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programme scientifique
Mardi 13 octobre 2009
| 10h00-16h00 |
Ewgli meeting for Ewgli collaborators only, related to business aspects of the EWGLINET network and the transfer of the scheme to ECDC |
| 14h00-17h30 |
Accueil participants |
| 17h30-18h00 |
Discours de bienvenue
Tony Pugsley, Senior Executive-Vice President for Scientific Affaire, Institut Pasteur, Paris, France
Carmen Buchrieser, Institut Pasteur, Paris, France |
| 18h00 |
Session d'ouverture
Modérateur : Nicholas P. Cianciotto, Northwestern University Medical School,
Chicago, USA |
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Barry Fields, Center of Disease Control, Atlanta, USA
Environmental approaches to the prevention of legionellosis |
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Carol Joseph, Health Protection Agency, London, UK
Legionnaires' disease in Europe 1995 - 2008: Trends and challenges |
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Jörg Hacker, Robert Koch Institut, Berlin, Germany
Legionella. A model organism for Genomics and Cellular Microbiology |
| 19h30 |
Cocktail de Bienvenue à l' Institut Pasteur |
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Mercredi 14 octobre 2009
| 8h30-10h15 |
Session 1:
Epidemiology and Clinical aspects a) disease, diagnosis and treatment |
Modérateur : Didier Che, Institut de Veille Sanitaire, Saint-Maurice, France |
| 8h30-9h00 |
Miguel Sabria, University of Barcelona, Spain
Clinical aspects of Legionnaires´Disease |
| 9h00-9h30 |
Paul H Edelstein, University of Pennsylvania, Philadelphia, USA
Antimicrobial therapy for Legionnaires' disease, still in need of improvement |
| 9h30-9h45 |
Maria Luisa Pedro-Botet, Spain
Legionella pneumonia (LP) in immunosuppressed (IS) patients |
| 9h45-10h00 |
Frances Graham, New Zealand
Changing Epidemiologic Trends of Legionellosis in New Zealand, 1979 - 2008 |
| 10h00-10h15 |
Lauri Hicks, USA
Travel-Associated Legionnaires' Disease Surveillance in the United States, 25-28 |
| 10h15-10h45 |
Pause-café |
| 10h45-12h30 |
Session 2:
Clinical aspects b) detection and subtyping |
Chair: Jaana Kusnetsov, National Public Health Institute, Kuopio, Finland |
| 10h45-11h15 |
Christian Lück, University Dresden, Germany
Microbiological diagnostic methods for the detection of Legionella infections |
| 11h15-11h45 |
Timothy G. Harrison, Health Protection Agency, London, UK
Legionella pneumophila DNA sequence-based typing: progress, pitfalls and perspectives. |
| 11h45-12h00 |
Patrick Yang, USA
Evaluation of a fully integrated point-of-testing system for the detection of viable Legionella pneumophila |
| 12h00-12h15 |
Valeria Gaia, Switzerland
MALDI-TOF MS based protein mass fingerprinting: a rapid and reliable method for the identification of Legionella spp. |
| 12h15-12h30 |
Jonas Lundström, Sweden
An improved and rapid sequence-based method for typing of Legionella pneumophila. |
| 12h30-14h00 |
Déjeuner à l' Institut Pasteur |
| 14h00-15h30 |
Session Poster |
| 15h30-17h15 |
Session 3:
Host - Microbe interactions: a) secretion systems and their substrates |
Modérateur : Craig Roy, Yale University, USA |
| 15h30-15h55 |
Nicholas Cianciotto, North Western University, Chicago, USA
Type II protein secretion, siderophores, and pigment and what they mean for Legionella ecology and pathogenesis |
| 15h55-16h20 |
Joseph Vogel, Washington University, St Louis, USA
The Legionella Dot/Icm type IVB secretion system |
| 16h20-16h45 |
Antje Flieger, Robert Koch Institut, Berlin, Germany
Legionella pneumophila phospholipases and their mode of secretion |
| 16h45-17h00 |
Li Xu Luo, USA
Inhibition of Host Vacuolar H+-ATPase Activity by a Legionella pneumophila effector |
| 17h00-17h15 |
Mariella Lomma, France
Legionella pneumophila infections involve bacterial F-box proteins |
| 17h15-17h45 |
Pause-café |
| 17h45-18h45 |
Session 4: Host - Microbe interactions:
b) metabolism and virulence |
Modérateur : Philippe Glaser, Institut Pasteur |
| 17h45-18h15 |
Paul Hoffman, University of Virginia, Charlottesville, USA
The Legionella pneumophila Developmental Cycle: Role in Survival and Pathogenesis |
| 18h15-18h45 |
Michele Swanson, Michigan University, USA
Legionella pneumophila virulence as a response to starvation |
| 18h45-19h00 |
Yury Belyi, Russia
Cytotoxic glucosyltransferases of Legionella pneumophila |
| 19h15-20h30 |
“Wine and cheese” party |
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Jeudi 15 octobre 2009
| 9h00-10h45 |
Session 5: Immunology and host susceptibility |
Modérateur : Ralph Isberg, Tufts University, Boston, USA |
| 9h00-9h30 |
Tom Hawn, University Washington, Seattle, USA
Genetic variation & the pulmonary innate immune response to Legionella |
| 9h30-9h45 |
Catarina Nogueira, USA
Dendritic cells rapidly undergo apoptosis to limit intracellular replication of Legionella pneumophila |
| 9h45-10h00 |
Tatiana Silveira, Brazil
Pore formation is an Nlrc4/Ipaf inflammasome-dependent host cell response against virulent Legionella species that express flagellin |
| 10h00-10h15 |
Juliane Lippmann, Germany
Type I IFNs mediate innate intracellular defense to Legionella pneumophila |
| 10h15-10h45 |
Pause-café |
| 10h45-12h30 |
Session 6: Microbe - Environment interactions:
a) cell biology, protozoa, biofilms |
Modérateur : Agnes Ullmann, Institut Pasteur |
| 10h45-11h15 |
Michael Steinert, University Braunschweig, Germany
Proteomic and functional characterization of outer membrane vesicles and Legionella-containing phagosomes |
| 11h15-11h45 |
Hubert Hilbi, University of Zürich, Zürich, Switzerland
Signals produced and exploited by Legionella |
| 11h45-12h15 |
Howard A. Shuman, Columbia University, New York, USA
Host determinants of Legionella infection |
| 12h15-12h30 |
Sophie Pécastaings, France
A new method of producing Legionella pneumophila biofilms in a minimal medium |
| 12h30-12h45 |
Rafael A. Garduno, Canada
Mature infectious forms (MIFs) and MIF-pellets as factors in the transmission of Legionnaires' disease |
| 12h45-14h00 |
Déjeuner à l' Institut Pasteur |
| 14h00-15h30 |
Session Poster |
| 15h30-17h15 |
Session 7: Microbe - Environment interactions:
b) detection in natural and artificial reservoirs - survival, persistence |
Modérateur : Yann Héchard, Université de Poitiers, France |
| 15h30-16h00 |
Paola Borella, Modena University, Italy
Risk factors for Legionella contamination and persistence in potential sources of infection |
| 16h00-16h30 |
Shin-ichi Yoshida, Kyushu University, Fukuoka, Japan
Legionella physiology in the environment |
| 16h30-16h45 |
Rinske Valster, Netherlands
Detection of hosts for Legionella pneumophila in freshwater by enrichment of free-living protozoa in a biofilm-batch system |
| 16h45-17h00 |
Sharon G. Berk, USA
Long-term survival of novel amoeba-associated bacteria compared with Legionella pneumophila under conditions of hydration and desiccation |
| 17h00-17h30 |
Pause-café |
| 17h30-18h45 |
Session 8: Legionella prevention and control |
Modérateur : Maria Luisa Ricci, Istituto Superiore di Sanita, Rome, Italy |
| 17h30-18h00 |
Katherine Ricketts, Health Protection Agency, London, UK
Travel associated Legionnaires' disease in Europe 2008: reporting and response |
| 18h00-18h30 |
Janet Stout, Special pathogens Unit, Pittsburg, USA
Legionella and the Conundrum of Low Risk Buildings: A Very Modest Proposal |
| 18h30-18h45 |
John V. Lee, UK
An international trial of quantitative PCR for monitoring Legionella in artificial water systems |
| 19h30 |
Dîner de gala |
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Vendredi 16 octobre 2009
| 8h30-10h15 |
Session 9:
Epidemiology: a) nosocomial infections and Legionella control in hospitals |
Modérateur : Paul H. Edelstein, University of Pennsylvania Medical Center,
Philadelphia, USA |
| 8h30-9h00 |
Loreen Herwaldt, University of Iowa Hospital, USA
Decontamination of Hospital Water Supplies: A Review of the Literature and the University of Iowa's Experience |
| 9h00-9h30 |
Jérôme Etienne, University Lyon, France
Nosocomial infections, Legionella strain characterization and host-related risk factors |
| 9h30-9h45 |
Sebastian Crespi, Spain
Legionellosis Prevention Guidelines: Better, but Not Well |
| 9h45-10h00 |
Claressa Lucas, USA
The impact of monochloramine introduction on Legionella colonization in a hospital potable water system. |
| 10h00-10h15 |
Susanne Surman-Lee, UK
Lessons learnt from investigating hospital-acquired legionellosis and the remedial actions in England. |
| 10h15-10h45 |
Pause-café |
| 10h45-12h30 |
Session 10: Epidemiology:
b) outbreaks and population genetics and taxonomy |
Modérateur : Carmen Pelaz, Instituto de Salud Carlos III, Madrid, Spain |
| 10h45-11h15 |
Antoni Plasencia, Public Health Catalonia, Spain
Managing public health crises: from legionellosis to pandemic influenz |
| 11h15-11h45 |
Rod Ratcliff, Infectious disease laboratories, Adelaide, Australia
Ecological diversity within Legionella |
| 11h45-12h00 |
Mireia Coscollá, Spain
Multiple Legionella strains infection detected by sequence analysis directly from respiratory samples |
| 12h00-12h15 |
Igor S. Tartakovskiy, Russia
From large community outbreak in Verhnaya Pyshma to effective prevention of legionellosis in Russia. |
| 12h15-12h30 |
Joana Costa, Portugal
Molecular evolution of dotA gene in Legionella pneumophila: contribution of natural environmental isolates. |
| 12h30-14h00 |
Déjeuner à l' Institut Pasteur |
| 14h00-15h30 |
Session Poster |
| 15h30-16h45 |
Session 11: Genomics and Comparative genomics |
Modérateur : Howard Shuman, Columbia University, New York, USA |
| 15h30-16h00 |
Carmen Buchrieser, Institut Pasteur, Paris, France
Legionella pneumophila and Legionella longbeachae pathogenesis: new insights gained form comparative and functional genomics |
| 16h00-16h15 |
Brian Shelton, USA
Polymorphic loci in Legionella pneumophila serogroup 1 |
| 16h15-16h30 |
Olga Shevchuk, Germany
Proteomic analysis of a Legionella-containing phagosome in Dictyostelium |
| 16h30-16h45 |
Ivan Moszer, France
Genome re-annotation and web resources for Legionella pneumophila species |
| 16h45-17h15 |
Pause-café |
| 17h15-18h45 |
Session 12: Functional genomics |
Modérateur : Michele Swanson, University of Michigan Medical Center, Ann Arbor, USA |
| 17h15-17h45 |
Elisabeth Hartland, University Melbourne, Australia
Hidden protein treasures revealed in the Legionella genome |
| 17h45-18h00 |
Frank Schuren, Netherlands
Epidemiological genome analysis of a large Dutch Legionella pneumophila strain collection identifies five markers highly correlated with pathogenic strains |
| 18h00-18h15 |
Tamara O'Connor, USA
Solving functional redundancy amongst effectors of the bacterial pathogen, Legionella pneumophila |
| 18h15-18h30 |
Barbara Weissenmayer, Irland
Analysis of the transcriptome of Legionella pneumophila under infection conditions using RNA.seq |
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Samedi 17 octobre 2009
| 9h00-10h15 |
Session 13: Gene regulation in the environment and the host |
Modérateur : François Vandenesch, National Reference Center for Legionella and INSERM U851, Lyon, France |
| 9h00-9h30 |
Klaus Heuner, Robert Koch Institut, Berlin, Germany
The Flagellar Regulon of Legionella pneumophila and the Expression of Virulence Traits |
| 9h30-9h45 |
Tobias Sahr, France
Two small ncRNAs jointly govern virulence and transmission in Legionella pneumophila |
| 9h45-10h00 |
Xavier Charpentier, USA
Parasexual behavior in response to genotoxic stress in Legionella pneumophila |
| 10h00-10h15 |
Prix Alcora |
| 10h15-10h45 |
Pause-café |
| 10h45-12h30 |
Session 14: Cell biology - protozoa - macrophages |
Modérateur: Elizabeth Hartland, University of Melbourne, Melbourne, Australia |
| 10h45-11h15 |
Craig Roy, Yale University, USA
Establishment of a vacuole that supports Legionella pneumophila replication |
| 11h15-11h45 |
Youssef Abu Kwaik, University of Louisville, Buffalo, USA
Exploitation of conserved eukaryotic pathways by L. pneumophila |
| 11h45-12h15 |
Ralph Isberg, Tufts University, Boston, USA
Doubling up as a way to combat resilience |
| 12h15-12h30 |
Conclusions |
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