecular basis of bacterial virulence and survival in infected hosts and in the environment", Spetsai,
Greece, September 2002
- Co-organization of the International Symposium on Threat of infection : “Microbes of high pathogenic potential –Strategies for detection, control and
eradication », joint Meeting of the Académie des Sciences, Paris, the Deutsche Akademie d er Naturfrscher Leopoldina, Halle, and the Research Center for
Infectious Diseases of the University of Würzburg ;Würzburg, Germany, July 2004
- Chair of the Gordon Research Conference : “Molecular mechanisms of bacterial adhesion and signaling", Newport, USA, August 2005
- Co-organization of the Colloquium “Frontiers in Microbiology and Infectious Diseases”. Académie des Sciences, Institut de France, Paris, France,
September 2005
- Co-organization of the “Gene regulation in health and disease” meeting, Paris, France, March 2006
- Organization of EMBO/FEBS/FEMS Lecture Course "Molecular basis of bacterial virulence and survival in infected hosts and in the environment",
Spetsai, Greece, September 2006
- Co-organization, as Member of the Program Committe, of the 2006 ASCB Annual Meeting in San Diego, US, December 2006
- Co-Organization of the IUBMB/FEBS/ICGEB/UNESCO lecture course ´†Molecular and Cellular Basis of Infection†ª Hermanus, South Africa, March
2008
- Co-Organisation of the EMBO/FEBS pratical course « Cell Biology of Host-Pathogen Interactions » Institut Pasteur , Paris, August 2008
- Co-organization of the 5th EIMID meeting, Arc-et Senans, France October 2008
Major publications
-J.L. Gaillard, P. Berche, C. Frehel, E. Gouin and P. Cossart (1991). Entry of L. monocytogenes into cells is mediated by internalin, a repeat protein
reminiscent of surface antigens from Gram-positive cocci. Cell, 65 : 1127-1141.
-C. Kocks, E. Gouin, M. Tabouret, P. Berche, H. Ohayon and P. Cossart (1992). Listeria monocytogenes-induced actin assembly requires the actA gene
product, a surface protein. Cell, 68 : 521-531.
-E. Friedrich, E. Gouin, R. Hellio, C. Kocks, P. Cossart and D. Louvard (1995). Targeting of Listeria monocytogenes ActA protein to the plasma
membrane as a tool to dissect both actin-based cell morphogenesis and ActA function. EMBO J., 14 : 2731-2744.
-S. Cudmore, P. Cossart, G. Griffiths and M. Way (1995). Actin-based motility of vaccinia virus. Nature, 378 : 636-638.
-J. Mengaud, H. Ohayon, P. Gounon, R. M. Mege and P. Cossart (1996). E-cadherin is the receptor for internalin, a surface protein required for entry of
Listeria monocytogenes into epithelial cells. Cell, 84 : 923-932.
-P. Cossart, P. Boquet, S. Normark and R. Rappuoli (1996). Cellular Microbiology emerging. Science, 271 : 315-316.
-K. Ireton, B. Payrastre, H. Chap, W. Ogawa, H. Sakaue, M. Kasuga and P. Cossart (1996). A role for Phosphoinositide 3-kinase in bacterial invasion.
Science, 274 : 780-782.
-I. Lasa, E. Gouin, M. Goethals, K. Vancompernolle, V. David, J. Vandekerckhove and P. Cossart (1997). Identification of two regions in the aminoterminal
domain of ActA involved in the actin comet tail formation by Listeria monocytogenes. EMBO J., 16 : 1531-1540.
-B.B. Finlay, and P. Cossart (1997). Exploitation of mammalian host cell functions by bacterial pathogens. Science, 276 : 718-725.
-P. Mourrain, I. Lasa, A. Gautreau, A.Pugsley and P. Cossart (1997). ActA is a dimer. Proc. Natl. Acad. Sci. USA, 94 : 10034-10039.
-E. Gouin, H. Gantelet, C. Egile, I. Lasa, H. Ohayon, V. Villiers, P. Gounon, P.J. Sansonetti and P. Cossart (1999). A comparative study of the actinbased
motilities of the pathogenic bacteria Listeria monocytogenes, Shigella flexneri and Rickettsia conorii. J. Cell Sci., 112 : 1697-1708
-M. Lecuit, S. Dramsi, C. Gottardi, M. Fedor-Chaiken, B. Gumbiner and P. Cossart (1999). A single amino-acid in E-cadherin responsible for hostspecificity
towards the human pathogen Listeria monocytogenes. EMBO J., 18 : 3956-3963.
-M. Marino, L. Braun, P. Cossart and P. Ghosh (1999) . Structure of the InlB Leucine-rich repeats, a domain that triggers host cell invasion by the
bacterial pathogen. Mol. Cell., 4 : 1063-1072.
-L. Braun, B. Gebrehiwet, and P. Cossart (2000). gC1q-R/p32, a C1q-binding protein, is a receptor for the InIB invasion protein of Listeria
monocytogenes. EMBO J., 19 : 1458-1466.
-M. Lecuit, R. Hurme, J. Pizzaro-Cerda, H. Ohayon, B. Geiger and P. Cossart (2000). A role for α – and β-catenins in bacterial uptake. Proc. Natl.
Acad. Sci., USA, 97 : 10008-10013.
-H. Bierne, E. Gouin, P. Roux, P. Caroni, H. Yin and P. Cossart (2001). A role for cofilin and LIM-kinase in bacterial induced phagocytosis. J. Cell
Biol., 155 : 101-112.
-M. Lecuit, S. Vandormael-Pournin, Jean Lefort, M. Huerre, P. Gounon, C. Dupuy, C. Babinet and P. Cossart (2001). A transgenic model for listeriosis:
role of internalin in crossing the intestinal barrirer. Science, 292 : 1722-1725.
-P. Glaser, xx authors , J. Wehland, and P. Cossart (2001). Comparative genomics of Listeria species. Science, 294 : 849-853.
-H.Ogata, S. Audic, P. Renesto-Audiffren, P.-E. Fournier, V. Barbe, D. Samson, V. Roux, P. Cossart, J. Weissenbach, J.-M. Claverie and D. Raoult.
(2001). Mechanisms of Evolution in Rickettsia conorii and R. prowazekii. Science, 293 : 2093-2098.
-J. Johansson, P. Mandin, A. Renzoni, C. Chiaruttini, M. Springer and P. Cossart (2002). An RNA Thermosensor Controls Expression of Virulence
Genes in Listeria monocytogenes. Cell, 110 : 551-561.
-E. Gouin, C. Egile, P. Dehoux, V. Villiers, J. Adams, F. Gertler, R. Li and P. Cossart (2004). The RickA Protein of Rickettsia conorii activates the
Arp2/3 complex Nature, 427 : 457-461.
-M. Lecuit, D.M. Nelson, S. D. Smith, H. Khun, M. Huerre, M.C. Vacher-Lavenu, J. I. Gordon and P. Cossart. (2004). Targeting and crossing of the
human maternofetal barrier by Listeria monocytogenes is dependent upon interactions between bacterial internalin and trophoblast
E-cadherin. Proc.Natl.Acad.Sci., USA, 101-16 : 6152-6157.
-P.Cossart and P. Sansonetti. (2004). Bacterial Invasion : The paradigms of enteroinvasive pathogens. Science. 304 : 242-248.
-S. Seveau, H. Bierne, S. Giroux, M.-C. Prévost and P. Cossart. (2004). Role of lipid rafts in E-cadherin- and HGF-R/Met-mediated entry of Listeria
monocytogenes into host cells. J. Cell Biol., 166 : 743-753.
-D. Cabanes, S. Sousa, A. Cebria, M. Lecuit, F. Garcia-del Portillo and P. Cossart. (2005) Gp96 is a receptor for a novel Listeria monocytogenes
virulence factor, Vip, a surface protein. EMBO J. , 24 : 2827-2838.
-S. Sousa, D. Cabanes, C. Archambaud, F. Colland, E. Lemichez, M. Popoff, S. Boisson-Dupuis, E. Gouin, M. Lecuit, P. Legrain and P. Cossart. (2005).
ARHGAP10 is necessary for α-catenin recruitment at adherens junctions and for Listeria invasion. Nat. Cell. Biol., 7 : 954-960
-E.Veiga and P. Cossart. (2005) Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells. Nat. Cell. Biol., 7 : 894-900.
-J.J. Martinez, S. Seveau, E. Veiga-Chacon, S. Matsuyama and P. Cossart (2005).Identification of Ku70, a component of the DNA-dependent protein
kinase, as a receptor involved in Rickettsia conorii invasion of mammalian cells. Cell, 123 : 1013-1023.
-J. Pizarro-Cerda and P. Cossart. (2006). Bacterial adhesion and entry into host cells. Cell, 124 : 715-727.
-E. Veiga, P. Cossart (2007) Listeria InlB takes a different route to Met.Cell, 130 :218-9.
- M. Hamon, H. Bierne and P. Cossart (2006). Listeria monocytogenes : a multifaceted model. Nat. Rev. Microbiol., 4 : 423-434.
- I. Boneca,, O. Dussurget , D. Cabanes, MA Nahori, S. Sousa, M. Lecuit, E. Psylinakis, V. V. Bouriotis , JP Hugot, M. Giovannini, A. Coyle, J. Bertin, A. Namane, JC Rousselle, N. Cayet, MC Prevost, V. Balloy, M. Chignard, D. Philpott, P. Cossart* , SE Girardin.(2007) A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. Proc Natl Acad Sci USA 104:997-1002.
- M. A. Hamon, E. Batsche, B. Regnault, T. Nam Tham, S. Seveau, C. Muchardt and P. Cossart (2007) Histone modifications induced by a family of bacterial toxins. Proc Natl Acad Sci USA, 104 13467-72
- E. Veiga, J A Guttman, M Bonazzi, E. Boucrot, A. Toledo-Arana, A. E. Lin, J. Enninga, J, Pizzaro-Cerda, B. Brett Finlay, T. Kirchhausen, P. Cossart (2007). Invasive and adherent bacterial pathogens co-opt host cell clathrin during infection. Cell Host & Microb. 15: 340-351
- O. Disson, S. Grayo, E. Huillet, G. Nikitas, F. Langa-Vives, O. Dussurget, M. Ragon, A. Le Monnier, C. Babinet, P. Cossart and M. Lecuit (2008) Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis. Nature, 455 : 1114-8
Last update: 16th february, 2009
