|
The EMBO conference series "Tuberculosis 2012" is
an international congress on
Tuberculosis and its causative organism Mycobacterium tuberculosis
to be held
from September 11-15, 2012 at the Conference Centre of the Institut
Pasteur, Paris.
Website: http://www.pasteur.fr/tuberculosis2012/
SCIENTIFIC PROGRAM
Tuesday,
September 11th, 2012
|
2.00 - 5.30 pm
|
Registration
|
|
|
|
|
5.00 - 5.45 pm
|
Welcome
addresses and perspectives
|
|
|
|
|
|
Alice Dautry
(General Director, Institut Pasteur, Paris, France)
Roland Brosch
(Organizing committee, Institut Pasteur, Paris, France)
Hannu Laang (European
Commission, Brussels, Belgium)
EC investment in TB research in FP7
Christian
Lienhardt (Stop TB Department, WHO, Geneva, Switzerland)
TB control post Millenium Development Goals 2015 -
the driving role of research
|
|
|
|
|
5.45 - 7.15 pm
|
Opening
Keynote lectures
Chair: Pedro
Alzari (Institut
Pasteur, Paris, France)
|
|
|
|
|
5.45 - 6.30 pm
|
Patrick
Brennan (Colorado State University, Fort Collins,
USA)
The Cell Envelope of
Mycobacterium tuberculosis and New Drug Discovery against
Tuberculosis
|
|
6.30 - 7.15 pm
|
Stewart
Cole (EPFL, Lausanne, Switzerland)
|
|
|
Tuberculosis in time and space
|
|
7.15 pm
|
Welcome
Reception at Institut Pasteur
|
Wednesday,
September 12th, 2012
|
8.30 - 10.15 am
|
Session
1: Mycobacterial Evolution, Genetic Diversity
& Conservation
Chair: Philip
Supply (CNRS, Institut Pasteur Lille, France)
|
|
|
|
|
8.30 - 8.55 am
|
Roland Brosch (Institut Pasteur Paris, France)
Where
does it come from - where does it go? The evolution of the
tubercle bacillus
|
|
9.00 - 9.25 am
|
Stefan
Niemann (Research
Center Borstel, Germany)
Mycobacterium tuberculosis genome
diversity: random noise or more?
|
|
9.30 - 9.45 am
|
Inaki
Comas (Center For Public Health Research, Valencia,
Spain)
Parallel population expansions of the tuberculosis
bacilli and anatomically modern humans (short
talk)
|
|
9.45 - 10.10 am
|
Eric Rubin
(Harvard Medical School,
Boston, USA)
Mycobacterium tuberculosis
mutants as profilers
|
|
|
|
|
10.15 -10.45 am
|
Coffee
break
|
|
|
|
|
10.45
am-12.45 pm
|
Session
2: Mycobacterial Biology & Physiology
Chair:
Tanya Parish
(Univ. of London, UK)
|
|
|
|
|
10.45 -11.10 am
|
Christophe
Guilhot (CNRS, IPBS Toulouse, France)
Polyketide-derived lipids in
Mycobacterium tuberculosis interaction with the host
|
|
11.15 -11.30 am:
|
Gabriela
Gago (IBR,
Rosario, Argentina)
Transcriptional regulation of lipid biosynthesis
in mycobacteria (short talk)
|
|
11.30 -11.55 am
|
Rajesh S. Gokhale (CSIR-Institute of Genomics and Integrative
Biology, India)
Understanding dynamic chemico
cellular trestle to elucidate mycobacterial physiology
|
|
12.00 -12.15 pm
|
Olga Schubert (ETH Zurich, Switzerland)
The
Mtb Proteome Atlas: A compendium of assays for complete,
quantitative proteome analysis of Mycobacterium
tuberculosis (short talk)
|
|
12.15 -12.40 pm
|
John McKinney (EPFL Lausanne, Switzerland)
Microbial individuality and
antibiotic tolerance
|
|
|
|
|
12.45 - 2.00 pm
|
Lunch
|
|
1.45 - 3.15 pm
|
Poster
session 1
|
|
|
|
|
3.15 - 4.45 pm
|
Session
3: Novel Transport Systems in
Mycobacteria
Chair: Wilbert Bitter (VU, Amsterdam, The Netherlands)
|
|
|
|
|
3.15 - 3.40 pm
|
Daria Bottai (University of Pisa, Italy)
The ESX-5 type VII secretion
system of Mycobacterium tuberculosis, a major modulator of
host-pathogen interaction
|
|
3.45 - 4.00 pm
|
Edith Houben (VU medical
center, Amsterdam, The Netherlands) Composition of the Type VII secretion system
membrane complex (short talk)
|
|
4.00 - 4.15 pm
|
Alexandre
Gouzy (IPBS
CNRS-University of Toulouse, France)
A
novel amino acid permease system for Mycobacterium tuberculosis
nitrogen acquisition and host colonization (short talk)
|
|
4.15 - 4.40 pm
|
Michael
Niederweis (Univ. of Alabama, Birmingham, USA)
Death by Mycobacterium
tuberculosis
|
|
|
|
|
4.45 - 5.15 pm
|
Coffee break
|
|
|
|
|
5.15 - 7.00 pm
|
Session
4: Adaptation
to Changing Environment
Chair: Riccardo
Manganelli (University of Padua, Italy)
|
|
|
|
|
5.15 - 5.40 pm
|
Sabine
Ehrt (Weill Cornell Medical College, New York, USA)
Mycobacterium tuberculosis mutants
in central carbon metabolism
|
|
5.45 - 6.00 pm
|
Digby Warner (IIDMM, Univ.
of Cape Town, ZA)
BacA is essential for vitamin B12 transport in
Mycobacterium tuberculosis (short
talk)
|
|
6.00 - 6.15 pm
|
Kristine
Arnvig (NIMR,
Mill Hill, London, UK)
Small
RNAs in Mycobacterium tuberculosis: Overlooked, Underrated,
Unappreciated? (short
talk)
|
|
6.15 - 6.30 pm
|
Babak
Javid (Tsinghua
University, Beijing, China)
Mistranslation
results in mycobacterial drug tolerance (short talk)
|
|
6.30 - 6.55 pm
|
Christopher
Sassetti (Univ. of Massachusetts, Worcester, USA)
Endogenous anti-inflammatory
pathways modulate TB disease
|
|
|
|
|
7.00 - 8.30 pm
|
Wine and Cheese
|
Thursday,
September 13th, 2012
|
8.30 am-10.15 am
|
Session
5: The search for novel antigens and correlates of protection
Chair: Claude Leclerc (Institut Pasteur,
Paris, France)
|
|
|
|
|
8.30 - 8.55 am
|
Camille Locht (INSERM, Institut Pasteur Lille,
France)
TB or not TB: that is the
question of latency
|
|
9.00 - 9.25 am
|
Gilla
Kaplan (Univ.
New Jersey, Newark, USA)
The host immune response during
control of Mtb infection and latency versus progression to active
TB disease
|
|
9.30
- 9.45 am
|
Cecilia Lindestam Arlehamn (La Jolla Institute for
Allergy, CA, USA) Memory T cells in latent
Mycobacterium tuberculosis Infection are directed against three
antigenic islands rather than PE/PPE motifs and are confined in a
CCR6+CXCR3+ Th1 subset (short talk)
|
|
9.45 - 10.10 am
|
Stefan Kaufmann (Max Planck Inst. for
Infect. Biology, Berlin, Germany)
Biomarkers for TB: Better diagnosis of disease and better understanding of pathogenesis
|
|
|
|
|
10.15 - 10.45 am
|
Coffee
break
|
|
|
|
|
10.45 am -12.45 pm
|
Session
6: Novel vaccine strategies (session sponsored by TBVI)
Chair: Jelle Thole (TuBerculosis Vaccine Initiative (TBVI),
Netherlands)
|
|
|
|
|
10.45 - 11.10 am
|
Carlos Martin (University of Zaragoza, Spain)
Disarming the tubercle bacillus:
On the way to a new attenuated vaccine against tuberculosis
|
|
11.15 - 11.30 am
|
Leander Grode (Vakzine Projekt Management, Hannover, Germany)
Phase
II status report of VPM1002, a novel recombinant BCG vaccine
against tuberculosis (short talk)
|
|
11.30 - 11.55 am
|
Peter
Andersen (Statens Serum Institut,
Copenhagen, Denmark)
TB subunit vaccines; maintaining
the balance in long term relationship
|
|
12.00 - 12.15 pm
|
Yuelan Yin (Jiangsu Key Laboratory of Zoonosis, Yangzhou,
China)
Comparison of different routes of vaccination with
a recombinant attenuated Listeria monocytogenes::fbpB-esat-6 for
eliciting cellular immune response in mice (short talk)
|
|
12.15 - 12.40 pm
|
Helen Mc Shane (University of Oxford, UK)
Insights in Immunology from MV85A
Vaccination Trials
|
|
|
|
|
12.45 - 2.00 pm
|
Lunch
|
|
1.45 - 3.15 pm
|
Poster
session 2
|
|
|
|
|
3.15 - 4.50 pm
|
Session
7: Biochemistry and chemical biology I
Chair: Andrew
Munro (Univ. of Manchester, UK)
|
|
|
|
|
3.15 - 3.40 pm
|
Luiz
Pedro de Carvalho (NIMR, London, UK)
Metabolomic profiling of
mycobacterial orphan enzymes
|
|
3.45 - 4.00 pm
|
Michael
Zimmermann (ETH Zurich, Switzerland)
Metabolic adaptations during Mycobacteria's
transition into the non-replicative state (short
talk)
|
|
4.00 - 4.15 pm
|
Emilie Layre (Brigham and Women's Hospital, Boston, MA, USA)
Using
comparative lipidomics to identify new virulence factors of
Mycobacterium tuberculosis (short talk)
|
|
4.15 - 4.40 pm
|
John
Blanchard (Albert Einstein College of Medicine, New
York, USA)
Control of Enzymatic Activity in
Mycobacterium tuberculosis
|
|
|
|
|
4.45 - 5.15 pm
|
Coffee
break
|
|
|
|
|
5.15 - 6.30 pm
|
Session
8: Biochemistry
and chemical biology II
Chair: Laurent
Fraisse (Sanofi-Aventis,
France)
|
|
|
|
|
5.15 - 5.40 pm
|
Marco
Bellinzoni (Institut Pasteur, Paris, France)
FHA-mediated regulation of central metabolism in Mycobacterium
tuberculosis
|
|
5.45 - 6.00 pm
|
Laurent
Kremer
(CNRS,
Universite de Montpellier, France)
Phosphorylation of mycobacterial PcaA inhibits
mycolic acid cyclopropanation: consequences for intracellular
survival and for phagosome maturation block (short
talk)
|
|
6.00 - 6.25 pm
|
Carl Nathan (Weill Cornell Medical College,
New York, USA)
Inhibitors of Non-Replicating M.
tuberculosis
|
|
|
|
|
8.00 pm
|
Congress
dinner (La Coupole)
|
Friday,
September
14th, 2012
|
8.30 - 10.15 am
|
Session
9: Mycobacterial Resistance and the Need for New Drug Targets
Chair: Brigitte
Gicquel (Institut Pasteur, Paris, France)
|
|
|
|
|
8.30 - 8.55 am
|
Erik
Boettger (University of Zurich, Switzerland)
Drug resistance and fitness in Mycobacterium
tuberculosis
|
|
9.00 - 9.25 am
|
Ying Zhang (Johns Hopkins University, Baltimore, USA
& Fudan University, Shanghai, China)
Persister Drug Targets: Lesson
From Pyrazinamide
|
|
9.30 - 9.45 am
|
Lydia Tabernero (University of Manchester,
UK)
Non-bactericidal drugs for the
treatment of tuberculosis (short talk)
|
|
9.45 - 10.10 am
|
Mary
Jackson (Colorado State University, Fort Collins, USA)
New approaches to targeting cell
envelope biogenesis in Mycobacterium tuberculosis
|
|
|
|
|
10.15 - 10.45 am
|
Coffee
break
|
|
|
|
|
10.45 am - 12.45 pm
|
Session
10: Search for Novel Drug
Candidates to cure TB
(session
sponsored by Sanofi)
Chair: Katarina
Mikusova (Comenius University, Bratislava, Slovakia)
|
|
|
|
|
10.45 - 11.10 am
|
Vadim
Makarov ( Bakh Institute of Biochemistry, Moscow,
Russia)
Discovery and development of new
antituberculosis leads - benzothiazinones - by classic medicinal
chemistry approaches
|
|
11.15 - 11.40 am
|
Priscille Brodin
(INSERM, Institut Pasteur Lille, France)
High-content
cell-based screening- insights in biology and drug targets of
Mycobacterium tuberculosis
|
|
11.45 am - 12.00 pm
|
Ulf
Nehrbass
(Institut
Pasteur Korea, Seongnam, Republic of Korea) Discovery of Q203, a potent clinical
candidate for the treatment of MDR and XDR tuberculosis (short
talk)
|
|
12.00 - 12.15 pm
|
Helena
Boshoff (TRS,
NIAID, NIH, Bethesda, MD, USA)
Mycobacterium
tuberculosis drug discovery: does fast food or calorie
restriction matter? (short
talk)
|
|
12.15 - 12.40 pm
|
David
Sherman (Seattle
Biomedical Research Institute, USA)
Are old targets the best targets?
|
|
|
|
|
12.45 - 2.00 pm
|
Lunch
|
|
1.45 - 3.15 pm
|
Poster
session 3
|
|
|
|
|
3.15 - 4.45 pm
|
Session
11: Host-pathogen interactions I
Chair: Jean
Louis Herrmann ( EPIM
EA3647, UVSQ, Versailles, France France)
|
|
|
|
|
3.15 -3.40 pm
|
Peter
Peters (Netherland
Cancer Institute, Amsterdam, Netherlands)
Type VII Secretion System of
mycobacteria; towards visualization of nanomachines in their native
cellular environment using electron cryo-microscopy
|
|
3.45 - 4.00 pm
|
Roxane Simeone (Institut
Pasteur Paris, France)
Single-cell FRET imaging reveals phagosomal
rupture by Mycobacterium tuberculosis as cause of toxicity and
host cell death (short talk)
|
|
4.00 - 4.15 pm
|
Anna Coussens (MRC NIMR,
London, UK & University Of Cape Town, ZA)
Sodium 4-Phenylbutyrate (PBA) enhances the
immunomodulatory actions of 25-hydroxyvitamin D3 during macrophage
Mycobacterium tuberculosis (MTB) infection and restricts MTB
growth via macrophage-dependant and independent mechanisms (short talk)
|
|
4.15 - 4.40 pm
|
David Russell (Cornell University, Ithaca, NY, USA)
Elucidating the metabolic
constraints of the intra-macrophage environment
|
|
|
|
|
4.45 - 5.15 pm
|
Coffee
break
|
|
|
|
|
5.15 - 7.00 pm
|
Session
12: Host-pathogen interactions II
Chair: Douglas
Young (Imperial College and
NIMR, London, UK)
|
|
|
|
|
5.15 - 5.40 pm
|
Olivier Neyrolles (CNRS, IPBS Toulouse, France)
Novel insights into
Mycobacterium tuberculosis
physiology and virulence
|
|
5.45 - 6.10 pm
|
Monica
Hagedorn (Bernhard
Nocht Institut, Hamburg, Germany)
Hide and Seek - Mapping
mycobacteria infection in Dictyostelium
|
|
6.15 - 6.30 pm
|
Ludovic Desvignes (NYU School
of Medicine, New York, NY, USA) Dynamic roles of type I and type II interferons
in early infection with Mycobacterium tuberculosis (short talk)
|
|
6.30 - 7.00 pm
|
Lalita Ramakrishnan
(University of
Washington, Seattle, USA)
Dissecting and countering an
inflammatory pathway to TB susceptibility
|
|
|
|
|
|
on
your own for dinner
|
Saturday,
September
15th, 2012
|
9.00 - 11.00 am
|
Session
13: Animal models and beyond
Chair: Laleh
Majlessi (Institut Pasteur, Paris, France)
|
|
|
|
|
9.00 - 9.25 am
|
Jacques Grosset (John Hopkins University,
Baltimore, USA & KwaZulu-Natal
Research Institute, SA)
Mining the mouse: latest insights
into TB chemotherapy
|
|
9.30 - 9.55 am
|
Joanne
Flynn (University
of Pittsburgh, Pittsburgh, USA)
Looking inside the granuloma for
answers about TB
|
|
10.00 - 10.25 am
|
Ludovic Tailleux (Institut
Pasteur, Paris, France)
Mycobacterial dissemination
during tuberculosis
|
|
10.30 - 10.55 am
|
Stephanie
Boisson-Dupuis (Inserm Necker - Rockefeller
group, Paris/New York, France/USA)
Tuberculosis is not only an
infectious disease but also a genetic disorder
|
|
|
|
|
11.00 - 11.30 am
|
Coffee
break
|
|
|
|
|
11.30 am - 1.00 pm
|
Closing Keynote
lectures and outlook
Chair: Stephen
Gordon (University College Dublin, Ireland)
|
|
|
|
|
11.30 am - 12.10 pm
|
Anne O'Garra (MRC, Mill Hill, London,
UK)
The immune response in tuberculosis: from mouse models to human disease
|
|
12.15 - 12.55 pm
|
Clif
Barry (NIH, Bethesda, USA)
Inconvenient truths from the
clinic
|
|
|
|
|
1.00 pm
|
Closing
comments / End of congress
|
Status: September 2, 2012
|
|
