SCIENTIFIC PROGRAM

Last update: 9/12/07 5:00 pm

Monday September 17th, 2007 8.00 am-9.00 am Registration of participants 9.00 am-10.30 am Welcome Address: Alice Dautry, Christine Petit et Moshe Yaniv Session 1: Allosteric Mechanisms Chairs: Stuart Edelstein et Henri Buc 9.10: AChBP: a model system for nicotinic acetylcholine receptor ligand binding Titia Sixma, The Netherlands Cancer Institute, Amsterdam, The Netherlands 9.40: An archaic proton-gated ion channel as a bacterial ancestor of nicotinic receptors Pierre-Jean Corringer, Institut Pasteur, Paris, France 10.00: Inhibitory and extitatory neurotransmission mediated by glycine : focus on receptor mechanisms Heinrich Betz, MPI for Brain Research, Frankfurt, Germany 10.30 am-11.00 am Coffee break 11.00 am-11.30 Session 1: Allosteric Mechanisms (continuation) 11.00: Mechanisms of allosteric modulation of the nicotinic acetylcholine receptor Jonathan Cohen, Harvard Medical School, Boston, USA 11.30: Allosteric modulation of GABA-A receptors Richard W. Olsen, University of California Los Angeles, USA 12.00: Genetic alterations in hippocampal glutamate receptors and spatial learning Peter Seeburg, MPI for Medical Research, Heidelberg, Germany 12.30 - 2.00 pm Lunch   Session 2: Neuromuscular junction/ Synaptogenesis Chair: Heinrich Betz 2.00: Insights into the disease process in familial motoneuron disease Pico Caroni, FMI for Biomedical Research, Basel, Switzerland 2.30: Acetylcholinesterase, structural diversity and functional localization Jean Massoulié, Ecole Normale Supérieure, Paris, France 3.00: On the footmarks of Claude Bernard, Daniel Bovet and Jean-Pierre Changeux: the mechanisms of action of presynaptic enzymatic neurotoxins Cesare Montecucco, University of Padova, Italy 3.30: Nicotinic receptors from basic function to neurological diseases Daniel Bertrand, University of Geneva, Switzerland 4.00 pm-4.30 pm Coffee break 4.30 pm-6.00 pm Session 2: Neuromuscular junction/ Synaptogenesis (continuation) Chair: Martin Karplus 4.30: Nicotinic receptor: from the structure to a gating mechanism Antoine Taly, Université de Strasbourg, France 5.00: Lipid rafts, intracellular transport and clustering of acetylcholine receptors Jean Cartaud, Université Pierre et Marie Curie, Paris, France 5.30: Dynamics in cholinergic ligand design: from static structure and conformational fluctuations to molecular recognition Palmer Taylor, University of California San Diego, La Jolla, USA   Tuesday September 18th, 2007 8.00 am-8.30 am Opening welcome desk 8.30 am-10.00 am Session 3: Genetic specification of neurons and axonal pathways Chairs: Catherine Dulac et Hannah Monyer 8.30: Dissecting a circuit for olfactory behavior Cori L. Bargmann, The Rockefeller University, New York, USA 9.00: Molecules and mechanisms that wire the brain Marc Tessier-Lavigne, Genentech, Inc., S. San Francisco, USA 9.30: Genetic specification of circuit assembly in the spinal cord Silvia Arber, University of Basel, Switzerland 10.00 am-10.30 am Coffee break 10.30 am-12.00 Session 3: Genetic specification of neurons and axonal pathways (continuation) 10.30: Motor neuron cell death in development and disease Christopher Henderson, Columbia University, New York, USA 11.00: The nicotinic synapse: a worm perspective Jean-Louis Bessereau, Ecole Normale Supérieure, Paris, France 11.30: Transcriptional control of neurogenesis François Guillemot, National Institute for Medical Research, London, UK 12.00 - 1.30 pm Group picture + Lunch 1.30 pm-4.00 pm Session 4: Neuronal networks Chairs: Jean-Antoine Girault et Bernard Roques 1.30: The computational logic of networks in motion Sten Grillner, Karolinska Institute, Stockholm, Sweden 2.00: Intracellular signaling pathways involved in behaviors related to nicotine addiction Marina Picciotto,Yale University, New Haven, USA 2.30: Structure and function of IP3 receptor /Ca2+ channel and its cell function Katsuhiko Mikoshiba, RIKEN Brain Science Institute, Japan 3.00: Functions of individual hippocampal circuits in different aspects of episodic memory Susumu Tonegawa, Massachusetts Institute of Technology, Cambridge, USA 3.30: The pyramidal neuron in cognition Javier De Felipe, Cajal Institute, Madrid, Spain 4.00 pm-4.30 pm Coffee break 4.30 pm-6.30 pm Session 4: Neuronal networks (continuation) Chair: Christian de Duve 4.30: Molecular and cellular mechanisms of neuronal migration in the cerebellar system Constantino Sotelo, Neuroscience Institute, Alicante, Spain 5.00: Epigenetic programming of gene expression and function Michael Meaney, Mc Gill University, Montreal, Canada 5.30: Characterization of identified GABAergic interneurones at the cellular and network level Hannah Monyer, University of Heidelberg, Germany 6.00: Tracking consciousness through time and space Stanislas Dehaene, Collège de France, Paris, France   Wednesday September 19 th, 2007 8.00 am-8.30 am Opening welcome desk 8.30 am-10.30 am Session 5: Sensory processing, learning and cognition Chairs: Peter Seeburg et Jean-Michel Heard 8.30: Studying neural networks with invasive functional magnetic resonance imaging Nikos Logothetis, MPI for Biological Cybernetics, Tuebingen, Germany 9.00: Internal representations of the olfactory world Richard Axel (EMBO lecteurship), Columbia University, New York, USA 9.30: Hereditary deafness and molecular physiology of hearing Christine Petit, Institut Pasteur, Paris, France 10.00: Molecular bBiology of pheromone signals in mammals: from genes to behaviors Catherine Dulac, Harvard University, Cambridge, USA 10.30 am-11.00 am Coffee break 11.00 am-12.30 pm Session 5: Sensory processing, learning and cognition (continuation) Chairs: Henri Korn et André Syrota 11.00: Integrating newborn neurons into adult circuits Pierre-Marie Lledo, Institut Pasteur, Paris, France 11.30: The objectivity of subjective truths Semir Zeki, University of London, UK 12.00: Memory traces in cortex: the cognitive strength of their molecular weakness Yadin Dudai, The Weizmann Institute of Science, Rehovot, Israel 12.30 pm - 2.00 pm Lunch 2.00 pm-4.20 pm Session 5: Sensory processing, learning and cognition (continuation) Chair: Joël Bockaert 2.00: Modeling prefrontal cortex: ringing the changes on the challenges of Changeux Michael Arbib, University of Southern California, Los Angeles, USA 2.30: Animal models of cholinergic function Uwe Maskos, Institut Pasteur, Paris, France 2.50: Cholinergic mechanisms in dopaminergic cell firing Philippe Faure, Institut Pasteur, Paris, France 3.10: Role of the neuronal nicotinic receptors in cognitive functions Sylvie Granon, Institut Pasteur, Paris, France Session 6: Evolution and disease 3.30: Genetics of mental retardation Jean-Louis Mandel, Institut de génétique et de biologie moléculaire et cellulaire, Illkirch, France 4.00: Keeping track of time, synapses and autism Thomas Bourgeron, Institut Pasteur, Paris, France 4.20 pm-4.50 pm Coffee break 4.50 pm-7.20 pm Session 6: Evolution and disease (continuation) Chair: Christine Petit et Jacques Mallet 4.50: Channelopathies of muscle and nerve Bertrand Fontaine, AP-HP Pitié-Salpêtrière, Paris, France 5.00: Roles of receptors in nicotine addiction and in neuroprotection Henry Lester, California Institute of Technology, Pasadena, USA 5.50: Acute brain neuroprotection by scavenging blood glutamate Vivian Teichberg, The Weizmann Institut of Science, Rehovot, Israel 6.20: GPR37 receptor and Parkinson's disease Glauco Tocchini-Valentini, Istituto di Biologia Cellulare-CNR, Roma, Italy 6.50: Maternal genome and embryonic development: a role for serotonin Jacques Mallet, AP-HP Pitié-Salpêtrière, Paris, France Closing remarks: Jean-Pierre Changeux Download the scientific program (PDF format)