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SCIENTIFIC PROGRAM
Tuesday, October 13th, 2009
| 10:00 am-4:00 pm |
Ewgli meeting for Ewgli collaborators only, related to business aspects of the EWGLINET network and the transfer of the scheme to ECDC |
| 2:00 pm-5:30 pm |
Registration |
| 5:30 pm-6:00 pm |
Welcome addresses
Tony Pugsley, Senior Executive-Vice President for Scientific Affaire, Institut Pasteur, Paris, France
Carmen Buchrieser, Institut Pasteur, Paris, France |
| 6:00 pm |
Opening Session
Chair: Nicholas P. Cianciotto, Northwestern University Medical School,
Chicago, USA
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Barry Fields, Center of Disease Control, Atlanta, USA
Environmental approaches to the prevention of legionellosis |
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Carol Joseph, Health Protection Agency, London, UK
Legionnaires' disease in Europe 1995 - 2008: Trends and challenges |
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Jörg Hacker, Robert Koch Institut, Berlin, Germany
Legionella. A model organism for Genomics and Cellular Microbiology |
| 7:30 pm |
Welcome Reception at Institut Pasteur |
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Wednesday, October 14th, 2009
| 8:30 am-10:15 am |
Session 1:
Epidemiology and Clinical aspects a) disease, diagnosis and treatment |
Chair: Didier Che, Institut de Veille Sanitaire, Saint-Maurice, France |
| 8:30am-9:00 am |
Miguel Sabria, University of Barcelona, Spain
Clinical aspects of Legionnaires´Disease |
| 9:00 am- 9:30 am |
Paul H Edelstein, University of Pennsylvania, Philadelphia, USA
Antimicrobial therapy for Legionnaires' disease, still in need of improvement |
| 9:30 am-9:45 am |
Maria Luisa Pedro-Botet, Spain
Legionella pneumonia (LP) in immunosuppressed (IS) patients |
| 9:45 am-10:00 am |
Frances Graham, New Zealand
Changing Epidemiologic Trends of Legionellosis in New Zealand, 1979 - 2008 |
| 10:00 am-10:15 am |
Lauri Hicks, USA
Travel-Associated Legionnaires' Disease Surveillance in the United States, 25-28 |
| 10:15 am-10:45 am |
Coffee break |
| 10:45 am-12:30 am |
Session 2:
Clinical aspects b) detection and subtyping |
Chair: Jaana Kusnetsov, National Public Health Institute, Kuopio, Finland |
| 10:45 am-11:15 am |
Christian Lück, University Dresden, Germany
Microbiological diagnostic methods for the detection of Legionella infections |
| 11:15 am-11:45 am |
Timothy G. Harrison, Health Protection Agency, London, UK
Legionella pneumophila DNA sequence-based typing: progress, pitfalls and perspectives. |
| 11:45 am-12:00 am |
Patrick Yang, USA
Evaluation of a fully integrated point-of-testing system for the detection of viable Legionella pneumophila |
| 12:00 am-12:15 am |
Valeria Gaia, Switzerland
MALDI-TOF MS based protein mass fingerprinting: a rapid and reliable method for the identification of Legionella spp. |
| 12:15 am-12:30 am |
Jonas Lundström, Sweden
An improved and rapid sequence-based method for typing of Legionella pneumophila. |
| 12:30 am-2:00 pm |
Lunch at Institut Pasteur |
| 2:00 pm-3:30 pm |
Poster session |
| 3:30 pm-5:15 pm |
Session 3:
Host - Microbe interactions: a) secretion systems and their substrates |
Chair: Craig Roy, Yale University, USA |
| 3:30 pm-3:55 pm |
Nicholas Cianciotto, North Western University, Chicago, USA
Type II protein secretion, siderophores, and pigment and what they mean for Legionella ecology and pathogenesis |
| 3:55 pm-4:20 pm |
Joseph Vogel, Washington University, St Louis, USA
The Legionella Dot/Icm type IVB secretion system |
| 4:20 pm-4:45 pm |
Antje Flieger, Robert Koch Institut, Berlin, Germany
Legionella pneumophila phospholipases and their mode of secretion |
| 4:45 pm-5:00 pm |
Li Xu Luo, USA
Inhibition of Host Vacuolar H+-ATPase Activity by a Legionella pneumophila effector |
| 5:00 pm-5:15 pm |
Mariella Lomma, France
Legionella pneumophila infections involve bacterial F-box proteins |
| 5:15 pm-5:45 pm |
Coffee break |
| 5:45 pm-7:00 pm |
Session 4: Host - Microbe interactions:
b) metabolism and virulence |
Chair: Philippe Glaser, Institut Pasteur |
| 5:45 pm-6:15 pm |
Paul Hoffman, University of Virginia, Charlottesville, USA
The Legionella pneumophila Developmental Cycle: Role in Survival and Pathogenesis |
| 6:15 pm-6:45 pm |
Michele Swanson, Michigan University, USA
Legionella pneumophila virulence as a response to starvation |
| 6:45 pm-7:00 pm |
Yury Belyi, Russia
Cytotoxic glucosyltransferases of Legionella pneumophila |
| 7:00 pm-8:30 pm |
“Wine and cheese” party |
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Thursday, October 15th, 2009
| 8:45 am-10:00 am |
Session 5: Immunology and host susceptibility |
Chair: Ralph Isberg, Tufts University, Boston, USA |
| 8:45 am-9:15 am |
Tom Hawn, University Washington, Seattle, USA
Genetic variation & the pulmonary innate immune response to Legionella |
| 9:15 am-9:30 am |
Catarina Nogueira, USA
Dendritic cells rapidly undergo apoptosis to limit intracellular replication of Legionella pneumophila |
| 9:30 am-9:45 am |
Tatiana Silveira, Brazil
Pore formation is an Nlrc4/Ipaf inflammasome-dependent host cell response against virulent Legionella species that express flagellin |
| 9:45 am-10:00 am |
Juliane Lippmann, Germany
Type I IFNs mediate innate intracellular defense to Legionella pneumophila |
| 10:00 am-10:30 am |
Coffee break |
| 10:30 am-12:30 am |
Session 6: Microbe - Environment interactions:
a) cell biology, protozoa, biofilms |
Chair: Agnes Ullmann, Institut Pasteur |
| 10:30 am-11:00 am |
Michael Steinert, University Braunschweig, Germany
Proteomic and functional characterization of outer membrane vesicles and Legionella-containing phagosomes |
| 11:00 am-11:30 am |
Hubert Hilbi, University of Zürich, Zürich, Switzerland
Signals produced and exploited by Legionella |
| 11:30 am-12:00 am |
Howard A. Shuman, Columbia University, New York, USA
Host determinants of Legionella infection |
| 12:00 am-12:15 am |
Sophie Pécastaings, France
A new method of producing Legionella pneumophila biofilms in a minimal medium |
| 12:15 am-12:30 am |
Rafael A. Garduno, Canada
Mature infectious forms (MIFs) and MIF-pellets as factors in the transmission of Legionnaires' disease |
| 12:30 am-2:00 pm |
Lunch at Institut Pasteur |
| 1:30 pm-3:00 pm |
Poster session |
| 3:00 pm-4:30 pm |
Session 7: Microbe - Environment interactions:
b) detection in natural and artificial reservoirs - survival, persistence |
Chair: Yann Héchard, Université de Poitiers, France |
| 3:00 pm-3:30 pm |
Paola Borella, Modena University, Italy
Risk factors for Legionella contamination and persistence in potential sources of infection |
| 3:30 pm-4:00 pm |
Shin-ichi Yoshida, Kyushu University, Fukuoka, Japan
Legionella physiology in the environment |
| 4:00 pm-4:15 pm |
Rinske Valster, Netherlands
Detection of hosts for Legionella pneumophila in freshwater by enrichment of free-living protozoa in a biofilm-batch system |
| 4:15 pm-4:30 pm |
Sharon G. Berk, USA
Long-term survival of novel amoeba-associated bacteria compared with Legionella pneumophila under conditions of hydration and desiccation |
| 4:30 pm-4:50 pm |
Coffee break |
| 4:50 pm-6:05 pm |
Session 8: Legionella prevention and control |
Chair: Maria Luisa Ricci, Istituto Superiore di Sanita, Rome, Italy |
| 4:50 pm-5:20 pm |
Katherine Ricketts, Health Protection Agency, London, UK
Travel associated Legionnaires' disease in Europe 2008: reporting and response |
| 5:20 pm-5:50 pm |
Janet Stout, Special pathogens Unit, Pittsburg, USA
Legionella and the Conundrum of Low Risk Buildings: A Very Modest Proposal
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| 5:50 pm-6:05 pm |
John V. Lee, UK
An international trial of quantitative PCR for monitoring Legionella in artificial water systems |
| 7:30 pm |
Gala dinner |
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Friday, October 16th, 2009
| 8:30 am-10:15 am |
Session 9:
Epidemiology: a) nosocomial infections and Legionella control in hospitals |
Chair: Paul H. Edelstein, University of Pennsylvania Medical Center,
Philadelphia, USA |
| 8:30 am-9:00 am |
Loreen Herwaldt, University of Iowa Hospital, USA
Decontamination of Hospital Water Supplies: A Review of the Literature and the University of Iowa's Experience |
| 9:00 am-9:30 am |
Jérôme Etienne, University Lyon, France
Nosocomial infections, Legionella strain characterization and host-related risk factors |
| 9:30 am-9:45 am |
Mireia Coscollá, Spain
Multiple Legionella strains infection detected by sequence analysis directly from respiratory samples |
| 9:45 am-10:00 am |
Claressa Lucas, USA
The impact of monochloramine introduction on Legionella colonization in a hospital potable water system. |
| 10:00 am-10:15 am |
Susanne Surman-Lee, UK
Lessons learnt from investigating hospital-acquired legionellosis and the remedial actions in England. |
| 10:15 am-10:45 am |
Coffee break |
| 10:45 am-12:30 pm |
Session 10: Epidemiology:
b) outbreaks and population genetics and taxonomy |
Chair: Carmen Pelaz, Instituto de Salud Carlos III, Madrid, Spain |
| 10:45 am-11:15 am |
Antoni Plasencia, Public Health Catalonia, Spain
Managing public health crises: from legionellosis to pandemic influenz |
| 11:15 am-11:45 am |
Rod Ratcliff, Infectious disease laboratories, Adelaide, Australia
Ecological diversity within Legionella |
| 11:45 am-12:00 am |
Sebastian Crespi, Spain
Legionellosis Prevention Guidelines: Better, but Not Well
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| 12:00 am-12:15 am |
Igor S. Tartakovskiy, Russia
From large community outbreak in Verhnaya Pyshma to effective prevention of legionellosis in Russia. |
| 12:15 am-12:30 am |
Joana Costa, Portugal
Molecular evolution of dotA gene in Legionella pneumophila: contribution of natural environmental isolates. |
| 12:30 am-2:00 pm |
Lunch at Institut Pasteur |
| 2:00 pm-3:30 pm |
Poster Session |
| 3:30 pm-4:45 pm |
Session 11: Genomics and Comparative genomics |
Chair: Howard Shuman, Columbia University, New York, USA |
| 3:30 pm-4:00 pm |
Carmen Buchrieser, Institut Pasteur, Paris, France
Legionella pneumophila and Legionella longbeachae pathogenesis: new insights gained form comparative and functional genomics |
| 4:00 pm-4:15 pm |
Brian Shelton, USA
Polymorphic loci in Legionella pneumophila serogroup 1 |
| 4:15 pm-4:30 pm |
Olga Shevchuk, Germany
Proteomic analysis of a Legionella-containing phagosome in Dictyostelium |
| 4:30 pm-4:45 pm |
Ivan Moszer, France
Genome re-annotation and web resources for Legionella pneumophila species |
| 4:45 pm-5:15 pm |
Coffee break |
| 5:15 pm-6:45 pm |
Session 12: Functional genomics |
Chair: Michele Swanson, University of Michigan Medical Center, Ann Arbor, USA |
| 5:15 pm-5:45 pm |
Elisabeth Hartland, University Melbourne, Australia
Hidden protein treasures revealed in the Legionella genome |
| 5:45 pm-6:00 pm |
Frank Schuren, Netherlands
Epidemiological genome analysis of a large Dutch Legionella pneumophila strain collection identifies five markers highly correlated with pathogenic strains |
| 6:00 pm-6:15 pm |
Tamara O'Connor, USA
Solving functional redundancy amongst effectors of the bacterial pathogen, Legionella pneumophila |
| 6:15 pm-6:30 pm |
Barbara Weissenmayer, Irland
Analysis of the transcriptome of Legionella pneumophila under infection conditions using RNA.seq |
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Saturday, October 17th, 2009
| 9:00 am-10:15 am |
Session 13: Gene regulation in the environment and the host |
Chair: François Vandenesch, National Reference Center for Legionella and INSERM U851, Lyon, France |
| 9:00 am-9:30 am |
Klaus Heuner, Robert Koch Institut, Berlin, Germany
The Flagellar Regulon of Legionella pneumophila and the Expression of Virulence Traits |
| 9:30 am-9:45 am |
Tobias Sahr, France
Two small ncRNAs jointly govern virulence and transmission in Legionella pneumophila |
| 9:45 am-10:00 am |
Xavier Charpentier, USA
Parasexual behavior in response to genotoxic stress in Legionella pneumophila |
| 10:00 am-10:15 am |
Alcora prize |
| 10:15 am-10:45 am |
Coffee break |
| 10:45 am-12:30 am |
Session 14: Cell biology - protozoa - macrophages |
Chair: Elizabeth Hartland, University of Melbourne, Melbourne, Australia |
| 10:45 am-11:15 am |
Craig Roy, Yale University, USA
Establishment of a vacuole that supports Legionella pneumophila replication |
| 11:15 am-11:45 am |
Youssef Abu Kwaik, University of Louisville, Buffalo, USA
Exploitation of conserved eukaryotic pathways by L. pneumophila |
| 11:45 am-12:15 am |
Ralph Isberg, Tufts University, Boston, USA
Doubling up as a way to combat resilience |
| 12:15 am-12:30 pm |
Closing remarks |
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