EMBO conference series



Scientific program

Invited speakers



Social program

Registration fees

Online registration

Call for abstracts


Practical Information

Contact: tuberculosis2012@pasteur.fr

Important Dates:


Online registration opens:
December 2, 2011


Early fee registration deadline:
June 15, 2012


Abstract submission deadline:
June 15, 2012






The EMBO conference series "Tuberculosis 2012" is an international congress on
Tuberculosis and its causative organism Mycobacterium tuberculosis to be held
from September 11-15, 2012 at the Conference Centre of the Institut Pasteur, Paris.


Website: http://www.pasteur.fr/tuberculosis2012/




Tuesday, September 11th, 2012


2.00 - 5.30 pm




5.00 - 5.45 pm

Welcome addresses and perspectives




Alice Dautry (General Director, Institut Pasteur, Paris, France)

Roland Brosch (Organizing committee, Institut Pasteur, Paris, France)
Hannu Laang (European Commission, Brussels, Belgium)

EC investment in TB research in FP7

Christian Lienhardt (Stop TB Department, WHO, Geneva, Switzerland)

TB control post Millenium Development Goals 2015 - the driving role of research



5.45 - 7.15 pm

Opening Keynote lectures

Chair: Pedro Alzari (Institut Pasteur, Paris, France)



5.45 - 6.30 pm

Patrick Brennan (Colorado State University, Fort Collins, USA)

The Cell Envelope of Mycobacterium tuberculosis and New Drug Discovery against Tuberculosis

6.30 - 7.15 pm

Stewart Cole (EPFL, Lausanne, Switzerland)


Tuberculosis in time and space


7.15 pm

Welcome Reception at Institut Pasteur


Wednesday, September 12th, 2012


8.30 - 10.15 am

Session 1: Mycobacterial Evolution, Genetic Diversity & Conservation

Chair: Philip Supply (CNRS, Institut Pasteur Lille, France)



8.30 - 8.55 am

Roland Brosch (Institut Pasteur Paris, France)

Where does it come from - where does it go? The evolution of the tubercle bacillus

9.00 - 9.25 am

Stefan Niemann (Research Center Borstel, Germany)

Mycobacterium tuberculosis genome diversity: random noise or more?

9.30 - 9.45 am

Inaki Comas (Center For Public Health Research, Valencia, Spain)

Parallel population expansions of the tuberculosis bacilli and anatomically modern humans (short talk)

9.45 - 10.10 am

Eric Rubin (Harvard Medical School, Boston, USA)

Mycobacterium tuberculosis mutants as profilers



10.15 -10.45 am

Coffee break



10.45 am-12.45 pm

Session 2: Mycobacterial Biology & Physiology

Chair: Tanya Parish (Univ. of London, UK)



10.45 -11.10 am

Christophe Guilhot (CNRS, IPBS Toulouse, France)

Polyketide-derived lipids in Mycobacterium tuberculosis interaction with the host

11.15 -11.30 am:

Gabriela Gago (IBR, Rosario, Argentina)

Transcriptional regulation of lipid biosynthesis in mycobacteria (short talk)

11.30 -11.55 am

Rajesh S. Gokhale (CSIR-Institute of Genomics and Integrative Biology, India)

Understanding dynamic chemico cellular trestle to elucidate mycobacterial physiology

12.00 -12.15 pm

Olga Schubert (ETH Zurich, Switzerland)

The Mtb Proteome Atlas: A compendium of assays for complete, quantitative proteome analysis of Mycobacterium tuberculosis (short talk)

12.15 -12.40 pm

John McKinney (EPFL Lausanne, Switzerland)

Microbial individuality and antibiotic tolerance



12.45 - 2.00 pm


1.45 - 3.15 pm 

Poster session 1



3.15 - 4.45 pm

Session 3: Novel Transport Systems in Mycobacteria

Chair: Wilbert Bitter (VU, Amsterdam, The Netherlands)



3.15 - 3.40 pm

Daria Bottai (University of Pisa, Italy)

The ESX-5 type VII secretion system of Mycobacterium tuberculosis, a major modulator of host-pathogen interaction

3.45 - 4.00 pm

Edith Houben (VU medical center, Amsterdam, The Netherlands) Composition of the Type VII secretion system membrane complex (short talk)

4.00 - 4.15 pm

Alexandre Gouzy (IPBS CNRS-University of Toulouse, France)

A novel amino acid permease system for Mycobacterium tuberculosis nitrogen acquisition and host colonization (short talk)

4.15 - 4.40 pm

Michael Niederweis (Univ. of Alabama, Birmingham, USA)

Death by Mycobacterium tuberculosis



4.45 - 5.15 pm

 Coffee break



5.15 - 7.00 pm

Session 4: Adaptation to Changing Environment

Chair: Riccardo Manganelli (University of Padua, Italy)



5.15 - 5.40 pm

Sabine Ehrt (Weill Cornell Medical College, New York, USA)

Mycobacterium tuberculosis mutants in central carbon metabolism

5.45 - 6.00 pm

Digby Warner (IIDMM, Univ. of Cape Town, ZA)

BacA is essential for vitamin B12 transport in Mycobacterium tuberculosis (short talk)

6.00 - 6.15 pm

Kristine Arnvig (NIMR, Mill Hill, London, UK)

Small RNAs in Mycobacterium tuberculosis: Overlooked, Underrated, Unappreciated? (short talk)

6.15 - 6.30 pm

Babak Javid (Tsinghua University, Beijing, China)

Mistranslation results in mycobacterial drug tolerance (short talk)

6.30 - 6.55 pm

Christopher Sassetti (Univ. of Massachusetts, Worcester, USA)

Endogenous anti-inflammatory pathways modulate TB disease



7.00 - 8.30 pm

 Wine and Cheese


Thursday, September 13th, 2012


8.30 am-10.15 am

Session 5: The search for novel antigens and correlates of protection

Chair: Claude Leclerc (Institut Pasteur, Paris, France)



8.30 - 8.55 am

Camille Locht (INSERM, Institut Pasteur Lille, France)

TB or not TB: that is the question of latency

9.00 - 9.25 am

Gilla Kaplan (Univ. New Jersey, Newark, USA)

The host immune response during control of Mtb infection and latency versus progression to active TB disease

9.30 - 9.45 am

Cecilia Lindestam Arlehamn (La Jolla Institute for Allergy, CA, USA) Memory T cells in latent Mycobacterium tuberculosis Infection are directed against three antigenic islands rather than PE/PPE motifs and are confined in a CCR6+CXCR3+ Th1 subset (short talk)

9.45 - 10.10 am

Stefan Kaufmann (Max Planck Inst. for Infect. Biology, Berlin, Germany)

Biomarkers for TB: Better diagnosis of disease and better understanding of pathogenesis



10.15 - 10.45 am

Coffee break



10.45 am -12.45 pm

Session 6: Novel vaccine strategies (session sponsored by TBVI)

Chair: Jelle Thole (TuBerculosis Vaccine Initiative (TBVI), Netherlands)



10.45 - 11.10 am

Carlos Martin (University of Zaragoza, Spain)

Disarming the tubercle bacillus: On the way to a new attenuated vaccine against tuberculosis

11.15 - 11.30 am

Leander Grode (Vakzine Projekt Management, Hannover, Germany)

Phase II status report of VPM1002, a novel recombinant BCG vaccine against tuberculosis (short talk)

11.30 - 11.55 am

Peter Andersen (Statens Serum Institut, Copenhagen, Denmark)

TB subunit vaccines; maintaining the balance in long term relationship

12.00 - 12.15 pm

Yuelan Yin (Jiangsu Key Laboratory of Zoonosis, Yangzhou, China)

Comparison of different routes of vaccination with a recombinant attenuated Listeria monocytogenes::fbpB-esat-6 for eliciting cellular immune response in mice (short talk)

12.15 - 12.40 pm

Helen Mc Shane (University of Oxford, UK)

Insights in Immunology from MV85A Vaccination Trials



12.45 - 2.00 pm


1.45 - 3.15 pm 

Poster session 2



3.15 - 4.50 pm

Session 7: Biochemistry and chemical biology I  

Chair: Andrew Munro (Univ. of Manchester, UK)



3.15 - 3.40 pm

Luiz Pedro de Carvalho (NIMR, London, UK)

Metabolomic profiling of mycobacterial orphan enzymes

3.45 - 4.00 pm

Michael Zimmermann (ETH Zurich, Switzerland)

Metabolic adaptations during Mycobacteria's transition into the non-replicative state (short talk)

4.00 - 4.15 pm

Emilie Layre (Brigham and Women's Hospital, Boston, MA, USA)

Using comparative lipidomics to identify new virulence factors of Mycobacterium tuberculosis (short talk)

4.15 - 4.40 pm

John Blanchard (Albert Einstein College of Medicine, New York, USA)

Control of Enzymatic Activity in Mycobacterium tuberculosis



4.45 - 5.15 pm

Coffee break



5.15 - 6.30 pm

Session 8: Biochemistry and chemical biology II

Chair: Laurent Fraisse (Sanofi-Aventis, France)



5.15 - 5.40 pm

Marco Bellinzoni (Institut Pasteur, Paris, France)

FHA-mediated regulation of central metabolism in Mycobacterium tuberculosis

5.45 - 6.00 pm

Laurent Kremer (CNRS, Universite de Montpellier, France)

Phosphorylation of mycobacterial PcaA inhibits mycolic acid cyclopropanation: consequences for intracellular survival and for phagosome maturation block (short talk)

6.00 - 6.25 pm

Carl Nathan (Weill Cornell Medical College, New York, USA)

Inhibitors of Non-Replicating M. tuberculosis



8.00 pm

Congress dinner (La Coupole)


Friday, September 14th, 2012


8.30 - 10.15 am

Session 9: Mycobacterial Resistance and the Need for New Drug Targets  

Chair: Brigitte Gicquel (Institut Pasteur, Paris, France)   



8.30 - 8.55 am

Erik Boettger (University of Zurich, Switzerland)

Drug resistance and fitness in Mycobacterium tuberculosis

9.00 - 9.25 am

Ying Zhang (Johns Hopkins University, Baltimore, USA & Fudan University, Shanghai, China)

Persister Drug Targets: Lesson From Pyrazinamide

9.30 - 9.45 am

Lydia Tabernero (University of Manchester, UK)

Non-bactericidal drugs for the treatment of tuberculosis (short talk)

9.45 - 10.10 am

Mary Jackson (Colorado State University, Fort Collins, USA)

New approaches to targeting cell envelope biogenesis in Mycobacterium tuberculosis



10.15 - 10.45 am

Coffee break



10.45 am - 12.45 pm

Session 10: Search for Novel Drug Candidates to cure TB

(session sponsored by Sanofi)

Chair: Katarina Mikusova (Comenius University, Bratislava, Slovakia)   



10.45 - 11.10 am

Vadim Makarov ( Bakh Institute of Biochemistry, Moscow, Russia)

Discovery and development of new antituberculosis leads - benzothiazinones - by classic medicinal chemistry approaches

11.15 - 11.40 am

Priscille Brodin (INSERM, Institut Pasteur Lille, France)

High-content cell-based screening- insights in biology and drug targets of Mycobacterium tuberculosis

11.45 am - 12.00 pm

Ulf Nehrbass (Institut Pasteur Korea, Seongnam, Republic of Korea) Discovery of Q203, a potent clinical candidate for the treatment of MDR and XDR tuberculosis (short talk)

12.00 - 12.15 pm

Helena Boshoff (TRS, NIAID, NIH, Bethesda, MD, USA)

Mycobacterium tuberculosis drug discovery: does fast food or calorie restriction matter? (short talk)

12.15 - 12.40 pm

David Sherman (Seattle Biomedical Research Institute, USA)

Are old targets the best targets?



12.45 - 2.00 pm


1.45 - 3.15 pm 

Poster session 3



3.15 - 4.45 pm

Session 11: Host-pathogen interactions I

Chair: Jean Louis Herrmann ( EPIM EA3647, UVSQ, Versailles, France France)



3.15 -3.40 pm

Peter Peters (Netherland Cancer Institute, Amsterdam, Netherlands)

Type VII Secretion System of mycobacteria; towards visualization of nanomachines in their native cellular environment using electron cryo-microscopy

3.45 - 4.00 pm

Roxane Simeone (Institut Pasteur Paris, France)

Single-cell FRET imaging reveals phagosomal rupture by Mycobacterium tuberculosis as cause of toxicity and host cell death (short talk)

4.00 - 4.15 pm

Anna Coussens (MRC NIMR, London, UK & University Of Cape Town, ZA)

Sodium 4-Phenylbutyrate (PBA) enhances the immunomodulatory actions of 25-hydroxyvitamin D3 during macrophage Mycobacterium tuberculosis (MTB) infection and restricts MTB growth via macrophage-dependant and independent mechanisms (short talk)

4.15 - 4.40 pm

David Russell (Cornell University, Ithaca, NY, USA)

Elucidating the metabolic constraints of the intra-macrophage environment



4.45 - 5.15 pm

Coffee break



5.15 - 7.00 pm

Session 12: Host-pathogen interactions II

Chair: Douglas Young (Imperial College and NIMR, London, UK)



5.15 - 5.40 pm

Olivier Neyrolles (CNRS, IPBS Toulouse, France)

Novel insights into Mycobacterium tuberculosis  physiology and virulence

5.45 - 6.10 pm

Monica Hagedorn (Bernhard Nocht Institut, Hamburg, Germany)

Hide and Seek - Mapping mycobacteria infection in Dictyostelium

6.15 - 6.30 pm

Ludovic Desvignes (NYU School of Medicine, New York, NY, USA) Dynamic roles of type I and type II interferons in early infection with Mycobacterium tuberculosis (short talk)

6.30 - 7.00 pm

Lalita Ramakrishnan (University of Washington, Seattle, USA)

Dissecting and countering an inflammatory pathway to TB susceptibility




on your own for dinner


Saturday, September 15th, 2012


9.00 - 11.00 am

Session 13: Animal models and beyond  

Chair: Laleh Majlessi (Institut Pasteur, Paris, France)



9.00 - 9.25 am

Jacques Grosset (John Hopkins University, Baltimore, USA & KwaZulu-Natal Research Institute, SA)  

Mining the mouse: latest insights into TB chemotherapy

9.30 - 9.55 am

Joanne Flynn (University of Pittsburgh, Pittsburgh, USA)

Looking inside the granuloma for answers about TB

10.00 - 10.25 am

Ludovic Tailleux (Institut Pasteur, Paris, France)

Mycobacterial dissemination during tuberculosis

10.30 - 10.55 am

Stephanie Boisson-Dupuis (Inserm Necker - Rockefeller group, Paris/New York, France/USA)

Tuberculosis is not only an infectious disease but also a genetic disorder



11.00 - 11.30 am

Coffee break



11.30 am - 1.00 pm

Closing Keynote lectures and outlook

Chair: Stephen Gordon (University College Dublin, Ireland)



11.30 am - 12.10 pm

Anne O'Garra (MRC, Mill Hill, London, UK)

The immune response in tuberculosis: from mouse models to human disease

12.15 - 12.55 pm

Clif Barry (NIH, Bethesda, USA)

Inconvenient truths from the clinic



1.00 pm

Closing comments / End of congress



Status: September 2, 2012